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Nusantara Medical Science Journal
Published by Universitas Hasanuddin
ISSN : 24609757     EISSN : 25977288     DOI : -
Core Subject : Science,
Materials Science & Nanotechnology Neuroscience
Nusantara Medical Science Journal (NMSJ) is an open access, peer-reviewed journal published by Faculty of Medicine, Hasanuddin University twice a year in June and December. NMSJ encompasses all basic and molecular aspects of medical sciences, with an emphasis on the molecular studies of biomedical problems and molecular mechanisms. Subjects suitable for publication include, but are not limited to the following fields of Cardiovascular; Allergy and immunology; Cancer and stem cells; Endocrinology; Gastroenterology; Tropical and Infectious Disease; and Internal medicine.
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Articles 112 Documents
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Analisis Secara Bakteriologik, Imunoserologik dan Polymerase Chain Reaction terhadap Sampel Pasien Suspek Limfadenitis tuberkulosis Nur Afiah; Mansyur Arief; Mochammad Hatta
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.8442

Abstract

Latar Belakang: Penelitian ini bertujuan menganalisis kemampuan tes imunoserologi, bakteriologi dan sitologi untuk mendeteksi Mycobacterium tuberculosis berdasarkan tes Polymerase Chain Reaction (PCR) pada penderita suspek limfadenitis tuberkulosa. Penelitian dilakukan secara cross sectional pada 35 sampel di RS Dr. Wahidin Sudirohusodo, RSD Labuang Baji, Laboratorium Patologi Anatomi Swasta dan Laboratorium Biologi Molekuler Fakultas Kedokteran Unhas. Ditemukan hasil positif paling banyak berturut-turut pada tes sitologi (80%), tes ICT (68,5%), tes PCR (62,8%), tes apusan basil tahan asam (BTA) (31,5%). Sensitivitas dan spesifisitas tes sitologi (72,3% dan 7,69%), tes ICT (63,64% dan 23,08%), dan tes apusan BTA (22,73% dan 58,85%) terhadap PCR. Sedangkan sensitivitas dan spesifisitas kombinasi tes Mycotec TB dengan BTA (22,73% dan 84,62%), kombinasi tes ICT dengan sitologi (50% dan 30,77%) dan kombinasi tes BTA dengan sitologi (22,73% dan 61,54%). Tes sitologi mempunyai sensitivitas yang paling tinggi terhadap PCR lalu diikuti oleh tes ICT, tes apusan BTA, sedangkan spesifisitasnya paling tinggi pada tes apusan BTA, lalu tes ICT dan tes sitologi. Nilai sensitivitas kombinasi tes ICT dengan sitologi lebih tinggi daripada kombinasi tes ICT dengan BTA dan kombinasi tes BTA dengan tes sitologi BTA yang mempunyai nilai yang sama.    
The Relationship Between Histopathological Grading and Metastasis in Colorectal Carcinoma Patients Rahmawati Minhajat; Andi Fachruddin Benyamin; Upik Andariana Miskad
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.8786

Abstract

Introduction: To Colorectal cancer (CRC) is a malignancy in the large intestine caused by uncontrolled cell growth. The cause of death due to metastasis and the prognosis is determined by the stage that can be assessed using Dukes classification or TNM (Tumor Nodes Metastasis) staging system. Determination of histopathological grading is important because of the differences in radiosensitivity, local behaviour and the metastasis tendency. The aim of this study is to determine the relationship between histopathological grading and metastasis in colorectal cancer patients. Methods:  This study is a cross-sectional study using secondary data from the medical records of CRC patients at the RS. Dr. Wahidin Sudirohusodo and its networking hospital, that were obtained by consecutive sampling. Inclusion criteria are all patients who had surgery and have the results of histopathology, radiology and other datas that may be used as a reference for determining the staging based on the Dukes classification and TNM staging system Results: The number of CRC patients during January 2008 to April 2012 was 268 patients, 55,6% of them were males and mostly their age were around 51-60 years old (25,4%). Most of the CRC location was in the rectum (61,2%) and the highest number of metastasis location was in lymph nodes (40,4%).  Out of 179 patients who had result of histopathological examination, adenocarcinoma type (100%) and moderately differentiated adenocarcinoma (45,3%) were the most frequently histopathological grading found. Most of the CRC stage based on the TNM staging system was stage IV (27,4%) and based on the Dukes classification was stage D (26,8%).   There is a significant relationship (p<0,001) between histopathological grading and metastasis, and it showed that poorly differentiated adenocarcinoma was more frequent in advanced stage, based on both the Dukes classification and TNM staging system. Conclusions: There is a significant relationship between histophological grading and metastasis. Poorly differentiated adenocarcinoma is more likely to be found in advanced stage of CRC.
Perbandingan Remifentanil Kontinu 0.15 Mcg/Kgbb dengan Fentanyl 3 Mcg/Kgbb pada Intubasi Endotrakeal Diukur Menggunakan Pupillometer (AlgiScan®) Fauzan Bachtiar Amin; Alamsyah A.A Husain; Andi Muhammad Takdir Musba; Muh Ramli Ahmad
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.9912

Abstract

Introduction: All opioids have varying levels of sedative effects with increasing dosages, although with different strengths. Therefore, the opioid component as a sedative regiment is usually maintained at minimum dose for adequate analgesic with regard to patient comfort. Along with the progress of knowledge, parameters have been found to measure the level of analgesic and sedative. Methods: The principle of measurement is done by using the diameter of pupil and then analyzed through AlgiScan and compared to certain standards. The using of pupilometers AlgiScan in assessing the level of sedative analgesic will reduce the level of subjectivity and errors in measurement. Results: The use of Remifentanil has a faster effect of sedative as proven by lower “AlgiScan” score in the pre-intubation phase. In addition, the use of Remifentanil also provides a hemodynamic view of lower arterial pressure, both pre and post intubation condition. Conclussion: Both Remifentanil and fentanyl are able to provide analgesic with sedative and stable hemodynamics. Remifentanil is proven to be superior with better and faster effect and also faster substance elimination with lower doses.
Efektivitas Lidokain Intravena Kontinyu Perioperatif Terhadap Intensitas Nyeri Dan Total Konsumsi Opioid Pasca Bedah Dekompresi Dan Stabilisasi Posterior Vertebra Fadli Rachman; Ratnawati R; Andi Muhammad Takdir Musba
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.10154

Abstract

introduction: Intravenous lidocaine had been used as multimodal analgesia strategy in treating acute postoperative pain. This study aimed to examine the effectivity of perioperative intravenous lidocaine infusion on pain intensity and total opioid requirements postoperative. Methods:  This study was  a double blind randomized control trial on ASA physical status I-II, aged 18-60, BMI 18-30 kg/m2 underwent to spine decompression and stabilisation surgery in Wahidin Sudirohusodo general hosputal, Makassar. Results:   The samples were randomly devided into lidocaine group ( n=28) received lidocaine 1,5 mg/kg before intubation, followed by 1,5 mg/kg/hour intraoperative and 1 mg/kg/hour untl 12 hour postoperative, and the control group (n=28) received placebo NaCl 0,9%. The data were analyzed with Chi-square test, independent-t test, and Mann-Whitney test, and considered significant if the p value <0,05. The study result showed that compared to the control group, the pain intensity of lidocaine group were lower in measurement time 6 (p=0,05),12 (p=0,045) and 24 (p=0,031) hour postoperative but not in 2 (p=148) and 4 (p=0,472)  hour postoperative. Total fentanyl consumption 24 hour postoperative  were lower in lidocaine group ( 418,32±146,45 vs 579,86±145,29 ; p=0,000). Conclusions:  This study concluded that administration of intravenous lidocaine infusion perioperative able to reduce pain intensity dan total opioid requirements after spine decompression and stabilisation surgery.
Gambaran Radiologik Pneumonia pada Anak dengan Menggunakan Foto Thorax dan Ultrasonografi Paru di Rumah Sakit Wahidin Sudirohusodo Makassar Jeri J; Sri Asriyani; Amiruddin L; Arifin Seweng
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.11045

Abstract

Pendahuluan Pneumonia menjadi penyebab utama kematian pada anak di bawah usia 5 tahun selama beberapa dekade. Foto X-ray dada adalah modalitas diagnostik yang paling umum digunakan. Namun, karena efek radiasi sinar-X, ultrasonografi menjadi semakin populer untuk diagnosis pneumonia pada anak-anak. Penelitian ini bertujuan untuk membandingkan dan menilai kesesuaian (agreement) antara hasil pemeriksaan x-ray dada dan ultrasonografi untuk diagnosis pneumonia pada anak-anak. Metode: Penelitian ini dilakukan di Bagian Radiologi Rumah Sakit Umum Pusat Dr. Wahidin Sudirohusodo Makassar dan Rumah Sakit Pendidikan Universitas Hasanuddin Makassar dari bulan Februari sampai April 2020. Jumlah sampel sebanyak 44 pasien berusia antara 1 hari sampai kurang dari 18 tahun. Tes Kappa digunakan untuk menilai kesesuaian antara kedua metode. Hasil: Hasil penelitian menunjukkan bahwa gambaran pneumonia pada anak berdasarkan hepatisasi pada USG paru menunjukkan kesesuaian yang signifikan dengan tanda konsolidasi pada foto thorax (koefisien Kappa = 0,560, p <0,05). Elemen hyperechoic linier pada ultrasonografi paru dengan tanda air bronchogram dan infiltrat pada foto toraks juga menunjukkan kesesuaian yang baik (koefisien Kappa = 0,596, p <0,05). Selain itu, tanda lesi anechoic pada ultrasonografi paru dengan gambar ground glass opacity (GGO) pada radiografi dada menghasilkan koefisien Kappa 0,495 dan p <0,05. Kesimpulan: Pneumonia pediatrik dimanifestasikan pada ultrasonografi sebagai hepatisasi, hyperechoic linear elements, dan pathologic B-line, sedangkan pada rontgen dada dimanifestasikan sebagai konsolidasi dan infiltrat. Kesepakatan yang baik ditemukan antara konsolidasi x-ray dengan hepatisasi pada ultrasonografi, antara elemen hyperechoic linier pada ultrasonografi dengan infiltrat pada x-ray, serta antara lesi anechoic pada ultrasonografi dengan GGO pada rontgen dada
Gambaran Ultrasonografi Kelainan Endometrium pada Penderita Kanker Payudara yang Mendapat Terapi Hormonal di Rumah Sakit Wahidin Sudirohusodo Hijriah Thayyib; Mirna Muis; Bachtiar Murtala
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.13408

Abstract

Pendahuluan: Penelitian ini bertujuan untuk menilai gambaran ultrasonografi kelainan endometrium pada penderita kanker payudara yang mendapat terapi hormonal di Rumah Sakit Wahidin Sudirohusodo. Metode:  Penelitian ini dilaksanakan di Rumah Sakit Umum Pemerintah Wahidin Sudirohusodo Makassar mulai bulan Januari sampai bulan Mei 2020. Sampel sebanyak 66 pasien yang telah mendapat terapi hormonal minimal 6 bulan berturut-turut dan dilakukan pemeriksaan ultrasonografi transvaginal. Metode analisis yang dilakukan adalah Uji Chi Square/Uji Fisher dan Uji T Independen. Hasil:   Pada penelitian ini, rentang usia terbanyak pasien kanker payudara adalah antara 41 – 50 tahun. Dari 66 pasien yang diteliti, terdapat 34 pasien yang premenopause dan 32 pasien yang menopause. Terdapat 46 pasien yang mendapat terapi Tamoxifen, 20 pasien yang mendapat terapi Aromatase inhibitor. Kesimpulan: Hasil penelitian menunjukkan tidak terdapat hubungan yang bermakna antara penebalan endometrium pada pemeriksaan ultrasonografi transvaginal dengan pemberian terapi hormonal pada penderita kanker payudara dengan nilai p=0,232. Terdapat hubungan bermakna antara status menstruasi dengan penebalan endometrium pada penderita kanker payudara yang mendapat terapi hormonal dengan nilai p=0,002. Terdapat hubungan bermakna antara Indeks Massa Tubuh (IMT) dengan penebalan endometrium pada penderita kanker payudara yang mendapat terapi hormonal dengan nilai p=0,037. Tidak terdapat hubungan bermakna antara penggunaan kontrasepsi hormonal terhadap penebalan endometrium dengan nilai p=0,946. Tidak terdapat hubungan yang bermakna antara nullipara dengan kejadian penebalan endometrium dengan nilai p=0,256
Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy Nasrawati Basir; Yulia Yusrini Djabir; Arif Santoso
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.13450

Abstract

Introduction:  The first-line regimen for tuberculosis (TB) treatment comprises Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, these drugs are known to potentially cause hepatotoxicity. This study aimed to evaluate hepatotoxicity incidence in patients during intensive phase of anti-tuberculosis treatment focusing on post-incidence therapy. Methods:  The study involved pulmonary TB patients who were admitted to the National Lung Health Center due to hepatotoxicity after receiving fixed-dose combination of antituberculosis drugs (FDC-AT) in September-October 2019. Drug-related hepatotoxicity is defined as an increase in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 2.5 times of the normal upper limit (ULN) with an increase in bilirubin level. Results:  There were 8 patients admitted to the center due to hepatotoxicity, 4 of them experienced grade 3 (severe) hepatotoxicity, during which the ALT, AST, bilirubin levels increased 5-10 times of the ULN. The post-hepatotoxicity treatment includes the cessation of FDC-AT treatment followed by hepatoprotective supplements. Following two weeks of treatments, the biomarker levels of two out of four patients went back to normal and the AT therapy was resumed. Meanwhile, the other two patients continued to receive the hepatoprotective therapy for up to 8 weeks. However, when the treatment failed to bring the transaminase level back to normal, a different AT regimen was prescribed. Conclusions: The cessation of FDC-AT and the use of hepatoprotective supplements for two to eight weeks were able to alleviate the AT-induced severe hepatotoxicity. A close monitoring of liver biomarkers is warranted to prevent the incidence of hepatotoxicity in patients receiving antituberculosis
Pulmonary Tuberculosis CT-Scan Features and Sputum Smear in Tertiary Referral Hospital Nur Amelia Bachtiar; Sri Asriyani; Bachtiar Murtala; Irawaty Djaharuddin; Andi Alfian Zainuddin; Nikmatia Latief
Nusantara Medical Science Journal Volume 5 No. 2 Juli - Desember 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i2.13489

Abstract

Introduction: Management of pulmonary tuberculosis (PTB) from primary and secondary health centers might affect the result of sputum acid-fast bacilli (AFB) smear and features of lung computed tomography scan (CT-scan) presented in tertiary hospitals. The study aims to investigate comparison between CT-scan features of PTB with sputum AFB smear in Wahidin Sudirohusodo Hospital as the top referral hospital in the Eastern part of Indonesia. Methods: This is a retrospective study of patients diagnosed as PTB by pulmonologist of nine months period. Patients with available CT-scan and sputum AFB smear results are included in the study. CT-scan features re-evaluated with RadiAnt DICOM viewer for standardized reading. The relationship between data obtained was analyzed with a chi-square test. Results: Sixty-one PTB patients were entered into the study. The three most common features found in CT were consolidation (93.4%) followed by Tree-in-bud (91.8%), and fibrosis calcification (85.2%). Relationship of CT features and sputum AFB smear was significant on cavity (p-value: 0.002) and pleural effusion (p-value: 0.020). However, unlike cavity (OR = 1.667), pleural effusion has opposite relationship (OR = 0.205) with sputum AFB smear. Conclusions: Pulmonary tuberculosis CT features seen in top referral hospitals can be very severe with consolidation and tree-in-buds as the most common features found in more than 90% of the cases. Feature of cavity may help radiologist to distinct highly active PTB with positive sputum AFB smear while presence of pleural effusion should raise the suspicion from pulmonologists to add further laboratory investigation.
The Potential of Rosuvastatin in Stabilizing Lipid Profile and Improving Clinical Outcomes in Covid-19 Patients with Coronary Heart Disease William Suciangto; Haerani Rasyid; Nada Indira Ramadhani Nasrum; Muhammad Zaki Rahmani
Nusantara Medical Science Journal Volume 6 Issue 1, January - June 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i1.12243

Abstract

Introduction : The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global challenge since December 2019 cause by its severe symptoms and high mortality rate. Some comorbidities are associated with clinical outcomes in COVID-19 patients, one of them is cardiovascular disease, including coronary heart disease (CHD). Statins are popularly used as the lipid controller in CHD patients. Not only controlling the lipid profile, statins also can reduce the inflammation process in COVID-19 patients. This review aims to determine the activity of statins and its potential to improve the clinical manifestation of COVID-19 patients with CHD. Methods : The method used in this paper is to examine and review the literature journal that has been published last 10 years. Results : Recent studies have shown that statins capable to control the lipid, also lowering the LDL cholesterol and increasing the HDL cholesterol. And other trials have shown that statin also have ability to reduce the inflammation and inhibit further cell damage by binding mpro, a protease produced by SARS-COV2. Conclusions:  Based on those studies, we conclude that statins have the potential effect as adjuvant therapy for clinical improvement in COVID-19 patients with CHD.
Characteristics of Pain Based on Numerical Rating Scale in Maxillofacial Trauma Patients Treated with Open Reduction Internal Fixation Yohanes Yoppy Purnomo; Endang Sjamsudin; Eka Marwansyah Oli'i
Nusantara Medical Science Journal Volume 6 Issue 1, January - June 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i1.13855

Abstract

Introduction: Open Reduction Internal Fixation (ORIF) is one of the maxillofacial bone fracture treatment procedures. Post-surgical pain is generally assessed by Numerical Rating Scale (NRS). Objective: To obtain information about pain characteristics in post-ORIF patients based on NRS. Methods: This study is an observational study with a retrospective descriptive approach. The research was conducted at Hasan Sadikin General Hospital (RSHS) Bandung in January 2018 - December 2019 based on medical record data. The data collected included age, gender, fracture area, diagnosis, duration of surgery, number of plates and screws, pre-surgical and post-surgical pain based on NRS, pain intensity measured every 8 hours postoperatively for 24 hours. Results: In this study, 65 medical records were obtained. The most frequent characteristics of the subjects were young adults aged 17-30 years (56.92%) and males (86.15%). The most frequent fracture locations were the mandible area (48.67%) and the most frequently performed surgery was at the mandibular area (60.46%). Regarding the duration of the surgery, most of the surgeries lasted for 61-120 minutes (32.30%) with the most used plates were plates (1-10 holes) and plates (11-20) holes, both having the same percentage (38.46%), and the most frequently used screw was screw (1-10) (49.23%). The most frequently used analgesics was Ketorolac (87.69%) and The NRS pain scale for ORIF was a mild type of surgery with an NRS scale of 1-3. The mean of pre-ORIF surgery patients showed a mild pain intensity with a percentage of 92.30% and postoperatively resulted in mild pain with a percentage of 95.38%. Conclusion: Characteristics of pain based on NRS in maxillofacial trauma patients treated with ORIF indicate mild pain and could be the result of the influence of analgesic drugs or subjective assessments, therefore, further research is needed to obtain a more precise assessment of the pain.

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