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INDONESIA
Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 392 Documents
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Correlation Between Pharyngeal Residue With Food Consistency In Neurogenic Dysphagia Patients Using FEES At RSMH Palembang Puspa Zuleika; Apriandini Mirdasari Putri; Erial Bahar
Biomedical Journal of Indonesia Vol. 8 No. 2 (2022): Vol 8, No 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i2.140

Abstract

Introduction. Disorders of swallowing process starting from preparation and bolus transportation called dysphagia. Supporting examination for dysphagia is Fiberoptic Endoscopic Examination of Swallowing (FEES). Aims to determine correlation between pharyngeal residues and food consistency in neurogenic dysphagia patients. Methods. Observational study using cross-sectional design. Data was collected from medical records of 32 patients with neurological disorders complaints swallowing who underwent FEES examination at RSMH January 2021 to July 2022. Statistical analysis using SPSS 24.0. Results. Participants was 32 patients with neurogenic dysphagia with the most male sex, 19 patients (59.4%), the most age group ≥  60 years, 17 patients (53.1%). 18 patients had comorbidities (59.4%) with the highest number hypertension 15 patients (50%). Highest leakage in water group with 9 (37.5%) out of 24 experiments while in the filtered porridge group 12 (37.5%) out of 32 experiments. Highest penetration occurred in water 41.7% and filtered porridge 40.9%. Highest aspiration in filtered porridge was 34.4%. Somers’ d correlation test obtained p value 0.028, there was significant correlation between types of food and degree of residual valleculas, and the strength was very weak (ra value: 0.138). The piriform sinus region, obtained p value 0.014, there was significant correlation between type of food and degree of residual piriform sinus and the value of the strength also very weak (ra 0.153). Conclusion. There is significant correlation between types of food and degree of residual valleculas and piriform sinuses. As food resistance increases, the residual degree of valleculas and piriform sinuses will also increase.
In-silico Analysis Of Maricaffeoylide From Avicennia Marina Using Molecular Docking With Tumor Necrosis Factor Receptor Lulu Setiyabudi; Nila Fadila Ulya; Septiana Indratmoko; Mika Tri Kumala Swandari
Biomedical Journal of Indonesia Vol. 8 No. 1 (2022): Vol 8, No 1, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i1.141

Abstract

Introduction. Bioactive metabolites was isolated from Avicennia marina fruit belongs to a new caffeoyl derivative, maricaffeoylide. It was a class of phenolic compounds such as caffeic acid which had potential as anticancer, anti-inflammatory, and antioxidant activity. One of proinflammatory cytokine that play a role in regulating immune cells against cancer is TNF-α. In-silico analysis is often used to molecular docking. It was carried out to determine the interaction molecule between bioactive compound and receptor. The purpose of this study is to analysed of interaction maricaffeoylide and TNF-α receptor using molecular docking. In this study, molecular docking will be carried out to determine the interaction and affinity of the bond energy. Methods. The method used in this research is experimental which is carried out in silico using molecular docking. Maricaffeoylide was prepared by using Marvin Sketch and TNF-α receptor was downloaded from pdb. Molecular docking was carried out ligand and receptor preparation, validation, molecular tethering using Pyrx-Autodock Vina, and visualization by BIOVIA. Result. The result of the conformation of the maricaffeoylide has an energy of 69.77 kcal/mol. The gridbox is adjusted at center coordinates x = 14.85; y = -6.50; and z = -6.70 and at dimensions x = 31, y = 35, and z = 63 Ǻ. The Lipinski’s rule for drug-likeness was confirmed. Conclusion. Molecular docking of maricaffeoylide against TNF-α receptors was successfully performed with a docking score of -6.1 kcal/mol involving the interaction van der Waals, hydrogen, alkyl, and carbon hydrogen.
Mother’s Knowledge And Attitude Towards VIA Test For Early Detection Of Cervical Cancer At Puskesmas 5 Ilir Palembang Naufal Fikri Ismail; Rizal Sanif; Hadrians Kesuma Putera
Biomedical Journal of Indonesia Vol. 8 No. 2 (2022): Vol 8, No 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i2.145

Abstract

Introduction. Cervical cancer ranks among the leading causes of death in women worldwide. In Indonesia, the incidence of cervical cancer is particularly high and is expected to rise further in the future. However, a lack of knowledge and fear of the VIA test may be to blame for low screening uptake. This study was conducted to learn about mother's knowledge and attitude toward the VIA test at Puskesmas 5 Ilir Palembang. Methods. This study using descriptive method with cross-sectional design. The total sample size of people who met both inclusion and exclusion criteria is 94. Sociodemographic information, such as education, age, and employment status, is gathered through questionnaires. Results. The results of a study comparing mothers' knowledge and attitudes toward the IVA test by gender with different levels of education found that mothers' knowledge and attitudes were distributed more evenly among those with higher levels of education. Distribution of mothers' knowledge and attitudes toward the VIA test by age, those between the ages of 35 and 44 reported having low knowledge (17%) and low attitude (20%). Based on the distribution of mothers' knowledge and attitudes about the VIA test by occupation, it showed that homemakers fared worse, with fewer than 32 people possessing the necessary level of knowledge and only 28 mothers displaying the necessary level of attitude. Conclusion. Respondents between the ages of 35 and 44 with a secondary school education and a job as a mother in the home have a lower-than-average distribution of knowledge and values.
Characteristics Of Stress Urinary Incontinence (SUI) Patients In Dr. Mohammad Hoesin General Hospital On 2019 To 2021 Raisa Sabila; Hadrians Kesuma Putra; Rara Inggarsih
Biomedical Journal of Indonesia Vol. 8 No. 2 (2022): Vol 8, No 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i2.150

Abstract

Introduction. Stress urinary incontinence (SUI) is a condition where urine comes out accidentally due to intraabdominal pressure increase when sneezing, coughing, laughing, or weightlifting. SUI often occurs in women and has a negative impact on quality of life. However, not many patients visit the hospital for treatment. This research aims to describe the characteristics of SUI patients in Dr. Mohammad Hoesin General Hospital 2019-2021. Methods. This research is a descriptive observational study with a cross-sectional approach using patient’s medical records in Dr. Mohammad Hoesin General Hospital 2019-2021. The sample in this study are 15 samples taken by total sampling. Results. This study found that SUI was common in patients aged 41-60 years (66,7%). The majority of patients were multiparous (93,3%) and had experienced menopause (86,7%). Most of the patients gave birth spontaneously (80,0%), were obese (53,3%), had a duration of the second stage labor >1 hour (60,0%), had given birth to a baby with birth weight ≥3.000 g (80,0%), and has had an episiotomy (73,3%). The majority of SUI patients had no history of neurological disorders (93,3%). Every SUI patients were treated with anterior colporrhaphy (100,0%). Conclusion. SUI often occurs in patients aged 41-60 years, multiparous, menopausal, obese in BMI, has a history of  >1 hour second stage labor, has given birth to a baby with a birth weight ≥3.000 g, and has had an episiotomy. SUI patients at Dr. Mohammad Hoesin General Hospital were treated with anterior colporrhaphy.
Neuroprotective Effect Of Angiotensin Receptor Blocker Syarinta Adenina; Nita Parisa; Rulan Adnindya
Biomedical Journal of Indonesia Vol. 8 No. 2 (2022): Vol 8, No 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i2.152

Abstract

Angiotensin Receptor Blocker, ARB, is a drug that acts on the AT1 receptor so as to inhibit Ang II stimulation. Ang II stimulates the main activity of the angiotensin renin system. Recent research has shown the presence of components of the RAS system in the brain, and the neuroprotective effects of the brain. ARB drugs can enter the brain and protect the blood brain flow, maintain the function of the blood brain barrier and reduce cerebral hemorrhage. The neuroprotective effect of ARB not only arises from improved cerebrovascular blood flow (improved access to oxygen and nutrients) but also decreased factors that can cause brain injury, including decreased excitotoxicity of glutamate which causes inflammatory response and apoptosis, decreased inflammatory response of interleukin-1β and bacterial endotoxin. In addition, there are additional effects through the PPARγ activation mechanism. Based on these benefits ARBs can be developed for the purpose of treating various brain disorders, in this case improving cognitive function, such as vascular dementia, Alzheimer's disease, Parkinson's disease, traumatic brain injury, stroke, and others.
Carbohydrate Intake Of Medical Students And Its Relation To Waist Circumference And Blood Pressure Irinne Karina Putri; Ardesy Melizah Kurniati; Swanny Swanny; Liniyanti D. Oswari; Veny Larasaty; Syarinta Adenina
Biomedical Journal of Indonesia Vol. 8 No. 2 (2022): Vol 8, No 2, 2022
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/BJI.v8i2.153

Abstract

Introduction. Metabolic syndrome is the constellation of metabolic abnormalities that are associated with an increased risk of cardiovascular disease and diabetes melitus. The prevalence of metabolic syndrome in younger people is increasing along with the increased prevalence of obesity. Waist circumference and blood pressure measurement are simple examinations for early detection of metabolic syndrome. Excessive consumption of carbohydrates is one of the factors that cause health problems. But the data of these measurements and food records of medical students in Universitas Sriwijaya were not documented yet. Methods. This study was an observational analytic cross-sectional study with proportionate stratified random sampling. This study used primary data from forms, questionnaires, food records, and physical examinations collected from 275 medical students. The data were analyzed with an independent t-Test for normally distributed data or with Mann Whitney for not normally distributed data. Results. There was a significant relationship between carbohydrate intake and waist circumference (p-value = 0,048) but no relationship between carbohydrate intake and blood pressure (p-value for systolic blood pressure = 0,720 and diastolic blood pressure = 0,847). Conclusion. These findings show an association between carbohydrate intake and waist circumference, but no association between carbohydrate intake and blood pressure (systolic and diastolic blood pressure).
Mucinous Tumors of the Ovary: Current Diagnosis in Histopathological Perspective Florinda Ilona; Dyah Ayu Woro; Reza Aditya Digambiro
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.163

Abstract

Epithelial malignant tumors account for around 90% of all ovarian malignancies and are the most deadly gynecological malignancies and mucinous borderline ovarian tumors are the most common cases in Asia. According to World Health Organization (WHO) 2020, mucinous ovarian tumors are divided into mucinous cystadenoma, borderline mucinous tumor and mucinous carcinoma. Histopathological features of benign, borderline and invasive mucinous carcinoma can be found together in one tumor. The coexixtence of these varied morphological features makes it difficult to establish a diagnosis due to the limited section evaluated and the large size of tumor. It can contribute to inaccurate diagnosis due to heterogeneity of the morphological features. Metastatic mucinous tumors which often resemble primary mucinous tumors in the ovaries.
Genetics of Familial Hypercholesterolemia Ziske Maritska; Aditya Rafrenda; Amirah Adillah; Balqis Wulandari; Endah Rahmadani; Ernes Putra Gunawan; Khumaisiyah Khumaisiyah; Nur Rakhman Pratama; Trizky Nataza Putra
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.166

Abstract

Cholesterol is a necessary component of numerous physiologic processes that must be strictly regulated. Multiple genetic disorders, such as Familial Hypercholesterolemia, frequently induce dysfunctional cholesterol metabolism. Familial hypercholesterolemia (FH) is a frequent hereditary autosomal co-dominant marked by disarray by increased plasma amounts of low-density lipoprotein (LDL) cholesterol and premature cardiovascular disease. Familial Hypercholesterolemia (FH) is increasing but often remains underdiagnosed. This review aims to outline existing information on Familial Hypercholesterolemia with a focus on genetics, diagnostic strategies, treatments, and guidelines for management.
Potency of Pulai (Alstonia Scholaris) As an Immunostimulant Antania Phelia Zen; Soilia Fertilita
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.167

Abstract

South Sumatera is one of provinces in Indonesia with broad peat soil ecosystem. Pulai or Alstonia scholaris is an evergreen plant commonly grow in peat soil ecosystem dan can be found in numerous areas in South Sumatera. Pulai has been globally used as traditional medicine to treat various kinds of disease ranging from gastrointestinal disorder, skin diseases, to anti-cancer. Therefore, researchers have been intrigued to analyze pharmacological aspect of Pulai. Several prior studies have found a large number of compounds within Pulai and a handful of them have been proved to function as anti-oxidant, anti-inflammation, anti-malaria, and even as immunomodulator. The present article is aimed to give preferences around the potential of Pulai or Alstonia scholaris as immunostimulant.
The Role of Probiotics as An Adjuvant Therapy for Sepsis Against Multidrug-Resistant Bacteria Ruhsyahadati Ajisman; Rinita Amelia; Rahma Triyana; Roland Helmizar; Sri Nani Jelmila; Nana Liana; Dian Puspita; Letvi Mona
Biomedical Journal of Indonesia Vol. 9 No. 3 (2023): Vol 9, No 3, 2023
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v9i3.170

Abstract

The role of probiotics on sepsis, particularly when induced by multidrug-resistant (MDR) bacteria, is mediated through complex biochemical pathways. Probiotics demonstrate a capacity to effectively combat infections and reduce mortality rates in sepsis cases. A significant contributor to this efficacy is attributed to the short-chain fatty acids (SCFAs) produced by these probiotics. SCFAs play a critical role in modulating the immune system, primarily by influencing the production of inflammatory cytokines, fortifying the integrity of intestinal epithelium, preventing cellular apoptosis, and maintaining the balance of gut microbiota. Moreover, probiotics are instrumental in counteracting the detrimental impacts of excessive antibiotic use, which is a major contributing factor to the emergence of MDR bacterial strains. The integration of probiotics with conventional therapeutic approaches offers a viable and potentially effective strategy in the management of sepsis caused by MDR bacteria, suggesting a promising direction for future clinical interventions.

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