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Padjadjaran Journal of Dentistry
Published by Universitas Padjadjaran
ISSN : 19790201     EISSN : 25496212     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Padjadjaran Journal of Dentistry or known as PJD, is an English-language scientific periodicals published by the Faculty of Dentistry Universitas Padjadjaran thrice a year on every March, July and November. The submission process of manuscript is open throughout the year. All submitted manuscripts will go through the double-blind peer review and editorial review before being granted with acceptance for publication. Designed as a medium of information and scientific knowledge, Padjadjaran Journal of Dentistry publishes numerous research articles, in the area of Oral Biology, Dental Material Science and Technology, Oral and Maxillofacial Surgery, Pedodontics, Dental Public Health and Community Dentistry, Conservative Dentistry, Periodontics, Prosthodontics, Orthodontics, Oral Medicine, Dental Radiology, as well as with their development through interdisciplinary and multidisciplinary approach. Initially published as Padjadjaran Journal of Dentistry (PJD) magazine ISSN 1979-0201(print) on 2007 in form of printed issues. In 2017, the magazine had its online published version under the same with ISSN 2549-6212 (online) in accordance with the policy of LIPI. Padjadjaran Journal of Dentistry has been using Open Journal System requiring all writers to register in advance before they are allowed to upload the manuscript they write online. Afterwards, the editors, peer reviewers, and writers can monitor the manuscript processing. Several other changes are informed in the Journal History.
Arjuna Subject : -
Articles 1,022 Documents
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Antibacterial activity of mangosteen (garcinia mangostana linn.) leaf ethanol extract against oral pathogenic bacteria: a laboratory experimental study Rahmawati, Dicha Yuliadewi; Arron, Yabest; Bitik, Alexander; Hadinata, Michael; Naliani, Silvia; Aiumdee, Prashyaneeyasak; Sugiaman, Vinna Kurniawati
Padjadjaran Journal of Dentistry Vol 38, No 1 (2026): March 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no1.67633

Abstract

Introduction: Nature-based medicines are multi-component agents that work in a multi-targeted manner with minimal side effects. Mangosteen leaves (Garcinia mangostana L.) contain flavonoids, tannins, and saponins that serve as antibacterial agents. This research aimed to analyze alternative agents to chlorhexidine mouthwash derived from natural ingredients. Methods: This laboratory experimental study observed the inhibition zone diameters of mangosteen leaf ethanol extract at concentrations ranging from 3.125% to 100% against P. gingivalis, A. actinomycetemcomitans, and S. sanguinis using the disc diffusion method. One-Way ANOVA followed by Tukey HSD tests were used to analyze the statistical differences among the bacterial groups across all concentrations. Results: The 100% concentration exhibited the largest inhibitory zones: 14.78 ± 0.60 mm for P. gingivalis, 11.08 ± 0.02 mm for A. actinomycetemcomitans, and 10.55 ± 0.48 mm for S. sanguinis. One-Way ANOVA and Tukey HSD tests showed a p-value of 0.000, indicating a significant antibacterial effect against P. gingivalis, A. actinomycetemcomitans, and S. sanguinis. Conclusion: Ethanol extract of mangosteen leaves (Garcinia mangostana L.) exhibits significant antibacterial activity, with the highest inhibitory effect observed at a 100% concentration.
Multi-target potential of moringa oleifera-derived compounds against cariogenic and endodontic virulence proteins revealed by molecular docking: an in silico experimental study Amin, Meiny Faudah; Kurnia, Dikdik; Ariwibowo, Taufiq; Hardi, Dicky
Padjadjaran Journal of Dentistry Vol 38, No 1 (2026): March 2026
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol38no1.65729

Abstract

Introduction: Dental infections are multifactorial diseases involving bacterial biofilms and host immune responses. Natural compounds with antibacterial activity, such as Moringa oleifera, have been explored as alternatives to conventional antibiotics.  This study aimed to evaluate the interaction profiles of four Moringa oleifera–derived compounds against multiple virulence-associated proteins of cariogenic and endodontic pathogens using in silico molecular docking. Methods: This study was an in silico experimental study using molecular docking simulations to evaluate the binding energy of four M. oleifera-derived compounds (eugenol, trans-anethole, arachidonic acid, and phytosphingosine) with five key virulence-associated proteins of cariogenic and endodontic pathogens (Cystalysin, SrpA, FimA, RadD, and Ddl). AutoDock 4.0 was used for the docking simulations. Docking results were analyzed based on binding energy (ΔG) and inhibition constant (Ki) values. The best binding conformations were selected according to the lowest binding energy and visualized to identify key ligand–protein interactions using Discovery Studio Visualizer. Results: The phytosphingosine-Ddl exhibited the lowest binding energy of -7.42 kcal/mol, followed by eugenol with three different receptors (Cystalysin, SrpA, and FimA) and arachidonic acid-RadD. The lowest inhibition constant was shown by the phytosphingosine-Ddl complex at 3.61 µM. Each compound interacted with various targets, but phytosphingosine exhibited the most consistent and widespread predicted binding via hydrogen bonds with Glu222, Arg291, Glu306, Asp293, Lys251, and hydrophobic interactions of Phe295, Phe245, Phe175, and Leu145. Conclusion: This in silico molecular docking study demonstrated that Moringa oleifera–derived compounds, particularly phytosphingosine, exhibit strong binding affinity toward key virulence-associated proteins of cariogenic and endodontic pathogens. These findings highlight the potential of M. oleifera as a natural source of antibacterial agents and support further experimental validation of its therapeutic applications in oral infections.

Page 103 of 103 | Total Record : 1022

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