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All Journal Medical Journal of Indonesia Indonesian Journal of Cardiology Heart Science Journal Cardiovascular and Cardiometabolic Journal (CCJ) Narra J Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Hasan, Harris
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Relationship Between Neutrophil-to-Lymphocyte Ratio and High-Density Lipoprotein with Major Cardiovascular Events in Acute Myocardial Infarction with ST-Segment Elevation Undergoing Primary Percutaneous Coronary Intervention at Adam Malik Hospital, Medan Adam, Faisal; Hasan, Harris; Haykal, T. Bob
Journal of Society Medicine Vol. 4 No. 8 (2025): August
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v4i8.231

Abstract

Introduction: Coronary artery calcium score (CACS) is a specific indicator of coronary atherosclerosis that plays a role in assessing the degree of calcification in atherosclerosis. Diastolic function is the first aspect of cardiac function to be impaired in ischemic heart disease. This study aims to determine the relationship between calcium scoring and diastolic dysfunction. Methods: This analytical observational study with cross-sectional design evaluated the relationship between coronary artery calcium score (CACS) and left ventricular diastolic function in patients with stable CAD. Data were collected retrospectively from medical records at RSUP H. Adam Malik Medan during Nov 2023-Nov 2024. CACS was assessed using coronary CT scan, while left ventricular diastolic function was measured by echocardiography. Data analysis used chi-square test, Mann-Whitney U test, and ROC curve analysis to evaluate CACS threshold in predicting diastolic dysfunction. Results: Among 158 analyzed samples, 113 patients had diastolic dysfunction. A calcium score ≥100 was found in 46.2% of patients, showing 1.318 times higher risk of diastolic dysfunction versus those with scores <100 (p = 0.006; 95% CI 1.083–1.605). ROC analysis showed CACS had moderate predictive ability for diastolic dysfunction with AUC of 0.647 (p = 0.004). A calcium score threshold of 45 had 65.5% sensitivity and 62.2% specificity in detecting diastolic dysfunction. Type 2 diabetes mellitus, urea, and creatinine levels were also significantly associated with diastolic dysfunction (p < 0.05). Conclusion: Calcium score shows a significant relationship with diastolic dysfunction in stable CAD patients and can predict diastolic dysfunction in patients undergoing coronary CT scan.
Incidence of Bleeding Complications in Acute ST-Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention Ferhat, Muhammad; Lubis, Anggia Chairuddin; Safri, Zainal; Mukhtar, Zulfikri; Hasan, Harris; Haykal, Teuku Bob; Siregar, Yasmine Fitrina; Andra, Cut Aryfa
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 3 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i3.21143

Abstract

Background: This study aims to comprehensively describe the incidence, types, and associated risk factors of bleeding complications in patients with ST-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI), addressing a critical gap in the literature given the global burden of cardiovascular disease and the inherent bleeding risks of contemporary antithrombotic therapies. Methode: This retrospective cross-sectional study will investigate the incidence and types of bleeding complications, along with associated risk factors, in ST-elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PPCI) at Adam Malik Hospital Medan, analyzing data from May 2022 to December 2024 through ethical review and statistical analysis using SPSS version 23. Result: Of 245 STEMI patients undergoing primary PCI, 42.9% experienced bleeding, predominantly minor (BARC 1 and 2, 94.2% combined), with significant associations observed between bleeding and lower hemoglobin, higher leukocyte and creatinine levels, higher TIMI score, Killip class 3 and 4, diabetes, use of maintenance heparin, and increased mortality (84.6% of all deaths occurred in bleeding patients), while hematuria and puncture site hematoma were the most common bleeding sources. Conclusion: This study found that 42.9% of 245 STEMI patients undergoing primary PCI experienced bleeding complications, predominantly minor (94.2%), with an average age of 55.22 years and a male majority. Keyword: Bleeding complications, Acute Coronary Syndrome (ACS), ST-Elevation Myocardial Infarction (STEMI), Primary Percutaneous Coronary Intervention (PPCI)
PEACH Score Validation of Postoperative In-Hospital Mortality in Adult Congenital Heart Disease Patients at Haji Adam Malik General Hospital Medan Zebua, Juang Idaman; Nasution, Ali Nafiah; Ketaren, Andre Pasha; Hasan, Harris; Akbar, Nizam Zikri
Jurnal Kardiologi Indonesia Vol 46 No 4 (2025): October - December, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.2016

Abstract

In “PEACH Score Validation of Postoperative In-Hospital Mortality in Adult Congenital Heart Disease Patients at Haji Adam Malik General Hospital Medan” (Indonesian Journal of Cardiology, 44(2), 61-7. https://doi.org/10.30701/ijc.1546), there is an error noted. An error has been found in the PDF version of this article. The DOI printed in the PDF is incorrect. The correct DOI is https://doi.org/10.30701/ijc.1546. The error occurs only in the PDF; the DOI listed in the article metadata is already correct.The publisher apologizes for any inconvenience caused by this error.DOI of original article: https://doi.org/10.30701/ijc.1546
Association between atherogenic index of plasma and coronary lesion severity in NSTEMI patients Nasution, Umi Hazzar; Sitepu , Andika; Haykal, Teuku Bob; Siregar, Yasmine; Lubis, Hilfan Ade Putra; Ketaren, Andre Pasha; Hasan, Harris
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.13

Abstract

Background: Early identification of the severity of coronary lesions is very important to determine the appropriate management strategy, especially in patients with non-ST-elevation myocardial infarction (NSTEMI). Objective: This study aimed to determine the relationship between the Atherogenic Index of Plasma (AIP) and the severity of coronary lesions in NSTEMI patients. Methods: This study was an analytical observational cross-sectional design conducted at Haji Adam Malik Hospital, Medan, in 2023. Data were collected from medical records of NSTEMI patients and coronary angiography results. Statistical analysis was performed to assess the relationship between AIP and the severity of coronary lesions, including bivariate tests and multivariate logistic regression. Result: A total of 101 NSTEMI patients were included in this study. AIP values were significantly higher in patients with moderate to severe coronary lesions compared to those with mild lesions. An AIP ≥ 0.434 showed a sensitivity of 64.1% and specificity of 67.6% in predicting moderate to severe lesions. Multivariate analysis showed that AIP was the strongest independent predictor of coronary lesion severity, along with age, diabetes mellitus, and ejection fraction. Conclusion: AIP is significantly associated with the severity of coronary lesions in NSTEMI patients and can be used as a simple yet effective risk indicator.
Risk Factor–Weighted Clinical Probability for Predicting Obstructive Coronary Artery Disease in Patients Presenting with Unstable Angina Batubara , Gio Justisia; Hasan , Refli; Nasution , Ali Nafiah; Hasan, Harris; Lubis, Anggia Chairuddin; Andra, Cut Aryfa
Journal of Society Medicine Vol. 5 No. 3 (2026): March
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71197/jsocmed.v5i3.271

Abstract

Introduction: Determining the optimal invasive strategy for patients with unstable angina remains challenging, often resulting in unnecessary coronary angiography. Existing risk scores, including the GRACE and TIMI scores, were not designed to predict obstructive coronary artery disease. This study evaluated the predictive performance of a risk factor–weighted clinical likelihood model. Methods: This retrospective analytical cohort study included 150 patients with low-to intermediate-risk unstable angina who underwent coronary angiography at a tertiary hospital. Predictive accuracy was assessed using receiver operating characteristic analysis and compared with the Diamond Forrester, Fladseth, guideline-based criteria, GRACE, and TIMI scores. Obstructive disease was defined as significant stenosis or physiologically relevant lesions. Results: The prevalence of obstructive coronary disease was 60%. The model demonstrated superior discrimination, with an area under the curve of 0.885, which exceeded that of the comparator models. At a threshold score, 42.7% of angiographies were safely deferred, with a negative predictive value of 76.6%. Calibration improved after model adjustment. Conclusion: The risk factor–weighted clinical likelihood model provides a robust prediction of obstructive coronary artery disease in patients with unstable angina. This may support objective decision-making and enable a more selective invasive strategy, thereby reducing unnecessary procedures while maintaining diagnostic safety.
Tp-e/QTc ratio as a potential non-invasive marker of coronary lesion severity assessed by SYNTAX score in non-ST segment elevation myocardial infarction Ginting, Yehezkiel Bastanta; Sitepu, Andika; Ketaren, Andre Pasha; Hasan, Harris; Lubis, Anggia Chairuddin; Haykal, Teuku Bob; Ginting, Daniel
Heart Science Journal Vol. 7 No. 3 (2026): Predicting Restenosis in Coronary Artery Disease
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.03.8

Abstract

Background: Accurate assessment of coronary lesion burden in the initial stage is the basis for appropriate therapy in NSTEMI patients. As a parameter derived from the ECG that reflects ventricular repolarization variability, the Tp-e/QTc ratio is suggested as a noninvasive predictor for assessing anatomical complexity. Objective: Investigating the relationship of Tp-e/QTc with the severity of coronary lesions on angiography assessed using the SYNTAX score, in patients with NSTEMI. Methods: Utilized a retrospective cohort approach with a cross-sectional design. In total, 141 patients were selected by utilizing purposive sampling. The Tp-e and QTc intervals were manually measured from 12-lead ECGs using the tangent method, and the Tp-e/QTc ratio was calculated. SYNTAX scores were independently determined by two interventional cardiologists. Data were analyzed using bivariate and multivariate analyses. Result: Higher SYNTAX group (0.26 ± 0.047) had higher Tp-e/QTc than lower SYNTAX group (0.21 ± 0.052). Tp-e/QTc showed a positive correlation with SYNTAX score (r = 0.395; p < 0.001) and remained an independent predictor (β = 0.332; p = 0.001). The ROC curve displayed strong discrimination (AUC = 0.817), a cut-off of 0.24 yielded 82.7% sensitivity and 76.4% specificity. Conclusion: Tp-e/QTc is associated with angiographic complexity in NSTEMI and may support early risk stratification prior to angiography.
Co-Authors Akbar, Nizam Zikri Ambari, Ade Meidian Anandini, Hesti Andra, Cut A. Andra, Cut Aryfa Anggoro Budi Hartopo Anggraeni, Vita Yanti Ardini, Tengku Winda Arityanti, Dean Badai Bhatara Tiksnadi Batubara , Gio Justisia Chan, Muhammad Ikhsan Cholid Tri Tjahjono Dangana, Amos Daniel Ginting Desandri, Dwita Rian Dwiputra, Bambang Erwan, Nabila Erina Faisal Adam, Faisal Febrianora, Mega Ferhat, Muhammad Fitra, Maha Ginting, Yehezkiel Bastanta Hasan, Refli Hashmi, T. Rifqi Haykal, T. Bob Hergaf, Indah Widyasari Ilyas, Kamal Kharrazi Irsad Andi Arso, Irsad Andi Kesumawardani, Enggar Sari Ketaren, Andre Pasha Khaidirman, Sophia K. Khairunnisah, Dina Krevani, Citra Kiki Lubis, Anggia Chairuddin Lubis, Hilfan Ade Putra Lubis, Hilfan AP. Makes, Indira Kalyana Muhammad Ridwan Mukhtar, Zulfikri Nasution , Ali Nafiah Nasution, Ali Nafiah Nasution, Umi Hazzar Putra, Muhammad Hafiz Mahruzza Qhabibi, Faqrizal Ria Ramzi, Defriyan Raynaldo, Abdul Halim Reynaldo, Abdul Halim Rita Hamdani Safri, Zainal Sarastri, Yuke Sinaga, Akbar Siregar, Yasmine Sitepu , Andika Sitepu, Andika Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Teuku Bob Haykal Yasmine Fitrina Siregar Zebua, Juang Idaman