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Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.

Hubungan Kadar D-Dimer Dan Jenis Histopatologi Kanker Paru Karsinoma Bukan Sel Kecil Terhadap Respons Kemoterapi Berdasarkan Recist 1.1 Firdaus, Elman Dani; Infianto, Andreas; Windarti, Indri; Soemarwoto, Retno Ariza S; Ekawati, Diyan; Sinaga, Fransisca T.Y.; Hendarto, Gatot Sudiro; Lyanda, Apri; Kusumajati, Pusparini; Ajipurnomo, Adhari
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 7 (2025): Volume 12 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i7.20247

Kanker paru tetap menjadi penyebab utama kematian terkait kanker secara global, terutama pada pria di Indonesia. Sekitar 80 % kasus didiagnosis sebagai Kanker Paru Bukan Sel Kecil (KPKBSK), terutama Adenokarsinoma dan Karsinoma Sel Skuamosa. Kadar D-Dimer yang meningkat, yang menunjukkan keadaan hiperkoagulasi, dapat menjadi penanda potensial untuk memprediksi hasil pengobatan dan prognosis keseluruhan. Metode: Dalam penelitian ini, 61 pasien KPKBSK yang menjalani tiga siklus kemoterapi lini pertama dilibatkan. Sebelum pengobatan, kadar D-Dimer diukur, dan jenis histopatologi ditentukan melalui pemeriksaan patologi anatomi. Respons kemoterapi dinilai menggunakan RECIST 1.1. Distribusi respons: Partial Response (27,9 %), Stable Disease (19,7 %), dan Progressive Disease (52,5 %). Terdapat perbedaan signifikan secara statistik dalam kadar D-Dimer antar kelompok tersebut (p = 0,001). Kelompok Partial Response memiliki median kadar D-Dimer 1.229 ng/mL (Mean Rank = 18,32), kelompok Stable Disease menunjukkan mean 1.335,67 ng/mL (SD = 624,30; Mean Rank = 21,13), dan kelompok Progressive Disease memiliki median 2.586 ng/mL (Mean Rank = 41,44). Kadar D-Dimer ≥1.654 ng/mL secara signifikan terkait dengan peningkatan risiko Progressive Disease, dengan sensitivitas 78,1 % dan spesifisitas 76 %. Subtipe histopatologi (Adenokarsinoma vs. Karsinoma Sel Skuamosa) tidak berkorelasi signifikan dengan respons kemoterapi (p = 0,717). Kadar D-Dimer berkorelasi dengan respons kemoterapi pada pasien KPKBSK, menunjukkan potensi penggunaannya sebagai prediktor, sedangkan jenis histopatologi tidak memengaruhi hasil terapi.

The Contribution Hypoalbumin Status on Diagnosing LF-LAM TB Ag Versus Xpert MTB/Rif in Patients Pulmonary Tuberculosis Eksa, Dwi Robbiardy; Hendarto, Gatot Sudiro; Sinaga, Fransisca Tarida Yuniar; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Gozali, Achmad; Ajipurnomo, Adhari
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 10, No 1 (2025): March
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v10i1.3092

In 2023, the global prevalence of tuberculosis (TB) reached 8.2 million cases. This represents the highest recorded figure associated with delayed diagnostics and a rising incidence of tuberculosis cases. Tuberculosis prevalence is elevated among individuals with compromised immune systems, including those with HIV and hypoalbuminemia, who exhibit increased vulnerability to infection. The challenge of sputum ejection impedes diagnosis, highlighting the need for a rapid and economical early detection method. The LF-LAM TB-Ag assay provides an alternative method for determining the presence of Lipoarabinomannan in urine, which is a component of the Mycobacterium tuberculosis cell wall. This study evaluated the efficacy of the LF-LAM TB-Ag assay compared to the Xpert MTB/RIF method for diagnosing tuberculosis. A comparative cross-sectional study was conducted at Abdoel Moeloek Hospital in Lampung Province, Indonesia, between January 2023 and June 2024. A total of 52 suspected pulmonary tuberculosis patients, who were HIV-negative and had hypoalbumin status, were evaluated using both the LF-LAM TB-Ag and Xpert MTB/RIF assays. The Wilcoxon and Chi-square tests have been utilised to assess the efficacy of LF-LAM TB-Ag in comparison to Xpert MTB/RIF. A p-value below 0.002 was considered statistically significant. Xpert MTB/RIF demonstrated improved diagnostic accuracy for tuberculosis in individuals with hypoalbuminemia. This study emphasises the necessity for early detection of pulmonary tuberculosis in patients with hypoalbuminemia. The combining of LF-LAM TB-Ag with Xpert MTB/RIF improves detection, especially among high-risk populations, thereby enabling prompt treatment and enhanced disease management.

Pengaruh Kadar Albumin Terhadap Prognosis Pada Pasien ARDS Karena Infeksi Paru Sari, Pralia Winda; Sinaga, Fransisca Tarida Yuniar; Hidayat, Hidayat; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Ajipurnomo, Adhari; Gozali, Achmad
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 8 (2025): Volume 12 Nomor 8
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i8.20269

Acute Respiratory Distress Syndrome (ARDS) merupakan edema paru nonkardiogenik dan suatu kasus kegawatdaruratan yang disebabkan oleh faktor risiko. Penyakit ARDS pertama kali dilaporkan sebagai serangkaian kasus dari Denver pada tahun 1967. Karakteristik ARDS antara lain terjadi pada fase akut, dengan edema alveolar, yang ditandai hipoksemia akut, serta beberapa penurunan fungsi organ. Epidemiologi ARDS sebesar 10,4% dari total pasien Intensive Care Unit (ICU) di Indonesia ARDS. Tujuan dari penelitian ini untuk mengetahui peran albumin sebagai prognosis pada pasien ARDS. Penelitian analisis observasional dengan menggunakan desain kohort prospektif, dan pengambilan data menggunakan data primer. Teknik pengambilan sampel menggunakan consecutive sampling sebanyak 39 peserta yang dirawat di RS Abdul Moeloek dengan kriteria usia lebih dari 19 tahun dan ARDS disebabkan oleh infeksi paru akibat bakteri,virus dan jamur, serta bersedia mengikuti penelitian. Penelitian dilakukan selama 1 tahun dari bulan januari sampai Desember 2023. Dari 39 sampel penelitian didapatkan sebanyak 23 orang pria dan 16 orang perempuan. Hasil penelitian menunjukkan ARDS ringan sebanyak 10 orang, ARDS sedang sebanyak 13 orang, dan ARDS berat sebanyak 16 orang. Dari 39 pasien sebanyak 82,1% memiliki nilai hipoalbuminemia. Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara albumin dengan prognosis pada ARDS (p value= 0,044).

HUBUNGAN FUNGSI PARU DAN SEKUELE RADIOGRAFI TORAKS TERHADAP KUALITAS HIDUP PASIEN PASCA INFEKSI COVID-19 DI RUMAH SAKIT BATIN MANGUNANG KABUPATEN TANGGAMUS, LAMPUNG Silaen, David Tongon; Ekawati, Diyan; Messah, Anse Diana Valentiene; Soemarwoto, Retno Ariza S.; Infianto, Andreas; Sinaga, Fransisca TY; Ajipurnomo, Adhari; Gozali, Achmad; Kusumajati, Pusparini
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 9 No. 2 (2025): AGUSTUS 2025
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v9i2.48150

Penelitian ini bertujuan untuk mengetahui hubungan antara fungsi paru dan sekuele radiografi toraks terhadap kualitas hidup pasien pasca infeksi COVID-19 di Rumah Sakit Batin Mangunang, Kabupaten Tanggamus, Lampung. Penelitian ini menggunakan desain potong lintang. Penelitian dilakukan pada Juni 2022 hingga Desember 2023 dengan total sampel 59 orang. Hasil penelitian menunjukkan bahwa mayoritas responden berusia 25–45 tahun, berjenis kelamin laki-laki, dengan gejala sisa terbanyak berupa kelelahan, serta sebagian besar tidak memiliki komorbiditas, tidak merokok, dan memiliki indeks massa tubuh berlebih. Gangguan fungsi paru ditemukan pada 45,8% pasien, terdiri dari gangguan restriktif (30,5%), obstruktif (10,2%), dan tipe campuran (5,1%). Sebanyak 66,1% pasien menunjukkan sekuele radiografi toraks, terutama berupa fibrosis. Penurunan kualitas hidup ditemukan pada 27,1% pasien. Dari analisis bivariat didapatkan hasil bahwa tidak terdapat hubungan antara sekuele radiografi toraks dan kualitas hidup pasien. (p value=0,793) dan terdapat hubungan antara penurunan kualitas hidup dengan gangguan fungsi paru baik dari gangguan obstruksi (p value < 0,001) atau restriksi (p value = 0,043).

Epidemiological Patterns Of Lung Adenocarcinoma With Pleural Metastasis: Lessons From RSUD Ahmad Yani Metro Saputra, Tetra Arya; Fitriyah, Fitriyah; Infianto, Andreas; Listiandoko, Raden Dicky Wirawan; Wibowo, Adityo; Sukarti, Sukarti; Morfi, Chicy Widya; Azka, Laisa
JKM (Jurnal Kebidanan Malahayati) Vol 11, No 8 (2025): Volume 11 Nomor 8 Agustus 2025
Publisher : Program Studi Kebidanan Fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkm.v11i8.22116

Latar Belakang: Efusi pleura ganas (EPG) merupakan manifestasi stadium lanjut dari berbagai keganasan, paling sering kanker paru, dan berhubungan dengan morbiditas yang tinggi serta prognosis yang buruk. Data epidemiologi menunjukkan bahwa laki-laki dan perokok lebih banyak terdampak, kemungkinan akibat paparan karsinogen dan risiko pekerjaan yang lebih tinggi.Tujuan: Mendeskripsikan karakteristik demografi, distribusi pekerjaan, dan kebiasaan merokok pada pasien dengan diagnosis EPG, serta membahas kemungkinan penyebab dominasi kasus pada laki-laki dan perokok.Metode: Penelitian deskriptif potong lintang dilakukan pada 77 pasien dengan EPG terkonfirmasi secara sitologi atau histopatologi. Data usia, jenis kelamin, pekerjaan, dan riwayat merokok diperoleh dari rekam medis dan dianalisis menggunakan statistik deskriptif.Hasil: Mayoritas pasien berjenis kelamin laki-laki (59,4%) dan berusia >40 tahun (96,9%). Pekerjaan terbanyak adalah petani (37,5%), diikuti oleh pekerja konstruksi (15,6%). Sebagian besar pasien (62,5%) adalah perokok, dengan proporsi perokok berat mencapai 43,8%. Dominasi laki-laki perokok mencerminkan paparan karsinogen terkait tembakau dan debu pekerjaan yang lebih tinggi.Kesimpulan: EPG lebih banyak ditemukan pada laki-laki usia lanjut dengan riwayat merokok signifikan dan pekerjaan berisiko tinggi. Upaya pencegahan sebaiknya difokuskan pada program berhenti merokok dan pengurangan paparan risiko pekerjaan pada kelompok ini.Saran: Untuk mengatasi meningkatnya beban kanker paru-paru, beberapa strategi kunci direkomendasikan. Memperkuat program skrining kanker paru-paru sangat penting, terutama bagi kelompok berisiko tinggi seperti pria di atas 40 tahun, perokok berat, dan individu dengan paparan karsinogen tinggi di tempat kerja. Kata kunci: adenokarsinoma paru, efusi pleura ganas, sitologi cairan pleura, merokok, paparan pekerjaan, Indeks Brinkman. ABSTRACT Background: Malignant pleural effusion (MPE) is a late-stage manifestation of various malignancies, most commonly lung cancer, and is associated with significant morbidity and poor prognosis. Epidemiological data indicate that men and smokers are disproportionately affected, possibly due to higher exposure to carcinogens and occupational hazards.Objective: To describe the demographic characteristics, occupational distribution, and smoking habits of patients diagnosed with MPE, and to discuss possible explanations for the predominance among men and smokers.Methods: A descriptive cross-sectional study was conducted on 77 patients with confirmed MPE. Data on age, gender, occupation, and smoking history were obtained from medical records and analyzed using descriptive statistics.Results: The majority of patients were male (59.4%) and aged >40 years (96.9%). Farming was the most common occupation (37.5%), followed by construction work (15.6%). Most patients (62.5%) were smokers, with heavy smokers accounting for 43.8%. The predominance of male smokers reflects higher exposure to tobacco-related carcinogens and occupational dusts.Conclusion: MPE is more prevalent in older males with significant smoking history and high-risk occupations. Preventive measures should target smoking cessation and reduction of occupational exposures in these groups.SuggeStion To address the rising burden of lung cancer, several key strategies are recommended. Strengthening lung cancer screening programs is crucial, particularly for high-risk groups such as men over 40 years old, heavy smokers, and individuals with high occupational exposure to carcinogens. Keywords : lung adenocarcinoma, malignant pleural effusion, pleural fluid cytology, smoking, occupational exposure, Brinkman Index.

The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia Syahruddin, Elisna; Soeroso, Noni Novisari; Ananda, Fannie Rizki; Wulandari, Laksmi; Setijadi, Ana Rima; Ermayanti, Sabrina; Pratiwi, Suryanti Dwi; Infianto, Andreas; Andayani, Novita; Munir, Sri Melati; Pratama, Avissena Dutha; Kusumawardani, Ida Ayu Jasminarti Dwi; Haryati, Haryati; Duyen, Natalie; Hanif, Muhammad Alfin; Lim, Darren Wan-Teck
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.22-30

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI. Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression. Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001). Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.

Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.

Aktualisasi Manajemen Tatalaksana Penyakit Paru Obstruktif Kronik (PPOK) dan Asma pada Fasilitas Kesehatan Tingkat Pertama (FKTP) di Kota Metro Mustofa, Syazili; Infianto, Andreas; Soemarwoto, Retno Ariza; Saputra, Tito Tri; Rosari HS, Felicya; Dorisman, Hari; ., Fitriyah
JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Vol. 8 No. 2 (2023): JURNAL PENGABDIAN MASYARAKAT RUWA JURAI
Publisher : FK Unila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jpmrj.v8i2.3235

Penyakit Paru Obstuktif Kronik (PPOK) dan Asma merupakan penyakit tidak menular di bidang paru yang merupakan penyakit kronik dan masih menjadi masalah utama di Indonesia. Penyakit ini menjadi salah satu penyakit yang masih membutuhkan penanganan yang tidak hanya dilakukan di rumah sakit namun juga harus dimulai dari Fasilitas Kesehatan Tingkat Pertama (FKTP). Dari data yang didapatkan di dinas Kesehatan Kota Metro masih banyak pasien dengan Asma dan PPOK yang masih belum teredukasi dengan baik. Rendahnya tingkat pengetahuan masyarakat di Kota Metro serta dikarenakan kurangnyainformasi kesehatan yang mereka terima sehingga solusi yang ditawarkan untuk mengatasi masalah itu dengan dilakukan penyuluhan dan pembaharuan ilmu yang bertujuan untuk meningkatkan pengetahuan, kesadaran, sikap, dan tindakan dokter dalam melakukan penanganan terhadap penyakit Asma dan PPOK. Diharapkan dengan diadakan kegiatan penyuluhan ini pengelolaan terhadap penyakit tidak menular bidang paru di Provinsi Lampung pada khususnya Kota Metro dapat terkelola dengan baik serta secara tidak langsung dapat meningkatkan derajat kesehatan masyarakat dengan peran dokter yang ada diFKTP. Metode yang digunakan dalam kegiatan ini adalah penyuluhan, yang dilanjutkan dengan diskusi. Mitra sasaran dalam kegiatan ini adalah 40 orang dokter di FKTP Kota Metro. Evaluasi keberhasilan pada kegiatan penyuluhan terdiri dari evaluasi awal dan evaluasi akhir. Tim pengabdian masyarakat pada kegiatan ini yaitu dokter spesialis paru dari Departemen Pulmonologi dan Kedokteran Respirasi Fakultas Kedokteran Universitas Lampung, RSUD dr. H. Abdul Moeloek Lampung. Hasil kegiatan ini menunjukkan peningkatan tingkat pemahaman sebesar 30% sehingga keseluruhan peserta memiliki pemahamanbaik. Selain itu, terjadi diskusi interaktif yang mengeksplorasi lebih dalam tentang manajemen penyakit Asma dan PPOK. Diharapkan promosi kesehatan ini dapat meningkatkan dokter di FKTP dalam melakukan manajemen penyakit Asma danPPOK.Kata kunci: PPOK, asma, promosi kesehatan

Comparative Diagnostic Accuracy of LF-LAM TB Antigen and Xpert MTB/RIF in Pulmonary Tuberculosis among Underweight Patients Eksa, Dwi Robbiardy; Hendarto, Gatot Sudiro; Sinaga, Fransisca TY; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Gozali, Achmad; Ajipurnomo, Adhari
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/7brxv447

Background: In 2023, the global incidence of tuberculosis (TB) reached 8.2 million cases. It is the highest on record due to delayed diagnoses and a rising number of TB patients. Tuberculosis is more prevalent among patients with compromised immune systems, including those with HIV and malnutrition (BMI <18.5 kg/m2), who exhibit increased vulnerability to infection. The challenge of sputum expulsion impedes diagnosis, requiring a rapid, cost-effective early-detection technique. The lateral flow lipoarabinomannan TB antigen (LF-LAM TB-Ag) assay provides an alternate method for identifying lipoarabinomannan in urine, a constituent of the Mycobacterium tuberculosis cell wall. This study assessed the effectiveness of the LF-LAM TB-Ag assay compared with the Xpert MTB/RIF assay for TB diagnosis. Methods: A comparative cross-sectional study was conducted at Abdul Moeloek Hospital, Lampung Province, from January 2023 to June 2024. A total of 52 suspected pulmonary TB patients with HIV-negative status and underweight BMI were evaluated using both the LF-LAM TB-Ag and Xpert MTB/RIF assays. Results: Chi-square tests were used to compare the performance of LF-LAM TB-Ag with Xpert MTB/RIF. The LF-LAM TB-Ag test had a sensitivity of 79.59% and a specificity of 100% (P=0.002). Conclusion: This study underscores the necessity for early detection of pulmonary TB in underweight individuals. The integration of LF-LAM TB-Ag with Xpert MTB/RIF improves detection, especially in high-risk populations, enabling prompt treatment and enhanced disease management.

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