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All Journal AQUATIC SCIENCE & MANAGEMENT JURNAL ILMIAH PLATAX Jurnal Ilmiah Tatengkorang Jurnal Mandala Pengabdian Masyarakat
Balansa, Walter
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Environmental Science Immunology & microbiology Public Health Social Sciences

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The first record of the rare Leucetta avocado sponge from Sangihe Islands, Indonesia Rieuwpassa, Frets J.; Balansa, Walter
JASM Vol. 10 No. 2 (2022): OCTOBER
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jasm.v10i2.48431

Abstract

Calcareous sponges represent the rarest class of marine sponges, constituting only 4% of the currently known sponge species globally. While abundant of demosponges have been reported from various locations in Indonesia, only 40 species of calcareous sponges have been identified in the country over the past 200 years. This suggests the rarity of these sponges and a significant knowledge gap regarding the Leucetta sponge in Indonesia. The objective of this study was to describe the biology of a calcareous sponge belonging to the genus Leucetta, which was collected from the Sangihe Islands in Indonesia. Morphological analysis was conducted using a modified acid digestion method, and the obtained data were compared to reported data for Leucetta sponges. The sponge exhibited triactine spicules, which are characteristic of Leucetta species. The number list of Indonesian Leucetta sponges was determined through a literature search. Previous research indicated that 40 identified calcareous sponges were reported in Indonesia between 1890 and 2023. Interestingly, L. avocado is known as a native sponge to Palau, although this species and closely related species have been reported elsewhere. Therefore, it is predicted that the current distribution of L. avocado in the Sangihe Islands and Bali could be attributed to a combination of the Indonesian Throughflow, sexual propagation, or stepping stone scenarios. This research provides new insights into the biology of L. avocado from Indonesia.
A New and Practical Method for Measuring Sponge Spicules Rieuwpassa, Frets J.; Tomasoa, Aprelia M.; Palawe, Jaka F. P.; Rieuwpassa, Fredrik; Mege, Revolson Alexius; Balansa, Walter
Jurnal Ilmiah Platax Vol. 11 No. 2 (2023): ISSUE JULY-DECEMBER 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v11i2.47882

Abstract

Binocular light microscopy (BLM) is an excellent match for a scanning electron microscope (SEM) and a trinocular light microscope equipped with a micrometer (TLM). The practicality, user-friendliness, and short-time analysis of BLM make this method a good choice for spicule analysis. However, its effectiveness and accuracy are yet to be confirmed. This study aimed to validate the effectiveness of BLM by comparing its usefulness to both TLM and the gold standard methods. BLM was first subjected to measuring megascleres and microscleres of 2 sponges. Then, by using the If function built-in Excell and t-test in SPSS 16.0, the compatibility of BLM was evaluated against SEM by measuring the length of spicules from 4 Sangihe sponges and their counterpart species from different locations. Furthermore, the t-test analysis was used to validate the compatibility and effectiveness of our method to the TLM by measuring the spicules of four sponges. Both the F-function and the t-test analysis proved BLM was compatible with SEM with both measurements showing a perfect match for megascleres typed spicules of 4 compared sponges. This new technique also showed a perfect match with SEM (p = 0.367, t-test) and with TLM (p = 0.963, t-test). Keywords: Spicules, sponges, SEM, Wallacea, biomaterial, sponge taxonomy
Exploring Metabolites Of Green Algae Caulerpa Spp. To Discover Putative Inhibitors Of Dpp-4, A New Antidiabetic Target Protein: Molecular Docking Compounds from Marine Green Algae Balansa, Walter
Jurnal Ilmiah Platax Vol. 11 No. 2 (2023): ISSUE JULY-DECEMBER 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v11i2.48061

Abstract

Diabetes mellitus (DM) remains a serious global health threat, claiming a million lives every year and affecting nearly 9% of the adult population who suffer from this impaired insulin sensitivity disease. The Dipeptidyl peptidase-4 (DPP-4) enzyme has recently attracted attention because of its crucial role in insulin signaling, making this enzyme an interesting and emerging target for antidiabetic drug discovery. This study aimed to explore reported metabolites from marine algae of the genus Caulerpa as DPP-4 inhibitors through computational studies using CB-dock 2, Protein-Ligand Interaction Profiler, SwissAdme, and pkCMS. Molecular docking allowed the identification of 7 hit compounds with strong binding affinities (8.4 kcal to 9.3 kcal/mol) against DPP-4 target enzyme PDB ID: 3G4I. Four hits showed stronger binding affinity than two DPP-4 specific inhibitors and FDA-approved antidiabetic drugs, sitagliptin (8.4 kcal/mol) and linagliptin (9.0 kcal/mol). Following a molecular modification of the hit compounds using a bioisosterism-like approach and ADMET evaluation with pkCMS, three putative DPP-4 inhibitors were identified. They showed either stronger binding affinities or better ADMET profiles than sitagliptin and linagliptin, suggesting their promising potential as DPP-4 inhibitors. However, further optimized bioisoterism, in silico and in vivo studies, and clinical-based trials are required to confirm their antidiabetic activity. Keywords: Antidiabetic, Caulerpa racemosa, caulerpin, DPP-4
Antifungal Potential Of The Sponge Styllisa Flabelliformis Against The Pathogenic And Resistant Aspergillus Fungi Tomasoa, Aprelia Martina; Rieuwpassa, Frets Jonas; Azhari, Deidy; Ijong, Frans Gruber; Mege, Revolson Alexius; Tanod, Wendy Alexander; Balansa, Walter
Jurnal Ilmiah Platax Vol. 11 No. 1 (2023): ISSUE JANUARY-JUNE 2023
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v11i1.48603

Abstract

Together with bacterial and viral infection, fungal infection represents the world's top ten killer diseases, desperately requiring new antifungal drugs. This research aimed to evaluate the antifungal activity of the sponge Styllisa flabelliformis against the pathogenic fungi Aspergillus flavus and Aspergillus parasiticus by the standard agar diffusion technique. Three concentrations (1, 10, and 10 mg/mL) for the extract and 0.5 mg/mL for ketoconazole and fluconazole were prepared and evaluated in triplicate against the tested fungi. Whereas ketoconazole poorly inhibited A. parasiticus and fluconazole weakly inhibited A. flavus, the extract of S. flabelliformis exerted antifungal activity against A. parasiticus (6.8 ± 1.8; 8.3 ± 3.2; and 9.5 ± 2.1) mm and A. flavus (6.8 ± 1.1; 11.5 ± 1.4; and 14.3 ± 1.1) mm 1, 10 and 100 mg/mL respectively. PASS analysis showed jasplakinolide as a promising antifungal agent with potential activity (Pa) of 0.736. STITCH analysis further confirmed that jasplakinolide worked by inhibiting the expression of cytoskeleton genes that prevented fungi from synthesizing chitin and inhibiting the formation of the fungi’s cell walls and hyphae, different from the ergosterol synthesis inhibition in ketoconazole and fluconazole, implying the potential of jasplakinolide as an antifungal agent.
PKM BUDIDAYA SPONS SECARA IN SITU UNTUK PRODUKSI BAHAN AKTIF BERKELANJUTAN DAN RAMAH LINGKUNGAN DI KELURAHAN ENEPAHEMBANG TAHUNA TIMUR Balansa, Walter; Azhari, Deidy; Tomasoa, Aprelia M.; Langi, Edwin O.
Jurnal Ilmiah Tatengkorang Vol 2 (2018): Jurnal Ilmiah Tatengkorang
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat, Politeknik Negeri Nusa Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (256.291 KB) | DOI: 10.1234/tkrg.v2i0.144

Abstract

Spons laut merupakan sumber penting molekul-molekul berpotensi medis seperti antibiotik, antikanker, antimalaria, antidiabetik dengan Ara-A (antibiotik) dan Ara-C (antikanker) sebagai contoh obat berbasis spons. Tetapi spons biasanya mengandung bahan bioaktif dalam jumlah sangat terbatas yang sering memicu panen spons secara berlebihan dari alam dan berpotensi merusak lingkungan laut. Beruntung, budidaya spons secara in situ (dikembangkan di lokasi dimana spons itu diambil) telah memperlihatkan hasil positif sehingga berpotensi memberikan solusi untuk produksi bahan bioaktif secara berkelanjutan sekaligus ramah lingkungan. Masalahnya, masyarakat pesisir dan pengambil kebijakan pada umumnya belum mengetahui potensi spons sebagai sumber berbagai sumber berbagai kandidat obat dan pendapatan tambahan yang pada gilirannya dapat bermuara pada perlindungan laut. Sebagai solusi, tim pengusul pertama-tama akan memperkenalkan berbagai potensi farmakologis dan ekonomi spons melalui penyuluhan dan diksusi langsung dengan mitra selain melalui pembekalan teknik-teknik budidaya spons.
PEMBUATAN AKUARIUM DAN SIRKULASI AIR UNTUK BUDIDAYA IKAN GIRU Amphiprion sp. DI KAMPUNG TALENGEN KECAMATAN TABUKAN TENGAH Tomasoa, Aprelia; Balansa, Walter; Melupite, Billy; Makawekes, Steward Imanuel
Jurnal Ilmiah Tatengkorang Vol 5 No 1 (2021): Jurnal Ilmiah Tatengkorang
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat, Politeknik Negeri Nusa Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54484/tkrg.v5i1.344

Abstract

Akuarium secara umum selalu dijadikan sebagai wadah untuk membudidayakan ikan hias, baik ikan air tawar maupun air laut. Salah satu jenis ikan hias air laut yang dibudidayakan menggunakan akuarium yaitu ikan giru atau yang lebih dikenal dengan nama ikan badut, klon atau nemo. Membudidayakan ikan giru di dalam akuarium mengharuskan adanya substrat yang baik untuk ikan giru yang memberikan perlindungan dan tempat berteduh untuk ikan giru serta sirkulasi air yang baik untuk menjaga kualitas dan kuantitas air sebagai media pemeliharaan ikan itu. Kegiatan pengabdian kemitraan masyarakat ini dilakukan kepada kelompok masyarakat di Kampung Talengen yang bertujuan memberi pengetahuan tentang pembuatan wadah akuarium dan sirkulasi air dalam budidaya ikan giru. Kegiatan ini dilakukan mencakup kunjungan lapangan (survei), penyampaian materi, pelatihan, evaluasi dan monitoring. Hasil kegiatan yang telah dilakukan menunjukkan kelompok masyarakat Kampung Talengen sudah mengenal dan dapat membuat akuarium secara mandiri serta menyusun shelter berupa mangkuk tanah liat sebagai substrat tempat penempelan anemone dan pompa filter. Selanjutnya hasil evaluasi dan pemantauan menunjukkan masyarakat Kampung Talengen tidak menghadapi kendala dalam membuat akuarium. Hanya saja dalam penanganan ikan giru tahap awal perlu dilakukan secara baik untuk mengurangi tingkat stress ikan dan anemone. Beberapa orang dari mereka telah berinisiatif untuk melakukan budidaya ikan giru di akuarium yang sudah ada. Hal tersebut menunjukkan penerimaan masyarakat untuk menerapkan teknologi budidaya ikan hias air laut menggunakan akuarium yang relatif baru di Kampung Talengen. Aquariums have been effectively used for rearing both freshwater and seawater ornamental fish. One important marine ornamental fish cultivable in an aquarium is the clownfish or better known as nemo. Rearing clownfish in an aquarium requires good substrates for anemones that provide the clownfish with protection and shelter as well as good water circulation to maintain water quantity and quality as a rearing medium for the fish. Conducted in Talengen village, this community partnership service aimed to provide knowledge to Talengen village’s community on how to design aquarium well equipped with water circulation for clownfish cultivation. This community service involved field survey, demonstrations on how to construct aquarium, substrate for anemone and water pump, training, evaluation and monitoring. The results showed that the community in Talengen Village already knew how to build a fish aquarium, created shelter in form of a clay bowl as a substrate for anemone and installed water filter pumps for maintaining water quality. Although the local people did not have any problems in constructing an aquarium equipped with substrate for anemone and water circulation, they need further training on how to handle clownfish and anemones properly to reduce the animals’ levels of stress. With our team’s help, however, the people in the village have taken initiative to cultivate clownfish in aquariums provided through this community service, strongly suggesting the public's acceptance of the relatively new technology the practice of clownfish cultivation introduced to them.
RESTORASI MANGROVE BERBASIS KOMUNITAS PESISIR: PENYEMAIAN, MONITORING, DAN TANTANGAN EKOLOGI Rieuwpassa, Frets; Wibowo, Indra; Choesin, Devi Nandita; Gansalangi, Ferdinand; Tomasoa, Aprelia Martina; Sambeka, Yana; Nursatya, Safira Meidina; Wibowo, Arie; Balansa, Walter; Barlian, Anggraini
Jurnal Ilmiah Tatengkorang Vol 8 No 2 (2024): Jurnal Ilmiah Tatengkorang
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat, Politeknik Negeri Nusa Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54484/tkrg.v8i2.665

Abstract

As a collaborative effort between the School of Life Sciences (SITH) Institute Technology Bandung (ITB), Polnustar, and the people of Salurang, this community service aimed to restore the coastal area of Salurang village, Sangihe Islands, North Sulawesi, through various initiatives, including mangrove rehabilitation and sponge cultivation. This report specifically focuses on the propagation of 1,500 Rhizophora apiculata propagules to combat severe sedimentation from local mining and reclamation, which degraded the coastal area and reduced fish populations. Initial monitoring showed a 95.20% success rate for R. apiculata, later dropping to 78.87% due to plastic waste, animal disturbances, and tidal conditions. While the primary focus was on R. apiculata, the article also touched on the potential use of Calophyllum inophyllum, which successfully grew on different media for future restoration efforts. The monitoring process involved Polnustar and local residents tracking growth and survival every 30 days, with SITH ITB conducting more thorough checks 60 days after propagation. These activities, including guest lectures and hands-on training, significantly enhanced local conservation knowledge and environmental stewardship. The findings highlight the potential of mangrove restoration in Salurang village, demonstrating that coastal restoration is achievable with proper management, adaptive strategies, and active community engagement. Sebagai bagian dari kolaborasi antara Sekolah Ilmu dan Teknologi Hayati (SITH) Institut Teknologi Bandung (ITB), Polnustar, dan masyarakat Salurang, kegiatan pengabdian masyarakat ini bertujuan untuk memulihkan wilayah pesisir desa Salurang, Kepulauan Sangihe, Sulawesi Utara, melalui berbagai inisiatif, termasuk rehabilitasi mangrove dan budidaya spons. Artikel ini secara khusus berfokus pada propagasi 1.500 propagul Rhizophora apiculata untuk mengatasi sedimentasi berat akibat penambangan lokal dan reklamasi, yang telah merusak wilayah pesisir dan mengurangi populasi ikan. Pemantauan awal menunjukkan tingkat keberhasilan R. apiculata sebesar 95,20%, yang kemudian menurun menjadi 78,87% akibat sampah plastik, gangguan hewan, dan kondisi pasang surut. Meskipun fokus utama adalah pada R. apiculata, artikel ini juga menyinggung potensi penggunaan Calophyllum inophyllum yang berhasil tumbuh pada media yang berbeda untuk upaya restorasi di masa depan. Proses pemantauan melibatkan Polnustar dan warga setempat dalam memantau pertumbuhan dan kelangsungan hidup propagul setiap 30 hari, dengan SITH ITB melakukan pemeriksaan lebih mendalam 60 hari setelah propagasi. Kegiatan ini, termasuk kuliah tamu dan pelatihan langsung, secara signifikan meningkatkan pengetahuan konservasi lokal dan pengelolaan lingkungan. Hasil pengabdian masyarakat ini mengindikasikan potensi restorasi mangrove di desa Salurang, menunjukkan bahwa pemulihan pesisir berpotensi dicapai dengan manajemen yang tepat, strategi adaptif, dan keterlibatan aktif masyarakat
In-Silico Optimization of Macrolactin A from Sponge-Associated Bacteria and Its Derivatives as Eco-Friendly Antifoulants Balansa, Walter; Riyanti; Hinonaung, Jelita Siska Herlina
Jurnal Ilmiah PLATAX Vol. 13 No. 2 (2025): ISSUE JULY-DECEMBER 2025
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35800/jip.v13i2.65278

Abstract

Marine biofouling causes significant economic and environmental damage creating an urgent demand for eco-friendly antifoulants. This in silico study aimed to evaluate the antifouling efficacy and ecotoxicological profile of macrolactin A (1), previously isolated from Indonesian sponge-associated Bacillus spp., alongside its computationally generated derivatives (1a-1f, 2a–2k) using Biotransformer 3.0. Molecular docking was utilized to assess binding affinities against key protein targets—the bacterial BAM complex, GSK-3 , and acetylcholinesterase (AChE)—and used EPI Suite™ to predict environmental safety. All tested compounds exhibited robust binding affinities (  kcal/mol) against all targets likely binding to allosteric sites. ANOVA revealed significant differences ( ) in binding strength, with derivatives displaying a distinct preference for GSK-3  over AChE and BAM ( ). However, the broad-spectrum affinity across all three targets supports a potential multi-mechanism mode of action. Crucially, most derivatives showed low toxicity and bioaccumulation potential compared to commercial antifoulants such as Irgarol 1501, SeaNine 211, and Selektope®. Notably, analogues 1a-1c and 2e were predicted to be readily biodegradable. This study identified 1a–1c and 2e as leading candidates for eco-friendly antifoulants and provides a strong basis for future experimental development of novel, sustainable marine coating candidates. Keywords: ecofriendly antifouling; in silico; macrolactin; molecular docking; sponge-associated bacteria
Multi-Species Mangrove Restoration and Community Engagement for Coastal Resilience in Salurang Rieuwpassa, Frets; Wibowo, Indra; Choesin, Devi Nandita; Gansalangi, Ferdinang; Yuanita, Nita; Tomasoa, Aprelia Martina; Wuaten, Julius Frans; Dzaky, Muhammad Luqman; Sidauruk, Gaberaja Samuel Roosevelt; Mozes, Getruida Nita; Barlian, Anggraini; Balansa, Walter
Jurnal Mandala Pengabdian Masyarakat Vol. 6 No. 2 (2025): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v6i2.768

Abstract

Ekosistem pesisir Salurang, Kabupaten Sangihe, Sulawesi Utara, menghadapi ancaman abrasi kritis yang diperparah oleh degradasi ekosistem mangrove dan kerusakan infrastruktur pelindung yang menyebabkan kerugian ekologis dan sosio-ekonomi. Salah satu strategi mitigasi adalah menerpakan rehabilitasi mangrove mono-spesies, yang telah terbukti tidak memadai dan kurang efektif untuk restorasi lingkungan jangka panjang. Keadaan ini mendorong penerapan pendekatan restorasi multi-spesies yang lebih holistik. Pengabdian kepada masyarakat kolaboratif antara ITB, Polnustar dan masyarakat Kampung Salurang ini bertujuan mengevaluasi potensi restoratif dari pendekatan multi-spesies yang pada fase ini berfokus pada kelangsungan hidup mangrove Rhizophora apiculata dan Calophyllum inophyllum. Monitoring selama 90 hari pasca-penanaman menunjukkan tingkat kelangsungan hidup C. inophyllum (82,48%) yang signifikan lebih tinggi dibandingkan R. apiculata (53,70%). Perbedaan ini diduga berhubungan erat dengan kerentanan R. apiculata terhadap tekanan lingkungan di muara sungai Salurang yang terdegradasi (sedimentasi, sampah, fluktuasi salinitas), sementara C. inophyllumdi lokasi relatif terlindung menunjukkan adaptasi yang optimal. Meskipun demikian, tingkat kelangsungan hidup R. apiculata masih lebih baik dari beberapa inisiatif mono-spesies di beberapa tempat lain. Hasil ini juga menegaskan pentingnya alokasi spesies berdasarkan kesesuaian ekologis dan menyoroti urgensi reintroduksi spesies kunci lain seperti Nypa fruticans untuk meningkatkan resiliensi ekosistem. Pendekatan partisipatif melalui Focus Group Discussion (FGD) dan pelibatan masyarakat aktif dalam seluruh tahapan program telah memperkuat relevansi solusi lokal, menumbuhkan rasa kepemilikan, dan mengintegrasikan kearifan lokal dengan data ilmiah. Kegiatan pengabdian kepada masyarakat ini menggarisbawahi model rehabilitasi pesisir dengan yang mengintegrasikan ilmu pengetahuan, kearifan lokal, dan partisipasi komunitas dalam upaya merestorasi pesisir dan mengoptimalkan manfaat multifungsi sumber daya lokal. Ketik abstrak bahasa Indonesia di sini.
Co-Authors Aprelia Martina Tomasoa, Aprelia Martina Arie Wibowo Azhari, Deidy Barlian, Anggraini Devi Nandita Choesin, Devi Nandita Dzaky, Muhammad Luqman Frans Gruber Ijong Frets Jonas Rieuwpassa Gansalangi, Ferdinand Gansalangi, Ferdinang Hinonaung, Jelita Siska Herlina Langi, Edwin O. Makawekes, Steward Imanuel Melupite, Billy Mozes, Getruida Nita Nita Yuanita, Nita Nursatya, Safira Meidina Palawe, Jaka F. P. Revolson Mege Rieuwpassa, Fredrik Rieuwpassa, Frets Rieuwpassa, Frets J. Riyanti Sidauruk, Gaberaja Samuel Roosevelt Tomasoa, Aprelia Tomasoa, Aprelia M. Wendy Alexander Tanod Wibowo, Indra Wuaten, Julius Frans Yana Sambeka