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All Journal HAYATI Journal of Biosciences Jurnal Biodjati Jurnal Ilmiah Tatengkorang Narra J Riwayat: Educational Journal of History and Humanities
Wibowo, Indra
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Characterization of Orexin Gene in Tilapia (Oreochromis niloticus):Regulator Feeding Appetite, and Correlation with Reproductive Factors Simanjuntak, Ricky Febrinaldy; Barlian, Anggraini; Wibowo, Indra; ., Rukisah
Jurnal Biodjati Vol 9, No 2 (2024): November
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v9i2.32063

Abstract

The mechanism of energy allocation related to increased appetite and feed intake in fish involves several neuropeptides encoded by specific genes. Orexin (OX) is a peptide secreted in the pars tuberalis of the hypophysis that acts as a stimulator in appetite increase (orexigenic factor). However, the expression of different orexigenic factors varies among vertebrate species, reflecting their unique types and lineages. Therefore, this study aimed to identify genes encoding appetite in Tilapia. RNA isolation, complementary Deoxyribose Nucleic Acid (cDNA) cloning, and DNA amplification were performed from brain samples of gonadally mature Tilapia. The PCR products were subsequently sent to Macrogen.Inc for sequencing. The amplification results of Orexin with β-Actin (positive control) observed using agarose gel electrophoresis showed that the size of the nucleotide base product of each gene was 196 bp and 197 bp. Confirmation of sequencing results carried out using the Basic Local Alignment Search Tool (BLAST) method - National Center for Biotechnology Information (NCBI) for Orexin and β-Actin were 97% and 100%. Based on these results, it can be concluded that each target gene isolated from the tilapia brain showed homology/similarity with the sequence available in the NCBI database
Toxicity assessment and bioimaging potential of carbon dots synthesized from banana peel in zebrafish model Wijayanti, Ni PAD.; Permatasari, Fitri A.; Damayanti, Sophi; Anggadiredja, Kusnandar; Iskandar, Fery; Wibowo, Indra; Rachmawati, Heni
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1228

Abstract

Zebrafish serve as a pivotal model for bioimaging and toxicity assessments; however, the toxicity of banana peel-derived carbon dots in zebrafish has not been previously reported. The aim of this study was to assess the toxicity of carbon dots derived from banana peel in zebrafish, focusing on two types prepared through hydrothermal and pyrolysis methods. Banana peels were synthesized using hydrothermal and pyrolysis techniques and then compared for characteristics, bioimaging ability, and toxicity in zebrafish as an animal model. Pyrolysis-derived banana peel and hydrothermal-derived banana peel showed blue emission under ultraviolet light, indicating excitation-dependent behavior. To test their potential application for bioimaging, a soaking method was used using zebrafish that showed fluorescence intensity in the eyes, abdomen, and tail of zebrafish. Toxicity comparison showed that pyrolysis-derived banana peel had lower toxicity with 50% lethal concentrations (LC50) of 1707.3 ppm than hydrothermal-derived banana peel (LC50 993 ppm) in zebrafish. Both types of carbon dots showed significant differences (p<0.05) in hatching rates at 96 and 120 hours of exposure. Of the two methods for carbon dot synthesis from banana peel, the pyrolysis method had a higher toxicity threshold than the hydrothermal method, as indicated by the LC50 value and the number of zebrafish embryos that died, hatched delayed, and experienced malformation during their development.
The Effect of Papaya Derived Exosome-like Nanoparticle as a Potential Photoprotective Agent in Nanocosmetics Farid, Faticha Nasharo Qisthia; Barlian, Anggraini; Wibowo, Indra
HAYATI Journal of Biosciences Vol. 32 No. 4 (2025): July 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.4.920-930

Abstract

Indonesia, as a tropical nation, experiences year-round ultraviolet radiation exposure. Excessive ultraviolet radiation, particularly UVB, accelerates premature skin aging, known as photoaging. UVB radiation induces photoaging by damaging DNA and increasing the production of reactive oxygen species (ROS), which leads to oxidative stress and results in increased apoptosis, melanogenesis, senescence, cell cycle arrest, and reduced cell migration capacity. Thus, identifying agents that can mitigate photoaging is crucial for developing skincare therapies. One of the alternative therapies currently being developed is plant-derived exosome-like nanoparticles (PDENs). Papaya (Carica papaya), renowned for its flavonoid and phenolic content, exhibits potent antioxidant properties and has been extensively utilized in skincare formulations. Therefore, this study investigates the effects of papaya-derived exosome-like nanoparticles (CP-PDEN) on inhibiting photoaging in 1BR3 fibroblast cell lines and zebrafish. Results indicated that CP-PDEN effectively internalized into 1BR3 cells and was categorized as nontoxic. The study then examined photoprotective effects after UVB irradiation (100 mJ/cm2) and found that CP-PDEN treatment resulted in better viability and nuclear morphology. Furthermore, CP-PDEN accelerates wound closure in 1BR3 cells and decreases melanocyte count in zebrafish compared with controls. In conclusion, CP-PDEN significantly enhanced cell viability and migration and suppressed melanogenesis, indicating its potential for anti-photoaging skincare applications.
RESTORASI MANGROVE BERBASIS KOMUNITAS PESISIR: PENYEMAIAN, MONITORING, DAN TANTANGAN EKOLOGI Rieuwpassa, Frets; Wibowo, Indra; Choesin, Devi Nandita; Gansalangi, Ferdinand; Tomasoa, Aprelia Martina; Sambeka, Yana; Nursatya, Safira Meidina; Wibowo, Arie; Balansa, Walter; Barlian, Anggraini
Jurnal Ilmiah Tatengkorang Vol 8 No 2 (2024): Jurnal Ilmiah Tatengkorang
Publisher : Pusat Penelitian dan Pengabdian Kepada Masyarakat, Politeknik Negeri Nusa Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54484/tkrg.v8i2.665

Abstract

As a collaborative effort between the School of Life Sciences (SITH) Institute Technology Bandung (ITB), Polnustar, and the people of Salurang, this community service aimed to restore the coastal area of Salurang village, Sangihe Islands, North Sulawesi, through various initiatives, including mangrove rehabilitation and sponge cultivation. This report specifically focuses on the propagation of 1,500 Rhizophora apiculata propagules to combat severe sedimentation from local mining and reclamation, which degraded the coastal area and reduced fish populations. Initial monitoring showed a 95.20% success rate for R. apiculata, later dropping to 78.87% due to plastic waste, animal disturbances, and tidal conditions. While the primary focus was on R. apiculata, the article also touched on the potential use of Calophyllum inophyllum, which successfully grew on different media for future restoration efforts. The monitoring process involved Polnustar and local residents tracking growth and survival every 30 days, with SITH ITB conducting more thorough checks 60 days after propagation. These activities, including guest lectures and hands-on training, significantly enhanced local conservation knowledge and environmental stewardship. The findings highlight the potential of mangrove restoration in Salurang village, demonstrating that coastal restoration is achievable with proper management, adaptive strategies, and active community engagement. Sebagai bagian dari kolaborasi antara Sekolah Ilmu dan Teknologi Hayati (SITH) Institut Teknologi Bandung (ITB), Polnustar, dan masyarakat Salurang, kegiatan pengabdian masyarakat ini bertujuan untuk memulihkan wilayah pesisir desa Salurang, Kepulauan Sangihe, Sulawesi Utara, melalui berbagai inisiatif, termasuk rehabilitasi mangrove dan budidaya spons. Artikel ini secara khusus berfokus pada propagasi 1.500 propagul Rhizophora apiculata untuk mengatasi sedimentasi berat akibat penambangan lokal dan reklamasi, yang telah merusak wilayah pesisir dan mengurangi populasi ikan. Pemantauan awal menunjukkan tingkat keberhasilan R. apiculata sebesar 95,20%, yang kemudian menurun menjadi 78,87% akibat sampah plastik, gangguan hewan, dan kondisi pasang surut. Meskipun fokus utama adalah pada R. apiculata, artikel ini juga menyinggung potensi penggunaan Calophyllum inophyllum yang berhasil tumbuh pada media yang berbeda untuk upaya restorasi di masa depan. Proses pemantauan melibatkan Polnustar dan warga setempat dalam memantau pertumbuhan dan kelangsungan hidup propagul setiap 30 hari, dengan SITH ITB melakukan pemeriksaan lebih mendalam 60 hari setelah propagasi. Kegiatan ini, termasuk kuliah tamu dan pelatihan langsung, secara signifikan meningkatkan pengetahuan konservasi lokal dan pengelolaan lingkungan. Hasil pengabdian masyarakat ini mengindikasikan potensi restorasi mangrove di desa Salurang, menunjukkan bahwa pemulihan pesisir berpotensi dicapai dengan manajemen yang tepat, strategi adaptif, dan keterlibatan aktif masyarakat
Implementasi Strategi Percepatan Penghapusan Kemiskinan Ekstrem di Kabupaten Kotawaringin Barat Wibowo, Indra; Muhammad, Adji Suradji
Riwayat: Educational Journal of History and Humanities Vol 8, No 3 (2025): July, Social Studies, Educational Research and Humanities Research.
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Presidential Instruction Number 4 of 2022 concerning the Acceleration of the Eradication of Extreme Poverty targets 0 (zero) percent of extreme poverty by 2024. However, until December 2024 there is still data on poor people in West Kotawaringin Regency. Therefore, this study aims to determine how the implementation of the strategy to accelerate the eradication of extreme poverty is carried out by the West Kotawaringin Regency Government, Central Kalimantan Province. This study uses a qualitative descriptive approach using the concept of strategy implementation from J. David Hunger and Thomas L. Wheelen (2023) which is seen from program implementation, budget implementation and procedure implementation. Data sources are in-depth interviews and literature studies, report documents, and data from the Central Statistics Agency. The results of this study indicate that program implementation can be said to have covered the extreme poor, especially programs in the field of social assistance, while capital assistance and business assistance have not been maximized. Second, implementation in terms of the budget still needs to be improved, especially for strategies to increase community income, and third, from the implementation of procedures, there is innovation from the Regional Government through the Regent's Regulation concerning the repair of Uninhabitable Houses (RTLH) and assistance for the construction of new buildings.
Co-Authors ., Rukisah Aprelia Martina Tomasoa, Aprelia Martina Arie Wibowo Balansa, Walter Barlian, Anggraini Devi Nandita Choesin, Devi Nandita Farid, Faticha Nasharo Qisthia Gansalangi, Ferdinand HENI RACHMAWATI Iskandar, Fery Kusnandar Anggadiredja Muhammad, Adji Suradji Nursatya, Safira Meidina Permatasari, Fitri A. Rieuwpassa, Frets Simanjuntak, Ricky Febrinaldy Sophi Damayanti Wijayanti, Ni PAD. Yana Sambeka