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Profil Komorbiditas terhadap Kesembuhan Pasien TB-RO di RSUP Dr. H. A. Rotinsulu Nadia Indah Sari; Umi Yuniarni; Suwendar Suwendar
Bandung Conference Series: Pharmacy 87 - 94
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24522

Abstract. Drug-resistant tuberculosis (DR-TB) is a major health concern that requires complex treatment and continuous monitoring. Comorbidities may worsen patients’ clinical conditions, increase the risk of complications, and affect treatment outcomes. This study aimed to describe patient characteristics, the profile of comorbidities, and treatment outcomes among DR-TB patients at Dr. H. A. Rotinsulu General Hospital. This study employed a descriptive observational design with retrospective data collection using electronic medical records of DR-TB patients during the 2024–2025 period. The data included sex, age, types of comorbidities, and treatment outcomes. Data were analyzed descriptively and presented as frequencies and percentages. The results showed that most patients were male (54.5%), and adults constituted the largest age group (39.3%). The most frequently identified comorbidity was chronic obstructive pulmonary disease (COPD), affecting 25 patients (32.9%), of whom 23 recovered and 2 did not recover. Type 2 diabetes mellitus was identified in 20 patients (26.3%), with 17 patients recovering and 3 not recovering. Ischemic coronary artery disease (CAD) and systemic lupus erythematosus (SLE) were each identified in 2 patients, with 1 patient recovering and 1 not recovering. Comprehensive management and monitoring of comorbidities are necessary to support successful DR-TB treatment. Abstrak. Tuberkulosis resistan obat (TB-RO) merupakan masalah kesehatan yang memerlukan pengobatan kompleks dan pemantauan berkelanjutan. Komorbiditas dapat memperberat kondisi klinis, meningkatkan risiko komplikasi, serta memengaruhi keberhasilan pengobatan. Penelitian ini bertujuan untuk menggambarkan karakteristik pasien, profil komorbiditas, dan tingkat kesembuhan pasien TB-RO di RSUP Dr. H. A. Rotinsulu. Penelitian ini menggunakan metode deskriptif observasional dengan pengambilan data secara retrospektif melalui rekam medis elektronik pasien TB-RO periode 2024–2025. Data meliputi jenis kelamin, usia, jenis komorbiditas, dan hasil akhir pengobatan. Data dianalisis secara deskriptif serta disajikan dalam bentuk frekuensi dan persentase. Hasil menunjukkan bahwa sebagian besar pasien berjenis kelamin laki-laki (54,5%) dan kelompok usia dewasa merupakan kelompok terbanyak (39,3%). Komorbiditas yang paling sering ditemukan adalah penyakit paru obstruktif kronik (PPOK) sebanyak 25 pasien (32,9%), dengan 23 pasien sembuh dan 2 pasien tidak sembuh. Diabetes melitus tipe 2 ditemukan pada 20 pasien (26,3%), dengan 17 pasien sembuh dan 3 pasien tidak sembuh. Penyakit arteri koroner (coronary artery disease/CAD) iskemik dan lupus eritematosus sistemik (systemic lupus erythematosus/SLE) masing-masing ditemukan pada 2 pasien, dengan 1 pasien sembuh dan 1 pasien tidak sembuh. Komorbiditas perlu dikendalikan dan dipantau secara komprehensif untuk mendukung keberhasilan pengobatan TB-RO.

Efektivitas Antibiotik Pasien Rawat Inap Pneumonia Komunitas di RSUD Welas Asih Khalida Fitrah Qolbina; Umi Yuniarni; Suwendar Suwendar
Bandung Conference Series: Pharmacy 237 - 246
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24735

Abstract. Community-acquired pneumonia (CAP) remains a global health challenge due to its high mortality rate, making appropriate antibiotic selection essential to prevent treatment failure and the threat of resistance. This study aimed to analyze the effectiveness of various antibiotic regimens on clinical outcomes, including leukocyte count, body temperature, and respiratory rate. This analytical observational study with a cross-sectional design involved 123 inpatients at RSUD Welas Asih during the 2025 period, selected using a total sampling technique. Secondary data were obtained from medical records and analyzed both descriptively and statistically using the Wilcoxon test. The results showed that the majority of subjects were male (50.4%) and elderly (44.7%), with levofloxacin monotherapy (55%) and ceftriaxone (16%) being the predominant regimens used. Statistically, both antibiotics significantly reduced leukocyte levels (p<0.05), although temperature and respiratory rate parameters did not show similar significance, yet still achieved clinical stability by the third day. In conclusion, levofloxacin and ceftriaxone were the statistically most effective regimens, with further research using a larger sample size recommended. Abstrak. Pneumonia komunitas (community-acquired pneumonia) menjadi tantangan kesehatan global karena angka mortalitas yang tinggi, sehingga pemilihan antibiotik yang tepat sangat penting untuk mencegah kegagalan terapi dan ancaman resistensi. Penelitian ini bertujuan menganalisis efektivitas berbagai regimen antibiotik terhadap outcome klinis yang meliputi kadar leukosit, suhu tubuh, dan laju pernapasan. Studi observasional analitik dengan desain cross-sectional ini melibatkan 123 pasien rawat inap di RSUD Welas Asih periode 2025 yang diambil menggunakan teknik total sampling. Data sekunder diperoleh dari rekam medis dan diolah secara deskriptif serta statistik menggunakan uji Wilcoxon. Hasil menunjukkan mayoritas subjek adalah laki-laki (50,4%) dan lansia (44,7%), dengan penggunaan dominan monoterapi levofloksasin (55%) dan seftriakson (16%). Secara statistik, kedua antibiotik tersebut signifikan menurunkan kadar leukosit (p<0,05), meskipun parameter suhu dan napas tidak menunjukkan signifikansi serupa namun tetap mencapai stabilitas klinis pada hari ketiga. Kesimpulannya, levofloksasin dan seftriakson adalah regimen paling efektif secara statistik, dengan saran penelitian lanjutan menggunakan jumlah sampel yang lebih besar.

Evaluasi Efektivitas Eritropoietin terhadap Respons Hematologi Pasien Gagal Ginjal Kronis Agnia Aulia Syifa; Suwendar Suwendar; Andrian Hoerul Anwar
Bandung Conference Series: Pharmacy 275 - 284
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24771

Abstract. Chronic kidney disease (CKD) is commonly associated with anemia due to decreased erythropoietin production by the kidneys, resulting in impaired erythropoiesis and reduced hemoglobin, hematocrit, and erythrocyte levels. This study aimed to evaluate the effectiveness of erythropoietin-containing combination therapy based on changes in hemoglobin, hematocrit, and erythrocyte levels in CKD patients undergoing hemodialysis at Bandung Kiwari Regional Hospital. A descriptive observational study with a retrospective approach was conducted using medical records of 53 patients who met the inclusion and exclusion criteria. Data were analyzed descriptively, while statistical analyses were performed using the Shapiro–Wilk normality test followed by the Wilcoxon test. The results showed that 62% of patients achieved the target hemoglobin response of 0.5–1.5 g/dL. The combination of epoetin alfa and folic acid, as well as epoetin alfa, folic acid, and vitamin B12, significantly increased hemoglobin, hematocrit, and erythrocyte levels (p<0.05). In conclusion, erythropoietin-containing combination therapy was effective in improving hemoglobin, hematocrit, and erythrocyte levels in CKD patients undergoing hemodialysis. Abstrak. Gagal ginjal kronis (GGK) sering disertai anemia akibat penurunan produksi eritropoietin oleh ginjal yang mengganggu proses eritropoiesis sehingga menyebabkan penurunan kadar hemoglobin, hematokrit, dan eritrosit. Penelitian ini bertujuan mengevaluasi efektivitas terapi kombinasi yang mengandung eritropoietin berdasarkan perubahan kadar hemoglobin, hematokrit, dan eritrosit pada pasien gagal ginjal kronis yang menjalani hemodialisis di RSUD Bandung Kiwari periode Januari–Desember 2025. Penelitian ini merupakan penelitian observasional deskriptif dengan pendekatan retrospektif menggunakan data rekam medis 53 pasien yang memenuhi kriteria inklusi dan eksklusi. Data dianalisis secara deskriptif, sedangkan analisis statistik dilakukan menggunakan uji normalitas Shapiro–Wilk dan uji Wilcoxon. Hasil penelitian menunjukkan bahwa 62% pasien mencapai target respons peningkatan hemoglobin sebesar 0,5–1,5 g/dL. Terapi kombinasi epoetin alfa dan asam folat serta kombinasi epoetin alfa, asam folat, dan vitamin B12 meningkatkan kadar hemoglobin, hematokrit, dan eritrosit secara signifikan (p<0,05). Disimpulkan bahwa terapi kombinasi yang mengandung eritropoietin efektif meningkatkan kadar hemoglobin, hematokrit, dan eritrosit pada pasien gagal ginjal kronis yang menjalani hemodialisis.

Pola Penggunaan Obat pada Lansia Gagal Jantung Kongesti di RS X Bandung Zahra Aurelia Chendra; Suwendar Suwendar; Umi Yuniarni
Bandung Conference Series: Pharmacy 285 - 294
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24791

Abstract. Heart failure is a cardiovascular disease commonly occurring in older adults and is often accompanied by comorbidities, making treatment more complex. This study aimed to determine the drug utilization patterns, rationality of drug use, and treatment patterns among patients with heart failure and comorbid hypertension and type 2 diabetes mellitus at hospital X Bandung from January to December 2025. This study employed a descriptive observational design with a retrospective approach. Sampling was conducted using non-probability sampling with a total sampling method, resulting in 120 patients who met the inclusion criteria. The results showed that most patients were aged 55–65 years (53%) and were male (58%). The most common comorbidities were hypertension (33%) and type 2 diabetes mellitus (8%). Bisoprolol was the most frequently used drug, followed by furosemide, aspirin, atorvastatin, spironolactone, and sacubitril/valsartan. Most patients received combination therapy, with a five-drug combination being the most frequently used regimen. Abstrak. Gagal jantung merupakan salah satu penyakit kardiovaskular yang banyak terjadi pada lansia dan sering disertai komorbid sehingga terapi menjadi lebih kompleks. Penelitian ini bertujuan mengetahui pola penggunaan obat, rasionalitas penggunaan obat, serta pola terapi pada pasien gagal jantung dengan komorbid hipertensi dan diabetes melitus tipe 2 di RS X Bandung periode Januari–Desember 2025. Penelitian menggunakan metode deskriptif observasional dengan pendekatan retrospektif. Pengambilan sampel dilakukan dengan teknik non-probability sampling menggunakan metode total sampling, sehingga diperoleh 120 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan pasien terbanyak berusia 55–65 tahun (53%) dan berjenis kelamin laki-laki (58%). Komorbid terbanyak adalah hipertensi (33%) dan diabetes melitus tipe 2 (8%). Bisoprolol merupakan obat yang paling banyak digunakan, diikuti furosemid, aspirin, atorvastatin, spironolakton, dan sacubitril/valsartan. Sebagian besar pasien menerima terapi kombinasi, dengan kombinasi lima jenis obat sebagai regimen yang paling banyak digunakan.

Profil Pengobatan Berbasis Platinum Pada Pasien KPKBSK Stadium III di RS X Nibras Rojwa Putri Azahra; Suwendar Suwendar; Bambang Tri Laksono
Bandung Conference Series: Pharmacy 355 - 364
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24914

Abstract. Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer, with the majority of patients newly diagnosed at stage III. Platinum-based combination chemotherapy (platinum doublet) is the primary systemic treatment option for controlling disease progression. This study aims to determine the profile of platinum-based treatment and the characteristics of stage III NSCLC patients at Hospital X. This study employed a retrospective observational design using a cohort approach. The sample was selected using total sampling from secondary medical record data of stage III NSCLC patients who met the inclusion criteria and received their fourth cycle of platinum-based chemotherapy. The results showed that of the 90 patients, the majority were male (76.7%) and aged 60 years or older (63.3%). The majority of patients are employed (90.0%), had a history of smoking (51.1%), had adenocarcinoma as the histopathological type (58.8%), were in stage III C (52.2%), and had comorbidities such as COPD or other lung diseases (48.7%). The most commonly used platinum-based chemotherapy regimens were carboplatin + paclitaxel (53.3%), followed by cisplatin + pemetrexed (20.0%), and cisplatin + paclitaxel (16.7%). These findings provide an overview of patient characteristics and platinum-based treatment profiles to inform improved treatment strategies for patients with stage III NSCLC. Abstrak. Kanker paru jenis karsinoma bukan sel kecil (KPKBSK) merupakan jenis kanker paru terbanyak, di mana sebagian besar pasien baru terdiagnosis pada stadium III. Kemoterapi kombinasi berbasis platinum (platinum-doublet) menjadi pilihan utama terapi sistemik untuk mengontrol progresivitas penyakit. Penelitian ini bertujuan untuk mengetahui profil pengobatan berbasis platinum dan karakteristik pasien KPKBSK stadium III di Rumah Sakit X. Penelitian ini menggunakan desain observasional retrospektif dengan pendekatan kohort. Sampel diambil dengan teknik total sampling dari data sekunder rekam medis pada pasien KPKBSK stadium III yang memenuhi kriteria inklusi dan menerima kemoterapi berbasis platinum siklus ke-4. Hasil penelitian menunjukkan bahwa dari 90 pasien, didominasi oleh laki-laki (76,7%) dengan kelompok usia ≥ 60 tahun (63,3%). Mayoritas pasien bekerja (90,0%), memiliki riwayat merokok (51,1%), dengan jenis histopatologi adenokarsinoma (58,8%), stadium III C (52,2%), dan memiliki komorbiditas PPOK atau penyakit paru lainnya (48,7%). Kelompok kemoterapi berbasis platinum yang banyak digunakan adalah kelompok carboplatin + paclitaxel (53,3%), diikuti cisplatin + pemetrexed (20,0%), dan cisplatin + paclitaxel (16,7%). Temuan ini memberikan gambaran umum terkait karakteristik pasien dan profil pengobatan berbasis platinum untuk meningkatkan strategi pengobatan pada pasien KPKBSK stadium III.

Pemahaman Anemia dan Ketepatan Penggunaan Tablet Tambah Darah di Kecamatan Maja Fakhriyah Faris Syarafi; Suwendar Suwendar; Lanny Mulqie
Bandung Conference Series: Pharmacy 399 - 406
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.24969

Abstract. Anemia is a common health problem among adolescent girls and can affect their growth, development, productivity, and future reproductive health. One of the government’s efforts to prevent anemia is through a program that provides iron supplements; however, the program’s success depends on adolescent girls’ level of understanding and proper use of these supplements. This study aims to examine adolescent girls’ understanding of anemia and iron-rich tablets, as well as the accuracy of their use, in Maja Subdistrict, Majalengka Regency. The study employed a descriptive observational method with a cross-sectional approach among adolescent girls using a questionnaire. The results showed that the level of understanding regarding anemia was in the “adequate” category (68.05%), understanding of iron-rich tablets was in the “good” category (79%), and the accuracy of iron-rich tablet use was in the “good” category (95.5%). Additionally, knowledge regarding the prevention of anemia through nutrition was in the “adequate” category (67.5%). It can be concluded that adolescent girls in Maja Subdistrict have adequate understanding of anemia as well as good understanding and proper use of iron supplements; however, further education is still needed in several aspects to support optimal anemia prevention. Abstrak. Anemia merupakan salah satu masalah kesehatan yang banyak terjadi pada remaja putri dan dapat berdampak terhadap pertumbuhan, perkembangan, produktivitas, serta kesehatan reproduksi di masa mendatang. Salah satu upaya pencegahan anemia yang dilakukan pemerintah adalah melalui program pemberian tablet tambah darah (TTD), namun keberhasilan program tersebut dipengaruhi oleh tingkat pemahaman dan ketepatan penggunaan TTD oleh remaja putri. Penelitian ini bertujuan untuk mengkaji pemahaman mengenai anemia dan tablet tambah darah serta ketepatan penggunaan tablet tambah darah pada remaja putri di Kecamatan Maja, Kabupaten Majalengka. Penelitian menggunakan metode observasional deskriptif dengan pendekatan cross-sectional pada remaja putri menggunakan kuesioner. Hasil penelitian menunjukkan bahwa tingkat pemahaman mengenai anemia berada dalam kategori cukup (68,05%), pemahaman mengenai tablet tambah darah berada dalam kategori baik (79%), dan ketepatan penggunaan tablet tambah darah berada dalam kategori baik (95,5%). Selain itu, pengetahuan mengenai pencegahan anemia melalui gizi berada dalam kategori cukup (67,5%). Dapat disimpulkan bahwa remaja putri di Kecamatan Maja memiliki pemahaman yang cukup mengenai anemia serta pemahaman dan ketepatan penggunaan tablet tambah darah yang baik, namun masih diperlukan peningkatan edukasi pada beberapa aspek untuk mendukung pencegahan anemia secara optimal.

Perbandingan Aktivitas Antibakteri Ekstrak Daun Belimbing Manis terhadap Bakteri Penyebab Jerawat Devi Fitriyanti; Siti Hazar; Suwendar Suwendar
Bandung Conference Series: Pharmacy 509 - 516
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25146

Abstract. Acne vulgaris is a common inflammatory skin disorder, including in Indonesia with a prevalence reaches 80–85%. The increasing risk of bacterial resistance associated with prolonged antibiotic use has encouraged the exploration of natural antibacterial agents. Sweet starfruit (Averrhoa carambola L.) leaf are known to contain secondary metabolites with antibacterial properties. This study aimed to evaluate the antibacterial activity. The leaves were extracted by maceration using 70% ethanol. Antibacterial activity was evaluated using the agar well diffusion method at concentrations of 5%, 10%, 15%, 20%, 25%, and 30%. The 30% extract showed the highest antibacterial activity, with inhibition zones of 11.12 ± 0.38 mm against C.acnes and 11.62 ± 0.21 mm against S.epidermidis. Statistical analysis revealed significant differences among the treatment groups (p<0,05). The 70% ethanol extract of sweet starfruit (Averrhoa carambola L.) leaves possesses antibacterial activity against both acne-associated bacteria, with greater inhibitory activity against S.epidermidis than C.acnes. Abstrak. Jerawat (acne vulgaris) merupakah salah satu masalah kulit yang sering dijumpai diberbagai negara, termasuk Indonesia dengan prevalensi mencapai 80% - 85%. Penggunaan antibiotik jangka panjang berpotensi menyebabkan resistensi bakteri. Daun belimbing manis (Averrhoa carambola L.) merupakan salah satu tanaman yang mengandung metabolit sekunder yang diketahui memiliki aktivitas antibakteri daun belimbing manis. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri. Ekstrasi dilakukan dengan metode maserasi menggunakan etanol 70%. Uji aktivitas antibakteri dilakukan menggunakan difusi agar teknik sumuran pada konsentrasi 5%, 10%, 15%, 20%, 25%, dan 30%. Hasil menujukkan ekstrak daun belimbing manis pada konsentrasi 30% mampu menghasilkan diameter zona hambat sebesar 11,12 mm ± 0,38 terhadap C.acnes dan 11,62 mm ± 0,21 terhadap S.epidermidis. analisis statistik menunjukkan adanya perbedaan yang signifikan antar kelompok perlakuan (p<0,05). Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak memiliki aktivitas antibakteri terhadap C.acnes dan S.epidermidis, dengan aktivitas yang lebih baik terbaik bakteri S.epidermidis.

Efektivitas Antibiotik terhadap Parameter Klinis Pasien Pneumonia Pediatri di RSUD Bandung Kiwari Nurul Azmi Fatarani; Fetri Lestari; Suwendar Suwendar
Bandung Conference Series: Pharmacy 675 - 684
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25403

Abstract. Pneumonia is one of the leading causes of mortality and morbidity in children worldwide. The success of antibiotic therapy in patients with pneumonia is assessed not only by bacterial eradication but also by improvements in clinical parameters such as respiratory rate, oxygen saturation, and body temperature. This study aims to determine which antibiotics tend to be effective based on changes in these clinical parameters in pediatric pneumonia patients. The study used a descriptive observational design with a retrospective cross-sectional approach based on medical records of pediatric pneumonia patients who met the inclusion criteria. A total of 40 patients met the study criteria. All antibiotic regimens showed improvement in clinical parameters during the treatment period. The greatest reduction in respiratory rate was observed with the ceftriaxone regimen followed by azithromycin, with an average decrease of 17 breaths per minute. The greatest increase in oxygen saturation was achieved with the combination of cefotaxime and gentamicin, at 17%. The greatest reduction in body temperature occurred with the combination of levofloxacin and azithromycin, at 3.1°C. Nevertheless, cefotaxime monotherapy showed the most consistent trend of effectiveness across all clinical parameters, marked by a reduction in respiratory rate of 8.6 breaths/minute, an increase in oxygen saturation of 6.7%, and a reduction in body temperature of 2.0°C, Thus, it has the potential to be one of the effective regimens for the management of pediatric pneumonia; however, its use must still take the patient’s clinical condition into account. Abstract. Pneumonia is one of the leading causes of mortality and morbidity in children worldwide. The success of antibiotic therapy in patients with pneumonia is assessed not only by bacterial eradication but also by improvements in clinical parameters such as respiratory rate, oxygen saturation, and body temperature. This study aims to determine which antibiotics tend to be effective based on changes in these clinical parameters in pediatric pneumonia patients. The study used a descriptive observational design with a retrospective cross-sectional approach based on medical records of pediatric pneumonia patients who met the inclusion criteria. A total of 40 patients met the study criteria. All antibiotic regimens showed improvement in clinical parameters during the treatment period. The greatest reduction in respiratory rate was observed with the ceftriaxone regimen followed by azithromycin, with an average decrease of 17 breaths per minute. The greatest increase in oxygen saturation was achieved with the combination of cefotaxime and gentamicin, at 17%. The greatest reduction in body temperature occurred with the combination of levofloxacin and azithromycin, at 3.1°C. Nevertheless, cefotaxime monotherapy showed the most consistent trend of effectiveness across all clinical parameters, marked by a reduction in respiratory rate of 8.6 breaths/minute, an increase in oxygen saturation of 6.7%, and a reduction in body temperature of 2.0°C, Thus, it has the potential to be one of the effective regimens for the management of pediatric pneumonia; however, its use must still take the patient’s clinical condition into account. Abstrak. Pneumonia merupakan salah satu penyebab mortalitas dan morbiditas pada anak di seluruh dunia. Keberhasilan terapi antibiotik pada pasien pneumonia tidak hanya dinilai dari eradikasi bakteri, tetapi juga melalui perbaikan parameter klinis seperti frekuensi napas, saturasi oksigen, dan suhu tubuh. Penelitian ini bertujuan untuk menentukan antibiotik yang cenderung efektif berdasarkan perubahan parameter klinis tersebut pada pasien pneumonia pediatri. Penelitian menggunakan desain deskriptif observasional dengan pendekatan potong lintang retrospektif berdasarkan data rekam medis pasien pneumonia pediatri yang memenuhi kriteria inklusi. Sebanyak 40 pasien memenuhi kriteria penelitian. Seluruh regimen antibiotik menunjukkan perbaikan parameter klinis selama masa perawatan. Penurunan frekuensi napas terbesar ditemukan pada regimen ceftriaxone yang dilanjutkan azitromisin dengan penurunan rata-rata sebesar 17 kali/menit. Peningkatan saturasi oksigen terbesar diperoleh pada kombinasi cefotaxime dan gentamisin sebesar 17%. Penurunan suhu tubuh terbesar terjadi pada kombinasi levofloxacin dan azitromisin sebesar 3,1°C. Meskipun demikian, cefotaxime monoterapi menunjukkan kecenderungan efektivitas yang paling konsisten pada seluruh parameter klinis, ditandai dengan penurunan frekuensi napas sebesar 8,6 kali/menit, peningkatan saturasi oksigen sebesar 6,7%, serta penurunan suhu tubuh sebesar 2,0°C, sehingga berpotensi menjadi salah satu regimen yang efektif dalam penatalaksanaan pneumonia pediatri, namun penggunaannya tetap perlu mempertimbangkan kondisi klinis pasien.

Profil Regimen Kemoterapi pada Pasien Kanker Paru Stadium III Di RS X Periode 2023-2025 Adelia Nanda Maulana; Suwendar Suwendar; Bambang Tri Laksono
Bandung Conference Series: Pharmacy 807 - 816
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25747

Abstract. The prescription of chemotherapy (cytostatic drugs) as the primary treatment for lung cancer must be carried out with caution and under close supervision. This study aims to determine the rationale for regimen profile of chemotherapy to stage III lung cancer patients at X Hospital during the 2023–2025 period. The study was conducted as a descriptive observational study using a retrospective approach based on medical records of stage III lung cancer patients in the Inpatient Ward. . A total of 99 patients met the study criteria, with Non-Small Cell Lung Cancer (NSCLC) being the predominant type (92.9%). The Carboplatin–Paclitaxel regimen (45.5%) was found to be the most commonly used for NSCLC, while for Small Cell Lung Cancer (SCLC), it was the Etoposide–Carboplatin regimen (5.2%). The most commonly used supportive therapies included antiemetics, gastroprotectants, intravenous fluids and electrolytes, analgesics, corticosteroids, and bronchodilators. Abstrak. Peresepan kemoterapi (sitostatika) sebagai modalitas utama kanker paru harus dilakukan dengan kehati-hatian dan pengawasan ketat. Penelitian ini bertujuan untuk mengetahui profil regimen kemoterapi pada pasien kanker paru stadium III di Instalasi Rawat Inap RS X periode 2023–2025. Penelitian dilakukan secara observasional deskriptif dengan pendekatan retrospektif berdasarkan data rekam medis pasien kanker paru stadium III di Instalasi Rawat Inap. Sebanyak 99 pasien memenuhi kriteria penelitian, dengan dominasi Non-Small Cell Lung Cancer (NSCLC) (92,9%). Ditemukan Regimen kemoterapi Carboplatin - Paklitaksel (45,5%) paling banyak digunakan pada NSCLC, sedangkan pada Small Cell Lung Cancer (SCLC) adalah Etoposid Carboplatin (5,2%).. Terapi suportif yang paling banyak digunakan antara lain golongan antiemetik, gastroprotektor, cairan infus dan elektorlit, analgesik, koritkosteroid, serta bronkodilator

Aktivitas Antelmintik Ekstrak Etanol dan Fraksi Daun Jarak Pagar Secara In Vitro Tiara Hasya Juhara; Suwendar Suwendar; Siti Hazar
Bandung Conference Series: Pharmacy 817 - 826
Publisher : UNISBA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/bcsp.v6i2.25765

Abstract. In Indonesia, helminth infection prevalence ranges from 2.5% to 62%, driven by tropical climate, high population density, and low hygiene awareness. This study aimed to evaluate the anthelmintic activity of Jatropha curcas L. leaf extracts and fractions against adult pig roundworms (Ascaris suum), and to determine the PC50 and LC50 values. An experimental laboratory study used negative controls (0.5% CMC-Na), positive controls (pyrantel pamoate and piperazine citrate), and test groups treated with ethanol leaf extract (5%,10%,15%,20% and 25% w/v), an ethanol:water fraction (1%, 2%,4% and 8% w/v), and n-hexane and ethyl acetate fractions (1% and 2% w/v). Results showed the ethanol extract possessed anthelmintic activity, producing spastic-type paralysis. The 10% extract induced 50% paralysis, while 20% and 25% caused 60% mortality; the 8% ethanol:water fraction induced 40% paralysis. PC50 values for male and female worms were 9.0240% and 7.4542%; LC50 values were 27.3401% and 21.3944%. The fraction gave PC50 values of 43.2713% male and 14.1840% female. Abstrak. Di Indonesia, prevalensi infeksi cacing berkisar antara 2,5% hingga 62%, yang dipengaruhi oleh iklim tropis, kepadatan penduduk yang tinggi, dan rendahnya kesadaran akan kebersihan. Penelitian ini bertujuan untuk mengevaluasi aktivitas antelmintik ekstrak serta fraksi daun Jatropha curcas L. terhadap cacing Ascaris suum, serta menentukan nilai PC50 dan LC50. Penelitian eksperimental laboratorium ini menggunakan kontrol negatif (CMC-Na 0,5%), kontrol positif (pirantel pamoat dan piperazin sitrat), serta kelompok uji yang diberi perlakuan berupa ekstrak etanol daun (5%,10%,15%,20% dan 25% b/v), fraksi etanol-air (1%, 2%,4% and 8% b/v), serta fraksi n-heksana dan etil asetat (1% dan 2% b/v). Hasil menunjukkan ekstrak etanol memiliki aktivitas antelmintik dengan paralisis tipe spastik. Konsentrasi 10% menyebabkan paralisis 50%, sedangkan 20% dan 25% menyebabkan mortalitas 60%; fraksi etanol-air 8% menyebabkan paralisis 40%. Nilai PC50 cacing jantan dan betina masing-masing 9,0240% dan 7,4542%; nilai LC50 masing-masing 27,3401% dan 21,3944%. Fraksi etanol-air menghasilkan PC50 sebesar 43,2713% (cacing jantan) dan 14,1840% (cacing betina).

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