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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Medika: Medika
Laili, Ni'mah Hidayatul
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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The effect of Gandarusa Leaf extract (Justicia gendarussa Burm F.) Administration on Estradiol Hormone Level and the Amount of Antral Ovarium Follicle on Female Mice Laili, Ni'mah Hidayatul; Nasihun, Taufiqurrachman; Sumarawati, Titiek
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 9, No 2 (2018): December 2018
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2262.524 KB) | DOI: 10.30659/sainsmed.v9i2.2099

Abstract

Background: Physiologically, woman experiencing aging characterized by menopause. Gandar usa leaf contains isof lavon, a phytoesterogen expected to be used as esterogen replacement therapy.Objective: the aim of this research is to investigate the administrative ef fect of gandar usa leaf extract on the increase of estradiol hor mone level and the number of antral ovarium follicle of female mice.Methods: This is experimental study with posttest only control group research design. Samples are 24 balb-c female mice, aged 16-17 months, weighed 19-35 grams, divided into 4 groups. Control group (Ctrl-G) were given 0.48 ml aquadest; group JB10-G, JB20-G, and JB30-G, each were given gandar usa leaf extract with concentration 10%, 20%, dan 30% in volume 0.48 ml orally twice a day. Af ter treatment, dissection were conducted to make ovarium histology preparation with Hematoxylin Ehrlich-Eosin staining, obser vation were conducted using microscope.Results: Post hoc analysis indicated that the estradiol level and the number of antral ovarium follicle on administration of gandar usa leaf extract with concentration 10%, 20%, dan 30% are signif icantly higher, p < 0.05. The increase of estradiol level with extract concentration of 10% are signif icantly negatively cor related with the number of antral ovarium follicles p<0.05. negatively cor related with the number of antral ovarium follicles p<0.05.Conclusion: The administration of gandar usa leaf extract increase the estradiol hor mone level and the number of antral ovarium follicle in female mice.
Pendampingan Pengelolaan Sampah Berbasis Komunitas Menuju Ecohealthy Campus dan Desa Wisata Sehat Sugiyatmi, Tri Astuti; Saleh, Rachmat; Tamrin, Nasrullah; Seruni, Eka Nurul Hidayah Puspa; Awaluddin, Awaluddin; Egok, Adipura Atmadja; Rizky, Vincentia Ade; Rahayu, Avinda Sari Kanthi; Joni, Maria Selviana; Latifah, Umi; Laili, Ni'mah Hidayatul
Jurnal Medika: Medika Vol. 5 No. 1 (2026)
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/m5mtm120

Abstract

Permasalahan pengelolaan sampah yang belum optimal masih menjadi isu utama di kawasan pesisir Kota Tarakan, khususnya di Kelurahan Pantai Amal yang berfungsi sebagai kawasan wisata sekaligus lokasi Kampus Universitas Borneo Tarakan. Wilayah ini juga merupakan sentra budidaya rumput laut, di mana penggunaan botol plastik sebagai pelampung berkontribusi terhadap timbulan sampah pesisir yang berdampak pada kesehatan lingkungan. Kegiatan pengabdian kepada masyarakat ini bertujuan meningkatkan pengetahuan, kesadaran, dan komitmen sosial petugas kebersihan Universitas Borneo Tarakan serta anggota Kelompok Swadaya Masyarakat (KSM) Tempat Pengolahan Sampah (TPS) 3R (Reduce, Reuse, Recycle) Amal Jaya dalam pengelolaan sampah berbasis prinsip 3R dan kesehatan lingkungan. Metode yang digunakan adalah pendampingan komunitas melalui penyuluhan interaktif, diskusi, pemberian media edukasi, serta demonstrasi pembuatan komposter metode Takakura. Evaluasi dilakukan secara deskriptif menggunakan pre-test dan post-test serta observasi partisipasi peserta. Kegiatan dilaksanakan dalam dua tahap pada 30 September dan 7 Oktober 2025. Hasil kegiatan menunjukkan tingkat pengetahuan peserta berada pada kategori tinggi, disertai peningkatan pemahaman dan keterlibatan aktif. Kegiatan ini menghasilkan komitmen kolektif untuk melanjutkan pendampingan KSM TPS 3R guna mendukung terwujudnya Ecohealthy Campus dan Desa Wisata Sehat Pantai Amal.
Co-Authors Awaluddin Awaluddin Egok, Adipura Atmadja Joni, Maria Selviana Rahayu, Avinda Sari Kanthi Saleh, Rachmat Seruni, Eka Nurul Hidayah Puspa Sugiyatmi, Tri Astuti Tamrin, Nasrullah Taufiqurrachman Nasihun Titiek Sumarawati Umi Latifah Vincentia Ade Rizky