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All Journal Universa Medicina Jurnal Ilmu Kedokteran dan Kesehatan Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Ilmu Faal Olahraga Indonesia Current Research on Biosciences and Biotechnology Multidiciplinary Output Research for Actual and International Issue (Morfai Journal) Makara Journal of Health Research Tirtayasa Medical Journal Jurnal Kedokteran Meditek Tirtayasa Medical Journal
Imelda Rosalyn Sianipar
Department Of Medical Physiology And Biophysics, Faculty Of Medicine Universitas Indonesia, Jakarta, Indonesia
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THE EFFECT OF HIBISCUS SABDARIFFA LINN ON TRABECULAR BONE MICROARCHITECTURE IN AN AGING MODEL DUE TO D-GALACTOSE INDUCTION: A HISTOMORPHOMETRIC STUDY Fransiscus Asisi Alfareza; Neng Tine Kartinah; Trinovita Andraini; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.22022656

Abstract

The aging process can cause an imbalance in bone remodeling and changes in trabecular bone microarchitecture. D-galactose induction is used as an experimental aging model because it can increase oxidative stress, while Hibiscus sabdariffa Linn. contains antioxidant compounds that have the potential to provide a protective effect on bone tissue. This study aims to analyze changes in trabecular bone microarchitecture in aging models due to D-galactose induction and the effect of Hibiscus sabdariffa Linn. This experimental study involved 22 samples divided into young normal (NM; n = 6), old normal (NA; n = 4), aging due to D-galactose induction (AA; n = 6), and aging due to D-galactose induction given by Hibiscus sabdariffa Linn. (AH; n = 6). Femur bone tissue was fixed, decalcified using formic acid, processed into paraffin blocks, and stained with hematoxylin-eosin. Trabecular bone images were taken in five fields of view using a 20× objective lens. Histomorphometric examination was performed to assess trabecular thickness (Tb.Th) and bone volume per tissue volume (BV/TV). Data met the assumptions of normality and homogeneity so they were analyzed using one-way analysis of variance followed by Tukey's post hoc test if there were significant differences. The significance level was set at p < 0.05. The mean Tb.Th in the NM, NA, AA, and AH groups were 71.61 ± 15.90 µm; 130.98 ± 11.31 µm; 120.61 ± 37.79 µm; and 100.48 ± 20.92 µm, respectively. There was a significant difference in Tb.Th values between groups with F (3,18) = 5.975 and p = 0.005. Post hoc test showed a significant difference between the NM and NA groups (p = 0.008) and between the NM and AA groups (p = 0.014). There was no significant difference between the AA and AH groups (p = 0.509). The mean BV/TV in the NM, NA, AA, and AH groups were 55.06 ± 11.06%, respectively.
Hubungan Posisi Dan Durasi Duduk Saat Penggunaan Komputer Dengan Keluhan LBP Pada Tenaga Kependidikan Di Universitas Sulltan Ageng Tirtayasa Yuda Nabella Prameswari; Alya Indah Gayatri; Imelda Rosalyn Sianipar
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 1 (2026): Volume 13 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i1.20880

Abstract

Low back pain (LBP) merupakan masalah kesehatan global yang sering dialami oleh pekerja dengan aktivitas duduk berkepanjangan, termasuk tenaga kependidikan. Tujuan studi ini adalah menganalisis hubungan posisi dan durasi duduk saat menggunakan komputer dengan kejadian LBP pada tenaga kependidikan Universitas Sultan Ageng Tirtayasa. Desain yang digunakan adalah observasional analitik dengan pendekatan potong lintang yang dilaksanakan di seluruh fakultas dan rektorat Universitas Sultan Ageng Tirtayasa. Analisis bivariat menggunakan uji Chi-square dan Fisher’s Exact menunjukkan bahwa postur duduk yang tidak ergonomis serta durasi duduk yang lama berhubungan signifikan dengan kejadian LBP, sedangkan indeks massa tubuh tidak menunjukkan hubungan yang bermakna. Kesimpulannya, postur duduk yang tidak tepat dan durasi duduk yang berkepanjangan merupakan faktor yang berhubungan signifikan dengan kejadian LBP pada tenaga kependidikan.
Myosin heavy chain as biomarker in the prevention of sarcopenia Desy Nofita Sari; Roman Ardian Goenarjo; Imelda Rosalyn Sianipar; Chin Leong Lim
Universa Medicina Vol. 45 No. 1 (2026)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2026.v45.88-98

Abstract

Sarcopenia, or the age-related loss of skeletal muscle mass and function, can reduce total muscle contractile capacity and increase the likelihood of physical disability in older adults. The loss of muscle mass and contractile performance is generally thought to be multifactorial, with as possible contributing factor an age-related shift in the expressed amounts of myosin heavy chain (MyHC) isoforms. The composition of adult human skeletal muscle consists of a mixture of three distinct MyHC isoforms (I, IIA, and IIX). This literature review aimed to explore studies focused on the signs of sarcopenia, the early detection of initial symptoms, and awareness among the aging population. We aimed to understand the molecular changes in muscle fibers as people age and to help inform the early intervention approach to prevent sarcopenia. The literature search was conducted in several databases between 2020 to 2025, including PubMed, ScienceDirect, and SpringerLink. The search terms consisted of “sarcopenia”, “muscle mass”, “early detection”, and “myosin heavy chain”. Inclusion criteria included original full-text English-language studies on the cellular and molecular physiology of sarcopenia. Molecular changes in myosin heavy chain vary across different age groups, suggesting the potential for early detection of muscle aging. The review is limited by the variability in the definition and measurement of sarcopenia across different studies, which may affect the generalizability of the findings. This review highlights the potential significance of identification and sarcopenia management in elderly individuals. The findings would be helpful for clinicians, researchers, and policymakers to improve elderly care and quality of life.
Co-Authors Ahmad Aulia Alya Indah Gayatri Amirah Yusnidar Antoni, Marcel Chin Leong Lim Desy Nofita Sari Fasha, Iqbal Fransiscus Asisi Alfareza Gabriella E.O Andrianti Gita Pratama Goenarjo, Roman Ardian Inna Rahmawati Iqbal Fasha Irena Ujianti Ita Marlita Sari Jalma, Monica Dwi Mukhlidah Hanun Siregar Murti, Krishna Aditya Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Nisa Kartika Komara Nuraditya, Robby Nuraini Diah Noviati Nurhadi Ibrahim Nurul Paramita Patwa Amani, Patwa Putu Indah Paramita Adi Putri Radiana Dhewayani Antarianto Rahmawati, Inna Retno Lestari Retno Lestari Robby Nuraditya Roman Ardian Goenarjo Samuel Febrian Wijaya Santoso, Dewi Irawati Soeria Sophie Yolanda Tazkia Nazla Hudzaifa Trinovita Andraini Wijaya, Samuel Febrian Yuda Nabella Prameswari