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Imelda Rosalyn Sianipar
Department Of Medical Physiology And Biophysics, Faculty Of Medicine Universitas Indonesia, Jakarta, Indonesia
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THE EFFECT OF HIBISCUS SABDARIFFA LINN ON TRABECULAR BONE MICROARCHITECTURE IN AN AGING MODEL DUE TO D-GALACTOSE INDUCTION: A HISTOMORPHOMETRIC STUDY Fransiscus Asisi Alfareza; Neng Tine Kartinah; Trinovita Andraini; Imelda Rosalyn Sianipar
Multidiciplinary Output Research For Actual and International Issue (MORFAI) Vol. 6 No. 5 (2026): Multidiciplinary Output Research For Actual and International Issue
Publisher : RADJA PUBLIKA

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Abstract

The aging process can cause an imbalance in bone remodeling and changes in trabecular bone microarchitecture. D-galactose induction is used as an experimental aging model because it can increase oxidative stress, while Hibiscus sabdariffa Linn. contains antioxidant compounds that have the potential to provide a protective effect on bone tissue. This study aims to analyze changes in trabecular bone microarchitecture in aging models due to D-galactose induction and the effect of Hibiscus sabdariffa Linn. This experimental study involved 22 samples divided into young normal (NM; n = 6), old normal (NA; n = 4), aging due to D-galactose induction (AA; n = 6), and aging due to D-galactose induction given by Hibiscus sabdariffa Linn. (AH; n = 6). Femur bone tissue was fixed, decalcified using formic acid, processed into paraffin blocks, and stained with hematoxylin-eosin. Trabecular bone images were taken in five fields of view using a 20× objective lens. Histomorphometric examination was performed to assess trabecular thickness (Tb.Th) and bone volume per tissue volume (BV/TV). Data met the assumptions of normality and homogeneity so they were analyzed using one-way analysis of variance followed by Tukey's post hoc test if there were significant differences. The significance level was set at p < 0.05. The mean Tb.Th in the NM, NA, AA, and AH groups were 71.61 ± 15.90 µm; 130.98 ± 11.31 µm; 120.61 ± 37.79 µm; and 100.48 ± 20.92 µm, respectively. There was a significant difference in Tb.Th values between groups with F (3,18) = 5.975 and p = 0.005. Post hoc test showed a significant difference between the NM and NA groups (p = 0.008) and between the NM and AA groups (p = 0.014). There was no significant difference between the AA and AH groups (p = 0.509). The mean BV/TV in the NM, NA, AA, and AH groups were 55.06 ± 11.06%, respectively.
Co-Authors Ahmad Aulia Amirah Yusnidar Antoni, Marcel Desy Nofita Sari Fasha, Iqbal Fransiscus Asisi Alfareza Gabriella E.O Andrianti Gita Pratama Goenarjo, Roman Ardian Inna Rahmawati Iqbal Fasha Irena Ujianti Ita Marlita Sari Jalma, Monica Dwi Mukhlidah Hanun Siregar Murti, Krishna Aditya Naibaho, Fitri Boru Neng Tine Kartinah Almuktabar Nisa Kartika Komara Nuraditya, Robby Nuraini Diah Noviati Nurhadi Ibrahim Nurul Paramita Nurul Paramita Patwa Amani, Patwa Putu Indah Paramita Adi Putri Radiana Dhewayani Antarianto Rahmawati, Inna Retno Lestari Retno Lestari Robby Nuraditya Roman Ardian Goenarjo Samuel Febrian Wijaya Santoso, Dewi Irawati Soeria Sophie Yolanda Tazkia Nazla Hudzaifa Trinovita Andraini Trinovita Andraini Wijaya, Samuel Febrian