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All Journal Jurnal Anestesi Perioperatif Majalah Kedokteran Nusantara The Journal Of Medical School Majalah Anestesia dan Critical Care Sumatera Medical Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Indonesian Journal of Anesthesiology and Reanimation (IJAR) Jurnal Health Sains Majalah Anestesia & Critical Care (MACC) The Journal of Society Medicine (JSOCMED)

Hanafie, Achsanuddin

Departemen/ SMF Anestesiologi Dan Terapi Intensif Fakultas Kedokteran Universitas Sumatera Utara/ Rumah Sakit Umum Pusat Haji Adam Malik Medan

Author-ID : 1154199

Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Patterns of Antibiotic Use in The One Hour Bundle Treatment of Sepsis Syaputra, Adhika; Wijaya, Dadik Wahyu; Hanafie, Achsanuddin
Journal of Society Medicine Vol. 1 No. 3 (2022): December
Publisher : CoinReads Media Prima

Introduction: Sepsis and septic shock are major health problems, affecting millions of people worldwide and a leading cause of death. Administration of broad-spectrum empiric antibiotics as a one hour sepsis bundle treatment is associated with antimicrobial resistance which has various adverse effects and reduces the quality of health services. The aim of this research was to determine the pattern of empiric antibiotic use in the management of one hour bundle of sepsis at Haji Adam Malik General Hospital Medan. Method: This study used a descriptive method from November 2022 to December 2022 in the Emergency Room (ER), Medical Inpatient Room, Surgical Inpatient Room, and Adult Intensive Care Unit (ICU) of Haji Adam Malik General Hospital Medan. This study used a consecutive sampling technique to recruit 42 sepsis patients who were given a one hour bundle of sepsis according to the inclusion and exclusion criteria. This descriptive analysis was used to determine the characteristics of the sample, namely age, sex, culture results, and antibiotic sensitivity test results. Results: The most common use of antibiotics in the one hour bundle sepsis strategy was ceftriaxone 1 gram in 20 patients (47.6%), Ampicillin-Sulbactam 1.5 grams in 10 patients (23.8%), Levofloxacin 750 mg in 6 patients (14.3%), Meropenem 1 gram in 4 patients (9.5%), and Ciprofloxacin 200 mg in 2 patients (4.8%). Conclusion: Antibiotic administration time is less than 1 hour in the one hour bundle strategy carried out in the ER. Most of the antibiotics given are in accordance with the antibiotic sensitivity test results, but there are still some patients who still experience resistance to the antibiotics.given so it is important to always or immediately carry out culture and sensitivity tests on patients so that the antibiotics given can be more optimal

Comparison of Oxytocin 10 IU Intravena Dilution of 10 ml Nacl 0.9% Bolus for 15 Seconds and 60 Seconds to Hemodynamics in Sectio Caesaria Patients with Spinal Anesthesia Ricardo, Dion; Hanafie, Achsanuddin; Hamdi, Tasrif
Journal of Society Medicine Vol. 1 No. 1 (2022): October
Publisher : CoinReads Media Prima

Introduction: Caesarean section (SC) is defined as the birth of a baby through an incision in the abdomen (laparotomy) and uterus (hysterotomy). Spinal anesthesia is the choice for elective SC because it is considered effective and efficient considering its simple technique and ability to provide adequate surgical anesthesia, easy administration, faster onset, and safety. Spinal anesthesia also provides early skin to skin contact which increases maternal satisfaction although the hypotension risk is higher compared to epidural anesthesia which is countered by sympathomimetic vasopressors administration. The aim to research was to compare the administration of 10 IU oxytocin diluted in 10 cc of 0.9% NaCl for 15 seconds with 60 seconds on hemodynamics in sectio caesarean patients under spinal anesthesia. Method: This study used an RCT (Randomized Clinical Trial) design with double blind, meaning that neither the research subjects nor the observers were aware of the treatment or intervention given. The study sample was patients who underwent Sectio Caesaria at Haji Adam Malik General Hospital Medan, and the Universitas Sumatera Utara Hospital which fulfilled the inclusion and exclusion criteria. Results: It was found that there was not a significant difference in MAP values between the 15-second and 60-second bolus groups with p-values for the 1st, 3rd, 5th, and 10th minutes respectively 0.804, 0.692, 0.568 , 0.216, 0.754, and 0.390. In addition, it is known that there was a significant difference in pulse values between the 15-second and 60-second bolus groups at 1, 3, 5, 10 and 15 minutes, with the results of the p-value before, 1, 3, 5, 10, and 15 minutes are 0.509, 0.464, 0.805, 0.055, 0.475 and 0.857 respectively. In this study, no side effects were found in either group between 15 second and 60 second boluses. Conclusion: There were no significant hemodynamic changes in both test groups (15 second and 60 second boluses), at 1, 3, 5, 10 and 15 minutes.

Hubungan Mean Platelet Volume dengan Skor Sequential Organ Failure Assessment pada Pasien Sepsis Nasution, Putra Fajar; Primaputra Lubis, Andriamuri; Hanafie, Achsanuddin
Majalah Anestesia & Critical Care Vol 43 No 2 (2025): Juni
Publisher : Perhimpunan Dokter Spesialis Anestesiologi dan Terapi Intensif (PERDATIN) / The Indonesian Society of Anesthesiology and Intensive Care (INSAIC)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55497/majanestcricar.v43i2.344

Latar Belakang: Sepsis adalah suatu disfungsi organ yang mengancam jiwa yang disebabkan oleh kelainan regulasi respon host terhadap infeksi. Skor Sequential Organ Failure Assessment (SOFA) digunakan untuk menilai tingkat keparahan penyakit berdasarkan derajat disfungsi organ secara serial. Mean platelet volume (MPV) adalah salah satu parameter trombosit di mana trombosit turut berperan dalam proses inflamasi penyakit infeksi akut dan kronis. Tujuan penelitian ini adalah untuk mengetahui hubungan Nilai MPV dengan skor SOFA pada pasien sepsis.Metode: Penelitian ini merupakan studi observasional dengan metode pengumpulan data secara kohort – prospective. Pengambilan sampel dilakukan secara konsekutif terhadap pasien penderita sepsis di ICU yang memenuhi kriteria penelitian. Analisis korelasi nilai MPV dengan skor SOFA pada pasien sepsis menggunakan uji korelasi Pearson. Semua uji statistik dengan nilai p < 0,05 dianggap bermakna.Hasil: Hasil penelitian didapatkan rerata nilai MPV H1 sebesar 9,20± 1,72 dengan skor SOFA H1 sebesar 7,81 ± 2,66. Hasil analisis statistik menunjukkan nilai r > 0,522 dengan nilai p<0,002. Rerata nilai MPV H3 sebesar 9,47±1,39 dengan skor SOFA H3 sebesar 7,96 ± 2,49. Hasil analisis statistik menunjukkan nilai r > 0,441 dengan nilai p <0,010. Temuan ini mengartikan bahwa terdapat hubungan yang bermakna antara MPV dengan skor SOFA dengan kekuatan korelasi yang kuat.Simpulan: Terdapat peningkatan nilai MPV pada pasien sepsis seiring dengan peningkatan skor SOFA, serta ditemukan hubungan nilai MPV dengan skor SOFA pada pasien sepsis baik di hari pertama maupun hari ketiga.

The Relationship of Lactate Albumin Ratio With Sofa Score As A Predictor of Sepsis Patients in The Intensive Care Room Karim, Tengku Abdul; Hanafie, Achsanuddin; Tanjung, Qadri Fauzi; Amelia, Rina
Jurnal Health Sains Vol. 6 No. 6 (2025): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v6i6.2619

Sepsis is a life-threatening organ dysfunction due to dysregulation of the host response to infection which causes systemic changes, namely an increase in the serum lactate/albumin ratio which is associated with mortality. Method:This study is a clinical observational analytical study with a prospective cohort design at fittingAdult patients diagnosed with sepsis in the integrated inpatient ward and intensive care ward at Haji Adam Malik General Hospital, Medan. The subject sampling technique used was non-probability sampling with a consecutive sampling method where 50 subjects were required. Bivariate analysis used the Pearson correlation test and the linear relationship between the lactate-albumin ratio value and the SOFA score used linear regression. A 95% confidence interval with a p value <0.05 was considered significantly significant Results :The results of the research on the first day found that the average LAR H1 was 0.59 + 0.51 (0.12-2.26) and the average SOFA H1 score was 7.32 + 1.88 (7) where an r value of 0.726 was obtained. indicates a high and significant correlation between Lactate Albumin Ratio and SOFA Score as a predictor of sepsis patients (p value = 0.000, p<0.05). On the third day, the average LAR H3 score was 0.12 + 0.29 (0.21-0.47) and the average SOFA H3 score was 9.58 + 2.01 (10) where an r value of 0.33 was found which indicates Very low and insignificant correlation between Lactate Albumin Ratio and SOFA Score as a predictor of sepsis patients (p value = 0.818, p > 0.05). Conclusion:The lactate-albumin ratio was strongly correlated with the SOFA score on the first day of adult patients diagnosed with sepsis in the integrated inpatient ward and intensive care ward.

Prophylactic Effectiveness of Phenylephrine 100 mcg and Ephedrine 10 mg on the Incidence of Spinal Anesthesia Induced Hypotension in Patients Undergoing Cesarean Section Etania, Cassandra; Hanafie, Achsanuddin; Lubis, Andriamuri Primaputra
Indonesian Journal of Anesthesiology and Reanimation Vol. 7 No. 2 (2025): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V7I22025.85-92

Introduction: Birth by cesarean section (C-section) has increased significantly, with a high risk of maternal hypotension due to spinal anesthesia. Objective: This study aims to compare the prophylactic effectiveness of phenylephrine 100 mcg and ephedrine 10 mg in preventing spinal anaesthesia induced hypotension in C-section patients. With a focus on safety and reducing the incidence of fetal acidosis, the results of the study are expected to provide clinical insights that can improve the safety and quality of care for pregnant women undergoing this procedure. Methods: This study compared the effectiveness of phenylephrine 100 mcg and ephedrine 10 mg in preventing hypotension due to spinal anesthesia in cesarean section patients in four hospitals in Medan, Indonesia. Using a double-blind design, 40 patients aged 18-40 years were randomly selected, and blood pressure and heart rate were measured before and after anesthesia. Data were analyzed using SPSS, and ethical aspects were taken care of through informed consent. Results: This study found that phenylephrine 100 mcg was more effective than ephedrine 10 mg in preventing spinal anaesthesia induced hypotension in cesarean section, with more stable blood pressure and mean arterial pressure (MAP) at the 5th, 10th, and 15th minutes (p-value < 0.05). Although ephedrine remained above 100 mmHg for systolic blood pressure (SBP), the incidence of nausea and vomiting was slightly higher in the ephedrine group. Results support phenylephrine as the primary choice for hypotensive management. Conclusion: Phenylephrine 100 mcg is more effective than ephedrine 10 mg in preventing hypotension due to spinal anesthesia, without increasing heart rate. Despite causing nausea, ephedrine has a higher incidence of vomiting. Ephedrine is recommended if phenylephrine is not available, with further studies needed for lower doses of phenylephrine.

Co-Authors Ahmad Fiza Putera Andrias Andrias Bastian Lubis Bisono, Luwih Dadik Wahyu Wijaya Dadik Wahyu Wijaya Etania, Cassandra Franz Josef Tarigan Hamdi, Tasrif Hasanul Arifin Heru Kurniawan Indrawan, Jhonsen Karim, Tengku Abdul Lubis, Andriamuri Primaputra Lubis, Asmin M. Teguh Prihardi Mohammer Pasha Muhamad Soleh Muhammad Fikri Muhammad Ihsan Mursin, Chairul M Nasution, Putra Fajar Nazaruddin Umar Primaputra Lubis, Andriamuri Qadri Fauzi Tanjung Ricardo, Dion Rina Amelia Simanjuntak, Ikrar Rananta Soejat Harto Syaputra, Adhika Wijaya, Dadik Wahyu

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