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All Journal Pharmascience Acta Pharmaciae Indonesia : Acta Pharm Indo Chemistry Indonesian Journal of Chemical Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Mandala Pharmacon Indonesia Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pena Medika : Jurnal Kesehatan Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Sosial dan Sains Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Jurnal Keperawatan dan Kesehatan (JKK) Kartika : Jurnal Ilmiah Farmasi
Nawangsari, Desy
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FORMULASI DAN EVALUASI SIFAT FISIK SEDIAAN GEL EKSTRAK ETANOL DAUN PETAI CINA (Leucanea leucocephala (Lam.) de Wit) DENGAN VARIASI KONSENTRASI BASIS KARBOPOL 940 Suri, Natasha Triska; Nawangsari, Desy; Febrina, Dina
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p33-40

Abstract

Chinese petai leaves (Leucaena leucocephala (Lam.) De Wit.) contain compounds in the flavonoid, saponin, and tannin groups that have antioxidant activity. Chinese petai leaves need to be developed in the form of a gel preparation with a karbopol 940 base. Karbopol 940 is a gelling agent that is very commonly used in cosmetic production due to its high compatibility and stability, non-toxicity when applied to the skin, and ease of spreading on the skin. This study aims to determine the formulation of ethanol extract gel from petai cina leaves with physical properties and physical stability, to assess the irritation effects on the skin of albino rabbits, and to evaluate the respondents' preference for the gel preparation. This research is an experimental study. The extraction method used was maceration with 70% ethanol as the solvent. The formulation of the ethanol extract gel from the Chinese petai leaves used a carbopol 940 base with concentration differences of F1 0,5%, F2 1%, and F3 2%. The research results showed that the organoleptic physical properties had a distinctive smell, were brown in color, and had a gel form. The homogeneity test indicated that the gel preparation was homogeneous. The pH test results met the standards. Based on statistical testing, it was found that pH, viscosity, and spreadability obtained p-value <0,05, indicating a significant difference due to the varying concentrations of carbopol used in each formula. The adhesion test results did not show a significant effect. In the irritation test, it showed very mild irritation and the preference level indicated the highest percentage of 34,60%.
Uji Efektivitas Salep Ekstrak Biji Kopi Robusta (Coffea canephora) Terhadap Penyembuhan Luka Sayat Pada Kulit Punggung Kelinci Yuliani, Anis Fitria; Samodra, Galih; Nawangsari, Desy
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.511

Abstract

Kopi robusta (Coffea canephora) ialah salah satu jenis kopi yang bayak dibudidayakan diIndonesia serta mempunyai posisi menonjol sebagai salah satu komoditas unggulan.Biji kopi diketahui mengandung sejumlah besar komponen antioksidan sepertiflavonoid, alkaloid, saponin, serta polifenol. Senyawa ini mempunyai sifat antiinflamasi yang terbukti efektif dalam pengobatan berbagai jenis luka. Riset inibermaksud menilai efektivitas salep yang mengandung ekstrak biji kopi robusta padakonsentrasi yang bervariasi untuk tujuan penyembuhan luka pada luka sayat. Jenis risetini ialah eksperimental. Formulasi salep dibuat menggunakan ekstrak biji kopi Robusta.Riset ini memanfaatkan tiga hewan uji serta lima kelompok perlakuan yang meliputisalep dengan kandungan ekstrak biji kopi Robusta 20%, 30%, serta 40%, kontrol positif,serta kontrol negatif. Semua kelinci diberikan luka sepanjang 2 cm serta kedalaman 0,1cm. Salep yang diuji dioleskan dua kali sehari pada luka selama dua minggu. Seluruhdata kuantitatif diuji secara statistic menggunakan ANOVA (Analysis Of Varian).Temuan riset memperlihatkan pada hari ke-8 dan ke-9, luka pada kontrol positif dankonsentrasi 40% sudah menutup dan tidak terdapat keropeng. Hasil uji statistikmemperlihatkan salep ekstrak biji kopi robusta berpengaruh terhadap parameterpanjang luka pada kelinci yaitu sebesar 0,003 (p?0,05). Berlandaskan temuan riset,disimpulkan bahwa formulasi salep ekstrak biji kopi Robusta menciptakan sediaanyang memenuhi kriteria serta konsentrasi yang ditentukan yakni signifikasi untukkonsentrasi 20% terhadap kontrol negatif sebesar 0.041, nilai signifikasi konsentrasi 30%terhadap kontrol negatif sebesar 0.039 dan nilai signifikasi konsentrasi 40% terhadapkontrol negatif sebesar 0.001 memberikan efektivitas dalam mempercepat prosespenyembuhan luka sayatan pada kelinci.
Formulasi Sediaan Krim Ekstrak Daun Petai Cina (Leucaena leucocephala Lam) pada Proses Penyembuhan Luka Insisi terhadap Kelinci (Oryctolagus cuniculus Ningtyas, Ichi Aprilia; Prabandari, Rani; Nawangsari, Desy
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.521

Abstract

Chinese petai leaves (Leucaena leucocephala Lam) have metabolite compounds that can heal incisional wounds, namely flavonoid and saponin compounds which are made in cream dosage form. An incisional wound is a wound caused by a sharp instrument cutting the skin and underlying tissue. The aim of this research was to determine the physical properties of the cream and the percentage of treatment of incisional wounds by petai cina leaf extract cream. The method used was an experimental method with 6 test treatment groups. Group 1 was positive control (Povidone iodine ointment), group 2 was negative control (cream base), group 3 was 4% concentration, group 4 was 8% concentration, group 5 was 16% concentration, and group 6 was without treatment. The extraction method is by remaceration using 70% ethanol solvent. The results of the research show that the physical properties in the organoleptic test have a distinctive odor, brown color with a semi-solid shape. The homogeneity test shows that the cream is homogeneous with a spreadability of 5.48 cm ± 0.2, a sticking force of 12.56 seconds ± 0.19, pH range of 5.8 ± 0.12, and viscosity of 1293 ± 0.04 which meets the range test the physical properties of the cream preparation. The incision wound healing test showed that concentrations of 8% and 16% could provide a fast wound healing effect for 10 days with a wound healing percentage of 100%. It can be concluded that the formulated cream meets the requirements and the cream can heal incisional wounds with a percentage of 100% for 10 days.
FORMULASI SEDIAAN HANDWASH EKSTRAK ETANOL DAUN BELIMBING WULUH (Averrhoa bilimbi L.) Amanda, Yusi Lusiana; Nawangsari, Desy; Setianingsih, Siti
Jurnal Keperawatan dan Kesehatan Vol 16 No 2 (2025): Jurnal Keperawatan dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Keperawatan Muhammadiyah Pontianak

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54630/jk2.v16i2.454

Abstract

Hands are a medium that can spread bacteria, this spread can be prevented by washing hands. Synthetic antibacterial ingredients such as triclosan in soap can damage the skin's normal flora. Starfruit leaves (Averrhoa bilimbi L.) are known to contain flavonoids, tannins, saponins and alkaloids. The aim of this research is to determine the physical properties and stability of handwash from the ethanol extract of starfruit leaves (Averrhoa bilimbi L.). This research uses experimental methods in making handwash with variations in the concentration of starfruit extract ethanol FI (10%), FII (12.5%) , and FIII (15%), the dosage for which physical properties were evaluated included organoleptic, homogeneity, pH, viscosity and foam height and stability tests were carried out using the cycling test method. Research shows that handwash preparations of ethanol extract of starfruit leaves have criteria according to soap standards set by SNI. The handwash preparation is homogeneous and the addition of the extract causes the preparation to be light brown in color, pH 8.2-9.7; viscosity 1,928-10,094 cPs; and foam height 1.53-1.93 cm. Has stable handwash preparation properties seen from the sig value. 2 tails > 0.05. Thus, the ethanol extract handwash from starfruit leaves has physical properties that comply with SNI including organoleptic, homogeneity, pH, viscosity and high foam and has stable properties.
Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C Nawangsari, Desy
Viva Medika Vol 12 No 02 (2019)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v11i02.464

Abstract

Avicel® PH is branded name from microcrystalline cellulose that is generally used in pharmaceutical preparations. Avicel® PH are being used as filler or binder in dosage formulas in tablets especially for direct compression because having a good flowing rate and a good compressibility. This study aims to compare the influence of the use Avicel® PH 101 and Avicel® PH 102 as a filler on of preparations a tablet of ascorbic acid. A method of the research was conducted by making granule of ascorbic acid tablet with the variation filler, then the granule was evaluate in .The results showed Avicel® PH 102 as a filler produce granule which better seen from the flowability, static angle of repose, carr’s index and hausner ratio .
PREPARASI DAN ISOLASI MIKROKRISTAL DARI AMPAS TEBU (Saccharum officinarum L.) Nawangsari, Desy; Pranbandari, Rani; Permatasari, Fenny
Viva Medika Vol 13 No 01 (2019)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v12i01.487

Abstract

Selulosa mikrokristal merupakan hasil isolasi dari alfa selulosa. Selulosa mikrokristal banyak digunakan dalam bidang farmasi. Salah satu bahan alam yang dapat dimanfaatkan untuk membuat selulosa mikkrokristal adalah ampas tebu. Ampas tebu mengadung 45,96% selulosa yang dapat diisolasi dengan tahapan delignifikasi menggunakan larutan basa, proses pemutihan serta hidrolisis alfa selulosa dengan pemanasan suhu tinggi menggunakan larutan asam encer. Rendemen selulosa mikrokristal dari ampas tebu 26,03%.
ISOLASI DAN IDENTIFIKASI RIMPANG TEMULAWAK (Curcuma xanthorrohza Roxb.) DAN BUNGA LAVENDER (Lavandula angustifolia Mill.) prabandari, rani; Nawangsari, desy; Sumargo, Kukuh Yunianto
Viva Medika Vol 13 No 01 (2019)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v12i01.488

Abstract

Essential oils are fragrance agents in plants. Essential oils have a volatile component in some plants with certain characteristics. At present, essential oils have been used as perfume, cosmetics, food additives and medicine. Empiric ethnopharmacology studies on aromatherapy plants show that Indonesia has 49 types of aromatic plants from 22 types of tribes, 12 of which are empirically used as aromatherapy with calming and refreshing effects (Sangat 1996 in Rahmawati, 2010). One example of aromatherapy used is the ginger rhizome (Curcuma xanthorrihza Roxb) and Lavender Flower (Lavandula angustifolia Mill.). This study aims to isolate and identify the essential oils of Temulawak rhizome (Curcuma xanthorrihza Roxb) and Lavender Flowers (Lavandula angustifolia Mill.). The essential oil isolation step uses the Steam Water Distillation method, after which the essential oil obtained is identified to ensure its purity. The results showed that Temulawak essential oil and Lavender essential oil were carried out using the water distillation method, obtained levels of 2.3% and 1.8%. Essential oils in Temulawak were identified by testing their physical properties which include specific gravity, solubility in ethanol 90%, solubility in chloroform and oil in NaCl. The identification results obtained in the Temulawak rhizome and Lavender plants are specific gravity 0.9436 and 0.8221. Solubility in ethanol 90% with a volume ratio of 1: 3.7 mL and 1: 3.3 mL. solubility in chloroform of 1: 3.3 mL and 1: 3.3 mL. on the addition of NaCl in the oil oil reduction occurs.
Evaluasi Fisik Facial Wash Ekstrak Daun Sirsak (Annona Muricata L.) Berbasis Gelling Agent Ulinnuha, Alvin; Fauziah, Fauziah; Kurniasih, Khamdiyah Indah; Nawangsari, Desy; Prabandari, Rani
Pharmacogenius Journal Vol 3 No 3 (2024): Pharmacy Genius
Publisher : Yayasan Inspirasi El Burhani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/pharmgen.v3i03.396

Abstract

Pendahuluan: Perbedaan jenis Gelling Agent dapat memengaruhi sifat fisik dari sediaan dikarenakan perbedaan sifat fisika kimianya. Konsentrasi Gelling Agent yang tidak sesuai standar seperti pemakaian dengan konsentrasi tinggi atau bobot molekul besar dapat menghasilkan sediaan gel yang sulit dikeluarkan pada kemasan. Tujuan: Tujuan penelitian ini adalah untuk mengetahui sifat fisik, iritasi primer, dan hedonik sediaan gel Facial Wash ekstrak daun sirsak dengan variasi Gelling Agent Na-CMC, HPMC, Carbopol 940. Metode: Metode pada penelitian ini menggunakan metode eksperimental laboratorium dengan 3 formula dimana formula 1 menggunakan basis Na-CMC, formula 2 menggunakan basis HPMC, dan formula 3 menggunakaan basis Carbopol 940. Hasil: Hasil uji sifat fisik sediaan menunjukkan semua formula memenuhi rentang persyaratan sifat fisik gel yang baik. Hasil uji iritasi diketahui bahwa semua formula tidak menimbulkan edema dan eritema pada hewan uji dan mendapatkan skor indeks iritasi primer sebesar 0,0. Hasil uji hedonik didapatkan hasil formula 3 menempati ranking pertama paling disukai kemudian formula 1 pada ranking 2 dan formula 2 pada ranking terakhir. Hasil pengujian statistik sifat fisik semua parameter menunjukan signifikansi < 0,05 yang artinya terdapat perbedaan signifikan antara F1, F2, F3 kecuali parameter tinggi busa dan persen daya busa menunjukan tidak ada perbedaan sinifikan antara F1, F2, F3 dengan signifikansi > 0,05. Kesimpulan: Kesimpulan pada penelitian ini adalah semua formula memiliki sifat fisik yang baik, tidak menimbulkan iritasi dan memiliki hasil kesukaan yang berbeda beda.
Aspirin Slow Release Tablet Formulation With Comparison Of HPMC And Pectin As Matrix Lestari, Kurni Ambar; Nawangsari, Desy; Sunarti, Sunarti
Pena Medika : Jurnal Kesehatan Vol. 13 No. 2 (2023): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v13i2.3700

Abstract

Aspirin is an antiplatelet drug that is used in the elderly as stroke therapy, while in elderly patients compliance with taking the drug often decreases. The aim was to determine the physical properties, dissolution, and stability of aspirin slow-release tablets with a comparison of HPMC and pectin as the matrix. Aspirin slow-release tablets were made in 3 formulas with HPMC and pectin ratios of 15%:10%, 12.5%:12.5%, and 10%:15%. Evaluation of slow-release tablets includes weight uniformity, size uniformity, hardness, friability, floating time, and dissolution tests. The data obtained was then analyzed using a one-way ANOVA. The results showed that in the physical properties test of the tablet, the results were F1, 2 and 3, including the weight uniformity test, the ANOVA results were 0.000<0.05, the size uniformity test was 0.055>0.05 in diameter and the thickness was 0.899>0.05, the hardness test was 0.355> 0.05, fragility test 0.780>0.05 and float time test at lag time F1 48 ± 3, F2 49 ± 4.35, F3 50 ± 1.52 at the duration time the results were 8 hours and in the F1 dissolution test 9, 20%, F2 10.14% and F3 8.14%. In physical stability, the results obtained were uniform tablet weight, uniform size, stable tablet hardness, stable tablet friability, and a stable floating time test, while in chemical stability, there was a change in the dissolution percentage, with the results on the 14th day of F1 stability being 11.79%. ,F2 11.05%, and F3 9.22%, and on the 28th day of stability, F1 10.55%, F2 10.51%, and F3 10.46%. Results that have significant differences (p<0.05) include weight uniformity (p=0.000)
FORMULASI SEDIAAN ORALLY DISINTEGRATING TABLET (ODT) ASPIRIN DENGAN SODIUM STARCH GLYCOLATE SEBAGAI SUPERDISINTEGRANT Putri, Arine Astika; Nawangsari, Desy; Kurniasih, Khamdiyah Indah
Pena Medika : Jurnal Kesehatan Vol. 14 No. 1 (2024): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31941/pmjk.v14i1.3713

Abstract

Aspirin adalah NSAID salisilat yang digunakan sebagaiagen antiplatelet dalam pengobatan stroke. Kematianakibat stroke dalam waktu 5 tahun, lebih dari separuhpasien stroke berusia dangt; Seorang berusia 45 tahunyang meninggal. Banyak pasien lanjut usia yang tidak maumenerima/mengonsumsi tablet karena takut tersedak ataukesulitan menelan. Tablet yang hancur secara oral (ODT) adalah sediaan yang lebih cepat hancur, hancur dalamwaktu kurang dari 60 detik bila dimasukkan ke dalammulut, dan tidak memerlukan tambahan air untuk ditelan. Tujuan penelitian ini adalah untuk mengetahui pengaruhkonsentrasi bahan penghancur sodium starch glycolateterhadap sifat fisik dan kelarutan formulasi aspirin orally disintegrating tablet (ODT) serta mengetahui konsentrasibahan penghancur sodium starch glycolate. zat dalamformulasi aspirin orally disintegrating tablet (ODT) yang sesuai dengan sifat fisik. Tablet Aspirin ODT diproduksidalam empat formulasi dengan konsentrasi sodium starch glycolate 0%, 10%, 15% dan 20%. Evaluasi tablet ODT meliputi keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, waktu larut tablet dan uji stabilitas. Data yang dihasilkan kemudian dianalisis menggunakanANOVA satu arah. Hasil penelitian menunjukkan bahwasifat fisik tablet F1, F2, F3 dan F4 meliputi uji keseragaman massa tablet yang menunjukkan hasilANOVA sebesar 0,000 kurang dari 0,05 yaitu selisih uji keseragaman ukuran diameter. . hasilnya 0,056 lebih dari0,05 jadi tidak ada bedanya dan hasilnya kental Selisih0,086 lebih dari 0,05 hasil uji kekerasan 0,000 kurang dari0,05 jadi ada beda hasil uji kerapuhan 0,125 lebih dari0,05 maka terdapat perbedaan, dan hasil uji waktu larut0,03 kurang dari 0,05 maka terdapat perbedaan. Uji disolusi menghasilkan F1 10,1%, F2 10,06%, F3 9,12% dan F4 9,3%. Pada uji kestabilan kimia uji disolusi, hasilpersentase disolusi mengalami perubahan kestabilan harike 14, F1 9,3%, F2 5,8%, F3 12,6% dan F4 12,6%, kestabilan 28 hari F1 10,6%, F2 8,88%, F3 8,9% . dan 8,9%. Mengenai kestabilan fisik, pengujian keseragamanberat tablet, keseragaman ukuran, kekerasan tablet, kerapuhan tablet dan waktu larut stabil tablet diperolehkarena uji stabilitas 0, 14 dan 28 memberikan hasil yang sama. Kata kunci: aspirin, sodium starch glycolate, orally disintegrating tablet
Co-Authors Adita Silvia Fitriana Alfianto, Hazim Fikri Amanda, Yusi Lusiana Deva Krisna Kadarani Dina Febrina Dzakiyyatunnisa, Hanifah Fauziah Fauziah Fauziah Fionaliasti, Fionaliasti Firdaus, Anisa Kautsar Fitri, Ely Nurul Fitriyani, Gita Handayani, Wike Deni Setyo Ikhwan Yuda Kusuma Inayah, Somatul Khasanah, Khuswatun Kurniasih, Khamdiyah Indah Lestari, Kurni Ambar Maulana, Restu Ningtyas, Ichi Aprilia Nur Rahmawati Permatasari, Fenny Prabandari, Rani Pranbandari, Rani Pujianti, Ayu Putri, Arine Astika Rachmawati, Ira Samodra, Galih Siti Setianingsih Sumargo, Kukuh Yunianto Sunarti Suri, Natasha Triska Turnip, Monika Maristella Ulinnuha, Alvin Umayah, Dani Yatul Yuliani, Anis Fitria Yunita, Fadella Nur