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All Journal Pharmascience Acta Pharmaciae Indonesia : Acta Pharm Indo Chemistry Indonesian Journal of Chemical Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Mandala Pharmacon Indonesia Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Pena Medika : Jurnal Kesehatan Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma INTERNATIONAL JOURNAL OF EDUCATION, INFORMATION TECHNOLOGY, AND OTHERS Kolaborasi Jurnal Pengabdian Masyarakat Jurnal Sosial dan Sains Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT Jurnal Keperawatan dan Kesehatan (JKK) Kartika : Jurnal Ilmiah Farmasi
Nawangsari, Desy
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Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Uji Aktivitas Antimikroba Ekstrak Daun Talas Pratama (Colocasia Esculenta (L.) Schott Var.Pratama) terhadap Pertumbuhan Pseudomonas Aeruginosa dan Propionibacterium Acnes Fionaliasti, Fionaliasti; Sunarti, Sunarti; Nawangsari, Desy
Jurnal sosial dan sains Vol. 4 No. 8 (2024): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v4i8.1497

Abstract

Latar Belakang: Infeksi mikroorganisme pada kulit umumnya disebabkan oleh Pseudomonas aeruginosa dan Propionibacterium acnes yang mana hal ini diatasi dengan tanaman yang memiliki efek antimikroba sehingga menyebabkan denaturasi membran sel mikroorganisme dan mikroorganisme tersebut mengalami dekomposisi yang menghambat pertumbuhannya. Daun talas diketahui memiliki aktivitas sebagai antimikroba, anti inflamasi dan antioksidan. Daun talas mengandung alkaloid, flavonoid, saponin, dan tannin sebagai senyawa penyusunnya. Talas telah tercatat memiliki kemampuan antimikroba untuk menghambat pertumbuhan beberapa jenis bakteri yang hidup di air, termasuk Vibro cholera, Salmonella sp., Escherichia coli, Pseudomonas aeruginosa. Tujuan: Penelitian ini bertujuan mengetahui aktivitas antimikroba dari ekstrak daun talas pratama (Colocasia esculenta (L.) Schott var. Pratama) dan mengetahui Diameter Daya Hambat (DDH) ekstrak etanolnya pada pertumbuhan Pseudomonas aeruginosa dan Propionibacterium acnes Metode: Penelitian ini dilakukan pembuatan ekstrak daun talas pratama dengan remaserasi selama 3 hari menggunakan etanol 96% lalu di skrining dan dilakukan uji aktivitas antibakteri dengan metode difusi cakram Hasil: Hasil penelitian bakteri Propionibacterium acnes mempunyai daya hambat pada konsentrasi 25% sebesar 9,38 mm, 30% sebesar 17,54 mm, 35% sebesar 14,91 mm dan kontrol positif klindamisin 16,22 mm. Pada hasil tersebut konsentrasi 30% dan 35% termasuk kategori kuat Kesimpulan: Pada pengujian ekstrak daun talas pratama dengan bakteri Pseudomonas aeruginosa tidak terdapat zona hambat, kecuali pada kontrol positif ciprofloxacin sebesar 26,94 mm.
Evaluasi Sifat Fisik Tablet Floating Ekstrak Etanol Daun Kelor (Moringa oleifera L.) Dengan Kombinasi Xanthan Gum Dan HPMC Sebagai Polimer Yunita, Fadella Nur; Nawangsari, Desy; Febrina, Dina
Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat 2025 Prosiding Seminar Nasional Penelitian dan Pengabdian Kepada Masyarakat (SNPPKM 2025)
Publisher : Universitas Harapan Bangsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/snppkm.v4i1.1401

Abstract

Moringa leaves (Moringa oleifera L.) have gastroprotective activity, making them suitable for use in floating tablets to prolong the residence time of drugs in the stomach. Floating tablets typically use xanthan gum and hydroxypropyl methylcellulose (HPMC) polymers as drug release matrices. This study aims to evaluate the physical properties of floating tablets made from ethanol extract of moringa leaves with a combination of xanthan gum and HPMC, as well as to determine the appropriate polymer concentration. Experimental studies were conducted with three formulas: F1 (15% xanthan gum; 5% HPMC), F2 (10% xanthan gum; 10% HPMC), and F3 (5% xanthan gum; 15% HPMC), using the wet granulation method. The physical properties of the granules were evaluated by testing the flow rate, Carr index, and Hausner ratio, then molded into 750 mg tablets and evaluated for physical properties (n = 3), including organoleptic properties, weight uniformity, size, hardness, friability, and floating test in 0.1 N HCl medium (pH 1.2; 37 ± 0.5 °C). The results showed that all formulations did not meet the weight uniformity and friability test (> 1%). Size uniformity and hardness (4–8 kg) met the requirements. The floating test showed that no formula was able to float for up to 30 minutes (floating lag time > 30 minutes; floating time = 0 minutes). It was concluded that the combination of xanthan gum and HPMC in the range of 5–15% did not produce moringa leaf extract floating tablets that met the physical parameters and floating test.
Evaluation of Chitosan as a Natural Disintegrant in the Formulation of Aspirin Orally Disintegrating Tablets nawangsari, Desy; Alfianto, Hazim Fikri; Pujianti, Ayu; Rahmawati, Nur; Kadarani, Deva Krisna
JSFK (Jurnal Sains Farmasi & Klinis) Vol 12 No 2 (2025): J Sains Farm Klin 12(2), August 2025
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.12.2.128-137.2025

Abstract

Aspirin is an antiplatelet that is used for the therapy and prevention of stroke, many strokes occur in elderly people. Orally Disintegrating Tablet (ODT) can be dissolved quickly making it easier for geriatric patients to swallow. This study aims to determine the effect of variation in the concentration of chitosan as a disintegrating agent on the physical properties of ODT aspirin. Aspirin ODT tablets were produced by direct compression in 3 formulas with variations of chitosan of 3.5%, 7% and 14%. The results showed that a chitosan concentration of 3.5% yielded optimal tablet properties: disintegration time of 23.66 seconds, friability of 0.41%, and dissolution of 96.81%. Statistically significant differences (p < 0.05) were observed among the formulations in terms of in hardness (p = 0.027), friability (p = 0.010) and disintegration time (p = 0.000). The disintegration mechanism of chitosan involves swelling, wicking, and strain recovery. At lower concentrations, chitosan promotes rapid water uptake and particle expansion, facilitating fast breakdown of the tablet matrix. In contrast, higher chitosan levels may induce gel formation that hinders water penetration, thus delaying disintegration. In conclusion, chitosan at a concentration of 3.5% effectively functions as a natural disintegrant in aspirin ODTs, offering rapid disintegration and high dissolution, which is suitable for geriatric patients with swallowing difficulties.
PENGARUH KONSENTRASI EKSTRAK WORTEL (Daucus carota L.) DALAM FORMULASI LOTION TERHADAP EFEKTIVITAS PENCERAHAN KULIT Fitri, Ely Nurul; Nawangsari, Desy; Kurniasih, Khamdiyah Indah
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1527

Abstract

Carrot (Daucus carota L.) is a natural source rich in β-carotene, an antioxidant compound that may inhibit melanin formation through the tyrosinase inhibition mechanism. This study aimed to determine the effect of varying concentrations of carrot extract in lotion formulations on skin-brightening effectiveness. This experimental laboratory study used four lotion formulations: a negative control, Formula 1 (5%), Formula 2 (10%), Formula 3 (15%), and a positive control (Kojie San® commercial lotion). The formulations were evaluated for physical characteristics (organoleptic, homogeneity, pH, spreadability, adhesion, and viscosity), safety through skin irritation testing, and skin-brightening effectiveness using a human skin tone set for 14 days on 25 female respondents. The results showed that all formulations met the physical property parameters, except for spreadability and adhesion, which were below the standard. No skin irritation was observed. Based on the skin-brightening test, 16% of respondents showed an improvement in skin brightness after 14 days of application, with Formula 3 (15%) exhibiting the highest effect, where 8% of respondents experienced a one-level increase on the skin tone scale compared to other formulations and the negative control. It can be concluded that the variation in carrot extract concentration affected the skin-brightening effectiveness, with the 15% formulation showing the highest result. These findings indicate that β-carotene in carrot extract has potential as a safe and effective natural active ingredient in cosmetic skin-lightening formulations.
OPTIMASI FORMULA DAN EVALUASI MASSA CETAK TABLET HISAP BERBAHAN YOGURT DENGAN METODE SIMPLEX LATTICE DESIGN Pujianti, Ayu; Nawangsari, Desy; Febrina, Dina
Jurnal Buana Farma Vol 5 No 4 (2025): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i4.1558

Abstract

Yocanserah® yogurt contains peanuts, ginger, and lemongrass, which have potential anti-diabetic properties. Yocanserah has a limited shelf life and sour taste, so it needs to be developed into a more acceptable lozenge formulation with a longer shelf life. The purpose of this study is to optimize the formulation of yogurt-based lozenge tablets using the simplex lattice design method. The materials or factors used in the optimization were Avicel PH 102, isomalt, and SSG, with the response being flow rate and compressibility. The data were analyzed using Design Expert software with the simplex lattice design method. The yogurt-based lozenge tablet mass was made using the wet granulation method with gelatin solution as a binder. The results showed that the tablet mass with variations in Avicel PH 102, isomalt, and SSG made using the wet granulation method produced flow rate and compressibility in accordance with the specifications. The use of variations in these three ingredients had a significant effect on the flow rate and compressibility of the tablet mass with a p-value < 0.05. The optimal formula for yogurt-based lozenge molding mass was obtained with a proportion of 49% Avicel PH 102, 1% isomalt, and 5% SSG, which produced a flow rate of 5.58 g/s and compressibility of 6.69% with a resulting desirability value of 0.311.
Pengaruh Suhu Penyimpanan Ekstrak Etanol Daun Pandan Wangi (Pandanus amaryllifolius Roxb) Terhadap Aktivitas Antioksidan Handayani, Wike Deni Setyo; Febrina, Dina; Nawangsari, Desy
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.862

Abstract

Pandanus amaryllifolius Roxb atau daun pandan wangi diketahui memiliki aktivitas antioksidan dengan kategori yang sangat kuat. Faktor lingkungan seperti kondisi pH, oksigen, cahaya dan suhu pada penyimpanan ekstrak dapat mempengaruhi aktivitas antioksidan. Salah satu faktor penting dalam ketidakstabilan senyawa antioksidan pada ekstrak yaitu adanya perbedaan dalam suhu penyimpanan. Penelitian ini bertujuan untuk mengetahui pengaruh suhu penyimpanan ekstrak etanol daun pandan wangi terhadap aktivitas antioksidan. Metode yang digunakan dalam penelitian ini adalah metode DPPH. Ekstrak etanol dari daun pandan wangi disimpan dalam tiga kondisi suhu yang berbeda yaitu pada suhu 27±2 ? (suhu ruang), suhu 5±2 oC (suhu dingin), dan suhu -10±2 ? (suhu beku) selama 14 hari (2 minggu). Selanjutnya, ekstrak etanol daun pandan wangi diuji aktivitas antioksidannya pada hari ke-0 dan ke-14. Hasil aktivitas antioksidan pada hari ke-0 sebesar 37,47 ppm dan hari ke-14 disuhu ruang sebesar 54,03 ppm, suhu dingin sebesar 42,52 ppm, dan suhu beku sebesar 59,55 ppm. Hasil analisis ANOVA dan uji lanjutan post hoc Tukey menunjukkan adanya perbedaan nilai IC50 pada seluruh suhu penyimpanan. Hal ini menunjukkan bahwa suhu penyimpanan berpengaruh nyata (p<0,05) terhadap nilai IC50.
Peningkatan Pengetahuan Masyarakat Desa Ajibarang Kulon Dalam Memanfaatkan Jahe (Zingiber Officinale) Sebagai Ramuan Herbal Untuk Kesehatan Cahyani, Intan Nur; Samodra, Galih; Nawangsari, Desy
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 6 No. 4 (2025): Edisi Oktober - Desember
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v7i1.7782

Abstract

Pengabdian kepada Masyarakat (PKM) ini dilaksanakan di Desa Ajibarang Kulon RT 01/RW 01 dengan sasaran ibu-ibu PKK yang belum pernah memperoleh edukasi mengenai pemanfaatan tanaman obat keluarga (TOGA). Tujuan kegiatan PKM ini adalah meningkatkan pemahaman masyarakat mengenai pemanfaatan jahe (Zingiber officinale) sebagai ramuan herbal untuk kesehatan keluarga. Kegiatan meliputi penyuluhan melalui ceramah dan diskusi, pembagian booklet, serta pemutaran video demonstrasi pembuatan wedang jahe. Perubahan tingkat pemahaman peserta dievaluasi melalui pre-test dan post-test. Hasil menunjukkan peningkatan nilai rata-rata dari 93 menjadi 98, serta kenaikan nilai minimum dari 60 menjadi 80. Analisis menggunakan Wilcoxon Signed Rank Test menghasilkan p = 0,025 (p < 0,05), yang menunjukkan adanya perbedaan signifikan sebelum dan sesudah penyuluhan. Secara keseluruhan, kegiatan ini efektif dalam meningkatkan pemahaman serta mendorong sikap positif masyarakat dalam memanfaatkan jahe sebagai ramuan herbal untuk kesehatan keluarga.
Co-Authors Adita Silvia Fitriana Alfianto, Hazim Fikri Amanda, Yusi Lusiana Cahyani, Intan Nur Deva Krisna Kadarani Dina Febrina Dzakiyyatunnisa, Hanifah Fauziah Fauziah Fauziah Fionaliasti, Fionaliasti Firdaus, Anisa Kautsar Fitri, Ely Nurul Fitriyani, Gita Handayani, Wike Deni Setyo Ikhwan Yuda Kusuma Inayah, Somatul Khasanah, Khuswatun Kurniasih, Khamdiyah Indah Lestari, Kurni Ambar Maulana, Restu Ningtyas, Ichi Aprilia Nur Rahmawati Permatasari, Fenny Prabandari, Rani Pranbandari, Rani Pujianti, Ayu Putri, Arine Astika Rachmawati, Ira Samodra, Galih Siti Setianingsih Sumargo, Kukuh Yunianto Sunarti Suri, Natasha Triska Turnip, Monika Maristella Ulinnuha, Alvin Umayah, Dani Yatul Yuliani, Anis Fitria Yunita, Fadella Nur