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All Journal ILMU KELAUTAN: Indonesian Journal of Marine Sciences Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia Jurnal Sapa Laut Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Mandala Pharmacon Indonesia Lansau: Jurnal Ilmu Kefarmasian
Sahidin, Idin
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Immunomodulatory Activity of Enau (Arenga pinnata) Leaf Extract on Macrophage Phagocytosis in Mice Yuliastri, Wa Ode; Sahidin, Idin; Isrul, Muhammad; Setiawan, La Ode Wawan
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, no. 3 (The 3rd Mandala Waluya International Conference on Pharmaceutical Science and
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i3.53970

Abstract

The immune system is vital in protecting the body from pathogens and harmful foreign substances. This study aims to evaluate the immunomodulatory activity of Arenga pinnata leaf extract on macrophage phagocytosis activity in mice (Mus musculus) and determine its optimal dosage. Extraction was conducted using the maceration method with 96% ethanol as the solvent. The immunomodulatory test was performed by measuring macrophage phagocytosis activity. Male mice were divided into six groups: a negative control (0.5% Na-CMC), a positive control (Stimuno® 0.013 mg/kgBW), and four treatment groups receiving Arenga pinnata leaf extract at doses of 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, and 400 mg/kgBW. After seven days of treatment, the mice were injected intraperitoneally with Staphylococcus aureus bacteria, and peritoneal fluid was collected for macrophage phagocytosis activity analysis under a microscope. The results showed that Arenga pinnata leaf extract significantly increased macrophage phagocytosis activity at 300 mg/kgBW and 400 mg/kgBW compared to the positive control. Phytochemical analysis revealed the presence of flavonoids, saponins, tannins, and triterpenoids, which contribute to its immunomodulatory effects. In conclusion, Arenga pinnata ethanol leaf extract exhibits potential as an immunomodulatory agent, particularly at 300 mg/kgBW and 400 mg/kgBW doses. However, further studies are necessary to explore its pharmaceutical applications and elucidate its mechanisms of action.
Anti-Inflammatory Activity of Ethanolic Extract Melophlus sp. and Callyspongia sp. from Southeast Sulawesi Fristiohady, Adryan; Sahidin, Idin; Sadarun, Baru; Purnama, La O. M. J.; Rahmatika, Nur S.; Tien, Tien; Haruna, Lidya A.; Yodha, Agung W. M.; Wahyuni, Wahyuni
Indonesian Journal of Pharmaceutical Science and Technology Vol 11, No 1 (2024)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v11i1.28809

Abstract

Marine sponges display significant potencies as an anti-inflammatory agent. Thus this study aims to investigate the effect of anti-inflammatory of Melophlus sp. and Callyspongia sp. by decreasing plasma IL-1β levels of rats. This study was conducted by detecting chemical constituents of extracts and their anti-inflammatory by measuring the plasma IL-1β level of animals.  Animals were acclimatized for seven days, followed at day-8 animals were induced by 1% carrageenan injection intraplantar. Animals were divided into ten groups (n=4) and treated orally according to groups which were C+ and K+ (diclofenac sodium 3598 ppm), C- and K- (Na CMC 0.5%), M50 (Melophlus sp 50 ppm), M100 (Melophlus sp 100 ppm), M200 ((Melophlus sp 200 ppm), C50 (Callyspongia sp. 50 ppm), C100 (Callyspongia sp. 100 ppm), and C200 (Callyspongia sp. 200 ppm). After being left out for 1 hour, blood was collected at the first, second, and third hour. Blood samples were then centrifugated and assayed with ELISA kit Rat IL-1β. Data collected were statistically analyzed. Both marine sponges contain flavonoid, saponin, alkaloid, and terpenoid. Tannin was only detected in Melophlus sp. Both marine sponges provided an effect in decreasing plasma IL-1β at the concentration of 100 ppm and 200 ppm. In conclusion, both extracts of Melophlus sp. and Callyspongia sp. have anti-inflammatory activity with effective concentration are 100 ppm. Keywords: Anti-Inflammatory; Plasma IL-1β; Melophlus sp.; Callyspongia sp.
Co-Authors Ajeng Diantini, Ajeng Amalia, Riezki Arfan Arfan Asasutjarit, Rathapon Badia, Esti Baru Sadarun Fadhliyah Malik Fristiohady, Adryan Galih, Olga Hadad, Nur Diana HANIFAH, SYIFA Harnita, Wa Ode Haruna, Lidya A. Haruna, Lidya Agriningsih Idrus, Loly Subhiaty Ilyas Y, Muhammad Ilyas Y., Muhammad Jabbar, Asriullah Jumadil Kardin, Laode Kirana, Rezky Marwah Malaka, Muh. Hajrul Malaka, Muhammad Hajrul Mirdayani, Eli Muhammad Isrul Nurpajriani, Nurpajriani Pascayantri, Asniar Purnama, La O. M. J. Purnama, La Ode Muh. Julian Purnama, La Ode Muhammad Julian Rahmatika, Nur S. Rusli, Nirwati Sahputra, Adi Saripuddin Setiawan, La Ode Wawan Tien Tien WAHYUNI wahyuni wahyuni Yodha, Agung W. M. Yodha, Agung Wibawa Mahatva Yulianti, Sri Samrina Yuliastri, Wa Ode