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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Medical and Health Science Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Jurnal Kedokteran Meditek
Handajani, Fitri
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PENGARUH EKSTRAK KULIT BATANG Rhizophora apiculata TERHADAP KADAR GLUKOSA DARAH Rattus norvegicus YANG DIINDUKSI DEKSAMETASON NABILA LARASATI, ARLISA; HANDAJANI, FITRI; PUTRO, SAPTONO; KOMALASARI, INTAN
Hang Tuah Medical Journal Vol 23 No 2 (2026): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i2.874

Abstract

Background: Dexamethasone is a glucocorticoid, if used long term it can cause increased oxidative stress and hyperglycemia. In diabetes patients, large amounts of antioxidants are needed as an antidote to free radicals in the body. Ethanol extract of Rhizophora apiculata stem bark has antioxidant and antidiabetic activity. Objective: This study aims to evaluate the effect of ethanol extract of Rhizophora apiculata bark on the blood glucose levels of white rats induced by dexamethasone. Methods: This research use 32 rats grouped into 4 groups. G (-), standard feed, G (+) induced by dexamethasone, GP 1 bark extraxt and induced by dexamethasone at the same time as giving mangrove bark extract, and DT 2, dexamethasone and mangrove bark extract, then on the 22nd day a blood sample was taken to measure blood glucose levels. Results: the average blood glucose level G- = 146.5; G+= 213.375; GP = 185.875; GT = 244.375. In the One Way Anova parametric test, significant results were obtained, 0.015 (p<0.05). Then in the Post Hoc LSD test; G- and G+ had a significance of 0.028 (p<0.05), while the G+ and GP and GT groups did not show significant differences. Conclusion: Subcutaneous dexamethasone induction treatment was proven to increase blood glucose levels in male Rattus norvegicus. Administration of ethanol extract of Rhizophora apiculata stem bark as prophylaxis or therapy was unable to reduce blood glucose levels of male Rattus norvegicus induced by dexamethasone.
Co-Authors Adhikara, Imam Manggalya Adiwinoto, Budiarto Andisari, Hendrata Erry ANNISA ULLYA RASYIDA Fadhilah, Farah Garianto, Efyluk Hapsari, Kinanti I KETUT TIRKA NANDAKA Iswara, Karisma Kasih Komalasari, Intan Kosala, Giselle Mutiadesi, Wahyu Prasasti Nabil Nabil Nabil, Nabil NABILA LARASATI, ARLISA Nugroho, Dhite Bayu PERMANA, I GEDE PUTU BAYU TIRTA Pranitasari, Nita Priadna, Astrid Ika Puspita, Angela Sampurna, William Wijaya Samsuddin, Mohammad Saptono Putro Sukmana, Judya Susanti, Vina Yanti TARUNA, DODY UNTARI, NI KOMANG SRI DEWI Vijaya, Ailya Tefanya Wibowo, Prajogo