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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Medical and Health Science Journal Journal of Social Research CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Jurnal Kedokteran Meditek Surabaya Biomedical Journal
Handajani, Fitri
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Effect of Rhizophora apiculata bark extract on SGOT levels in Rattus norvegicus induced by dexamethasone Sampurna, William Wijaya; Handajani, Fitri; Rasyida, Annisa Ullya; Nandaka, I Ketut Tirka
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 2 (2025): SEPTEMBER 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i2.4640

Abstract

Background: The liver's presence of fat has a histological picture with lipids>5%, and no secondary cause is called NAFLD. Rhizophora apiculata can serve as a therapeutic or prophylactic agent in NAFLD due to its flavonoid content. Objective: to ascertain the impact of Rhizophora apiculata extract administration on SGOT levels in white rats subjected to dexamethasone induction. Methods: The experimental animals were categorized into four groups: K- group, no treatment; K+ group, which was administered dexamethasone at a dosage of 5 mg/kg BW from the 15th to the 21st day; KP1 group, which received Rhizophora apiculata ethanol extract at a dosage of 56 mg/kg BW from the 8th to the 21st day, along with dexamethasone at 5 mg/kg BW from the 15th to the 21st day; and KP2 group, which was given Rhizophora apiculata ethanol extract at 56 mg/kg BW and dexamethasone at 5 mg/kg BW from the 15th to the 21st day. Result: The data were not normally distributed (p < 0.05), so the Kruskal-Wallis test was carried out, which yielded p < 0.05. Consequently, the post hoc test was continued, namely the Mann-Whitney U test. The post hoc test of the K-group and K+ obtained p < 0.05. The K+ group and KP1 and KP2 showed P > 0.05, indicating no significant difference. Conclusion: The Rhizophora apiculata extract at a dose of 56 mg/kg BW for 7 days can reduce SGOT levels in the Kp2 group.
Co-Authors Adhikara, Imam Manggalya Adiwinoto, Budiarto Andisari, Hendrata Erry Fadhilah, Farah Garianto, Efyluk Hapsari, Kinanti I KETUT TIRKA NANDAKA Kosala, Giselle Mutiadesi, Wahyu Prasasti Nabil Nabil Nabil, Nabil Nugroho, Dhite Bayu PERMANA, I GEDE PUTU BAYU TIRTA Pranitasari, Nita Priadna, Astrid Ika Rasyida, Annisa Ullya Sampurna, William Wijaya Samsuddin, Mohammad Shafwina Althaf, Aisha Sukmana, Judya Susanti, Vina Yanti TARUNA, DODY UNTARI, NI KOMANG SRI DEWI Vijaya, Ailya Tefanya Wibowo, Prajogo