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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Medical and Health Science Journal CoMPHI Journal : Community Medicine and Public Health of Indonesia Journal Hang Tuah Medical Journal Surabaya Biomedical Journal Jurnal Kedokteran Meditek
Handajani, Fitri
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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PENGARUH EKSTRAK KULIT BATANG Rhizophora apiculata TERHADAP KADAR GLUKOSA DARAH Rattus norvegicus YANG DIINDUKSI DEKSAMETASON NABILA LARASATI, ARLISA; HANDAJANI, FITRI; PUTRO, SAPTONO; KOMALASARI, INTAN
Hang Tuah Medical Journal Vol 23 No 2 (2026): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v23i2.874

Abstract

Background: Dexamethasone is a glucocorticoid, if used long term it can cause increased oxidative stress and hyperglycemia. In diabetes patients, large amounts of antioxidants are needed as an antidote to free radicals in the body. Ethanol extract of Rhizophora apiculata stem bark has antioxidant and antidiabetic activity. Objective: This study aims to evaluate the effect of ethanol extract of Rhizophora apiculata bark on the blood glucose levels of white rats induced by dexamethasone. Methods: This research use 32 rats grouped into 4 groups. G (-), standard feed, G (+) induced by dexamethasone, GP 1 bark extraxt and induced by dexamethasone at the same time as giving mangrove bark extract, and DT 2, dexamethasone and mangrove bark extract, then on the 22nd day a blood sample was taken to measure blood glucose levels. Results: the average blood glucose level G- = 146.5; G+= 213.375; GP = 185.875; GT = 244.375. In the One Way Anova parametric test, significant results were obtained, 0.015 (p<0.05). Then in the Post Hoc LSD test; G- and G+ had a significance of 0.028 (p<0.05), while the G+ and GP and GT groups did not show significant differences. Conclusion: Subcutaneous dexamethasone induction treatment was proven to increase blood glucose levels in male Rattus norvegicus. Administration of ethanol extract of Rhizophora apiculata stem bark as prophylaxis or therapy was unable to reduce blood glucose levels of male Rattus norvegicus induced by dexamethasone.
Efek Pemberian Eucheuma spinosum sebagai Profilaksis dalam Penghambatan Peningkatan SGPT pada Tikus yang Diinduksi Dexamethasone HANDAJANI, FITRI; PERMANA, I GEDE PUTU BAYU TIRTA; TARUNA, DODY; UNTARI, NI KOMANG SRI DEWI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.359

Abstract

Serum Glutamic Pyruvate Transaminase (SGPT) is a specific biomarker for detecting liver disease. This study aimed to determine the effect of giving 200 mg/Kg BW of Euchema spinosum extract as a prophylaxis against increasing SGPT in Rattus norvegicus rats injected with dexamethasone 8mg/Kg BW for six days. This experimental study with a randomized posttest-only control group design using 24 white male rats which were divided into three groups; group 1 was the untreated group, group 2 was given dexamethasone 8 mg/Kg BW for six days, the group 3 was given prophylactic 200 mg/Kg BW Eucheuma sp. extract for 13 days. After the treatment period, the group was terminated, and SGPT levels were measured using Cobas Integra. SGPT levels were then analyzed using SPSS. The normality test results for SGPT levels obtained a value of p> 0.05, and this value was only obtained from group 1 (p = 0.085) and group 2 (p = 0.224), while the group 3 showed that the distribution of data was not normally distributed (p = 0.022). The Kruskal-Wallis test showed a mean difference in SGPT levels between groups. The Mann-Whitney U test obtained a lower SGPT score in group 3 than in group 2 (p=0.007). Group 1, compared to group 3, decreased (p=0.001). Giving extract of Eucheuma sp. at a dose of 200 mg/Kg BW can inhibit the increase in SGPT levels in dexamethasone-induced white male rats (Rattus norvegicus).
Co-Authors Adhikara, Imam Manggalya Adiwinoto, Budiarto Andisari, Hendrata Erry ANNISA ULLYA RASYIDA Dhite Bayu Nugroho Fadhilah, Farah Garianto, Efyluk Hapsari, Kinanti I KETUT TIRKA NANDAKA Iswara, Karisma Kasih Komalasari, Intan Kosala, Giselle Mutiadesi, Wahyu Prasasti Nabil Nabil Nabil, Nabil NABILA LARASATI, ARLISA PERMANA, I GEDE PUTU BAYU TIRTA Pranitasari, Nita Priadna, Astrid Ika Puspita, Angela Sampurna, William Wijaya Samsuddin, Mohammad Saptono Putro Sukmana, Judya Susanti, Vina Yanti TARUNA, DODY UNTARI, NI KOMANG SRI DEWI Vijaya, Ailya Tefanya Wibowo, Prajogo