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Dafriani, Putri
Stikes Syedza Saintika Padang
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The Effect of Wharton’s Jelly Mesenchymal Stem Cells on Nestin Gene Expression in Alzheimer's Rat Models Annita, Annita; Telaumbanua, Arniat Christiani; Rahayu, Yanti; Dafriani, Putri; Panus, Hendri
Jurnal Kesehatan Saintika Meditory Vol 9, No 1 (2026): Mei 2026
Publisher : STIKES Syedza Saintika Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30633/jsm.v9i1.30890

Abstract

Alzheimer's disease (AD) is characterized by neurodegeneration and decreased neurogenesis due to neuroinflammation and free radical accumulation. Nestin is an intermediate filament protein that serves as a primary marker for neural progenitor cells in the neurogenesis process. This study aimed to analyze the effect of Wharton’s Jelly Mesenchymal Stem Cells (WJ-MSCs) administration on Nestin gene expression in an Alzheimer's rat model. This experimental study with a posttest-only control group design utilized male white rats (Rattus norvegicus) induced by Aluminum chloride (AlCl3) at a dose of 300 mg/kg BW orally for 5 days to model Alzheimer's pathology. A dose of 1×106 WJ-MSCs was injected intraperitoneally in the treatment group. One month post-therapy, Nestin gene expression from brain tissue was analyzed using quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and statistically tested with One-Way ANOVA. The results showed a statistically significant difference (p < 0.05), with a significant increase in Nestin gene expression in the WJ-MSCs treated group compared to the positive control group. It is concluded that the administration of WJ-MSCs effectively increases Nestin gene expression, indicating an improvement in the regeneration and neurogenesis processes in the brain tissue of Alzheimer's rat models.
Co-Authors Almahdy A Annita ., Apriyeni, Emira Diana Morika, Honesty eliza arman, eliza Fauzia, Hafni Fernando, Fenny Irman, Veolina Marlinda, Roza morika, honesty diana Nur, Siti Aisyah Panus, Hendri Rahayu, Yanti ratna dewi, ratna indah Resta, Harinal Afri Sari, Putri Minas telaumbanua, arniat christiani