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Aktivitas Antiangiogenesis Ekstrak Daun Dewandaru (Eugenia uniflora L.) pada Retina Tikus Wistar yang Diinduksi Streptozotocin Nilamsari, Karina Ayu; Fatimah, Nurmawati; Prabowo, Gwenny Ichsan
Jurnal Medik Veteriner Vol. 3 No. 1 (2020): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (763.807 KB) | DOI: 10.20473/jmv.vol3.iss1.2020.9-16

Abstract

Retinopati diabetik adalah komplikasi vaskular yang paling spesifik dari kedua tipe diabetes. Penyebab retinopati diabetik adalah adanya angiogenesis. Angiogenesis diinduksi oleh aktivasi Vascular Endothelial Growth Factor (VEGF). Kandungan Quercetin, salah satu flavonoid yang ada dalam daun Dewandaru (Eugenia uniflora L.) dapat menghambat VEGF. Penelitian ini bertujuan untuk mengetahui akativitas angiogenesis ekstrak Eugenia uniflora L. pada retina tikus yang diinduksi Streptozotocin (STZ). Penelitian ini menggunakan True Experimental Laboratory melalui metode Randomized Posttest Only Controlled Group Design dengan tikus wistar jantan yang dibagi menjadi 5 kelompok, yaitu kelompok kontrol negatif (K-) yang hanya diberikan diet standar tikus, pemberian STZ yaitu dengan dosis 40 mg/kgBB secara injeksi di intraperitoneal diberikan pada kelompok kontrol positif (K+), dan kelompok perlakuan (P1, P2, P3) dan dosis pemberian ekstrak Eugenia uniflora L. yaitu P1=50mg/kgBB, P2=100mg/kgBB, dan P3=200mg/kgBB secara peroral sehari sekali. Selama 1 bulan perlakuan, hasil glukosa darah 1 dan 2, kelompok K (-), K (+), dan P3 menunjukkan  peningkatan kadar glukosa, sedangkan P1 dan P2 menunjukkan penurunan kadar glukosa. Selama penelitian K (-), K (+), P1, P2, P3 menunjukkan peningkatan berat badan. Hasil pewarnaan HE didapatkan penurunan jumlah pembuluh darah pada kelompok perlakuan dengan perbedaan signifikan antara kelompok penelitian (p<0.05). Dapat disimpulkan bahwa pemberian ekstrak Eugenia uniflora L. pada retina tikus Wistar yang diinduksi STZ berpotensi menurunkan respon angiogenesis pada retina tikus yaitu dengan menurunkan jumlah pembuluh darah retina tikus.
IRREGULAR MENSTRUATION THERAPY WITH ACUPUNCTURE, POMEGRANATE PEEL AND GINGER HERBS Dimyati, Sinta Diyah; Suhariningsih, Suhariningsih; Fatimah, Nurmawati
Journal of Vocational Health Studies Vol. 4 No. 1 (2020): July 2020 | JOURNAL OF VOCATIONAL HEALTH STUDIES
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jvhs.V4.I1.2020.35-40

Abstract

Background: Menstruation is the process of regular discharging of blood in women. The menstrual cycle describes the distance between the first day of menstruation and the next menstruation which normally occurs within 28-35 days. According to Traditional Chinese Medicine, the menstrual cycle is used as a simple diagnostic way in viewing a woman's fertility status. Purpose: To determine the effect of acupuncture combination therapy at the Taichong (LV3), Sanyinjiao (SP6), Diji (SP8) and Qihai (CV6) point with herbal pomegranate peel (Punica granatum L.) and ginger (Zingiber officinale Rosc.) in irregular menstrual patients. Method: Treatment of irregular menstruation with acupuncture and herbal therapy methods. Acupuncture therapy is carried out at the Taichong (LV3), Sanyinjiao (SP6), Diji (SP8) and Qihai (CV6) point with the principle of helping to smooth out the flow of Qi and regulating the Chong & Ren vessels. In herbal therapy the patient is given decoction of herbal pomegranate peel (Punica granatum L.) and ginger (Zingiber officinale Rosc.). Result: Therapy using acupuncture and herbs to handling cases of irregular menstruation showed a good change in patient's menstrual cycle, this can make the patient's menstrual cycle after therapy to 36 days, which is almost closer to normal compared to before therapy with menstrual cycles exceeding 40 days. Conclusion: Acupuncture and herbal therapy can be continued so that the patient's menstrual cycle returns to normal.
IMPROVING KNOWLEDGE AND EMPOWERMENT OF PITASIDIA HEALTH CADRES ABOUT MEDICINAL PLANTS IN PATIENTS WITH DIABETES MELLITUS AND HYPERTENSION IN SINGOTRUNAN VILLAGE, BANYUWANGI SUB-DISTRICT, BANYUWANGI DISTRICT Mustika, Arifa; Fatimah, Nurmawati; Herisulistyo, Aldilatama; Dau, Daniel
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 3 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i3.2024.402-411

Abstract

Hypertension (HT) and Diabetes Mellitus type 2 (DM2) are the two most common non-communicable diseases in East Java, Indonesia. Therefore, there is a need for outreach about these two diseases and the use of herbal plants as complementary therapy. educational and learning practices are needed to be able to understand these two diseases and be able to make good herbal preparations such as Centella asiatica and Hibiscus sabdariffa so that the chemical compounds are not damaged. To provide education about HT and DM, herbal plant processing practices, and understanding the importance of regular health checks. The activity was conducted in Singotrunan Village, Banyuwangi Sub-district, Banyuwangi Regency, East Java Province. The stages of community service consist of preparation, implementation, and evaluation. The evaluation results showed that there was a 90% increase in the level of understanding after providing education on DM prevention, HT, and medicinal plants. Routine health checks found that most of the correspondents had random blood glucose levels and normal blood pressure. There was an increase in respondents' knowledge about hypertension and diabetes mellitus and the use of medicinal plants in helping the treatment of these diseases.
Stop Bullying Counseling as an Effort to Prevent Bullying Behavior that Occurs in Students at Ketabang Seruni Elementary School Surabaya Fatimah, Nurmawati; Khairul Rizki Purba, Abdul; Fithriyah, Izzatul; Purwaningsih, Sri; Setiawati, Yuani; Khaerunnisa, Siti; Akbar Kurniawan, Mohammad
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 9 No 3 (2024): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The phenomenon of bullying is a serious problem for child development in Indonesia. Bullying cases in Indonesia are ranked fifth in Indonesia world in bullying incidents (Jayani, 2019). Violence against students at school is a topic of discussion mainstream in the media. The incidence of bullying is 10-60% of children who receive ridicule, ridicule, expulsion, kicking or pushing at least once a week. Cases of bullying in Children can occur anywhere, anytime and by anyone. This makes this case still high incidence rate (Komisi Perlindungan Anak Indonesia, 2020). If this bullying incident continues for a long time, it will have an impact on the victim of bullying, both physically, psychologically and socially. The bullying case at Ketabang Seruni Elementary School Surabaya is of particular concern to the school principal. During break time, students are often heard making fun of each other, and there are friends who are alone because they are ostracized. As a leading public school in the city of Surabaya, hopes that its students can be a good for other schools by implementing free bullying at schools. The solution offered to solve this problem is to provide education to students at Ketabang Seruni Elementary School Surabaya by providing an explanation first about the purpose of the activity, then giving a questionnaire to the students about various things related to the meaning of bullying, types of bullying, causes of bullying, characteristics of perpetrators and victims of bullying, bad impacts of bullying, prevention of bullying, efforts to handle bullying prevention. Education is provided by providing materials using powerpoint media, leaflets and posters which are pasted on the school walls as a means of reminder for the entire community at school, including students, teachers, employees and parents. The result of this activity is that there is an increase in students' understanding of bullying and good practices are obtained by changing the way students socialize to be better and more polite. Keywords — Mental health; Education; Discrimination; Dignity
EFFECT OF THE LEAF Pettiveria alliacea EXTRACT ACTIVE COMPOUND ON Mycobacterium tuberculosis Munir, Ratna Sofaria; Fatimah, Nurmawati; Hermanto, Bambang
Folia Medica Indonesiana Vol. 53 No. 2 (2017): JUNE 2017
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (231.565 KB) | DOI: 10.20473/fmi.v53i2.6353

Abstract

Indonesia has a variety of herbal plants used as herbal/traditional medicines. Singawalang (Petiveria alliacea) is one of the herbal plants usually used in the United States as a cough medicine because of its expectorant effect. Singawalang plants are also widely used to cure tuberculosis. However, the investigations on the effects of toxicity on this plant leaf extract has not been done. This study aims to investigate the effects of active compounds in singawalang against Mycobacterium tuberculosis using a variety of solvents. The active compound of ethanol extract was obtained by maceration using ethanol solvent. The extract was then fractionated using column chromatography method, and using gradual eluent to produce fraction. The doses used were 0.5 mg/ml; 1 mg/ml; 2 mg/ml; 70% ethanol, h-hexane, benzene, chloroform, ethylacetate, silica gel 60GF254, Middlebrook 7H9, and 7H10. The reactions using Singawalang leaf extract with various solvents resulted in a reduction of the Mycobacterium tuberculosis colony growth, compared with the reaction on control treatment, treatment using DMSO 1%, and treatment using 70% ethanol. As a conclusion, the various solvents used did not make a significant difference. However, control treatment, treatment using DMSO 1%, and treatment using 70% ethanol had significant results.
Prevalence of The Most Common Disease Among the Community in Gili Iyang, Sumenep, Madura Island Alpha Fardah Athiyyah; Sulistiawati Sulistiawati; Nurmawati Fatimah; Linda Dewanti; Steven Christian Susianto; Novianto Edi Suharno
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 12 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is currently experiencing a shift in disease trends, this is marked by an increase in the prevalence of non-communicable diseases (NCDs). The prevalence of these NCDs is also increasingly observed among younger age groups due to rising risk factors such as overweight and obesity. This study aimed to determining the prevalence of the most common diseases and the health profile of the community in Gili Iyang, Sumenep. The samples included in this study were participant in Airlangga Community Hub 2024 in Gili Iyang Island, Sumenep Regency. There were several services in this community development including anthropometry measurement, physical examination and simple lab test. Data was collected and processed using a data processing application, Microsoft Excel. A total of 114 participant were included in this study, hypertension was the most prevalent disease during the community development program 30.1%, followed by hypercholesterolemia as the second most common condition 28.16%, and myalgia as the third leading cause of illness 17.48%. Urgent need for comprehensive health interventions, including routine screening, early management, and targeted health education programs to address the growing burden of NCDs.
Peningkatan Kemampuan Literasi Pemanfaatan Simplisia Tanaman Obat Herbal untuk Kesehatan Keluarga: Improvement of Literacy Skills in the Utility of Herbal Simplicia Medicine for Family Health Purba, Abdul Khairul Rizki; Sakina, Sakina; Hasanatuludhhiyah, Nurina; Fatimah, Nurmawati; Paramitha, Nabilah; Mukhoirotin, Mukhoirotin; Toyib, Muchammad
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 9 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i9.6971

Abstract

Indonesia has a variety of plants with various health benefits. Communities in small linkages such as families, RT, and RW can utilize family medicinal plants (TOGA) to maintain stamina so that immunity remains optimal. Educational efforts to utilize TOGA simplisia were carried out in the form of community service in Sumorame, Candi District, Sidoarjo Regency. A total of 38 participants attended the training. The methods used in this activity include counseling and workshops. The knowledge domain of traditional medicine increased by 47.6 points higher than the pretest. A total of 26 participants (68.4%) stated that they often used TOGA. The reasons for using TOGA include natural remedies (n = 22; 57.9%), maintaining stamina and health (n = 12; 31.6%), and first aid when sick before seeing a doctor (n = 4; 10.5%). During the training, participants mentioned 2 to 6 parts of TOGA with their properties. Participants received information about TOGA and its utilization from social media (15%), and mass media (10-14%). The information sources from academics are still low (3%). The community has the potential to use TOGA which can be considered to maintain health in the long term. They already know its utilization from generations and mass media information. Continuous education by academics and health workers is needed for public health and to drive the economy.
THALASSEMIA LITERACY: INCREASING KNOWLEDGE OF ORPHAN ADOLESCENTS ON THALASSEMIA Indiastuti, Danti Nur; Doman, Zahras Azimuth; Fatimah, Nurmawati; Nasution, Mhd Zamal; d'Arqom, Annette
Jurnal Layanan Masyarakat (Journal of Public Services) Vol. 8 No. 1 (2024): JURNAL LAYANAN MASYARAKAT
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jlm.v8i1.2024.086-095

Abstract

Thalassemia is the most common monogenic disease in Asia, including Indonesia that causes burdens for the government, patients, and families. As the sixth most non-communicable disease, thalassemia utilized IDR 600 billion in 2022 for more than 300 thousand cases. With, 3.8% of Indonesians carrying a mutation of thalassemia on their globin gene, this economic burden is projected will increase if no actions are taken. On the other hand, child marriage is reported to increase every year, including among orphans. Without proper knowledge and genetic testing on thalassemia, child marriage might contribute to the increasing of thalassemia patients. Thus, increasing knowledge on thalassemia among orphan adolescents is important. This community development uses several methods, including seminar, discussion, book, and poster, targeting the orphan adolescents (n= 40) in Mojokerta, East Java. A questionnaire on thalassemia was used to measure the knowledge, before and after the activity. The results show that the respondents have a moderate knowledge about thalassemia (median= 4 (0-9)), and increase to median=9 (3-10)) after the activities (p< 0.001). Even though overall knowledge is increased, several information including thalassemia is a genetic disease, not similar to blood cancer, not the only type of anemia (Q6), and how to diagnose thalassemia (Q9) still need to be emphasized. Taken together, direct and indirect approaches, such as seminar, discussion, book, and poster are effective in increasing thalassemia knowledge among orphan adolescents. These activities are more effective in targeting late adolescents, compared to early and middle adolescents. However, more effective methods are necessary to target Generation Z who are more familiar with the internet.
Prevalence of The Most Common Disease Among the Community in Gili Iyang, Sumenep, Madura Island Athiyyah, Alpha Fardah; Sulistiawati, Sulistiawati; Fatimah, Nurmawati; Dewanti, Linda; Christian Susianto, Steven; Edi Suharno, Novianto
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 12 (2025): COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Indonesia is currently experiencing a shift in disease trends, this is marked by an increase in the prevalence of non-communicable diseases (NCDs). The prevalence of these NCDs is also increasingly observed among younger age groups due to rising risk factors such as overweight and obesity. This study aimed to determining the prevalence of the most common diseases and the health profile of the community in Gili Iyang, Sumenep. The samples included in this study were participant in Airlangga Community Hub 2024 in Gili Iyang Island, Sumenep Regency. There were several services in this community development including anthropometry measurement, physical examination and simple lab test. Data was collected and processed using a data processing application, Microsoft Excel. A total of 114 participant were included in this study, hypertension was the most prevalent disease during the community development program 30.1%, followed by hypercholesterolemia as the second most common condition 28.16%, and myalgia as the third leading cause of illness 17.48%. Urgent need for comprehensive health interventions, including routine screening, early management, and targeted health education programs to address the growing burden of NCDs.
Peningkatan Daya Tahan Tubuh Warga yang Berisiko Tertular Tuberkulosis Melalui Peningkatan Pengetahuan Pemanfaatan Tanaman Kelor-Pegagan di Desa Beru, NTT Mustika, Arifa; Khaerunnisa, Siti; Fatimah, Nurmawati; Setiawan, Herley Windo; Amustikarani, Dewa Ayu Praba; Stefanus, Lusiana
Jurnal Pengabdian Masyarakat Bhinneka Vol. 4 No. 2 (2025): Bulan November
Publisher : Bhinneka Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58266/jpmb.v4i2.695

Abstract

Latar Belakang. Desa Beru terletak di Alok Timur, Sikka, Nusa Tenggara Timur, Indonesia., yang memiliki tersangka jumlah penderita diatas 400 orang, jumlah ini menduduki tempat pertama diantara desa lain di kecamatan tersebut. Data ini menunjukkan bahwa perlu dilakukan identifikasi permasalahan untuk mempercepat penurunan angka penderita tuberculosis. Permasalahan terkait tingginya isidensi dan prevalensi tuberkuosis di Desa Beru, Kecamata Sikka Alok timur, yang dapat diidentifikasi adalah tingginya angka penularan TB yang disebabakan oleh kurangnya sosialisasi dan edukasi tentang pengetahuan masyarakat tentang cara penularan TB dan pemahaman tentang daya tahan tubuh serta pemanfaatan bahan lokal untuk meningkatkan daya tahan Tujuan Kegiatan pengabdian kepada masyarakat adalah untuk meningkatkan daya tahan tubuh penderita tuberkulosis (TBC) serta warga yang berisiko tertular melalui peningkatan pengetahuan dan pemanfaatan tanaman herbal lokal, yaitu Kelor (Moringa oleifera) dan Pegagan (Centella asiatica). Program dilaksanakan di Desa Beru, Kabupaten Sikka, Nusa Tenggara Timur, melalui pendekatan edukatif-partisipatif yang melibatkan penyuluhan kesehatan, demonstrasi pembuatan olahan herbal, serta distribusi produk fungsional berbasis tanaman lokal. Hasil kegiatan menunjukkan peningkatan signifikan pada tingkat pengetahuan peserta mengenai TBC dan manfaat tanaman herbal sebesar 22%, serta peningkatan ketrampilan pembuatan teh kelor dan pegagan. Kegiatan ini mendukung pencapaian Tujuan Pembangunan Berkelanjutan (SDGs) terutama pada poin 3,2,1, dan 17melalui pemanfaatan sumber daya hayati lokal untuk kesehatan masyarakat. Kesimpulan adalah peningkatan pemahaman tentang Penggunaaan tanaman kelor dan pegagan terhadap peningkatan daya tahan tubuh sebesar 22% pada kader kesehatan Desa Beru, Maumere, NTT. Kader kesehatan Desa Beru, Maumere, NTT memperoleh pengetahuan dan ketrampilan tentang pembuatan teh kelor dan pegagan.