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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Majalah Kesehatan FKUB Medical Laboratory Technology Journal Jurnal Respirologi Indonesia Malang Respiratory Journal Jurnal Info Kesehatan
Yudhanto, Hendy Setyo
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Journal : Jurnal Info Kesehatan

 1 
The Effects of Black Garlic on Ovarian Malondialdehyde, Oviduct Muscle, and Endometrial Arterioles in Smoke-Exposed Rats Anandasari, Noni Fidya Ayu; Kridayanti, Novalia; Kaspirayanthi, Ni Ketut Devy; Nurseta, Tatit; Raras, Tri Yudani Mardining; Khotimah, Husnul; Reksohusodo, Subandi; Anita, Kenty Wantri; Yudhanto, Hendy Setyo
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1533

Abstract

The effect of cigarette smoke exposure on reproductive health has been widely studied, showing various physiological disorders induced by free radicals and oxidative stress. This study aimed to assess the protective effect of ethanol extract of black garlic (Allium sativum) on some reproductive parameters of female rats Rattus norvegicus exposed to subacute cigarette smoke. A proper experimental method with a post-test-only control group design was used, involving 25 rats divided into five groups with three different doses of the extract. The rats were exposed to cigarette smoke and then treated for 28 days. Results showed a significant decrease in ovarian Malondialdehyde levels and increased fallopian tube smooth muscle thickness in the extract-treated group. In addition, black garlic extract successfully increased the number of endometrial arterioles in the group exposed to cigarette smoke and extract, in contrast to the group exposed to cigarette smoke only. This study concludes that black garlic extract has the potential to be a protective agent against oxidative damage in the reproductive system of rats exposed to cigarette smoke, with effectiveness that depends on the dose of extract given. Further studies should investigate the long-term effects and optimal dosing of black garlic extract in humans. Additionally, exploring the molecular mechanisms behind its protective properties could enhance its application in reproductive health management.                 
Analysis of the Effect of Black Garlic (Allium sativum) Extract on Ovarian Follicular Atresia, Endometrial VEGF Expression, and Fallopian Tube Epithelial Cell Count in Rats (Rattus norvegicus) Exposed to Cigarette Smoke Kridayanti, Novalia; Anandasari , Noni Fidya Ayu; Kaspirayanthi, Ni Ketut Devy; Nurseta, Tatit; Raras, Tri Yudani Mardining; Khotimah, Husnul; Reksohusodo, Subandi; Angelica, Aina; Anita, Kenty Wantri; Yudhanto, Hendy Setyo
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1535

Abstract

Cigarette smoke exposure significantly impairs reproductive function in Rattus norvegicus. This study evaluated the protective effects of black garlic extract against such damage. Using a post-test-only control group design, 25 female Wistar rats were divided into five groups and exposed to cigarette smoke with or without varying doses of black garlic extract. After four weeks, results indicated that black garlic extract significantly increased Vascular Endothelial Growth Factor expression, enhanced fallopian tube secretory epithelial cell counts, and reduced ovarian follicular atresia in rats exposed to cigarette smoke. The group receiving 50 mg/kgBW of black garlic extract showed the most significant improvements. Statistical analysis, including One-way ANOVA, revealed significant differences between groups. Normality was assessed using the Shapiro-Wilk test, and homogeneity was confirmed with the Levene test. Significant decreases in ovarian follicular atresia (p < 0.05) and increases in Vascular Endothelial Growth Factor expression (p < 0.05) and secretory epithelial cell counts (p < 0.05) were observed in the 50 mg/kgBW treatment group compared to controls. In conclusion, black garlic extract offers dose-dependent protection against cigarette smoke-induced reproductive damage, with 50 mg/kgBW being the optimal dose. Further research should explore molecular mechanisms, long-term toxicity, and clinical applications in humans.              
Black Garlic Antioxidant Activity Test (Allium Sativum) Compound Types with DPPH Method (1,1-Difenil-2-Pikrilhidrazil) Asih, Sari Wulan; Nurseta, Tatit; Kusworini, Kusworini; Yudhanto, Hendy Setyo
JURNAL INFO KESEHATAN Vol 22 No 3 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss3.1552

Abstract

Antioxidants are needed to neutralize Reactive Oxygen Species (ROS) in the body and prevent cardiovascular, cancer, and premature aging as degenerative diseases. Antioxidants will provide resistance to free radicals and prevent damage in normal cells, proteins, and fats, and are able to break chain reactions without disrupting their function. Black Garlic has higher antioxidant properties than regular garlic. S-allyl cysteine (SAC) is a compound from Black Garlic that functions as an antioxidant that can affect the cell cycle in apoptosis, which can provide cell protection from free radical damage. In a study, it was said that a single type of Black Garlic extract obtained IC50 52.055 ppm (µg/mL) which is included in the category of high antioxidant activity. While in the antioxidant activity test, this study used a compound type of black garlic on the grounds that the price is more affordable and easy to find in traditional markets. This study aims to evaluate the potential of compound-type black garlic extract against free radicals by testing antioxidant activity using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method. The results of the compound type Black Garlic antioxidant test stated to have an IC50 value of 173 ppm (µg/mL) which is classified as moderate antioxidant activity. So researchers assume that the use of single type Black Garlic extract is more effective than compound type Black Garlic.              
Co-Authors AA Sudharmawan, AA Anandasari , Noni Fidya Ayu Anandasari, Noni Fidya Ayu Angelica, Aina Antariksa, Genta Asih, Sari Wulan Astuti, Tri Wahyu Chozin, Iin Noor Chozin, Iin Nur Djajalaksana, Susanthy Dwikarlina, Intan Erawati, Dini Rachma Eviana Norahmawati Fadli, Muhammad Luqman Harun Al Rasyid Husnul Khotimah Ihda Dian Kusuma Imam Suseno Indah Puji Lestari Isharanto, Artono Kaspirayanthi, Ni Ketut Devy Kenty Wantri Anita, Kenty Wantri Kridayanti, Novalia Kusworini Handono Naftali, Yokanan Parsama Putra, Ngakan Putu Pratiwi, Suryanti Dwi Putra, Ngakan Putu Parsama Rakhma, Sastia Retnani, Diah Prabawati Rini, Ni Made Rumaratu, Simon Petrus Hardiyanto santony, Santony Santoso, Agus Andreas Sartono, Teguh Rahayu Sasiarini, Laksmi Setiadi, Satya Setiawan, Ungky Agus Setyawan, Ungky Agus Subandi Subandi Sugiri, Jani Jane Rosihaningsih Sugiri, Yani Jane R. Sutrisno, Sutrisno Tatit Nurseta Tri Yudani MR Trimurtini, Asih Triwahju Astuti Wardhana, Koernia Kusuma Yaman, Muli