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All Journal Lantanida Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) SCIENTIA JOURNAL Jurnal Prima Medika Sains AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences International Journal of Islamic Education, Research and Multiculturalism (IJIERM) International Journal of Health and Pharmaceutical (IJHP)
Suyono, Tan
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Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Lantanida Journal

 1 
EFFECT OF GIVING MATOA FRUIT PEEL EXTRACT ON LEVELS OF SUPEROXIDE DISMUTASE (SOD), MALONDIALDEHYDE (MDA) AND HISTOLOGICAL FEATURES OF THE LUNGS OF RATS GIVEN CIGARETTE SMOKE EXPOSURE Levinna, Levinna; Suyono, Tan; Chiuman, Linda
Lantanida Journal Vol 11, No 2 (2023)
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v11i2.19113

Abstract

The matoa plant (Pometia pinnata) is known as a medicinal plant that has high antioxidant activity. Cigarette smoke produces free radicals and causes oxidative stress, a condition where the number of free radicals in the body exceeds the capacity to neutralize them. The aim of this study was to evaluate the levels of malondialdehyde (MDA), superoxide dismutase (SOD) and histopathological features of rat’s lung exposed to cigarette smoke and matoa peels extract. The research method uses laboratory experimental studies using rats as research subjects. The design used was Randomized Posttest Only with Control Group Design. 24 male white rats of the wistar strain were divided into 6 groups: normal, negative control, positive control, and group I, II, III were given matoa peels extract 3, 6, and 12 mg/kgBW respectively and exposure to cigarette smoke for 14 days. After 14 days, MDA, SOD and histopathological picture of the rats' lungs will be compared based on the group. Data analysis was carried out using a one-way ANOVA test. The results showed that matoa peels extract could reduce MDA levels and increase SOD activity in rats exposed to cigarette smoke (p value <0.05). Group that is given matoa peels extract 12 mg/kgBW can reduce lung tissue damage.
PENGARUH PEMBERIAN EKSTRAK DAUN BELALAI GAJAH TERHADAP KADAR MALONDIALDEHID DAN SUPEROKSIDA DISMUTASE PADA TIKUS DENGAN AKTIVITAS TINGGI Felix, Jesslyn; Suyono, Tan; Chiuman, Linda
Lantanida Journal Vol 11, No 2 (2023)
Publisher : UIN AR-RANIRY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/lj.v11i2.19116

Abstract

Clinacanthus nutans Lindau is known as the elephant trunk leaf which belongs to the Acanthaceae family. C. nutans can act as an antioxidant by reducing free radicals from the mitochondrial electron transport chain in the cell membrane. In this study, elephant trunk leaves will be studied regarding their content and antioxidant activity and their association with free radicals/Reactive Oxygen Species (ROS), which are compounds that are highly reactive. ROS can cause damage to cell integrity and functional cell disruption. Free radical reduction prevents lipid oxidation, which then reduces malondialdehyde (MDA) levels. By potentiating the antioxidant properties of Superoxide Dismutase (SOD) and reducing lipid peroxidation, C. nutans can reduce oxidative stress. The purpose of this study was to evaluate the effect of elephant trunk leaf extract on malondialdehyde and superoxide dismutase levels in rats with high activity. The research method used was laboratory experimental research with a Randomized Posttest Only with Control Group Design. In this study, 25 male white rats of the Wistar strain were divided into 5 groups: normal, negative control, and treatment I, II, III which were given elephant trunk leaf extract at successive doses of 50, 300, and 2000 mg/kg BW ( Weight). and high activity for 14 days. MDA measurements using a spectrophotometer and SOD using calorimetry were carried out after 14 days. The results showed that elephant trunk leaf extract reduced MDA levels and increased SOD activity in the blood plasma of rats induced by high activity (P value <0.05).
Co-Authors Bu'ulolo, Christian Siuwandy Chiuman, Linda Damayanti, Etha Wilda Hasiani Duha, Kristin Berlianta Dwi Puspitasari Edlin, Edlin Felix, Jesslyn Ferdinan, Sahna Ginting, Chrismis Novalinda Girsang, Ermi Halim, Valencia Angelina Happy, Happy irza Haicha Pratama J.H.T Rajagukguk, Samuel J.R.E Lumbantobing, Christina Khu, Adrian Kosasih, Michaela Kurnia, Felicia Lestari Ramadhani Nasution, Sri Levinna, Levinna Liena, Liena lister , Clarissa Lister, Clarissa Lubis, Nurul Sri Finna Mahrahmi, Asira Mucmaini, Rica Mutia, Maya Sari Nadia, Felanda A Napiah Nasution, Ali Napiah Nasuyion, Ali Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Nurlaela, Lia Oktaviani, Emma Pangestu Simarmata, Hans Panjaitan, Dian Parapat, Winny G I Putra Nasution, Pratama Sembiring, Imelda Sulistijanto, Eddy Sumiati Sumiati Suwarno Suwarno Tambunan, Andika Z Virgoh, Livia Widya Yanti Sihotang Wijaya, Franks