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All Journal JURNAL FARMASIMED (JFM) Indonesian Journal of Pharmaceutical and Clinical Research Jurnal Kesehatan Pasak Bumi Kalimantan Jurnal Pengmas Kestra (JPK)
Octora, Debi Dinha
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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The Lipid Profile and Aorta Histopathology On Hyperlipidemic Rat by Saurauia vulcani Korth. Leaves Extract Octora, Debi Dinha; Rosidah; Silalahi, Jansen; Satria, Denny
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.6521

Abstract

Abstract. Dyslipidemia is a pathological condition characterized by increased levels of total cholesterol, triglycerides and LDL and decreased levels of HDL. Dyslipidemia causes cardiovascular disease risk factors by increasing cholesterol levels, increasing triglyceride levels, lowering HDL levels, and increasing LDL levels, as well as decreasing the proliferation of cardiac aortic cells in dyslipidemic rats. The pirdot plant (Saurauia vulcani Korth.) has long been known by the Simalungun, Toba and Karo communities to have the potential to treat various diseases caused by disruption of lipid processes in the body. Pirdot leaves contain bioactive compounds of flavonoids, tannins and saponins that have the potential to improve lipid profiles and prevent cardiovascular disease. This study aims to determine the activity of EEDP on the lipid profile of dyslipidemic rats. Pirdot leaf simplicia powder was extracted by maceration with 96% ethanol solvent and the extract was used on 30 dyslipidemic rats which were divided into 6 groups. Group 1 (Na-CMC), group 2 (Atorvastatin), group 3, 4, 5, 6 EEDP doses of 50, 100, 200, 400 mg/kg BW were administered orally for 21 days. At the end of the treatment, the levels of total cholesterol (TC) and aortic cell proliferation were measured. The results showed that Saurauia vulcani Korth had water content (6.23%), water soluble extract (10.50%), simplicia content soluble in ethanol (14.77%), total ash content (7.05%) and acid insoluble ash content (0.48%). From the antidyslipidemic study it was shown that EEDP 400 mg/kg BW improved blood lipand to increase aortic cell proliferation dyslipidemic rats was 69.84±0.27. Based on the explanation above, it is concluded that EEDP has an antidyslipidemic effect.
The Relationship between Knowledge Level of Foot Care and Prevention of Diabetic Foot Ulcers in Diabetes Mellitus Patients at the Lok Bahu Community Health Center Samarinda Simarmata, Pratiwi Christa; Ahmad, Erwan; Octora, Debi Dinha; Wati, Syatria; Hayati, Kardina
Jurnal Kesehatan Pasak Bumi Kalimantan Vol 9, No 1 (2026): JKPBK Juni 2026
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/j.kes.pasmi.kal.v9i1.28164

Abstract

Introduction: Diabetes mellitus is a chronic disease that can cause various complications, one of which is diabetic foot ulcers. This complication can be prevented through proper foot care, but the success of prevention is greatly influenced by the patient's level of knowledge. Good knowledge allows patients to understand the risks, recognize early signs of wounds, and take preventive measures independently. This study aims to determine the relationship between the level of foot care knowledge and the prevention of diabetic foot ulcers in diabetes mellitus patients at the Lok Bahu Community Health Center in Samarinda. Methods: This study used a quantitative design with a cross-sectional approach with 70 respondents of diabetes mellitus patients selected through a purposive sampling technique. Data were collected using a questionnaire regarding the level of foot care knowledge and diabetic foot ulcer prevention behavior. Analysis used the Chi-Square test with a significance level of 0.05. Results: The results showed that most respondents had a good level of foot care knowledge as many as 44 respondents (62.9%) and a good level of diabetic foot ulcer prevention behavior as many as 60 respondents (85.7%). The statistical test results showed a p-value of 0.045, indicating a significant relationship between the level of foot care knowledge and the prevention of diabetic foot ulcers. Conclusion: The level of foot care knowledge is significantly related to the prevention of diabetic foot ulcers in patients with diabetes mellitus. Structured, ongoing, and applicable foot care education is needed to improve patients' ability to perform prevention independently.
Co-Authors Agnestine Jeliana Nababan AHMAD, ERWAN Denny Satria, Denny Ginting, Joe Cresnando Hayati, Kardina Hutahean, Delfi Mutiara Jansen Silalahi Jhoti Sumitra Koto, Rahmadona Mayasari, Dini Novidawati Boru Situmorang Pranata, Chandra Pratiwi Christa Simarmata Raini Panjaitan Ramadhani, Lili Reno Irwanto Romaulianna Theresia Marbun Rosidah Samuel Marpaung Sari, Delima Sitepu, Abdi Lestari Situmorang, Yuliana Syarifuddin, Aminah Nur Syatriawati Syatriawati Waruwu, Krismawati