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All Journal E-Jurnal Medika Udayana Berkala Ilmu Kesehatan Kulit dan Kelamin ISM (Intisari Sains Medis) : Jurnal Kedokteran Bali Dermatology and Venereology Journal Neurologico Spinale Medico Chirurgico Indian Journal of Forensic Medicine & Toxicology JOURNAL LA MEDIHEALTICO Bioscientia Medicina : Journal of Biomedicine and Translational Research Journal of Global Pharma Technology Journal of General Procedural Dermatology and Venereology Indonesia Bali Dermatology Venereology and Aesthetic Journal
I Gusti Ayu Agung Praharsini
Bagian Kulit Kelamin Fakultas Kedokteran Universitas Udayana
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Serum Interleukin-6 Levels are Positively Correlated with the Severity of Acne Vulgaris Triatmakusuma, Yogi; Praharsini, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman; Winaya, Ketut Kwartantaya; Karna, Ni Luh Putu Ratih Vibriyanti; Puspawati, Ni Made Dwi
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1056

Abstract

Acne vulgaris is a chronic inflammatory disease that affects the pilosebaceous unit. This disease occurs on the skin of the face, body, back, and other areas of the body, and can leave scars on the skin which can be temporary or permanent. Recent data shows that the inflammatory process is the initial process in the pathogenesis of acne, several pro-inflammatory cytokines, one of which is interleukin 6 (IL-6), which plays a role in acne vulgaris. Analytical observational study with a cross-sectional approach. The research was carried out from February - November 2023 at the Skin and Venereology Polyclinic, RSUP Prof. Dr. I.G.N.G. Ngoerah Denpasar and the Clinical Pathology Laboratory of Prof IGNG Ngoerah Hospital. The sample consisted of 47 samples of patients with acne and 20 samples without acne aged 8 - 45 years who were selected through consecutive sampling according to inclusion and exclusion criteria. A sample of 3 milliliters of venous blood is taken which will then be checked for IL-6 with an ELISA kit. Data analysis with SPSS version 24 and p value <0.05 is significant. The mean IL-6 serum levels in the acne group was 110.2 ± 88.3 pg/ml while in the non-acne group it was 26.7 ± 23.7 pg/ml. There was a significant difference in the category of IL-6 levels in the acne and non-acne groups (95% CI 55.1 - 155.3, p<0.001). The correlation analysis of IL-6 levels with the severity of acne was strongly positive (r=0.951, p<0.001).
Characteristics of skin aging at the Dermatology and Venereology Outpatient Unit at Prof. dr. I Goesti Ngoerah Gde Ngoerah General Hospital, Denpasar from January to December 2019 Tiara Evangelista; Ni Made Dwi Puspawati; Luh Made Mas Rusyati; I Gusti Ayu Agung Praharsini
Bali Dermatology Venereology and Aesthetic Journal BDVAJ - Volume 6, Issue 2 (December 2023)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/balidervenaesthj.v6i1.33

Abstract

Background: Skin aging is a complex biological process influenced by intrinsic and extrinsic factors. In addition, national data regarding skin aging is still scant. This research was carried out to learn the characteristics of skin aging at the Dermatology and Venereology outpatient unit of Prof. Dr. I G. N. G. Ngoerah General Hospital, Denpasar, in January-December 2019. Methods: This research is a quantitative descriptive study with a cross-sectional design. Sampling was carried out by total sampling with research subjects consisting of skin-aging patients at the Dermatology and Venereology Outpatient Unit of Prof. dr. I G. N. G. Ngoerah General Hospital in January-December 2019. The data collected consists of age, gender, smoking history, alcohol consumption history, body mass index, usage of sunscreen, duration of sun exposure, and Glogau scale classification. Descriptive analysis was carried out using SPSS ver. 23. Results: Twenty cases of skin aging were included. Most cases of skin aging were in the age group of 36-45 years old, all of whom were female, all of whom had no history of smoking, all of whom had no history of alcohol consumption, most body mass index classification was overweight, most do not use sunscreen, the duration of the sun exposure is mostly 30 minutes-6 hours, and the highest classification of the Glogau scale is group III. Conclusion: In this study, body mass index, usage of sunscreen, and duration of sun exposure are the main factors affecting skin aging.
Effect of 8% Purple Sweet Potato Extract Cream on Wrinkle Reduction, Skin Moisture, and Elasticity Laksmi, I Gusti Ayu Agung Mini; Praharsini, I Gusti Ayu Agung; Karmila, I Gusti Ayu Agung Dwi; Rusyati, Luh Made Mas; Suryawati, Nyoman; Winaya, Ketut Kwartantaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.1-8

Abstract

Background: Purple sweet potato has been shown to contain anthocyanins, polyphenols, flavonoids, and tannins that act as antioxidants and have the potential to correct signs of aging in the skin, such as wrinkles, lack of hydration, and pigmentation. Purpose: to known the potential of 8% purple sweet potato extract for wrinkles, moisture, and elasticity. Methods: A one-group experimental study with pre and post-test assessment. The subject is women with photoaging aged 30-45 years. A pre-test was conducted by examining wrinkles using the Glogau scale and a simple A-one scanner, treatment with 8% purple sweet potato extract cream for 6 weeks, and then a post-test at the end of the 6th week to check wrinkles, moisture, and elasticity using a simple A-one scan. Statistical tests using the SPSS program, version 25.0. The analysis performed was descriptive statistical and comparative analysis using a paired T test.  Result: A total of 25 respondents with a mean age ± SD of 38.22 ± 4.23 years, the most Glogau scale in type 2 is 22 respondents (88%), the most sun exposure for 30 minutes per day is 14 respondents (56%). The degree of wrinkles decreased after treatment -4.960±1.353 [95% CI -7.681-(-2.239); P=0.001]. The degree of moisture increased after treatment 8.840±2.990% (95% CI 2.829-14.851; P=0.005. The degree of elasticity increased after treatment 14.840±4.623 (95% CI 5.544-24.136; P=0.002). Conclusion: 8% purple sweet potato extract can reduce the degree of wrinkles, improve the degree of skin moisture, and improve the degree of skin elasticity.
Characteristic of Herpes Zoster in the Elderly at Prof. Dr. I.G.N.G. Ngoerah General Hospital: An Epidemiologic Study Hosea, Felicia Emiliana; Praharsini, I Gusti Ayu Agung
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 2 (2025): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.2.2025.84-89

Abstract

Background: Herpes zoster is a disease caused by the reactivation of the latent varicella zoster virus. Herpes zoster is the most common infection found in the elderly population. Epidemiologic data on herpes zoster infection among the elderly population in Bali remain limited. Purpose: The purpose of this study is to evaluate the characteristics of herpes zoster infection in elderly patients in order to provide clinical decision-making related to the management and prevention of herpes zoster in the elderly. Methods: This study uses a retrospective descriptive and gets its information from the medical records of herpes zoster patients at the Dermatovenereology Polyclinic at Prof. Dr. I.G.N.G. Ngoerah General Hospital from January 2019 to June 2022. The study population consisted of patients aged 60 years or older who were diagnosed with herpes zoster and received treatment at the polyclinic during the study period. Result: This study found that 33 elderly patients were diagnosed with herpes zoster. The age group 60-69 years found the most herpes zoster, with 18 (54.6%) patients and 17 (51.5%) male patients. The elderly patients had more comorbidities, which are 22 (66.7%) patients, with the majority having cancer, 7 of 22 patients (31.8%). The thoracic dermatome affected 13 patients (39.4%), multidermatome involvement affected 16 patients (48.4%), and post-herpetic neuralgia affected 22 patients (66.7%). Conclusion: This study found that elderly herpes zoster patients were mostly in the age group of 60-69 years, had cancer comorbidities, and involved multidermatomes.
A Retrospective Three-Year Analysis of Adult Scabies at a Tertiary Referral Center in Bali, Indonesia I Gusti Ayu Agung Praharsini; Luh Putu Sustiana Kartika Sari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 9 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i9.1388

Abstract

Background: Scabies, a parasitic infestation by Sarcoptes scabiei var. hominis, is a global health challenge with significant morbidity, particularly in tropical climates. While often studied in community settings, the profile of adult patients presenting to tertiary care facilities remains under-documented. This study aimed to delineate the clinical-demographic characteristics of adult scabies patients at a major referral hospital in Bali, Indonesia, to better understand this specific patient study. Methods: A retrospective, descriptive study was conducted utilizing electronic medical records from the Dermatology and Venereology outpatient clinic at Prof. Dr. I.G.N.G. Ngoerah General Hospital from January 2021 to December 2023. Following a total sampling method based on strict inclusion and exclusion criteria, data from 38 adult patients with a clinical diagnosis of scabies were extracted. The analysis focused on descriptive statistics to summarize patient demographics, contact history, and prescribed therapeutic regimens. Results: The study of 38 patients had a mean age of 34.1 ± 2.5 years. A male predominance was noted (n=22, 57.9%). The highest frequency of cases was in the 40-49 year age bracket (n=9, 23.7%). Most patients had completed senior high school (n=17, 44.7%) and were employed in the private sector (n=20, 52.6%). A family history of scabies was prevalent (n=18, 47.4%). While indirect transmission via shared clothing was rare (reported by only 7.9%), direct contact through bed sharing with at least one other person was common (n=24, 63.2%). The standard therapeutic protocol was combination therapy, with topical 5% Permethrin and oral antihistamines being the most frequent regimen (n=24, 63.2%). Conclusion: Adult scabies patients at this tertiary center are typically middle-aged, educated, working males. Transmission is overwhelmingly linked to intimate household contact, highlighting the inefficiency of fomite-based spread compared to direct skin-to-skin contact. The standard use of combination therapy reflects a proactive clinical approach to managing both the parasitic infestation and the complex immunologic cascade of pruritus. These findings provide a crucial clinical baseline for this specific patient population.
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Stefani Nurhadi
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 1 No. 2 (December 2018)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ya8fq451

Abstract

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state. Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris. Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method. Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% CI 2.765-8.332). Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
The positive correlation between serum malondialdehyde levels with vitiligo severity and activity I Gusti Ayu Agung Praharsini; Anak Agung Gde Putra Wiraguna; Putu Nila Wardhani Batan
Bali Dermatology Venereology and Aesthetic Journal BDVJ - Vol. 2 No. 1 (June 2019)
Publisher : Explorer Front

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/y650jm10

Abstract

Background: There are several theories that suggest melanocyte death in vitiligo, one example is oxidative stress theory. Oxidative stress primarily manifested by lipid peroxidation ultimately produce malondialdehyde. Malondialdehyde is a stable marker to assess an oxidative stress event. The correlation between serum malondialdehyde levels and vitiligo severity and activity remained controversial in previous studies. Objective: This study aimed to verify whether or not the serum MDA levels are positively correlated with vitiligo severity and activity. Methods: This study was an analytical cross-sectional study. which involved 64 subjects with vitiligo and 20 subjects without vitiligo. Serum MDA levels were measured to mark an oxidative stress event, whereas the severity and activity of vitiligo were clinically assessed with vitiligo area severity index (VASI) and vitiligo disease activity (VIDA) scoring system. Results: Total 64 subjects with vitiligo and 20 subjects without vitiligo participated in this study. Serum MDA mean levels of vitiligo subjects were significantly higher compared to subjects without vitiligo (p<0.05). Serum MDA levels had a strong positive correlation with VASI score (r=0.761; p<0.01). The strong positive correlation found between serum MDA levels with vitiligo activity assessed by VASI score in vitiligo subjects (r=0.609; p<0.01), and high serum MDA levels increased the risk for developing vitiligo (PR=7.62; 95% CI: 2.49-23.30; p<0.01). Serum MDA levels influenced vitiligo as much as 10.1%, meanwhile the remaining 89.9% were influenced by other variables apart from high serum MDA levels out of this study (R2=0.101; p<0.05). Conclusion: Serum MDA levels were positively correlated with vitiligo severity and activity, and high serum MDA levels increased the risk of developing vitiligo.
Characteristics of Cutaneous Lupus Erythematosus Patients in Dermatology and Venereology Outpatient Clinic Suryawati, Nyoman; Praharsini, I Gusti Ayu Agung; Elis Indira, I Gusti Ayu Agung; Darmaputra, I Gusti Nyoman
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 3 (2025): DECEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikkk.V37.3.2025.153-162

Abstract

Background: Cutaneous lupus erythematosus (CLE) is a specific skin manifestation of lupus erythematosus. This condition can be accompanied by systemic involvement that affect patient therapy and prognosis. The characteristics of CLE patients in Indonesia have not been widely reported. This study aims to determine the prevalence and characteristics of CLE patients at Dermatology and Venereology Outpatient Clinic of Allergy and Immunology Division at Ngoerah Hospital. Methods: This research used descriptive analysis with a cross-sectional design and total sampling method. Result: The total number of patients was 34, with prevalence of 6.7 cases per 1,000 patients. The majority of patients were female (85.3%), Balinese ethnicity (70.6%), unemployed (53%), with a high school/vocational high school education (56%), and risk factors of sun exposure (80.0%). Most patients had no family history of Lupus erythematosus (LE) (65.7%). The most frequent skin manifestation was chronic type CLE (28.6%). Based on The European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) score, 27 patients (77.1%) met Systemic lupus erythematosus (SLE) criteria. Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) activity, damage, and Mexican Systemic Lupus Erythematosus Disease Activity (MEX-SLEDAI) scores were 3.35±4.52, 0.88±1.96, and 7.5±5.09. Systemic therapy included methylprednisolone (47%) and hydroxychloroquine (35.2%), topical treatment included high to very high-potency steroids (67.6%), and sunscreen (14.7%). Response therapy was generally good in 68.6% of patients. Conclusion: The most common type of CLE is chronic cutaneous lupus erythematosus. Most patients improved, with the majority using systemic methylprednisolone and topical high-potency corticosteroids. Oral treatment responses tend to be good.
Co-Authors Agiel Fahlevie Choirunanda Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Gde Putra Wiraguna Anak Agung Indah Jayanthi Batan, Putu Nila Wardhani Cita Rosita Sigit Prakoeswa Daarshawnee Segar Darmaputra, I Gusti Nyoman Elice Wijaya Elis Indira, I Gusti Ayu Agung Febrina D Pratiwi Hasri Dewi Henny Wijaya Hosea, Felicia Emiliana I Dewa Made Rendy Sanjaya I Gde Nengah Adhilaksman I Gde Nengah Adhilaksman Sunyamurti Wirawan I Gede Raditya Narayana I Gusti Ayu Agung Dwi Karmila I Gusti Ayu Agung Elis Indira I Gusti Nyoman Darmaputra I Komang Arimbawa IGNA Wisnu Kresnan Dana Indira, I Gusti Ayu Agung Elis Jihan Prani Wibowo Ketut Kwartantaya Winaya Khathreen, Corry Laksmi, I Gusti Ayu Agung Mini Luh Gede Melia Puspita Sari Luh Made Mas Rusyati Luh Putu Sustiana Kartika Sari Made Wardhana Marvin Giantoro Muhammad Hidayatullah Syukri Ni Kadek Yunita Arsita Dewi Ni Luh Putu Ratih Vibriyanti Karna Ni Made Adi Tarini Ni Made Dwi Puspawati Ni Nengah Dwi Fatmawati Ni Wayan Evita Pradnya Dharmesti Nyoman Suryawati Nyoman Yoga Maya Pramita Nyoman Yoga Maya Pramita Pramita, I Gusti Ayu Sattwika Prima Saraswati Sanjiwani Sudarsa Putu Nanda Tediantini Putu Nila Wardhani Batan Putu Nila Wardhani Batan Putu Raisha Vishkariana Dewi Ratih Purnamasari Nukana Ricky Fernando Maharis Rikcy Fernando Maharis Riyana Noor Oktaviyanti Stefani Nurhadi Tiara Evangelista Triatmakusuma, Yogi Wicaksono, Rafael Lilik Winaya, Ketut Kwartantaya Wisnu Triadi Nugroho