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Restyana, Anggi
S1 Pharmacy Study Program STRADA Indonesia University
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Cost-Effectiveness Analysis Of Ceftriaxon And Chloramphenicol In Pediatric Patients With Tyfoid Fever In Hospital X, Jombang Regency Restyana, Anggi; Admaja, Wika; Nunki Rosa Fitria
Journal for Quality in Public Health Vol. 6 No. 2 (2023): May
Publisher : Master of Public Health Program Institut Ilmu Kesehatan STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/jqph.v6i2.446

Abstract

Typhoid fever is a disease caused by infection by the bacterium Salmonella typhi which infects the human digestive tract. Typhoid fever is spread all over the world, it is estimated that the incidence is between 11-21 million cases per year with a death rate reaching 215,000 (Rampengan, 2016). The main treatment for typhoid fever is by administering antibiotics and also bed rest. The first antibiotic administered as therapy for typhoid fever was chloramphenicol. But along with technological developments which affect the drug development as well, many new antibiotics for typhoid fever have been discovered, such as ceftriaxone antibiotic (Rampengan, 2016). This study aims to find out a more cost-effective therapy for the treatment in pediatric patients with typhoid fever in Jombang Public Hospital. This study used a cross-sectional research design with retrospective data collection. The samples in this study were 31 pediatric patients with typhoid fever with 16 patients were administering ceftriaxone injection antibiotic therapy and 15 patients were administering chloramphenicol injection antibiotic therapy. Data were identified using the cost-effectiveness analysis of ACER and ICER calculations with the long-of-stay therapy outcome. The results showed that ceftriaxone had a lower ACER value of IDR 1,687,279.88 with an effectiveness of 100%, compared to the ACER of chloramphenicol which had value of IDR 2,336,405.29 with an effectiveness of 86.67%. From these results it was concluded that ceftriaxone is more cost-effective than chloramphenicol.
Suitability Of Real Cost To Tariff Of INA-Cbgs Of Hypertensive Patients At X General Hospital Restyana, Anggi; Admaja, Wika
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.450

Abstract

Hypertension referred to as the "silent killer". Hypertension is a non-communicable disease that one of the leading causes death in the world. Increasing prevalence of hypertension based on measurements Indonesia in the population aged (18 years by 34.11% with the highest hypertension sufferers in South Kalimantan at 44.13% and the lowest prevalence of hypertension in Papua at 22.22%. In Indonesia, health costs keep increasing due to degenerative diseases. This study aims to determine the Real Cost of hypertensive patients and to determine the difference in Real Cost to the INA CBGs tariff of hypertensive inpatients at General Hospital X Kediri regarding the class of treatment, severity and length of treatment. This study was a descriptive quantitative research using a cross sectional design with retrospective data. The results of the study of the real cost of hospital of hypertensive patients with or without comorbidities at Public Hospital X Kediri was Rp.408,473,500. Meanwhile, the INA CBGs tariff was Rp.211,709,100 so that the difference obtained was negative Rp.196,764,400. The cost consists of class 1 treatment (13 patients) was Rp. (-32,884,800), class 2 (16 patients) was Rp. (-25,262,600) and class 3 (79 patients) was Rp. (-138,617,000). The difference in severity was mild severity (81 patients) of Rp. (-144,856,800), moderate severity (20 patients) of Rp. (-39,647,000) and severe severity (7 patients) of Rp. (-12,260,600). The difference in length of hospital stay 0-5 days (66 patients) was Rp.(-85,504,600), length of hospital stay 6-10 days (41 patients) was Rp.(-107,463,600) and length of hospital stay (10 days (1 patient) was Rp.(-3,796,200). The real cost of hospital was greater than the INA CBGs tariff, thus causing a negative cost difference that can make financial loss to the hospitals.
Cost Effectiveness Analysis of Antibiotics in Appendicitis Surgery Patients at Kediri City Hospital Restyana, Anggi; Admaja, Wika; Wibisono, Adi
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.617

Abstract

Pre and post-appendicitis guideline therapy include broad-spectrum antibiotics before surgery, appendectomy (laparoscopic or open), and follow-up antibiotics post-surgery in complicated cases of appendicitis. The incidence of appendicitis is estimated to be around 100 cases per 100,000 people per year, with a consistent incidence rate in Western countries and an increasing trend in developing regions. In Indonesia, there are 24.9 cases of acute appendicitis per 10,000 people. The use of antibiotics in appendicitis surgery has been widely used. In most studies, it is known that the most widely used types of prophylactic antibiotics are second or third generation cephalosporins or a combination of metronidazole, either given as a single dose, two or three doses. However, there has been no research on direct comparisons between antibiotics. Most studies have not found significant differences in the incidence of SSI. In Indonesia, health financing uses the National Health Insurance system which requires cost-effective therapy. This study aims to determine the cost-effectiveness between the use of cefoperazone-metronidazole and ceftriaxone. The perspective in this study uses the perspective of health care facilities. Costs are observed in two classes of care and effectiveness is measured through the incidence of Surgical Wound Infection. The results of cefoperazone-metronidazole antibiotic therapy compared to ceftriaxone in insurance patients obtained an ICER value of Rp 94,380.68,-. So the use of cefoperazone-metronidazole antibiotics will incur additional costs of Rp 94,380.68,- per increase in therapy outcomes. While in the analysis of the cost-effectiveness of cefoperazone-metronidazole antibiotic therapy compared to ceftriaxone in non-insured patients, the average cost was lower with higher effectiveness with cefoperazone-metronidazole antibiotic therapy than using therapy with ceftriaxone antibiotics. Thus, cefoperazone-metronidazole antibiotics can be considered as the main choice in non-insured patient therapy. In this study, no relationship was found between demographic factors, type of appendicitis and class of care on the incidence of surgical wound infections.
Co-Authors Admaja, Wika Amelia, Faresa Arlita Wulan Yuniar Bhakita Ulyaziza A Dinda Eviana Elly Megasari Evi Laela Sari Fendy Prasetyawan Fidi Setyawan Fitrani Khansa Hanie Kusuma Wardani Hanik Mariana Dewi Ida Kristianingsih Janik Kurniawati Khalimatus Nur Eka Agustanti Kumala Sari Poespita D.W Lailiyah, Munifatul La’ally Maula Muhammad Saddam Albiansyah Tohari Neni Probosiwi Nina Nur Jannah Nisa Azzahra Dentika Nunki Rosa Fitria Nur Fahma Laili Prasetyo, Eko Yudha savitri, Lisa Setyarti, Oksela Budi Shania Crhisnatasha Putri Tridoso Sapto A Tsamrotul Ilmi Ubanayo, Kristian Utrujjah Ihtiramidina Viky Yustriana Wardhani, Dita Kusuma Wibisono, Adi Wika Admaja Wika Admaja Wika, Wika Admaja Wiwik Dinah Sulistyowati Yogi Bhakti Marhenta Yuneka Saristiana