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Journal : Jurnal Farmasi Sandi Karsa

Antipyretic Effectiveness Test from Dragon (Pyrosia piloselloides) (L) M. G. Price) Leaves Extract in Male Marmutes (Cavia Procellus) Edi Kamal, Sainal; Prayitno, Suprapto; Hamdi, Syaibatul
Jurnal Farmasi Sandi Karsa Vol 7 No 1 (2021): Jurnal Farmasi Sandi Karsa (JFS)
Publisher : Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36060/jfs.v7i1.77

Abstract

This study aims to determine Effectiveness Of Dragon Scale Leaves (Pyrrosia piloselloides (L.) M. G. Price) As An Antipyretic In Male Marmut (Cavia porcellus) induced with 5% peptone. This study used 15 male guinea pigs which were divided into V groups. roup I was given negative control (Na. CMC 1% w/v), groups II, III and IV were given dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg and group V was given a positive control. (Paracetamol). previously induced with 5% peptone subcutan. measurements of body temperature rectally were carried out every 30 minutes, survived 4 hours. The results showed that the administration of dragon scales leaf extract at a dose of 250 mg/kg, 500 mg/kg, and 750 mg/kg of body weight gave an antipyretic effect against male guinea pigs and the most optimal effect is obtained at a dose of 750 mg/kgBW which is 129,05% compared to paracetamol which is 146,19%.