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All Journal BERKALA SAINSTEK Bulletin of Chemical Reaction Engineering & Catalysis Sinergi ROTOR: JURNAL ILMIAH TEKNIK MESIN UNEJ e-Proceeding JC-T (Journal Cis-Trans): Jurnal Kimia dan Terapannya SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Warta Pengabdian STATOR: Jurnal Ilmiah Mahasiswa Teknik Mesin Chemistry Indonesian Journal of Chemical Research CHEESA: Chemical Engineering Research Articles Dalton : Jurnal Pendidikan Kimia dan Ilmu Kimia Jurnal Kartika Kimia Jurnal Teknologi Jurnal Elemen J-Proteksion: Jurnal Kajian Ilmiah dan Teknologi Teknik Mesin Jurnal Teknik Kimia Indonesia International Journal on Food, Agriculture and Natural Resources (IJFANRES) Dedikasi: Jurnal Pengabdian kepada Masyarakat Jurnal Pijar MIPA Makara Journal of Science Logic : Jurnal Rancang Bangun Dan Teknologi Journal of Biobased Chemicals (JOBC) Jurnal Teknik Kimia dan Lingkungan Bulletin of Chemical Reaction Engineering & Catalysis Jurnal Penelitian Sains dan Teknologi Indonesia
Boy Arief Fachri
Department Of Chemical Engineering, Faculty Of Engineering, University Of Jember, Jalan Kalimantan 37, 68121 Jember
Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Biobased Chemicals (JOBC)

 1 
Quantitative Structure-Activity Relationship Study of Ester-Based Ferulic Acid Derivatives Against Cervical Cancer Cell (HELA) Helda Wika Amini; Istiqomah Rahmawati; Rizki Fitria Darmayanti; Boy Arief Fachri
Journal of Biobased Chemicals Vol. 1 No. 1 (2020): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (641.554 KB) | DOI: 10.19184/jobc.v1i1.109

Abstract

Quantitative structure-activity relationship (QSAR) has been studied for ferulic acid derivatives to determine the QSAR model able to predict anticancer. As the subject of this research was a set of experimentally calculated IC50 value data of 6 ferulic acid derivatives against cervical cancer cells (HELA). QSAR analysis was based on multilinear regression calculation on fitting subset using log (1/IC50) as the dependent variable, and dipole moment, partition coefficient in the n-octanol/water, and atomic net charges of the aromatic carbons as independent variables. The values of the descriptors were obtained from semiempirical PM3 quantum mechanic calculation. The relationship between log (1/IC50) and the descriptors was described by the result in the QSAR model. The QSAR model for ferulic acid derivatives against HELA cell lineswas developed with the statistical parameters of R=0.998; R2=0.999; SE=0.00857; and F=394. The calculated log (1/IC50) using QSAR Hansch Model for ferulic acid derivatives have excellent agreement with experimental data of Log (1/IC50).
Extraction of Antioxidant Compounds from Sargassum sp. Using Water and Ultrasound Assisted Extraction Method as A Derivation of Green Chemistry Principles Ratnasonia, Samantha Githa; Fachri, Boy Arief; Palupi, Bekti
Journal of Biobased Chemicals Vol. 2 No. 1 (2022): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.957 KB) | DOI: 10.19184/jobc.v2i1.118

Abstract

The content of bioactive compounds in Sargassum sp. already used in various fields. The Ultrasound Assisted Extraction (UAE) method and water solvent has met the principles of green chemistry so that it is used in this study as a method of extracting antioxidant compounds contained in Sargassum sp. The principle of green chemistry has the main goal of reducing or eliminating the impact of environmental damage. This research was conducted with several process variables, including the ratio of the sample mass to the volume of solvent (0.05 – 0.15 g/mL), time (30 – 40 minutes) and power (170 – 180 W) using the UAE method and water solvent (aquadest) on the total phenol value of Sargassum sp. result. Analysis of variance was carried out with the help of Design Expert software, Response Surface Method - Central Composite Design to determine the effect of the process variables carried out in the extraction process on the total phenol yield. The analysis of variance in this study shows the suitability between the research design and the results of the study which is indicated by an R2 value of 0.9785. The highest results were obtained with a variable ratio of sample mass to solvent volume of 0.18 (g/mL), time of 40 minutes and power of 180 W with a total phenol yield of 212.8 mg GAE/g and antioxidant activity of 12.3%.
Effect of Ethanol Solvents in the Extraction Process of Bioactive Compounds from Brown Seaweed (Sargassum sp.) with the Ultrasound Assisted Extraction Method Slamet Pujianto; Boy Arief Fachri; Istiqomah Rahmawati; Erna Subroto
Journal of Biobased Chemicals Vol. 2 No. 2 (2022): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v2i2.271

Abstract

Sargassum sp., part of brown algae, is traditionally used as animal feed. Nonetheless, Sargassum contains phenolic compounds that promise to be the raw material of natural antioxidants. The work is to extract phenolic compounds from Sargassum sp. in ethanol and to investigate the effect of the process on phenol yields. Several dried Sargassum sp. are milled in a certain size and extraction using ultrasound assisted extraction with ethanol solvent. Process variables are the extraction time (30-50 minutes) and the Ratio of Sargassum sp. to ethanol which is 5:100-15:100 (b/v), and power of 170-190 watts. Phenol compounds are quantified using the error acid method. The DPPH method is performed to check the antioxidant activity. To investigate the influence of the process, surface response methods based on central composite designs are applied in this work. 153.334 mgGAE/g in 30-minute extraction conditions, 170 watts of power, and a ratio between masses and solvents of 0.05. The antioxidant activity (IC50) of Sargassum sp. extract is 87.57 ppm.
Microwave Assisted Hydrolysis Ulva sp. Using HCl for the Production of Bioethanol Raw Materials Bekti Palupi; Nadia Ayumna Fa’iqoh; Alifia Rahma Putri Neysella; Boy Arief Fachri; Ditta Kharisma Yolanda Putri; Lukman Nulhakim; Maulida Septiyana
Journal of Biobased Chemicals Vol. 2 No. 2 (2022): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v2i2.272

Abstract

The challenges faced by the Indonesian state are increasing greenhouse gases, climate change, and depleting fossil fuel reserves. This requires the exploration of alternative energy that is environmentally friendly and sustainable. Algae biomass, especially Ulva sp. is one of the resources that have the potential for bioethanol production as an alternative energy producer. The purpose of this study is to determine the potential of Ulva sp. as raw material for bioethanol and to determine the effect of particle size, solvent concentration, and power on the hydrolysis process. This study used Ulva sp. as raw material. hydrolyzed with HCl solvent using the microwave assisted hydrolysis method. Hydrolysis with HCl concentrations of 0.1 N, 1 N, 2 N, variations of microwave power 150 watts, 300 watts, 450 watts, and particle sizes of 60 mesh, 80 mesh, and 100 mesh. Measurement of reducing sugar levels was carried out using the dinitro salicylic acid (DNS) method. The results showed that the best conditions for hydrolysis were when the HCl concentration was 0.1 N, the microwave power was 450 watts, and the particle size was 80 mesh which resulted in a reducing sugar content of 20.751 mg/mL.
Extraction of Phenolic Active Compounds from Coffee Leaves (Coffea sp.) Using the Ultrasound Assisted Extraction Method and Total Phenol Analysis Alfinaini, Nur Aini Dwi Alfinaini; Boy Arief Fachri; Pratamai Shelli; Helda Wika Amini; Istiqomah Rahmawati
Journal of Biobased Chemicals Vol. 3 No. 1 (2023): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v3i1.278

Abstract

Coffea sp. is one of the largest plantation commodities in Indonesia, especially coffee leaves containing phenolic compounds. This research was conducted to extract phenolic compounds using the Ultrasound-Assisted Extraction method with ethanol solvent which aims to determine the optimum operating conditions of extraction as well as the influence of variations in amplitude, time, and ratio of solvents produced. The experimental design was carried out using Design Expert 13 software with the response surface method box-Behnken design. The research variables used were amplitude variations (50%, 60%, and 70%), time (10, 20, and 30 minutes), and solvent ratios (0.1; 0.15; and 0.2 g/mL).Based on our study, these parameters affect the total phenolic content. The model equation for the total phenolic content of coffee leaves obtained is Y = 0.1349 – 0.0016 A – 0.0505 B + 0.0010 C + 0.0018 AB + 0.0043 AC – 0.0018 BC – 0.0004 A2 + 0.0178 B2 – 0.0014 C2 (R2 = 0.9758) with the optimum total phenolic content located in the 17th running of 0.209 mg GAE/g under conditions of 20 minutes, the ratio of material to solvent is 0.2 g/mL, and an amplitude of 50%.
Kinetika Ekstraksi Biji Kopi Arabika (Coffea Arabika) Lailatul Fatma; Nabilah Lu’aili Fauziah; Zuhriah Mumtazah; Helda Wika Amini; Boy Arief Fachri
Journal of Biobased Chemicals Vol. 4 No. 2 (2024): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v4i2.1325

Abstract

Biji kopi merupakan bibit tanaman kopi dan sumber minuman kopi. Biji kopi arabika mengandung minyak yang memiliki banyak manfaat. Proses ekstraksi minyak (zat terlarut) pada kopi dapat dilakukan melalui ekstraksi pelarut (leaching). Proses ekstraksi minyak biji kopi menggunakan n-heksana sebagai pelarut karena dapat melarutkan senyawa-senyawa yang mempunyai sifat yang sama. Tujuan dari penelitian ini adalah untuk mempelajari ekstraksi minyak atsiri dari biji kopi arabika dan mengetahui model kinetika ekstraksi minyak atsiri dari biji kopi arabika dengan cara leaching. Proses pemisahan minyak kopi dan pelarut menggunakan analisis termogravimetri dengan suhu 80℃ hingga massa sampel konstan. Variabel yang digunakan adalah suhu dan waktu. Waktu ekstraksi adalah 2 jam dengan waktu pengambilan setiap 10 menit. Suhu yang digunakan adalah 30°, 40°, dan 50℃ dengan perbandingan bahan dan pelarut 1:10. Hasil penelitian menunjukkan bahwa kinetika ekstraksi kopi arabika mengikuti model kinetika ekstraksi orde dua. Nilai parameter kinetika orde kedua ekstraksi minyak atsiri kopi arabika yaitu kapasitas ekstraksi (Cs) pada suhu 30°, 40°, dan 50℃ masing-masing sebesar 5,45836, 5,46, dan 5,46001 g L-1, laju reaksi awal. ekstraksi (h) sebesar 0,00762718, 0,00756716, dan 0,0104452 gL-1menit-1, konstanta laju ekstraksi (k) sebesar 0,000256, 0,000254, dan 0,00035 g-1L-1menit-1 , dan nilai determinasi sebesar 0,9965, 0,9967 dan 0,9983.
Kinetic Extraction of Moringa Oleifera Leaves using the Microwave Assisted Extraction (MAE) Method Rizky Pratama, Reinaldi; Ghina Shofiah Adibah Khoirunnisa; Ditta Kharisma Yolanda Putri; Helda Wika Amini; Boy Arief Fachri
Journal of Biobased Chemicals Vol. 4 No. 2 (2024): Journal of Biobased Chemicals
Publisher : Program Studi Teknik Kimia Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/jobc.v4i2.1379

Abstract

Daun kelor (Moringa oleifera) adalah bagian dari tumbuhan yang memiliki bentuk seperti daun dengan berbagai manfaat kesehatan dan gizi yang tinggi, serta terdapat kandungan vitamin, mineral, protein, dan senyawa bioaktif, serta memiliki sifat antioksidan dan antiinflamasi. Penelitian ini bertujuan untuk mempelajari ekstrasi, mengetahui keberadaan kandungan tannin pada daun kelor dan mengetahui model kinetika ekstraksi pada ekstrak yield daun kelor meggunakan metode Microwave Assisted Extraction (MAE). Proses ekstraksi daun kelor dilakukan dengan menggunakan pelarut etanol 96% dan menggunakan metode Microwave Assisted Extraction (MAE) dapat membantu memaksimalkan rendemen ekstraksi. Proses ekstraksi dilakukan dengan variasi daya 150 watt, rasio bahan terhadap pelarut 1:15 b/v dan waktu ekstraksi 2, 4, 6, 8, dan 10 menit. Hasil penelitian menunjukkan nilai rendemen tertinggi didapatkan pada waktu ekstraksi di menit ke 10 yaitu 10,25%. Model kinetika ekstraksi yang sesuai untuk mengekstraksi senyawa tanin dari daun kelor adalah orde 2, dimana nilai R2 lebih tinggi dibandingkan orde 1 dan nilainya hampir mendekati 1.
Co-Authors Abdul Malik Karim Amrullah Adrian, Febri Afred, Merymistika Yufrani Afwal, Diza Raudhatul Ahmad Syuhri Aini, Dwi Intan Noer Ainia, Hilda Huril Akbar Anugrah Ikhsani Akmal, Gavinda Tsubutul Al Fajri, Maktum Muharja Alex Ttesa Elsyamba Alfinaini, Nur Aini Dwi Alfinaini Alifia Rahma Putri Neysella Anggraini, Ranita Anggi Annisa, Yasmin Ansori Ansori Ardila Dwi Tresna Ari Susanti Arief Budiman Aris Zainul Muttaqin Asshofy , Muhammad Agil Atiqa Rahmawati Atiqa Rahmawati Azizi, Daffa Hafiziaulhaq Azzahrah, Anak Agung Nabilla Badril Azhar Badril Azhar Bekti Palupi Bimo Bayu Aji Buana, Nayyara Aida Danang Muharyanto Dianavita Fatimah Digdo Listyadi, Digdo Dihayat, Icha Shofia Dini Rahmawaty Ditta Kharisma Yolanda Ditta Kharisma Yolanda Putri Doddy Parningotan Elisah, Nor Elsyamba, Alex Ttesa Erna Subroto Farwah, Zilma Aliyah Fatimah, Dianavita Felix Arie Setiawan Firmansyah, Muhammad Sahrul Ghina Shofiah Adibah Khoirunnisa Gregah Pangayoman Hartanto P Habibatul Inayah Harti Arini Helda Wika Amini Helda Wika Amini Heni Pujiastuti Herdianto, Dimas Nur Hidayat, Debby Aurellia I Made Arimbawa Indrayani, Lilin Intan Hardiatama Istiqomah Rahmawati Istiqomah Rahmawati Kristianta, Franciscus Xaverius Lailatul Fatma Lestari, Afrila Tutut Dwijati Lukman Nulhakim Lumbantoruan, Sri Lestari M Edoward Ramadhan M Nurkoyim Kustanto M Yuda Pratama Maharani, Regita Gustiayu Pramisti Mahfud Mahfud Mahfud Mahfud Mahros Darsin Maktum Muharja Maulida Septiyana Meta Fitri Rizkiana Mizanurafi’ Ghifarhadi Prasiefa Mochamad Edoward Ramadhan Mohammad Nor Muhammad Reza Muhammad Reza Muharja, Maktum Mukhammad Fauzi Nabilah Lu’aili Fauziah Nadia Ayumna Fa’iqoh Naraismanti, Nirina Indi Nikita Meidi Nova Chintya Kurniawati Nova Chintya Kurniawati Nugraha, Briantara Agung Nugroho, Yeremia Prasetya Nur Karima Nur Karima Nurkoyim Kustanto Nurtsulutsiyah Nurtsulutsiyah Nurtsulutsiyah Nurtsulutsiyah Nurtsulutsiyah, Nurtsulutsiyah Permatasari, Ocita Galuh Pradipta, Shima Nuril Pratama, Ilyas Arya Pratamai Shelli Pravitasiwi, Nanda Tricya Julia Purimahua, Amanda Augre Maharani Puspita Sari Putri, Navisa Ayudia Putri, Salsabila Ananda R Rochmadi Rahman, Agus Ramadana, Ifan Ratnasonia, Samantha Githa Ratri Sekaringgalih Regita Gustiayu Pramisti Maharani Renald Rochman Mauludy Reswara Musyafa Rizalluddin, Muhammad Rizki Abdus Syatar Rizki Fitria Darmayanti Rizki Fitria Darmayanti Rizky Pratama, Reinaldi Rumaisha-Zuhriansyah, Rayya Safira Nur Oktavia Salsabila, Putri Ayu Santoso Mulyadi Sa’roni, Achmad Septianti, Kiki Shabrina, Nadhilah Sholeha, Irdatus Slamet Pujianto Suryagama, Muhammad Nabil Sutarsi, Suratsi Syatar, Rizki Abdus Tri Elok Setya Megasari Udroto, Firsta Retnaningtyas Uzinuzulla, Yunita Virda Wardani, Salza Belila Kusuma Wardhani, Maharani Tri Watiningsih, Lusi Karlina Wibowo, Jihan Nafila Wiwik Pratiwi Yakub Hendrikson Manurung Zuhriah Mumtazah