Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Jurnal Katalisator

The BATANG KEMUMU (Colacasia gigantea cv) SEBAGAI BAHAN BAKU OBAT ALAMI ANTIBAKTERI DAN ANTIKANKER Hesti Marliza; Trie Yuni Elfasyari Elfasyari; Faziyana; Sarina Sembiring Milala
JURNAL KATALISATOR Vol. 6 No. 1 (2021): jurnal Katalisator Volume 6 No 1, 2021
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (808.831 KB) | DOI: 10.62769/katalisator.v6i1.197

Abstract

Kemumu (Colocasia gigantea cv) is a type of taro whose stems and leaves are edible. Kemumu belongs to the type of taro whose properties and phytochemical content, in particular, have not been widely reported. This study aims to determine the phytochemical content of kemumu stem as well as antibacterial bioactivity test and cytotoxic test (anticancer initial test) which can be used as raw materials for natural medicine. The stem is extracted using three types of solvents with different levels of polarity, n-Hexane, Ethyl acetate, and Ethanol. Antibacterial activity test uses agar diffusion method with some 20%, 40%, and 60% concentrations. Cytotoxic activity was tested by the Brine Shrimps Lethality Test (BSLT) method. Phytochemical test results are known that the kemumu extract contains secondary metabolites such as flavonoids, alkaloids, tannins, terpenoids, and steroids. The ethyl acetate extract contains flavonoids, tannins, terpenoids, and steroids. Antibacterial activity was found in ethyl acetate extract with a concentration of 40% with an inhibition zone of 17.5 mm. The highest LC50 value was also in the ethyl acetate extract of kemumu, which was 7.14 ppm. This value indicates a high level of toxicity so that ethyl acetate extract of kemumu acts as an antibacterial and anticancer.
HPLC-DAD PROFILING OF SIDR LEAVES AND ROASTED CANDLENUT FOR ALOPECIA THERAPY Elfasyari, Trie Yuni; Zulfisa; Mevy Trisna
JURNAL KATALISATOR Vol. 10 No. 2 (2025): Jurnal Katalisator, Volume 10 No 2 Oktober 2025
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v10i2.3455

Abstract

Alopecia is a dermatological disorder characterised by progressive hair loss, often impairing patients’ quality of life. Conventional therapies, such as minoxidil and finasteride, have demonstrated efficacy; however, their adverse effects have prompted the search for natural-based alternatives. Sidr leaves (Ziziphus spina-christi L.) and roasted candlenut seeds (Aleurites moluccanus L.) have been traditionally employed in ethnopharmacology for hair treatment, yet scientific data on their phytochemical composition remain limited. This study aimed to identify and quantify the major bioactive constituents in purified aqueous extracts of sidr leaves and roasted candlenut seeds using high-performance liquid chromatography coupled with diode-array detection (HPLC-DAD), and to assess their potential implications in alopecia therapy. Powdered sidr leaves and roasted candlenut seeds were extracted, fractionated, and analysed on a C18 column using a gradient acetonitrile–water mobile phase. The results revealed that sidr leaves are rich in rutin hydrate (245.64 ± 0.73 mg/L), accompanied by gallic acid (47.63 ± 0.43 mg/L) and quercetin (6.85 mg/L), whereas roasted candlenut seeds predominantly contain quercetin (27.00 mg/L). Rutin functions as an antioxidant and angiogenesis stimulator, gallic acid exhibits anti-inflammatory activity, and quercetin acts as a 5α-reductase inhibitor relevant to androgenetic alopecia. In conclusion, the phytochemical profiles of sidr leaves and roasted candlenut seeds support their potential use as phytotherapeutic candidates for alopecia management.