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Formulation and in-vitro antioxidant evaluation of α-mangostin, piperin, curcumin in oral patch and their combination Suharyani, Ine Suharyani; Mardianingrum, Richa; Falya, Yuniarti; Pratama, Rizki; Mas'ud, Ibnu; Daruwati, Isti
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.29906

Abstract

Natural antioxidants have been developed in various formulations as alternatives to reduce the side effects associated with synthetic antioxidants. α-Mangostin exhibits strong antioxidant properties, although its behavior in combination with other herbal compounds remains unclear. The aim of this study was to formulate a combination of α-M, piperine, and curcumin into an oral patch and to evaluate the antioxidant properties of α-M when combined with piperine and curcumin, both known natural antioxidants. The oral patches were prepared by incorporating the active compounds (α-mangostin, piperine, and curcumin) into a matrix of hydroxypropyl methylcellulose (HPMC), gelatin, and chitosan. Glycerin was added as a plasticizer. Organoleptic assessment, along with evaluations of pH, weight, folding endurance, and moisture absorption capacity, confirmed the successful formulation of α-mangostin (MP), piperine (PP), curcumin (CP), and combination (MPCP) patches as oral delivery systems. All patches maintained a pH above 5.5. The thicknesses of MP, PP, CP, and MPCP were measured at 0.14 ± 0.02 mm, 0.17 ± 0.01 mm, 0.15 ± 0.02 mm, 0.11 ± 0.01 mm, and 0.16 ± 0.02 mm, respectively. The combination of these natural compounds enhanced folding endurance compared to the individual curcumin and piperine patches, while slightly reducing antioxidant activity. The co-formulation of α-mangostin, piperine, and curcumin into a single oral patch demonstrated a modest decline in antioxidant capacity. This study aimed to assess the impact of combining multiple antioxidant-rich natural compounds within a single delivery system.
An Analysis of the Financial Performance of BUMDes in Enhancing Village Revenue: A Case Study of Rejoagung Village, Kedungwaru District, Tulungagung Regency. Pratama, Rizki; Murdiyanto, Edi; Mahaputra, Agung Pambudi
Journal of Practical Management Studies Vol. 3 No. 2 (2025): JPMS - September (2025)
Publisher : CV. Jala Berkat Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61106/jpms.v3i2.91

Abstract

This study aims to analyze the financial performance of RejoagungMakmur Village-Owned Enterprise (BUMDes) in Rejoagung Village, determine the contribution of BUMDes financial management to increasing village original income (PADes), and identify supporting and inhibiting factors in BUMDes financial performance. The method uses a quantitative approach with multiple linear regression analysis techniques. The financial ratios analyzed include profitability and operational efficiency. The calculation results show that RejoagungMakmurBUMDes has quite good financial performance. Partial tests show that liquidity has a significant effect on village original income with a significance value of 0.010 and a contribution of 42.0%. Profitability also has a significant effect with a significance value of 0.004 and a contribution of 42.7%. Operational efficiency has a significant effect with a significance value of 0.014 and a contribution of 58.8%. Furthermore, simultaneous tests show that the three variables together have a significant effect on PADes with a significance value of 0.000 and a contribution of 67.4%. This study provides strategic recommendations for strengthening BUMDes institutions and governance in a sustainable manner.
PENGARUH BERMAIN GAME ONLINE TERHADAP PERILAKU KOMUNIKASI SISWA KELAS XII JURURSAN MIPA SMA NEGERI 1 ANDONG Izdni Rahmawati, Fina; Jabal, Harjanti; Pratama, Rizki
Journal Media Public Relations Vol. 2 No. 2 (2022): Journal Media Public Relations
Publisher : Program Studi Ilmu Komunikasi Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jmp.v2i2.766

Abstract

Penelitian ini dilakukan untuk mengetahui dan menganalisis Pengaruh Game Online terhadap Perilaku Komunikasi Siswa SMA Negeri 1 Andong. Penelitian ini merupakan penelitian kuantitatif dengan menggunakan data primer yang diperoleh dari kuesioner dan diukur dengan menggunakan skala likert. Data dianalisis menggunakan uji regresi sederhana. Populasi penelitian ini adalah siswa kelas XII Jurusan MIPA SMA Negeri 1 Andong dengan jumlah siswa sebanyak 300 dimana sampel yang diambil hanya 26% atau 78 siswa yang dijadikan sampel untuk penelitian ini. Hasil penelitian ini menunjukkan bahwa game online tidak memiliki pengaruh terhadap perilaku komunikasi.