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All Journal Jurnal Anestesiologi Indonesia Jurnal Anestesi Perioperatif Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Patria Artha Management Journal Patria Artha Journal of Accounting Dan Financial Reporting JURNAL MUTIARA NERS Indonesian Journal of Anesthesiology and Reanimation (IJAR) Solo Journal of Anesthesi, Pain and Critical Care Patria Artha Journal of Community
Lubis, Bastian
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Correlation Between Total Lymphocyte Count and SOFA Score in Adult Sepsis Patients: A Cross-Sectional Study in An ICU Setting Wicaksono, Desmiko Haryo; Lubis, Bastian; Bisono, Luwih
Indonesian Journal of Anesthesiology and Reanimation Vol. 8 No. 1 (2026): Indonesian Journal of Anesthesiology and Reanimation (IJAR)
Publisher : Faculty of Medicine-Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijar.V8I12026.42-47

Abstract

Introduction: Sepsis is a life-threatening organ dysfunction due to dysregulation of the host’s response to infection, which causes systemic changes, namely a decrease in the Total Lymphocyte Count value, which is related to mortality. Sepsis remains a major global health challenge due to its complex pathophysiology, heterogeneous clinical presentation, and high mortality despite advances in critical care management. Early identification of immune dysregulation is crucial for risk stratification and timely intervention. Simple, accessible, and cost-effective biomarkers derived from routine laboratory examinations are therefore needed to support early assessment of disease severity in patients with sepsis.Objective: This research is an observational analytical study with a cross-sectional approach in adult patients diagnosed with sepsis in integrated inpatient wards and intensive care wards at Haji Adam Malik Hospital Medan. Methods: The subject sampling technique used was non-probability sampling with a consecutive sampling method where 115 subjects were required. Bivariate analysis used the Spearman correlation test on the Total Lymphocyte Count value and SOFA score with a 95% confidence interval, with a p-value <0.05 considered significantly significant. Results and Discussion: The results of the research on the first day found that the average lymphocyte count was 0.92 + 0.29 (0.78) and the average SOFA score was 9.96 + 2.88 (11), where an r-value of -0.783 was obtained, which indicates a high and significant negative relationship between lymphocyte count and SOFA score as a predictor of sepsis patients (p-value = 0.001, p <0.05). Conclusion: Lymphocyte count has a strong negative correlation with the SOFA score in adult patients diagnosed with sepsis in integrated inpatient wards and intensive care wards.
Association Between Eccentricity Index and Stroke Volume Variation in Septic Patients: A Cross-Sectional Observational Study Julita, lda; Lubis, Bastian; Bangun, Chrismas Gideon
Jurnal Anestesi Perioperatif Vol 14, No 1 (2026)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15851/jap.v14n1.4625

Abstract

Introduction: Fluid overload (FO) is common in septic ICU patients and increases morbidity and mortality. Assessing fluid status remains challenging. Stroke Volume Variation (SVV) is a dynamic parameter of fluid responsiveness, while the Eccentricity Index (EI) reflects right ventricular geometric changes due to volume overload. This study evaluated the relationship between EI and SVV in patients with sepsis.Methods: This cross-sectional study included 29 newly diagnosed septic patients admitted to the ICU of Adam Malik Hospital. Fluid status was assessed within 24 hours after initial resuscitation (30 mL/kg crystalloids) based on the Surviving Sepsis Campaign. SVV was measured using an Ultrasonic Cardiac Output Monitor (USCOM), and EI was assessed by transthoracic echocardiography at end-systole using the Ryan protocol. FO was defined as SVV <10%.Results: Participants were 55.2% male, with a mean age of 47.17±12.25 years. Respiratory tract infection was the main source of sepsis (65.5%). A strong negative correlation was found between EI and SVV (r=–0.802; p<0.05). Significant differences in EI and SVV were observed between patients with and without FO (p<0.05).Discussion: Higher EI values were associated with lower SVV, indicating that septal deformation corresponds with fluid overload. EI may complement SVV in evaluating fluid status.Conclusion: EI shows a strong negative correlation with SVV in septic ICU patients and may serve as an adjunct parameter for fluid assessment. Further studies are required to confirm the diagnostic value.
PLASMA EXCHANGE THERAPY (TPE) IN MYASTHENIC CRISIS PATIENTS Prasetyo, Reza Fazri; Lubis, Bastian
Jurnal Ilmiah Keperawatan Vol 8 No 2 (2025): Jurnal Mutiara Ners
Publisher : Program Studi Ners UNIVERSITAS SARI MUTIARA INDONESIA

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Abstract

Myasthenic crisis is an acute exacerbation of myasthenia gravis that results in weakness of the respiratory muscles, potentially leading to acute respiratory failure and the necessity for mechanical ventilation support. Approximately 15-20% of individuals with myasthenia gravis will experience a myasthenic crisis at some point in their lives, making it one of the most dangerous and life-threatening complications if not addressed promptly. Fortunately, mortality rates associated with myasthenic crises are currently decreasing, partly due to the effectiveness of therapeutic plasma exchange (TPE). TPE therapy works by removing pathological antibodies, immune complexes, and cytokines from the plasma and replacing them with replacement fluid. In this report, we discuss the case of a 61-year-old man with myasthenia gravis who was admitted to the emergency department (ED) and then to the intensive care unit (ICU) for one day due to a myasthenic crisis. He was intubated and received mechanical ventilation support, followed by plasma exchange therapy, which resulted in clinical improvement.
The Relationship of Renal Resistive Index and Central Venous Pressure As Predictors of Acute Kidney Injury in Critically III Patients of Intensive Care Unit Adam Malik General Hospital Medan Wira, Muhammad Apriandi; Hanafie, Achsanuddin; Lubis, Asmin; Lubis, Bastian
Solo Journal of Anesthesi, Pain and Critical Care (SOJA) Vol 2, No 2 (2022): October 2022
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/soja.v2i2.59946

Abstract

Background: Changes in the doppler-based renal resistive index (RRI) occur prior to the changes of glomerular filtration rate (GFR) during the development of acute kidney injury (AKI) and during the healing process from AKI. Central venous pressure (CVP) is not only a marker for resuscitation, but also can determine the microcirculatory perfusion pressure as outflow obstruction.Objective: This study aims to determine the relationship between RRI and CVP as a predictor of AKI in critically ill patients admitted to the intensive care unit (ICU) of Adam Malik General Hospital.Methods: This was an observational study with prospective cohort design and diagnostic test method. This research was conducted at the Adam Malik General Hospital Medan from June to July 2020. Forty patients aging 18-65 years old who met the diagnostic criteria of sepsis and septic shock were examined for RI and CVP when admitted to the ICU.Results: RI had better sensitivity and specificity than CVP in predicting the incidence of AKI (sensitivity 68% vs 59%, specificity 77% vs 55.5%, Receiver operating characteristics (ROC) 0.870 vs 0.321 (95% confidence interval)).Conclusion: Based on the results of this study, the renal resistive index has better sensitivity and specificity than central venous pressure in predicting the incidence of AKI in critical patients in the ICU.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Hamid Agus Arman, Agus Akbar Akbar Amelia, Putri Amelia, Putri Bangun, Chrismas Gideon Bisono, Luwih Febrianti, Magfirah Fina Diana Hanafie, Achsanuddin Hartati, Ita Ilham Ilham Irina, Rr Sinta Irma Yanti Irvan , Nurmiati Irvan, Nurmiati Ismail Ismail Julita, lda Jumriani, Jumriani Krisna Rendi Awalludin Lubis, Asmin Muhammad Akil, Muhammad Murbayani Murbayani, Murbayani Murniati Murniati Nafiah Nasution, Ali Nasution, Silvanni Nurmiati Nurmiati Nurwahyuni Prasetyo, Reza Fazri REZKYAWAN, REZKYAWAN Rico, Rico Ridwan, Ridwan Risnah, Andi S, Suhendra Silvanni Nasution, Melati Suhendra Suhendra Syahputra, Imam wicaksono, desmiko haryo Wira, Muhammad Apriandi