Article Per Year (5 Year)
p-Index From 2021 - 2026
1.532
P-Index
This Author published in this journals
All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal SOLMA JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Journal of Indonesia Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) kawanad Pharmacon: Jurnal Farmasi Indonesia Indonesian Journal of Jamu
Viviandhari, Daniek
Unknown Affiliation
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Economics, Econometrics & Finance Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Safety Profile of Oral Anticoagulants in Elderly Atrial Fibrillation Patients: A Review Focused on Bleeding Risk in Secondary Stroke Prevention Viviandhari, Daniek; Wiyati, Tuti
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

The elderly population has the highest risks of bleeding due to oral anticoagulant use to prevent secondary stroke since causes higher levels of anticoagulant status fluctuation. However, the detailed information on safety issues regarding bleeding effect of oral anticoagulant from elderly population perspective with atrial fibrillation is still lacking. This narrative review was conducted to summarize the study findings from the present literature. This review was conducted using PubMed and Scopus database. Data were retrieved from 2017 until 2023. Articles were considered for inclusion if they discussed the safety of oral anticoagulant for secondary stroke prevention in Atrial Fibrillation (AF) patients. A total of 9 articles were extracted. The design of the studies, participant characteristics, and the risk of bleeding events were all assessed. The Hazard Ratio (HR) ranged from 2.82 to 0.58 across 5 trials. There were three occurrences of significant hemorrhage with delayed Non-Vitamin K Antagonist Oral Anticoagulants (NOACs) and seven cases with early NOACs. When comparing acute reperfusion to no reperfusion, the Odd Ratio (OR) of 1 study was 0.74. One study found that the incidence of significant bleeding was 2.1% in the case of standard warfarin use and 0% in the case of early apixaban use. Research comparing warfarin and rivaroxaban in patients with mild AF found a Relative Risk (RR) of 0.91. NOACs/Direct Oral Anticoagulants (DOACs) are relatively safe to use, while International Normalized Ratio (INR)-guided Vitamin K antagonists (VKAs) should be use with cautions in the elderly with AF for secondary stroke prevention concerning bleeding events, regardless of independence status (patient’s level of functional independence), presence of acute reperfusion treatment, Embolic Stroke of Undetermined Source (ESUS), Patent Foramen Ovale (PFO), and decreased renal function.
Co-Authors Ema Dewanti Ha, Hai-Anh Ingenida Hadning Kusumaningtyas, Triana Arum Lonica, Nitia Lusi Putri Dwita Maifitrianti Maifitrianti Maifitrianti, Maifitrianti Mouretha, Vrizca Mutia Isnarningtyas, Safitri Nuari, Yudha Rizky Nurhasanah Nurhasnah Nurhasnah Nurhasnah Perdianti, Pegi Pertiwi, Deasy Vanda Puspitasari, Elva Fitriani Rini Prastiwi Siti Fatmawati Fatimah, Siti Fatmawati Taufani, Indra Putra Verda Farida Wiyati, Tuti Wulandari, Nora Yumna, Nurina Faridah