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Dietary Vitamin D in Periodontal Diseases: A Scoping Review of Interventions and Assessments Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 15 No. 04 (2024): Jurnal EduHealt (inpres), Year 2024
Publisher : Sean Institute

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Vitamin D has gained significant attention for its potential role in periodontal health. This scoping review investigates the evidence on dietary vitamin D interventions and assessments in periodontal diseases, examining their impact on periodontal outcomes and identifying research gaps. Using the PRISMA for Scoping Reviews protocols, data were sourced from PubMed and Scopus, including studies focused on dietary vitamin D interventions in periodontal diseases. Exclusions were non-peer-reviewed articles, reviews, animal studies, and inaccessible full-text articles. A total of 22 studies were included: 11 experimental and 11 observational. Among experimental studies, vitamin D supplementation (n=7) was the most common intervention. Observational studies employed various dietary assessment methods, including 24-hour dietary recall (n=2), food frequency questionnaires (FFQ) (n=3), dietary supplement intake (n=3), and combined methods (n=3). Experimental findings suggest that vitamin D supplementation may enhance periodontal health, particularly when paired with non-surgical treatments. Mixed findings from observational studies and limited research on surgical contexts underscore the complexity of establishing definitive conclusions. These findings emphasize the need for standardized methodologies and further investigation to better understand the role of vitamin D in periodontal health.

The Streptococcus mutans ability to survive in biofilms and during dental caries formation: scoping review Anisauma UTAMANİNGYAS; Hening Tjaturina PRAMESTİ; Felisha Febriane BALAFİF
Journal of Syiah Kuala Dentistry Society Vol 7, No 2 (2022): December 2022
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v7i2.30295

Caries are the deterioration of dental hard tissue caused by acidic byproducts of bacterialcarbohydrate fermentation. The formation begins within the bacterial biofilm that covers the tooth's surface. Streptococcus mutans is the dominant bacteria in the biofilm, forming a multispecies biofilm on the tooth surface, growing, and surviving within it. S. mutans colony formation and acid formation can lead to tooth demineralization. The purpose of this scoping review is to determine the ability of S. mutans to survive in biofilms and during the formation of dental caries using articles from the chosen database. Articles published from 2016 until 2021 were searched for using the keywords: "Streptococcus mutans and caries or dental caries and survival ability or survivability and survival factor" in the PubMed, ScienceDirect, Cochrane, and Google scholar databases. Using PRISMA-Scr, existing articles were chosen based on inclusion and exclusion criteria. There were ten articles found that were suitable for review. The data presented in the article vary according to the study's location, purpose, method, and samples. The finding revealed that S. mutans survive in biofilms and caries formation due to their ability to activate enzymes, virulence factors of S. mutans, and the environmental conditions of the oral cavity. Aciduric; acidogenic; quorum sensing; ability to form GTFs, GBPs, ATPase, CSP, eDNA; and the ability to produce bacteriocin and autolysins all contribute to Streptococcus mutans' ability to survive in biofilms and during the formation of dental caries KEYWORDS: biofilm, caries, survival ability, survival factor, Streptococcus mutans.

Oral health assessment during Covid-19 pandemic: community self-report questionnaire Felisha Febriane BALAFIF; Agus SUSANTO; Indah Suasani WAHYUNI
Journal of Syiah Kuala Dentistry Society Vol 6, No 1 (2021): June 2021
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v6i1.21894

ABSTRACT The Covid-19 pandemic situation has affected community activities, work, income whichdecreased, psychological disorders such as stress, and limited accessibility to dental practice service,which is now for emergency cases only. This condition can affect oral health in the community. Thisstudy aimed to assess the oral health condition in the community during the Covid-19 pandemic. Thisstudy was implementing a cross-sectional research design. Data were obtained from onlinequestionnaires with the respondent's consent. The sample selection with inclusion criteria comprised 1960yearsoldwholivedinBandungWestJava.Theself-reportquestionnairefororalhealthassessmentwasfollowed,thepreviousresearch,byLevinetal.,2013.Ithasbeentrans-adaptedtoBahasaIndonesiaandvalidated.Respondentsofthestudywere380participants.Poororalhygienemaintenancewasthewrongfrequencyofbrushingteeth(12.1%),onlyvisitingthedentistwhenhavingatoothache(72.9%),andsmoking(7.9%).Oralhealthproblemsincludegingivalbleedingonbrushing(15.3%),toothmobility(13.2%),tooth cavities (62.9%), toothache (27.1%), and bad breath (22.6%). Most of the oral healthproblems were tooth cavities followed by toothache. The contributing factors include poor oral hygienemaintenance, improper brushing, smoking habits, and infrequent dental care. Furthermore, theaccessibility and availability of services in dental practice in the pandemic situation are limited.Therefore, it is reasonable to say that oral self-examination probably could minimize the distancingrelatedprobleminthisCovid-19pandemicsituationandbehelpfulintheearlydetectionoforalhealthproblems.KEYWORDS: assessment, Covid-19 pandemic, oral health

Dental Biofilm Formation: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 03 (2025): Jurnal EduHealt, Edition July - September , 2025
Publisher : Sean Institute

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Dental biofilm is a structured microbial community that adheres to the tooth surface and becomes embedded within a self-produced extracellular matrix. This matrix, rich in polysaccharides, proteins, and nucleic acids, enables microorganisms to survive environmental stresses and contributes to the onset of oral diseases such as caries and periodontitis. The purpose of this scoping review is to determine current knowledge the dental biofilm formation. The articles published from 2020 until 2025 were searched for using the keywords: "dental and biofilm and formation" in the PubMed, ScienceDirect, and Google scholar databases. Using PRISMA-Scr, existing articles were chosen based on inclusion and exclusion criteria. There were five articles found that were suitable for review. The data presented in the article vary according to the study's location, purpose, method, and samples. The major classes of extracellular polymeric substances that form the matrix are common to most biofilms and comprise carbohydrates, proteins, nucleic acids, and cell wall polymers, such as peptidoglycans and lipids. Several unique resistance mechanisms make biofilms particularly tough to manage. Biofilm bacteria employ multiple defense mechanisms, such as capsule protection, efflux pumps, membrane modifications, genetic adaptations, quorum sensing, metabolic dormancy, and stress responses, making them highly resistant to treatment and contributing to persistent infections.

Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen (Garcinia mangostana Linn.) rind extract against Aggregatibacter actinomycetemcomitans Hendiani, Ina; Susanto, Agus; Carolina, Dyah Nindita; Ibrahim, Rahmat; Balafif, Felisha Febriane
Padjadjaran Journal of Dentistry Vol 32, No 2 (2020): July 2020
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol32no2.27366

Introduction: The main contents of mangosteen (Garcinia mangostana Linn.) is xanthone with antibacterial activity. Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) was a gram-negative, facultative anaerobic bacillus that causes periodontal diseases such as localised aggressive periodontitis (LAP). Mangosteen rind extract could inhibit the growth of Porphyromonas gingivalis and A. actinomycetemcomitans. This study was aimed to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of mangosteen rind extract against A. actinomycetemcomitans. Methods: This study was an experimental and in-vitro study of antimicrobial properties of mangosteen (Garcinia mangostana Linn.).The extract of mangosteen was made by the maceration method using 70% ethanol solvent. A. actinomycetemcomitans (ATCC 43718) obtained from Laboratorium of Microbiology Airlangga University Surabaya. This study used a microdilution method and analysed using the Enzyme Linked Immune Sorbent Assay (ELISA). The determination of the MIC was measured using the formula for cell inhibition percentage. Three concentrations higher than the MIC standard were cultured on the Mueller Hinton agar. The lowest concentration on agar which was not found any growth of the bacterial colonies was determined as the MBC. Results: The results of this study indicated that the MIC and MBC of mangosteen rind extract against A. actinomycetemcomitans were 195.3 ppm and 1562.5 ppm, respectively. Conclusion: Mangosteen rind extract can inhibit and bactericide the growth of A. actinomycetemcomitans.

DIABETES MELITUS GESTASIONAL DAN KESEHATAN RONGGA MULUT IBU DAN ANAK: TINJAUAN LITERATUR Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.25042

Diabetes melitus gestasional (DMG) merupakan kondisi hiperglikemia spontan selama kehamilan, didiagnosis pada trimester kedua atau ketiga pada individu yang tidak menunjukkan tanda-tanda diabetes sebelum kehamilan. Sejumlah penelitian telah menemukan implikasi DMG terhadap kesehatan ibu dan anak, termasuk terhadap kesehatan rongga mulut. Tinjauan ini bertujuan untuk mengkaji secara komprehensif literatur-literatur yang mengevaluasi mengenai hubungan antara diabetes gestasional dan kesehatan rongga mulut ibu-anak, menyoroti aspek penting dari perawatan prenatal dan potensi dampak jangka panjang terhadap kesehatan rongga mulut. Kondisi hiperglikemia pada penderita DMG berkontribusi terhadap berbagai perubahan pada rongga mulut, seperti perubahan mikrobiota dan peningkatan risiko penyakit periodontal pada ibu maupun anak. Periodontitis juga dapat berkontribusi terhadap kondisi DMG, dimana translokasi bakteri periodontitis maupun faktor virulensinya ke sirkulasi sistemik dapat membebani kinerja sel imun inflamasi secara terus menerus sehingga meningkatkan pelepasan mediator proinflamasi dan vesikel ekstraseluler. Tinjauan ini menggaris bawahi perlunya penelitian lebih lanjut untuk mengeksplorasi strategi pencegahan dan intervensi yang dapat diterapkan untuk meningkatkan kesejahteraan ibu dan anak.

Bacteriology in Diagnosing Oral Odontogenic Infections: A Scoping Review Hazhiyyah, Nabila Ghassania; Dewi, Warta; Balafif, Felisha Febriane
Journal of Syiah Kuala Dentistry Society Vol 8, No 2 (2023): December 2023
Publisher : Dentistry Faculty

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/jds.v8i2.32710

Background: Odontogenic infection is an invasion of pathogenic microbes that originate from the tooth or its supporting structures and can spread to the surrounding tissue. Bacteriological examination to support the diagnosis. Objective: This study aims to discuss the role of bacteriological examination in helping to diagnose odontogenic infections. Method: Scoping review research type. Search for research gaps using the PCC strategy. PubMed, Scopus, ScienceDirect and Google Scholar databases were used to search for articles by entering keywords using Boolean Operators. Reporting of scoping review results using PRISMA-ScR guidelines. Results: Oral Streptococcus species in caries samples included S. mutans, S. salivarius, S. mitis and S. sanguis with the dominant bacteria being S. mutans. Results: The highest bacterial prevalence of odontogenic infections was Staphylococcus bacteria with high sensitivity to penicillin antibiotics. Periodontal pocket samples showed the highest differences in bacterial prevalence from the three articles, including Staphylococcus aureus, Fusobacterium nucleatum and Actinobacillus actinomycetemcomitans. Enterococcus was the dominant bacteria in two articles with samples taken from root canals. Odontogenic abscess samples showed that Gram-positive bacteria were more dominant than Gram-negative bacteria, which were the most common in the culture results of abscess patients. The spread of odontogenic infections in the facial space shows that Methicillin resistant Staphylococcus aureus (MRSA) strains are the dominant bacteria found. Conclusion: Bacteriological examination should be carried out to show the dominant bacteria that cause odontogenic infections, so that it has benefits to support the diagnosis and treatment plan by the dentist

Differences in handgrip strength and tooth loss between cognitively normal and impaired elderly: cross-sectional study Syamila, Rahmi Hasna; Sari, Kartika Indah; Balafif, Felisha Febriane; Gondowidjojo, Yolanda Dwiutami; Ong, Paulus Anam
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.62743

Introduction: The aging process in elderly individuals triggers changes in the brain that can lead to a decline in cognitive function, impacting quality of life. Age-related physiological changes affect the muscles around the oral cavity and the musculoskeletal system. These changes manifest as a decrease in the mass and strength of the chewing muscles. Tooth loss further exacerbates the ability to chew. This study aims to analyze differences in handgrip strength and tooth loss between cognitively normal and impaired elderly. Methods: Observational analytic with cross-sectional design using the Mann-Whitney comparative significance test and independent sample t-test with a significance level of p<0.05 was conducted. A purposive sampling technique was applied to a population residing in Dago Village, Bandung. The inclusion criteria included elderly individuals aged ≥60 years, both male and female, able to communicate effectively, and willing to participate in the study by signing an informed consent form. Cognitive function was assessed through interviews using the Mini Mental State Examination (MMSE), along with an examination of the number of missing teeth and hand grip strength measured with the Electronic Hand Dynamometer (Camry EH101). Analyzed data used the Mann–Whitney test. Results: A total of 34 subjects met the inclusion criteria from the total population of 71 older adults examined. The independent sample t-test for handgrip strength showed that elderly individuals with cognitive impairment had weaker handgrip strength (mean=14.250, SD=5.0285) compared to cognitively normal individuals (mean=22.281, SD=6.0204), with a p-value of 0.0001 (p<0.05). The Mann–Whitney test results for tooth loss indicated that elderly individuals with cognitive impairment experienced greater tooth loss (range=11–32 teeth, mean=20.78) compared to cognitively normal individuals (range=0–10 teeth, mean=13.81), with a p-value of 0.041 (p<0.05). Conclusion: There are differences in hand grip strength and tooth loss were found between cognitively normal and impaired elderly.

Quorum Sensing and the Transition from Symbiosis to Dysbiosis in Periodontal Biofilms: A Scoping Review Febriane Balafif, Felisha; Anggun Rafisa; Faisal Kuswandani; Nuroh Najmi
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Introduction: Quorum sensing (QS), a bacterial cell communication system, has emerged as a key regulator of community level biofilm dynamics, yet its role in mediating this ecological transition has not been systematically synthesized. This scoping review aimed to map and synthesize evidence published over the last decade on the role of quorum sensing in driving the transition from symbiosis to dysbiosis in periodontal biofilms. Methods: A scoping review was conducted in accordance with the PRISMA-ScR guidelines. Searches were performed in PubMed, Scopus, and Web of Science for studies published between 2016 and 2025 that investigated quorum sensing mechanisms in periodontal or subgingival biofilms using in vitro, ex vivo, or in vivo models. Data were charted and analyzed descriptively. Results: Sixty one studies met the inclusion criteria. Autoinducer-2 mediated signaling emerged as the most consistently reported quorum sensing pathway in periodontal biofilms. Quorum sensing was shown to regulate interspecies communication, biofilm maturation, metabolic cooperation, and coordinated virulence expression. Evidence indicated that quorum sensing primarily drives dysbiosis through functional reprogramming of microbial communities rather than through numerical dominance of specific pathogens. Several studies also linked quorum sensing activity to enhanced host inflammatory responses and alveolar bone loss in experimental models. Conclusion: Quorum sensing as a central ecological mechanism orchestrating the transition from symbiosis to dysbiosis in periodontal biofilms. By coordinating community wide microbial behavior, host and microbe interactions, quorum sensing contributes to sustained dysbiosis and periodontal inflammation.

Vitamin Deficiencies among Adult Patients with Recurrent Aphthous Stomatitis: A Systematic Review Rafisa, Anggun; Balafif, Felisha Febriane; Najmi, Nuroh; Kuswandani, Faisal
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Recurrent aphthous stomatitis (RAS) is a common inflammatory condition of the oral mucosa characterized by recurrent, painful ulcerations that significantly impair quality of life. Although its etiology is multifactorial, nutritional factors, particularly vitamin deficiencies, have been proposed as potential contributors through their roles in immune regulation, epithelial integrity, and wound healing. Evidence regarding vitamin status in adults with RAS, however, remains inconsistent. This systematic review aimed to synthesize and critically evaluate available evidence on vitamin levels in adult patients with recurrent aphthous stomatitis. A comprehensive literature search was conducted in PubMed and Scopus for studies published between January 2015 and December 2025, following PRISMA 2020 guidelines. Eligible studies included adult participants (≥18 years) diagnosed with RAS and reported serum or salivary vitamin levels. Observational and interventional studies were considered. Data were extracted on study characteristics, vitamin assessment methods, and key findings, and were analyzed descriptively. Seven studies met the inclusion criteria. Vitamin D was the most frequently investigated micronutrient, followed by vitamin B12 and other hematinic parameters. Several studies reported lower vitamin D levels in patients with RAS compared with controls, while others found similarly high rates of deficiency in both groups. Associations between vitamin levels and clinical severity of RAS were generally weak, although vitamin D deficiency was linked to increased ulcer multiplicity in one study. Vitamin B12 deficiency was primarily observed in populations with concomitant iron deficiency anemia rather than in otherwise healthy adults with RAS. Current evidence suggests that vitamin deficiencies, particularly vitamin D, may function as modifying or aggravating factors in adult RAS rather than direct causal agents. Further high-quality studies are required to clarify their clinical relevance and therapeutic implications.

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