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All Journal Majalah Kedokteran Bandung Padjadjaran Journal of Dentistry Jurnal Kesehatan Tambusai Jurnal EduHealth Jurnal of Syiah Kuala Dentistry Society
Felisha Febriane Balafif
Microbiology, Department Of Oral Biology Faculty Of Dentistry Universitas Padjadjaran, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Soy Isoflavone Mediated Modulation of IL-1β Related Inflammatory Pathways in Oral Mucosal Cells: A Scoping Review of Experimental Studies Najmi, Nuroh; Kuswandani , Faisal; Rafisa, Anggun; Balafif, Felisha Febriane
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

Background: Soy isoflavones, particularly genistein, have been widely studied for their anti-inflammatory properties. However, evidence regarding their modulatory effects on interleukin-1β (IL-1β)–related inflammatory pathways in oral mucosal tissues remains limited. Objective: This scoping review aimed to map the available experimental evidence on the effects of genistein on inflammatory responses associated with IL-1β in the oral cavity. Methods: A scoping review was conducted following a comprehensive literature search of PubMed and ScienceDirect databases. Articles published in English between 2016 and 2026 were screened using predefined keywords related to soy isoflavones, genistein, IL-1β, inflammation, and oral or periodontal tissues. Original experimental studies focusing on inflammatory modulation in oral or periodontal contexts were included. Results: From the literature search, only one experimental study met the inclusion criteria. The included study investigated a genistein-loaded folic acid–modified liposome-hydrogel composite for periodontitis treatment. The findings demonstrated that genistein exerted anti-inflammatory effects by modulating inflammatory cytokines, including IL-1β, and inhibiting the TLR4/MyD88/NF-κB signaling pathway. The study also reported improved inflammatory regulation through macrophage phenotype modulation and interaction with periodontal ligament stem cells. Conclusion: Current experimental evidence on the role of genistein in modulating IL-1β–related inflammation in the oral cavity is scarce. The limited findings suggest that genistein has potential anti-inflammatory effects in periodontal inflammation; however, further well-designed experimental studies focusing specifically on oral mucosal cells and inflammatory pathways are needed to support its therapeutic application.
Co-Authors Agus Susanto Agus Susanto Anggun Rafisa Anisauma UTAMANİNGYAS Diah Dhianawaty Dyah Nindita Carolina Faisal Kuswandani Faisal Kuswandani Gondowidjojo, Yolanda Dwiutami Hazhiyyah, Nabila Ghassania Hening Tjaturina Pramesti Ibrahim Rahmat Ina Hendiani, Ina Indah Suasani Wahyuni Kuswandani , Faisal Mieke Hemiawati Satari Nuroh Najmi Ong, Paulus Anam Sari, Kartika Indah Syamila, Rahmi Hasna Warta Dewi, Warta