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Satrijo, Budi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pain symptoms and delays healthcare decision-making in acute myocardial infarction Ainan, Shafa; Lukitasari, Mifetika; Sari, Efris Kartika; Ahsan, Ahsan; Rohman, Mohammad Saifur; Satrijo, Budi
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.16

Abstract

Background: Rapid initiation of reperfusion therapy in acute myocardial infarction (AMI) is vital for a favourable prognosis and is significantly affected by the duration from symptom onset to hospital arrival. Previous studies have indicated that cardiac autonomic neuropathy (CAN), prevalent in diabetic patients, may impair pain perception, potentially delaying healthcare-seeking behaviour Objective: This study aimed to compare chest pain characteristics and healthcare-seeking delays between patients with diabetes mellitus (DM) and without DM (non-DM) myocardial infarction. Methods: A cross-sectional study was conducted involving 93 subjects (35 DM and 58 non-DM) diagnosed with either ST-elevation myocardial infarction (STEMI, n=78) or non-ST elevation myocardial infarction (NSTEMI, n=15). Data on symptoms, including pain quality and healthcare-seeking timing within 72 hours of admission, were gathered via a standardized questionnaire. Result: Logistic regression analysis highlighted stabbing pain as a strong predictor (OR = 3.296, p-Value = 0.038), indicating that patients with this symptom are more than three times more likely to delay seeking care. Patients with DM are more frequently reported back-radiating stabbing pain (p<0.05). No significant differences between the groups were observed in pain symptomatology and decision-making delay, although DM patients were more likely to delay seeking care for over two hours. Conclusion: While pain characteristics showed no significant differences between DM and non-DM myocardial infarction patients, DM patients were prone to later healthcare engagement. This delay could be attributed to the misinterpretation of cardiac symptoms as diabetic complications, underscoring the need for targeted patient education. Therefore, strengthened patient education and routine screening for cardiovascular symptoms in individuals with diabetes are essential to support early detection and timely management.
Pengaruh Peningkatan Kadar Asam Urat Dengan Derajat Keparahan Stenosis Arteri Koroner Pada Penderita Sindrom Koroner Kronik Lestari, Defyna; Satrijo, Budi
Jurnal Klinik dan Riset Kesehatan Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.2.5

Abstract

Coronary artery disease (CAD) remains the most common cause of death globally despite advancements in treatment. Uric acid (UA) has been associated with the development of cardiovascular events in patients with Chronic Coronary Syndrome (CCS). Several hypotheses suggest that UA exerts a negative impact on coronary arteries and/or increases the risk of major adverse cardiovascular events (MACE).
Interaksi Antara Protein Morfogenetik Tulang, Kalsifikasi Vaskular, dan Sindrom Metabolik: Mekanisme dan Perspektif Terapi Sihotang, Fransiska; Satrijo, Budi
Jurnal Klinik dan Riset Kesehatan Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.2.6

Abstract

Vascular calcification (VC) is a pathological process marked by the abnormal deposition of calcium phosphate in the vascular wall, leading to increased arterial stiffness and the development of cardiovascular disease. Previously considered as a passive degenerative condition, vascular calcification is now understood as an actively regulated process involving vascular smooth muscle cells (VSMCs) and is influenced by metabolic disorders, especially metabolic syndrome (MetS). Metabolic syndrome, defined by insulin resistance, hypertension, dyslipidaemia, and central obesity, promotes vascular calcification via various molecular mechanisms, such as chronic inflammation, oxidative stress, and lipid dysregulation. Bone morphogenetic proteins (BMPs), particularly BMP-2, are essential for the osteogenic differentiation of vascular smooth muscle cells, facilitating vascular mineralisation and influencing cardiovascular morbidity. Increased BMP signalling in metabolic syndrome is associated with heightened vascular stiffness, endothelial dysfunction, and greater arterial calcification. This review examines the intricate relationship between vascular complications and metabolic syndrome, highlighting the role of bone morphogenetic proteins in vascular pathology. An enhanced comprehension of these molecular mechanisms may facilitate the development of novel treatment strategies designed to mitigate cardiovascular risk and enhance patient outcomes.
Co-Authors Abusari, Muchamad Afifah, Yuri Ahsan Ahsan Ainan, Shafa Anjarwani, Setyasih Aryanugraha, Teguh Ashari, Yordan Wicaksono Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Bayu Lestari Caesario, Fahreza Cholid Tri Tjahjono Djanggan Sargowo Efris Kartika Sari, Efris Kartika Emil Fathoni, Emil Firdaus, Achmad Jauhar Galuh, Lukitasari Ayu Hidayat Sujuti Hidayat Sujuti Indra Prasetya Indrihapsari, Pratiwi Iskandar Iskandar Kurnianingsih, Novi Kurniawan, Dea Arie Lestari, Bayu Lestari, Defyna Lukitasari, Mifetika Martini, Heny Mayangsari, Veny Millisani, Hayla Iqda Mohammad S. Rohman Mohammad Saifur Rohman Noverike, Nikhen Nugraha, Yudha Tria Putri, Valerinna Yogibuana Swastika Rahimah, Anna Fuji Rislan Faiz Muhammad Rizal, Ardian Rosandy, Kharima Ogit Saskia Dyah Handari Sihotang, Fransiska Suprayoga, Imam Mi'raj Swastika Putri, Valerinna Yogibuana Widito, Sasmojo Yogibuana, Valerinna zunardi, Lutfi hafiz