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Satrijo, Budi
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pain symptoms and delays healthcare decision-making in acute myocardial infarction Ainan, Shafa; Lukitasari, Mifetika; Sari, Efris Kartika; Ahsan, Ahsan; Rohman, Mohammad Saifur; Satrijo, Budi
Heart Science Journal Vol. 7 No. 1 (2026): Accelerating Clinical Breakthroughs: The Journey from Molecular Discovery to Pa
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.01.16

Abstract

Background: Rapid initiation of reperfusion therapy in acute myocardial infarction (AMI) is vital for a favourable prognosis and is significantly affected by the duration from symptom onset to hospital arrival. Previous studies have indicated that cardiac autonomic neuropathy (CAN), prevalent in diabetic patients, may impair pain perception, potentially delaying healthcare-seeking behaviour Objective: This study aimed to compare chest pain characteristics and healthcare-seeking delays between patients with diabetes mellitus (DM) and without DM (non-DM) myocardial infarction. Methods: A cross-sectional study was conducted involving 93 subjects (35 DM and 58 non-DM) diagnosed with either ST-elevation myocardial infarction (STEMI, n=78) or non-ST elevation myocardial infarction (NSTEMI, n=15). Data on symptoms, including pain quality and healthcare-seeking timing within 72 hours of admission, were gathered via a standardized questionnaire. Result: Logistic regression analysis highlighted stabbing pain as a strong predictor (OR = 3.296, p-Value = 0.038), indicating that patients with this symptom are more than three times more likely to delay seeking care. Patients with DM are more frequently reported back-radiating stabbing pain (p<0.05). No significant differences between the groups were observed in pain symptomatology and decision-making delay, although DM patients were more likely to delay seeking care for over two hours. Conclusion: While pain characteristics showed no significant differences between DM and non-DM myocardial infarction patients, DM patients were prone to later healthcare engagement. This delay could be attributed to the misinterpretation of cardiac symptoms as diabetic complications, underscoring the need for targeted patient education. Therefore, strengthened patient education and routine screening for cardiovascular symptoms in individuals with diabetes are essential to support early detection and timely management.
Pengaruh Peningkatan Kadar Asam Urat Dengan Derajat Keparahan Stenosis Arteri Koroner Pada Penderita Sindrom Koroner Kronik Lestari, Defyna; Satrijo, Budi
Jurnal Klinik dan Riset Kesehatan Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.2.5

Abstract

Coronary artery disease (CAD) remains the most common cause of death globally despite advancements in treatment. Uric acid (UA) has been associated with the development of cardiovascular events in patients with Chronic Coronary Syndrome (CCS). Several hypotheses suggest that UA exerts a negative impact on coronary arteries and/or increases the risk of major adverse cardiovascular events (MACE).
Interaksi Antara Protein Morfogenetik Tulang, Kalsifikasi Vaskular, dan Sindrom Metabolik: Mekanisme dan Perspektif Terapi Sihotang, Fransiska; Satrijo, Budi
Jurnal Klinik dan Riset Kesehatan Vol 5 No 2 (2026): Volume 5 No 2, Edisi Februari 2026
Publisher : RSUD Dr. Saiful Anwar Province of East Java

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jk-risk.05.2.6

Abstract

Vascular calcification (VC) is a pathological process marked by the abnormal deposition of calcium phosphate in the vascular wall, leading to increased arterial stiffness and the development of cardiovascular disease. Previously considered as a passive degenerative condition, vascular calcification is now understood as an actively regulated process involving vascular smooth muscle cells (VSMCs) and is influenced by metabolic disorders, especially metabolic syndrome (MetS). Metabolic syndrome, defined by insulin resistance, hypertension, dyslipidaemia, and central obesity, promotes vascular calcification via various molecular mechanisms, such as chronic inflammation, oxidative stress, and lipid dysregulation. Bone morphogenetic proteins (BMPs), particularly BMP-2, are essential for the osteogenic differentiation of vascular smooth muscle cells, facilitating vascular mineralisation and influencing cardiovascular morbidity. Increased BMP signalling in metabolic syndrome is associated with heightened vascular stiffness, endothelial dysfunction, and greater arterial calcification. This review examines the intricate relationship between vascular complications and metabolic syndrome, highlighting the role of bone morphogenetic proteins in vascular pathology. An enhanced comprehension of these molecular mechanisms may facilitate the development of novel treatment strategies designed to mitigate cardiovascular risk and enhance patient outcomes.
When bones meet blood vessels: BMP-2 expression and vascular calcification in a rat model of metabolic syndrome Sihotang, Fransiska Anggreni; Rohman, Muhammad Saifur; Satrijo, Budi; Sargowo, Djanggan; Rizal, Ardian
Heart Science Journal Vol. 7 No. 2 (2026): The Evolving Landscape of Heart Failure
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2026.007.02.14

Abstract

Background: Vascular calcification (VC) is a significant contributor to cardiovascular morbidity, particularly in conditions like metabolic syndrome (MetS). Bone Morphogenetic Protein-2 (BMP-2) is implicated in the osteogenic differentiation of vascular cells, potentially linking MetS to VC. Objective: This study aimed to investigate aortic BMP-2 expression and the presence of VC in a rat model of MetS and assess the effects of Metformin, Empagliflozin, and a green tea/green coffee extract combination. Methods: Male Sprague-Dawley rats were induced with MetS using a high-fat, high-sucrose diet combined with a low-dose streptozotocin injection (30 mg/kgBW). Rats were divided into five groups (n=5): Normal control (NORM), MetS (METS), MetS + Metformin (MFN, 500 mg/kgBW), MetS + Empagliflozin (EMP, 30 mg/kgBW), and MetS + GTCE (300 mg/kgBW green tea + 200 mg/kgBW green coffee). Treatments were administered daily via oral gavage for 9 weeks. Result: Aortic tissue was collected for histological analysis and qRT-PCR to measure relative BMP-2 mRNA expression. Histological analysis revealed calcification in the aortic wall of the METS group rats. Compared to the NORM group, BMP-2 mRNA expression was significantly upregulated in the METS group (p<0.001). Treatment with MFN, EMP, and GTCE significantly downregulated BMP-2 mRNA expression compared to the METS group (p<0.001 for all). Conclusion: This study demonstrates that MetS induction in this rat model might promotes aortic calcification and significantly increases BMP-2 mRNA expression. Pharmacological interventions with Metformin, Empagliflozin, and green tea/coffee extract attenuated the MetS-induced upregulation of BMP-2 expression. These findings suggest a potential role for BMP-2 in MetS-associated vascular changes.
Co-Authors Abusari, Muchamad Afifah, Yuri Ahsan Ahsan Ainan, Shafa Anjarwani, Setyasih Aryanugraha, Teguh Ashari, Yordan Wicaksono Aulanni'am Aulanni'am Aulanni'am, Aulanni'am Bayu Lestari Caesario, Fahreza Cholid Tri Tjahjono Djanggan Sargowo Efris Kartika Sari, Efris Kartika Emil Fathoni, Emil Firdaus, Achmad Jauhar Fransiska Anggreni Sihotang Galuh, Lukitasari Ayu Hidayat Sujuti Hidayat Sujuti Indra Prasetya Indrihapsari, Pratiwi Iskandar Iskandar Kurnianingsih, Novi Kurniawan, Dea Arie Lestari, Bayu Lestari, Defyna Lukitasari, Mifetika Martini, Heny Mayangsari, Veny Millisani, Hayla Iqda Mohammad S. Rohman Mohammad Saifur Rohman Muhammad Saifur Rohman Noverike, Nikhen Nugraha, Yudha Tria Putri, Valerinna Yogibuana Swastika Rahimah, Anna Fuji Rislan Faiz Muhammad Rizal, Ardian Rosandy, Kharima Ogit Saskia Dyah Handari Sihotang, Fransiska Suprayoga, Imam Mi'raj Swastika Putri, Valerinna Yogibuana Widito, Sasmojo Yogibuana, Valerinna zunardi, Lutfi hafiz