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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Kreativitas PKM Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya Jurnal Mandala Pengabdian Masyarakat Jurnal Abdi dan Dedikasi kepada Masyarakat Indonesia Borneo Journal of Pharmacy Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Kamaruddin, Harni Sartika
Program Studi Farmasi, Fakultas Sains Dan Teknologi, Universitas Sembilan Belas November Kolaka
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Borneo Journal of Pharmacy

 1 
Chemical Constituents and Antioxidant Activity of Melothria scabra Naudin Fruits Harni Sartika Kamaruddin; Megawati Megawati; Nurliana Nurliana; Carla Wulandari Sabandar
Borneo Journal of Pharmacy Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i4.2890

Abstract

The fruit of Melothria scabra Naudin is traditionally used by natives of South East Sulawesi and has economic values in the local markets. Nonetheless, little scientific information was gained from this plant to support its development for nutraceutical and pharmaceutical aspects. This study aimed to investigate the phytochemicals contained in the ethanol extract and organic fractions (methanol, ethyl acetate, and hexane) of the fruits using specific reagents and an LC-MS/MS analysis, as well as to evaluate their total phenolics, total flavonoids, and DPPH radical scavenging activity using a dot-blot staining and spectrophotometric assays. Results showed that the fruits of M. scabra contained alkaloids, tannins, flavonoids, terpenoids, and saponins. Six compounds were successfully identified from the ethanol extract of the fruits for the first time that is D-1-[(3-carboxypropyl)amino]-1-deoxyfructose (1), fructose-C3H5NO (2), valine (3), 1β, 3α, 9β-trihydroxyeudesma-5,11(13)-dien-12-oic acid (4), Cucurbitacin B-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (5), and 2-heptyl-3-hydroxy-4(H)-quinolone (6). Total phenolics in the extract and organic fractions were in the range of 54.2 ± 2.4 to 259.1 ± 8.4 mg GAE/g, while total flavonoids were in the range of 1.6 ± 0.2 to 22.4 ± 0.2 mg QE/g. The ethanol extract and its organic fractions (methanol and ethyl acetate) were potent radical scavengers with SC50 values ranging from 20.7 to 37.5 µg/mL when compared with ascorbic acid, gallic acid, and quercetin (SC50 of 2.8 to 9.4 µg/mL). This study concludes that M. scabra fruits could be developed as a source of natural antioxidant agents for nutraceuticals and pharmaceuticals purposes.
Tentative Identification of Compounds, Antioxidant, and Antimicrobial Activity of the Edible Part of Benincasa hispida L. fruit (Cucurbitaceae) Carla Wulandari Sabandar; Harni Sartika Kamaruddin; Reskiya Nur Insani; Rana Triana Amin; Zulkifli Zulkifli; Tien Tien
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4350

Abstract

The edible part of Benicasa hispida (Thunb.) Cogn. fruit is traditionally used in Southeast Sulawesi to treat high blood pressure, typhoid fever, and body cooling. The present study evaluated the chemical compounds present in the 80% ethanol of the edible part of the plant using phytochemical screening and an LC-MS analysis, antioxidant activity based on assays on total phenolics content (TPC), total flavonoids content (TFC), and DPPH, and antimicrobial activity towards Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Candida albicans. Phytochemical screening revealed the presence of tannins, flavonoids, terpenoids, steroids, and saponins in the extract. As many as eighteen compounds (1-18) were tentatively identified in the extract, including sugars, a simple phenolic, a tricarboxylic acid, a peptide, flavonoids, quinic acid derivatives, phytosterols, triterpenoids, and saponins. The extract exhibited remarkable antioxidant activity with an SC50 value of 23.4 µg/mL, although its TPC (1.1±0.1 mg GAE/g extract) and TFC (1.0±0.1 mg QE/g extract) values were considered in low amounts. The extract was found inactive to inhibit the microbial growths of all tested microbes. However, raffinose (3) present in the extract might be beneficial as a prebiotic to promote a healthy human gut. The study concludes that the 80% ethanol extract of the edible part of B. hispida fruit could be used to develop natural antioxidant agents and nutraceuticals.
Co-Authors Abd Gani Baeda Adillah, Rifda Afifa, Nur Agusriyadin, Agusriyadin Ahmat, Norizan Aladdin, Nor-Ashila Amalia, Vicky Amira Amira Angriani Angriani Azis, Muhammad Israwan Basyaruddin, Muh Carla Sabandar Carla Wulandari Sabandar Debi Yustisia, Wa Ode Dwidayati, Ari Eva Feriadi Evodius Nasus Firna, Firna Fitri, Andi Fitri Hendrawan Hendrawan Ica Aprilia Seleng Isnaeni Isnaeni Jalil, Juriyati Khafidzah Yusuf Lisdayanti, Nur Magfirah, Magfirah Marwan Marwan Masdin, Rahmat Megawati Megawati Muh Syahruddin Muh. Ansar Azali Muhamad Jalil Baari Muhammad Rayzhal Faturahman Nun Ainun Arap Nur Afifa Nurliana Nurliana Nurliana Nurliana Pratiwi, Ines Septiani Rana Triana Amin Reskiya Nur Insani Retno Wahyuningrum Retno Wahyuningrum Rezkiya Nur Insani Rina Hardianti Pratiwi Rina Rembah Rizki Kumalasari Salwan, Muh Manna Sri Gita Handayani Susianti Susianti Syahruddin, Muh. Tien Tien Tulak, Grace Tedy Wahyudi, Muh.Diki Wahyuni Hakim Yayang Rahmadani Yuniar, Rita Yunita, Alfiranty Zaskya Wati, Wa Ode Zulkifli Zulkifli