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All Journal Jurnal Impresi Indonesia Buletin Kedokteran dan Kesehatan Prima International Journal of Public Health Excellence (IJPHE) International Journal of Health and Pharmaceutical (IJHP) Jurnal Pendidikan Indonesia (Japendi)
Yani, Herlina
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Religion Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Obesity Model in White Male Wistar Rats: The Impact of Moringa (Moringa Oleifera) Flower Extract on Pancreatic Function as Deduced from Serum Amylase and Lipase Levels and the Histopathological Image of the Pancreas Devy; Jansen; Yani, Herlina
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.752

Abstract

Diabetes and obesity go hand in hand. Antidiabetic drugs are effective in treating diabetes. However, currently available antidiabetic drugs are too expensive, do not work, and cause major side effects. A significant therapeutic option for Diabetes Mellitus and obesity is using bioactive chemicals produced by plants. This compound is efficacious, easily accessible, safe, and affordable. The main aim of this study was to determine whether pancreatic extract from Moringa oleifera flowers affected blood amylase and lipase levels, as well as the histological appearance, of obese male Wistar white rats (Rattus norvegicus). This is a True experimental study, with the research design used as a test control Group Design. The research data was then analyzed with the help of SPSS using ANOVA and Post Hoc Test with LSD technique. This researcher used 24 male rats. Treatment with Moringa oleifera flower extract improves pancreatic function in obese Wistar white rats by reducing serum lipase and amylase levels. The results of research on serum lipase and amylase levels showed that a dose of 600mg/Kg BW improved pancreatic function in white rats of the Wistar strain that were obese.
The Relationship Between Medication Adherence Based on the Morisky Medication Adherence Scale 8 (MMAS-8) and the Degree of Disease Activity Based on the Disease Activity Score-28 (DAS28) in Rheumatoid Arthritis Patients at Royal Prima Hospital Amanda Anggraini Harahap, Putri; Yani, Herlina; Budi, Andre
International Journal of Health and Pharmaceutical (IJHP) Vol. 5 No. 4 (2025): November 2025 ( Indonesia - Thailand)
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51601/ijhp.v5i4.503

Abstract

Rheumatoid arthritis (RA) poses a major health challenge due to poor medication adherence impacting disease control. This study aimed to analyze the relationship between medication adherence (MMAS-8) and disease activity (DAS28) in RA patients. A quantitative cross-sectional design was employed at RS Royal Prima Medan (May-July 2025), targeting outpatient RA patients with consecutive sampling (n=69). Data were collected using validated MMAS-8 and DAS28-CRP instruments, analyzed via Kolmogorov-Smirnov normality tests and Spearman's correlation. Results showed moderate adherence (47.8%), low disease activity predominant (31.9%), and significant moderate positive correlation (r=0.400, p<0.001). Higher adherence is linked to better disease control. Conclusion: Medication adherence moderately influences RA disease activity; multifaceted interventions are recommended.
Hubungan C-Reactive Protein dengan Disease Activity Score 28 (DAS 28) dan Short Form 36 (Sf 36) pada Pasien Artritis Reumatoid (AR) di Rumah Sakit Royal Prima Frederiko Asido Sirait, Danni; Yani, Herlina; Budi, Andre; Suhartomi, Suhartomi
Jurnal Pendidikan Indonesia Vol. 6 No. 12 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i12.8924

Abstract

Artritis Reumatoid (AR) merupakan penyakit inflamasi kronik yang berdampak pada fungsi fisik, kondisi mental, dan kualitas hidup pasien. Hubungan antara tingkat aktivitas penyakit dan penanda inflamasi seperti C-Reactive Protein  (CRP) dengan kualitas hidup masih menunjukkan hasil yang bervariasi. Oleh karena itu, penelitian ini dilakukan untuk mengetahui hubungan antara C-Reactive Protein  dan DAS 28 terhadap SF 36 pada pasien Artritis Reumatoid (AR) di Rumah Sakit Royal Prima. Penelitian observasional ini menggunakan rancangan cross-sectional pada 60 orang pasien Artritis Reumatoid (AR) di Rumah Sakit Umum Royal Prima yang dipilih melalui teknik pengambilan sampel convenience sampling. Data yang dikumpulkan meliputi karakteristik pasien, skor DAS28, kadar CRP, dan skor kualitas hidup (SF36). Data dianalisis secara deskriptif. Korelasi Spearman digunakan untuk menguji hubungan skor DAS28 dan kadar CRP dengan skor SF-36, sedangkan korelasi Kendall tau digunakan untuk menilai hubungan tingkat progresivitas penyakit dan kelompok kadar CRP dengan kualitas hidup. Hasil penelitian ini menunjukkan bahwa terdapat korelasi lemah antara skor DAS28 dan kualitas hidup (p = 0,008; r = –0,339) serta komponen fisik (p = 0,008; r = –0,342), tetapi tidak dengan komponen mental (p = 0,073). Kadar CRP tidak berkorelasi dengan seluruh aspek kualitas hidup, dan hasil tetap tidak signifikan setelah pengelompokan. Maka, dapat disimpulkan bahwa aktivitas penyakit berhubungan dengan kualitas hidup total dan fisik pada pasien AR, sedangkan kadar CRP tidak menunjukkan hubungan bermakna. Faktor yang memengaruhi kualitas hidup pasien AR lebih terkait dengan tingkat aktivitas penyakit dibandingkan marker inflamasi
Co-Authors Alponso, Rudolf Amanda Anggraini Harahap, Putri Amir, Dwi Fenny Angie, Evelyn Budi, Andre Devy Elizabeth, Monalisa Fitriani, Dini Dwi Fransisca, Silvia Frederiko Asido Sirait, Danni Hanjaya, Hanjaya Jansen Johnson Hutapea Knelissen, Aldy Nicbrian Leslie, William Lubis, Elvi Sahara Masdalena, Masdalena Meilani, Inda Kania Nardi, Leo Nasution, Chairul Radjab Pakpahan, Estriyana Rahimi, Armon Rajagukguk, Horas Rajagukguk, Samuel Joshua Hamonangan Tua Rosari, Anita Sagala, Sefania Samin, Buter Sopacua, Erwin Suhartomi Suwarmo, Suwarmo Wilsen Wilsen, Wilsen Yensuari, Yensuari Zalzabila, Annisa