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All Journal Jurnal Sain Veteriner Jurnal SOLMA Jurnal Analis Kesehatan Jurnal Mitra Kesehatan Pharmaqueous Jurnal Laboratorium Khatulistiwa
Nugroho, Yusuf Eko
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Veterinary Other

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Ekspresi TNF-α Histopatologi Ginjal Pada Tikus Model Sepsis Sebagai Efek Preventif Diberi Nanoemulsi Burdock Yang Diinduksi Bakteri MRSA Faizal, Imam Agus; Nugroho, Yusuf Eko; Fauziah, Rahma Shifa; Yunadi, Frisca Dwi; Swandari, Mika Tri Kumala
Jurnal Sain Veteriner Vol 44, No 1 (2026): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.107607

Abstract

One of the natural ingredients utilized as a traditional medicinal herb is Arctium lappa L. or commonly called burdock. This plant has roots, leaves, seeds that have been used to treat infections and various skin disorders. Burdock is used for anti-inflammatory, anti-cancer, infection-fighting, and anti-tumor regulating activities. The purpose of this research is to determine the effect of Arctium lappa L. root extract on renal histopathology and tumor necrosis factor-alpha (TNF-α) expression in white rat sepsis model after Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria administration. Where in this research stage is divided into 5 groups of test animal treatment. Each group was injected with MRSA bacterial suspension with a standard MC Farland turbidity test of 0.5. The results of this research obtained that burdock root extract is able to inhibit inflammation of sepsis test animals caused by MRSA bacteria with the average value of TNF- α reaction presentation, namely K1 (-) (13.632; 14.756), K2 (+) (33.291; 29,568), K3 (150 mg/kg BW) (35,458; 33,273), K4 (300 mg/kg BW) (36,120; 28,731) K5 (450 mg/kg BW) (28,086; 228,084. So it can be stated that Arctium lappa L root extract is able to inhibit inflammation with the use of the most effective dose of 450 mg/kg BW.
DIFFERENCE IN WHITE BLOOD CELL COUNT IN STUDENTS CONSUMING HIGH-PROTEIN MILK AND THOSE NOT CONSUMING IT AT SMK MA'ARIF NU 2 AJIBARANG Adzani Azhar, Fadlilah; Farabi, Meka Faizal; Nugroho, Yusuf Eko
Jurnal Mitra Kesehatan Vol. 8 No. 02 (2026): Jurnal Mitra Kesehatan
Publisher : STIKes Mitra Keluarga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47522/jmk.v8i02.442

Abstract

Introduction : Leukocytes are an important part of the immune system that plays a role in fighting infection. Adequate protein intake, including from high-protein milk such as goat's milk, is believed to support the formation and function of leukocytes in the body. The protein, vitamin, and mineral content in goat's milk is known to play a role in supporting the immune system. This study aims to determine the difference in white blood cell counts between female students who consume high-protein goat milk and those who do not. Method: This study was conducted over a period of six months, from December to May 2025, at the TLM laboratory of SMK Ma'arif NU 2 Ajibarang. The research was conducted experimentally using a post-test only control group design on 28 female students in class XI TLM SMK Ma'arif NU 2 Ajibarang who were randomly selected using simple random sampling from the entire student population of the school, then divided into two groups, namely the treatment group (consuming high-protein goat milk) and the control group (not consuming). Data were obtained from examining the number of leukocytes using a manual method with an Improved Neubauer counting chamber. Result: The results showed that the average leukocyte count in the treatment group was 7946.43 cells/micoL, whereas in the control group it was 5885.71 cells/microL. The Independent Sample T-Test yielded a p- value rather than 0.001, which shows that there is a significant difference between the two groups. Conclusion: High consumption of protein-rich milk has a significant effect on increasing the number of leukocytes, making it a viable alternative for supporting the immune system of adolescent girls.
Co-Authors Adzani Azhar, Fadlilah Arelliza, Fatma Sheilla Dewi, Dini Puspo Dini Puspodewi Fauziah, Rahma Shifa Imam Agus Faizal Ira Pangesti Meka Faizal Farabi Mika Tri Kumala Swandari, Mika Tri Kumala Nugrahaeni, Dian Rahma Nurwahidah, Andi Tenri Priyanto, Anggih Putri, Reza Amelia Rusana Utami, Tri Fitri Yana Wijayanti, Faulia Triana yunadi, frisca dewi Yunadi, Frisca Dwi