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All Journal Jurnal Mandala Pharmacon Indonesia Jurnal Inovasi Farmasi Indonesia Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Pena Medika : Jurnal Kesehatan JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Journal for Quality in Public Health Jurnal Pharma Bhakta
Admaja, Wika
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary Other

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Analysis Potential Drug’s Interaction In Prescription Compouded At Arbai Pharmacy From January To March 2024 Sri Hartini, Indah; Shoviantari, Fenita; Admaja, Wika; Tuna, Hartati; Bhakti Marhenta, Yogi
Pena Medika : Jurnal Kesehatan Vol. 15 No. 2 (2025): PENA MEDIKA: JURNAL KESEHATAN
Publisher : Universitas Pekalongan

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Abstract

Prescriptions compounded are prescriptions that have the potential for drug’s interactions. Drug-drug interactions can occur pharmaceutically, pharmacokinetically, and pharmacodynamically. These interactions can cause a decrease in effectiveness, an increase in drug toxicity, resulting in the failure to achieve the expected therapeutic goals. The potential for drug-drug interactions can occur in both compounded and non-compounded prescriptions. Compounded prescriptions are often given to children to adjust the dosage as needed. This study aims to determine the potential for drug-drug interactions in compounded prescriptions at the Arbai Bandar Lor Pharmacy. This study is descriptive and non-experimental. Data collection was conducted retrospectively on compounded prescriptions from January to March 2024 that met the inclusion and exclusion criteria. Determining drug-drug interactions using the Drug Interaction Checker 2024 application Results and conclusions: Pharmaceutically, there were 2 unstable prescriptions (1.90%) and 103 compatible prescriptions (98.10%). The results of the analysis of potential drug-drug interactions were found in 21 prescriptions (20%). The mechanism of interaction was pharmacokinetic in 7 (46.67%) combinations and pharmacodynamic in 8 (53.33%) combinations, with a minor severity level in 4 (26.67%) cases and a moderate severity level in 11 (74.33%) cases, based on the Medscape Drug Interaction Checker reference.
Co-Authors Amelia, Faresa Bhakti Marhenta, Yogi Esti Ambar Widyaningrum Farida, Umul Fenita Shoviantari, Fenita Hartati Tuna, Hartati Hidayatunnisa, Shafira Indah Sri Hartini Khusnul Khulukia, Widya Kusumaratni, Dyah Ayu Marhenta, Yogi Bhakti Nunki Rosa Fitria Prasetyo, Eko Yudha Restyana, Anggi Salsabila, Amaliyah Seran, Krisogonus Ephrino Sri Hartini, Indah Ubanayo, Kristian Wahyuni, Kumala Sari Poespita Dewi Walujo, Djembor Sugeng Wibisono, Adi