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All Journal Buletin Farmatera Sumatera Medical Journal Indonesian Journal of Global Health research Cermin Dunia Kedokteran The Journal of Society Medicine (JSOCMED) Media Dermato-Venereologica Indonesiana Journal of General-Procedural Dermatology & Venereology Indonesia
Jusuf, Nelva Karmila
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Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of General-Procedural Dermatology

 1 
Pattern of pigmentation disorder in Cosmetic Dermatology Clinic H. Adam Malik General Hospital, Medan, 2012 - 2015 Jusuf, Nelva Karmila
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 2, No. 1
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Background: Abnormalities of pigmentation is a cosmetic problem which affects the overall appearance of an individual. Pigmentation disorder are caused by the increase (hypermelanosis) or the decrease (hypomelanosis) amount of melanin. Objective: To determine the pattern of pigmentation disorder in Cosmetic Dermatology Clinic H. Adam Malik General Hospital Medan in 2012-2015. Methods: A retrospective study using subject's medical records from the Cosmetic Dermatology Clinic H. Adam Malik General Hospital Medan in 2012 - 2015, presented descriptively. Results: In 2012 - 2015 the number of patients who visited the Cosmetic Dermatology Clinic were respectively 210, 228, 211, 142. Hypermelanosis were found respectively in 24.76%, 16.20%, 12.79%, 5.63%. Whereas hypomelanosis were found 18.10%, 9.21%, 8.53%, 8.45%. During 2012 - 2015 melasma was the most common disorder found among hypermelanosis group, followed by post inflammatory hyperpigmentation. Meanwhile vitiligo was the only diagnosis in hypomelanosis group. Each year most of the pigmentation disorder patients came from the age group 38-48 years old except in 2015. Women were more affected than men. Conclusion: In 2012-2014, the largest proportion of pigmentation disorder were hypermelanosis, mostly melasma. In 2015, it was hypomelanosis with vitiligo as the diagnosis.
Intense pulsed light (IPL) as adjuvant therapy for acne vulgaris: A case series Oentari, Widyaningsih; Sutrisno, Angie Regina; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicle with polymorphic clinical manifestation typically found on facial, neck and/or back area. The pathogenesis is complex and multifactorial. Management of acne vulgaris is determined based on its severity. Adjuvant therapies, such as intense pulsed light (IPL), have been described in accelerating the healing process during treatment. Case Illustration: We report two cases regarding the usage of IPL as adjuvant therapy in acne vulgaris. Both patients were diagnosed with moderate acne vulgaris. The first patient was given topical adapalene 0.1% gel every night and sunscreen in the morning, and the other patient was given clindamycin gel applied twice a day, benzoyl peroxide 2.5% cream applied once a day at night, and sunscreen in the morning. Both patients were treated using IPL as their adjuvant therapy every three weeks, with a total of 2 IPL sessions in 2 months. Evaluation using clinical and ultraviolet-induced red fluorescence (UVRF) examination showed gradual improvement. Discussion: IPL as an adjuvant therapy of acne vulgaris has been thought to interfere with the function of the sebaceous glands by its direct phototoxic effects and thermal damage. It also has bactericidal effects on C. acnes through the formation of free radicals. The combination of topical treatment and IPL yielded clinical improvements in both patients.Conclusion: IPL may be beneficial as adjuvant therapy in acne vulgaris in this case series.
Plasma malondialdehyde levels related to acne vulgaris severity Puspita, Fitri; Jusuf, Nelva Karmila; Yosi, Ariyati
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 5, No. 3
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Background: Acne vulgaris (AV) is a multifactorial disorder characterized by the formation of open and closed comedones, papules, pustules, nodules, and cysts. Oxidative stress plays a role in the pathogenesis of AV. Reactive Oxygen Species (ROS), especially lipid peroxides (LPO), plays a role in mediating acne inflammation. Malondialdehyde (MDA) is one of the byproducts of LPO commonly used as a biomarker of cell damage.Methods: This cross-sectional analytic study consisted of sixty patients with AV. The samples were taken from the blood plasma of AV subjects. An enzyme-linked immunosorbent assay (ELISA) examination was performed. The normality of data distribution was determined using the Kolmogorov-Smirnov test and the differences of plasma MDA levels based on the severity of AV were determined using the Kruskal-Wallis test. P valueResults: Acne vulgaris was predominantly found in women (70%), age group of 18 – 25 years old (73,33%), and patients with family history of AV (61,67%). Higher plasma MDA levels were found in women [5,5 (2,53 – 77,6) nmol/mL], age group of 26 – 35 years [5,66 (2,73 – 25) nmol/mL], and subjects with family history of AV [5,49 (2,53 – 77,6) nmol/mL]. Based on the severity of AV, the severe AV group had highest plasma MDA [13,85 (2,69 – 77,6) nmol/mL], followed by moderate AV group [4,46 (2,53-14,3) nmol/mL] and mild AV [3,78 (2,47-6,88) nmol/mL]. There were differences in plasma MDA level based on the severity of AV (p<0,001).Conclusion: There were differences in plasma MDA levels based on the severity of AV.
Bacterial sensitivity pattern to antibiotics in acne vulgaris at Universitas Sumatera Utara Hospital Medan, Indonesia in 2019 Sari, Lovena; Jusuf, Nelva Karmila; Putra, Imam Budi
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: The association between psoriasis and metabolic syndrome is appealing as the two may share a similar cross-linking systemic inflammation process. The inflammation processes occurring in obesity and psoriasis may aggravate one another. This raised the question of whether a low-calorie diet would possibly reverse the aforementioned process. This study aims to determine whether calorie restriction reduces psoriasis area and severity index (PASI) in obese patients with moderate-to-severe psoriasis receiving conventional treatment compared to no calorie restriction.Methods: We searched Pubmed/Pubmed Central, ScienceDirect, Cochrane library, EBSCOhost, and Scopus databases using keywords derived from our clinical question. The inclusion criteria were randomized clinical trial (RCT) or systematic review, published in English, and available in full-text.Results: We obtained 2 systematic reviews with meta-analyses by Ko et al. and Upala et al. Ko et al. included 6 RCTs which found that the inclusion of a low-calorie diet shows significant improvement in PASI 75 compared to standard therapy (RR 1.66; 95%CI 1.07, 2.58). Upala et al. also found significant improvement in PASI 75 in a meta-analysis of 7 RCTs (Pooled OR 2.92; 95%CI 1.39, 6.13), but shows moderately high heterogeneity between studies. Other secondary outcomes have also shown significant improvements, such as quality of life and metabolic parameters.Conclusion: The intervention of a low-calorie diet may significantly reduce PASI, improve quality of life and reduce comorbidities in obese patients with moderate-to-severe psoriasis, and thus can be recommended in psoriasis management.
Microneedling and platelet-rich plasma (PRP) treatment for mixed melasma Wulandari, Puteri; Jusuf, Nelva Karmila; Nasution, Khairina
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 1
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Background: Melasma, or chloasma, is an acquired pigmentary disorder caused by increased melanin in the epidermal and dermal layers, characterized by brown or gray patches on the face and neck. There are many treatment options available; however, the difficulties in treating melasma are frequent recalcitrants, high recurrence rate, irregularity in treatment, and the tendency of the patients to self-medicate.Case Ilustration: We report a case of mixed melasma treated by microneedling and topical PRP administration. Thirteen weeks following the therapy, the patient showed a favorable response brighter skin and substantial disappearance of brown patches.Discussion: Studies assessing the efficacy of microneedling and platelet-rich plasma (PRP) treatment for melasma are still lacking. However, melasma improvement has been reported in patients treated with microneedling and PRP. In this study, we provided a study of a patient with mixed melasma treated by microneedling and PRP, which showed a favorable improvement.Conclusion: Microneedling and PRP treatment showed a favorable response in a patient with melasma, with substantial disappearance of brown patches and a decrease in MASI (Melasma Area and Severity Index) score.
Co-Authors Al Hafiz, OK Muhammad Amalia, Rina Annisa Astari Danil, Rezkyana Deliana, Rizka Dhillon, Jesryn Eka Zhaki Safira Lubis Fitri Puspita Kartayana, Johan Khairina, Fadilah Oliv Lubis, Ade Fitriyani Lubis, Nabila Adani Meutia, Nanda Nasution, Khairina Oentari, Widyaningsih Putra, Imam Budi Rina Amelia Risanti, Rinda Chindra Rosyada, Rahma Sari, Lovena Siahaan, Ade Gustina Sutrisno, Angie Regina Tamba, Asnita Bella Putri Tasmil, Adina Miltania utami, dina rizki Wiryadana, Michelle Wulandari, Puteri Yosi, Ariyati