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All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Global Medical and Health Communication MNJ (Malang Neurology Journal) Jurnal Keperawatan Padjadjaran Smart Medical Journal Indonesian Journal of Medicine Callosum Neurology Journal : Jurnal Berkala Neurologi Bali Majalah Kedokteran Neurosains Abdimas Universal SEMAR Smart Society Empowerment Journal Neurona Biomedika
Stefanus Erdana Putra
Universitas Sebelas Maret
Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Journal : Neurona

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HUBUNGAN PENINGKATAN KADAR C-REACTIVE PROTEIN DENGAN PENURUNAN FUNGSI KOGNITIF PASIEN GERIATRI RAWAT JALAN Stefanus Erdana Putra; Muhammad Hafizhan; Raden Ajeng Hanindia Riani Prabaningtyas
NEURONA Vol 37 No 1 (2019)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i1.100

Abstract

THE RELATIONSHIP BETWEEN ELEVATED C-REACTIVE PROTEIN AND COGNITIVE FUNCTION DETERIORATION OF GERIATRIC OUTPATIENTSABSTRACTIntroduction: Geriatric patients have different characteristics compared to other patients in general, in which they potentially experiencing cognitive impairment, decreasing of physiological and functional status, also the immunological system. This situation causes various inflammatory reactions that play a role in the development of neurodegenerative diseases, including the increase production of acute phase protein called C-reactive protein (CRP).Aims: To determine the association  between the CRP serum concentration  elevation and the deterioration  of geriatric outpatients’s cognitive function at Neurology Clinic Sebelas Maret University Hospital.Methods: A cross-sectional study of geriatric patients at the Neurology Clinic of Sebelas Maret University Hospital, Surakarta.   The cognitive state was evaluated using Mini-Mental State Examination (MMSE) and those with MMSE score<24 were considered cognitively declined. Concentrations of serum CRP were measured. Multiple logistic regression analysis was used to calculate Odds ratios (ORs) for cognitive decline, adjusted for the covariates of age, sex, body mass index, and disease history.Results: There were 73 participants with mean age was 65.6 years old. There were 56,2% who were experiencing a cognitive decline. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1,44 for the second, 1,97 for the third, and 2,33 for the highest quartiles (p=0,035). The association between CRP levels and decreased cognitive function was found to be significant after adjusting for covariates. When data were stratified by sex, the association between CRP concentration and cognitive decline was observed in women.Discussions: This research  suggested an association  between higher CRP concentration  and lower cognitive function. Chronic inflammation might affect cognitive function in geriatric, particularly in women.Keywords: C-reactive protein, cognitive function, geriatric outpatientsABSTRAKPendahuluan: Pasien geriatri memiliki karakteristik yang berbeda dengan pasien pada umumnya, yaitu selain berpotensi mengalami gangguan fungsi kognitif juga menurunnya daya cadangan fisiologis serta status fungsional dan sistem imunologi. Keadaan ini menimbulkan berbagai reaksi inflamasi yang berperan dalam perkembangan penyakit neurodegeneratif, antara lain peningkatan produksi protein fase akut bernama C-reactive protein (CRP) oleh hepar.Tujuan: Mengetahui hubungan antara peningkatan kadar CRP dengan penurunan fungsi kognitif pasien geriatri rawat jalan di Poliklinik Saraf RS Universitas Sebelas Maret.Metode: Penelitian potong lintang terhadap pasien geriatri di Poli Saraf RS Universitas Sebelas Maret, Surakarta. Evaluasi fungsi kognitif menggunakan Mini-Mental State Examination (MMSE); dengan skor <24 dikategorikan mengalami penurunan fungsi kognitif. Kadar serum CRP masing-masing subjek juga diukur. Analisis regresi logistik berganda digunakan dalam menghitung rasio Odds (RO) untuk penurunan fungsi kognitif, dengan pengaturan kovariat usia, jenis kelamin, indeks massa tubuh, dan riwayat penyakit sebelumnya.Hasil: Didapatkan 73 subjek dengan rerata usia 65,6 tahun. Sebanyak 56,2% subjek mengalami penurunan fungsi kognitif. Dengan perbandingan relatif terhadap kuartil konsentrasi CRP terendah (pertama), RO yang telah diatur adalah 1,44 untuk kuartil kedua; 1,97 untuk kuartil ketiga; serta 2,33 untuk kuartil keempat (p=0,035). Hubungan kadar CRP dan penurunan fungsi kognitif ditemukan signifikan setelah disesuaikan dengan kovariat. Setelah dilakukan sub-analisis berdasarkan jenis kelamin, peningkatan kadar CRP terhadap penurunan kognitif secara signifikan terjadi pada subjek perempuan.Diskusi: Penelitian ini menunjukkan adanya hubungan antara peningkatan kadar CRP dengan penurunan fungsi kognitif. Inflamasi kronis memengaruhi fungsi kognitif geriatri khususnya perempuan.Kata kunci: C-reactive protein, fungsi kognitif pasien rawat jalan, geriatri
BANGKITAN SIMTOMATIK AKUT: INSIDENSI, ETIOLOGI, DAN MORTALITAS PASIEN RSUD GUNUNGSITOLI TAHUN 2015–2019 Stefanus Erdana Putra; Berkat Hia; Muhammad Hafizhan; Fauzi Novia; Isnaening Tyas; Astrida Fesky Febrianty
NEURONA Vol 38 No 2 (2021)
Publisher : PERDOSNI

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Abstract

Introduction: Acute symptomatic seizures are seizures that occur due to acute disorders of the central nervoussystem due to structural, infectious, inflammatory, and metabolic disorders. Acute symptomatic seizures and unprovokedseizures must be distinguished because they have different prognoses. Aim: To determine the incidence, etiology, and prognosis of acute symptomatic seizure patients treated inGunungsitoli Regional General Hospital during 2015-2019. Methods: This was a cross-sectional study in patients with acute symptomatic seizure in Gunungsitoli RegionalGeneral Hospital Nias District during 2015-2019. Data were obtained from the medical record in Gunungsitoli RegionalGeneral Hospital. Multiple logistic regression analysis was used to calculate odds ratios (ORs) of age for mortality. Results: There were 88 acute symptomatic seizure patients with a proportional comparison between males andfemales (1.1:1). The most prevalent encountered etiology of acute symptomatic seizure patients was metabolic disorders(51.14%) consisting of 25% uremia; 5.68% hyponatremia; 4.54% hyperglycemia; 6.83% hepatic; and 9.09% hypoglycemiawith a case fatality rate of 29.55%. Discussion: Characteristics of acute symptomatic seizures patients treated in Gunungsitoli Regional GeneralHospital were not affected by gender, with the most often encountered etiology was metabolic disorders. Keyword: Acute symptomatic seizure
Co-Authors Astrida Fesky Febrianty Astrida Fesky Febrianty Astrida Fesky Febrianty Atik Maftuhah B, Benedictus Baarid Luqman Hamidi Benedictus Benedictus Berkat Hia Berkat Hia Budianto, Pepi Cynthia Hanny Lestari Damayanti, Elok Dewi Hayu Kirana Diah Kurnia Mirawati Diah Kurnia Mirawati Diah Kurnia Mirawati Diah Kurnia Mirawati Diah Kurnia Mirawati Dian Nugroho Ervina Arta Jayanti Hutabarat Eti Poncorini Pamungkasari Faizal Muhammad Fauzi Novia Fauzi Novia Isnaening Tyas Fauzi Novia Isnaening Tyas Fauzi Novia Isnaening Tyas Hafizhan, Muhammad Hambarsari, Yetty Hamidi, Baarid Luqman Hamka, Muhammad Farid Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindia Riani Prabaningtyas Hanindya Riani Prabaningtyas Hapsari, Maria Yosita Ayu Hillary Hillary Hutabarat, Ervina Arta Jayanti Ilhamsyah, Rudi Isnaening Tyas Kenneth Tan Lawly Arrel Dionnie Greatalya Lestari Handayani Maria Sekar Cahyaningrum Muhammad Hafidzan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Muhammad Hafizhan Novian Anindito Santosa Novian Anindito Santosa Pepi Budianto Prabaningtyas, Hanindia Riani Prabaningtyas, Hanindya Riani Raden Ajeng Hanindia Riani Prabaningtyas Raden Ajeng Hanindia Riani Prabaningtyas Raden Andi Ario Tedjo Rahman, Awalil Rifqi Kurnia Rakhma, Titian Ristinawati, Ira Rivan Danuaji Rivan Danuaji Rivan Danuaji Siti Munawaroh Subandi Subandi Subandi Subandi Subandi Subandi Subandi Subandi Suroto Suroto Suroto Suroto Susilo, Wahyu Agung Tan, Kenneth Teddy Tejomukti Tedjo, Raden Andi Ario Tejomukti, Teddy Tristan, Christopher Daniel Veronika Ika Budiastuti Vivienne Tjung Vivienne Tjung Wahyu Agung Susilo Wahyu Gusti Randa Widhianingsih, Nella Lusti Wilson Arpin Yeremia Suryo Pratama Yetty Hambarsari