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ANALISIS KADAR SERUM GLUTAMIC PIRUVIC TRANSAMINASE DAN SERUM GLUTAMIC OXALOACETIC TRANSAMINASE PADA PASIEN TUBERKULOSIS YANG MENJALANI PENGOBATAN OBAT ANTI TUBERKULOSIS Salbiah, Salbiah; Diah Lestari; Dina Indarsita; Halimah Fitriani Pane; Yasmine Amira Fadila
Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Vol. 19 No. 1 (2024): Vol. 19 No. 1 (2024): Jurnal Ilmiah PANNMED Periode Januari - April 2024
Publisher : Poltekkes Kemenkes Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36911/pannmed.v19i1.2120

Abstract

Introduction: Since 1995, Indonesia began to adopt the Directly Observed Treatment Shortcourse Chemotherapy (DOTS) system in controlling tuberculosis. The main drugs recommended in this system are Antituberculosis Drugs (OAT) consisting of Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), and Ethambutol (E). The use of Anti-Tuberculosis Drugs can cause side effects which are still other problems, such as liver damage which is characterized by an increase in transaminase enzymes. Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT). Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT). Objective: the aim of this study is to determine whether there is a difference between SGOT and SGPT levels before and after treatment with Antituberculosis Drugs . Method: The research design was cross-sectional analytic using secondary data from examination results of SGOT and SGPT levels from adult tuberculosis sufferers who were undergoing treatment at Cileungsi Regional Hospital, totaling 70 people. The research was conducted from January to August 2023. Results: There was an increase in SGOT levels by 104%, namely from 21.61 IU/L before treatment to 43.47 IU/L and SGPT levels increased by 107%, namely from 16.41 IU/L before treatment to 34.47 IU /L.. The Wilcoxon test showed a significant difference of 0.000 (p <0.05) for SGOT and SGPT levels before and after treatment.. Conclusion: there is a significant difference between SGOT and SGPT levels before and after treatment with antituberculosis drugs.
Secondary Data Analysis: Comparison of ESBL- and Carbapenemase-Producing Bacterial Resistance from Pneumonia Patient Sputum Samples Husjain Djajaningrat; Atiek Kusumah; Angki Purwanti; Diah Lestari; Tri Prasetyorini
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 1 (2025): Desember
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i1.341

Abstract

Antibiotic resistance mediated by Extended-Spectrum Beta-Lactamase (ESBL) and Carbapenemase-producing bacteria represents a serious challenge in the management of pneumonia. This study aimed to compare the resistance patterns of ESBL- and Carbapenemase-producing bacteria isolated from sputum samples of pneumonia patients in specialized and non-specialized care units at Bekasi Hospital. A comparative descriptive study with a cross-sectional approach was conducted using secondary data from sputum culture and antibiotic susceptibility testing collected between 2015 and 2024. A total of 116 bacterial isolates were included through total sampling, consisting of 58 isolates from specialized units and 58 from non-specialized units. Data were analyzed using univariate analysis and bivariate analysis with the Chi-square test. The results showed that ESBL-producing Klebsiella pneumoniae was the most predominant isolate (39.7%) and was evenly distributed between both care settings. The highest resistance was observed against beta-lactam and cephalosporin antibiotics, while Meropenem and Amikacin remained highly effective against ESBL-producing bacteria. No significant difference was found in the distribution of ESBL and Carbapenemase-producing bacteria between specialized and non-specialized units (p = 0.707). In conclusion, the widespread presence of resistant bacteria across all care units highlights the need to strengthen resistance surveillance, implement comprehensive antibiotic stewardship programs, and enforce strict infection prevention and control measures throughout hospital settings.
The Application of Menstrual Hygiene Management towards the Elementary Students Hygiene Personal Attitude during Menstruation Sitohang, Nur Asnah; Diah Lestari; Cut Adeya Adella; Nu Asiah
Caring: Indonesian Journal of Nursing Science Vol. 7 No. 2 (2025): Vol 7 No 2 2025 Caring: Indonesia Journal of Nursing
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijns.v7i2.21794

Abstract

The main problem among adolescents related to menstruation is the lack of knowledge about Menstrual Health Management (MHM) and poor water sanitation. This study aims to determine the effectiveness of MHM on the knowledge and personal hygiene behavior of elementary school students in Medan. The research employed a quasi-experimental design with a one-group pretest-posttest approach. The population is all elementary school students in grades 4 and 5. The sample included 67 female and 43 male students, totaling to 110 participants. Data were collected using a questionnaire administered before the intervention (pretest), followed by a health education program consisting of lectures, discussions, and role plays, supported by LCD/PowerPoint presentasions, leaflets, and videos, and then after the intervention (posttest).The sampling technique used was total sampling. Dependent t-test analysis was utilized to assess the data. The results showed a significant difference in respondents’ knowledge before and after the intervention. For attitudes, the mean difference was 3.440 with a p-value of 0.000, indicating a significant effect of the intervention on respondents’ attitudes. Specifically, for male students, the mean difference in knowledge was 7.721 (p = 0.000), and the mean difference in attitudes was 1.628 (p = 0.000), confirming a significant improvement in both knowledge and attitudes after the intervention. Therefore, it is recommended that health workers implement MHM education programs to improve adolescent reproductive health status. Keyword: Menstrual hygiene knowledge, Attitude, Elementary student management