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All Journal Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Meditory : The Journal of Medical Laboratory AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Anakes: Jurnal Ilmiah Analis Kesehatan Caring : Indonesian Journal of Nursing Science Jurnal Ilmu Sosial, Pendidikan Dan Humaniora Global Jurnal Fisioterapi dan Kesehatan Indonesia Jurnal Yudistira Jurnal Ilmiah Research Student Jurnal Kesehatan Cendikia Jenius International Journal of Mathematics and Science Education
Diah Lestari
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Sensitivitas Antara Antibiotik Meropenem dan Seftazidin Terhadap Pseudomonas aeruginosa Strain ATCC 15442 Pada Pasien Pneumonia di RSUP dr. Cipto Mangunkusumo Jakarta Pusat Diah Lestari; Husyain Djajaningrat; Febri Wulan Dari; Dean Handimulya
Anakes : Jurnal Ilmiah Analis Kesehatan Vol. 11 No. 1 (2025): ANAKES: Jurnal Ilmiah Analis Kesehatan
Publisher : Universitas Mohammad Husni Thamrin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37012/anakes.v11i1.2500

Abstract

Pneumonia is an acute lower respiratory tract infection in the lung parenchyma that has a high level of treatment resistance and is a nosocomial bacterial transmission. One of the nosocomial bacteria in hospitals is Pseudomonas aeruginosa, which is a Multi Drug Resistant (MDR) bacteria, a pathogen that causes infections that are resistant to at least three antimicrobial agents. The antimicrobials included are meropenem and ceftazidime, these two antibiotics are the best choice of last-line drugs in the treatment of MDR bacteria. Effective prevention and treatment of bacterial colonization and infection in pneumonia patients needs to be done to reduce the negative impact of antibiotic use. The aim of this study was to determine the sensitivity between the antibiotics meropenem and ceftazidime against Pseudomonas aeruginosa bacteria in pneumonia patients at RSUPN dr. Cipto Mangunkusumo, Central Jakarta. The research method was analytical observational using a cross sectional design with medical record data sources on 105 pneumonia patients who underwent sputum culture examination. Data analysis using the Mann-Whitney Test at 95% CI (α = 0.05). The research results showed that the majority of patients were male, 69 people with an elderly age category of 51 people (48.6%). The results of the antibiotic sensitivity of meropenem were 76.25% and ceftazidime were 69.5%, with a p-value of 0.000. The average sensitivity of the antibiotic meropenem is 20.59, more sensitive than the antibiotic ceftazidime, an average of 20.50 with a difference in sensitivity of 9%. The conclusion is that there is a difference in the sensitivity of the antibiotics meropenem and ceftazidime against Pseudomonas aeruginosa bacteria in pneumonia patients at RSUPN Dr. Cipto Mangunkusumo, Central Jakarta, the antibiotic meropenem is more sensitive than the antibiotic ceftazidime.  Keywords: Meropenem, Pneumonia, Pseudomonas aeruginosa,  Seftazidim.
ANALISIS KADAR SERUM GLUTAMIC PIRUVIC TRANSAMINASE DAN SERUM GLUTAMIC OXALOACETIC TRANSAMINASE PADA PASIEN TUBERKULOSIS YANG MENJALANI PENGOBATAN OBAT ANTI TUBERKULOSIS Salbiah, Salbiah; Diah Lestari; Dina Indarsita; Halimah Fitriani Pane; Yasmine Amira Fadila
Jurnal Ilmiah PANNMED (Pharmacist, Analyst, Nurse, Nutrition, Midwivery, Environment, Dentist) Vol. 19 No. 1 (2024): Vol. 19 No. 1 (2024): Jurnal Ilmiah PANNMED Periode Januari - April 2024
Publisher : Poltekkes Kemenkes Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36911/pannmed.v19i1.2120

Abstract

Introduction: Since 1995, Indonesia began to adopt the Directly Observed Treatment Shortcourse Chemotherapy (DOTS) system in controlling tuberculosis. The main drugs recommended in this system are Antituberculosis Drugs (OAT) consisting of Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), and Ethambutol (E). The use of Anti-Tuberculosis Drugs can cause side effects which are still other problems, such as liver damage which is characterized by an increase in transaminase enzymes. Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT). Therefore, monitoring liver function is very important. The routine examination carried out is a serum transaminase examination, namely SGOT (AST) and SGPT (ALT). Objective: the aim of this study is to determine whether there is a difference between SGOT and SGPT levels before and after treatment with Antituberculosis Drugs . Method: The research design was cross-sectional analytic using secondary data from examination results of SGOT and SGPT levels from adult tuberculosis sufferers who were undergoing treatment at Cileungsi Regional Hospital, totaling 70 people. The research was conducted from January to August 2023. Results: There was an increase in SGOT levels by 104%, namely from 21.61 IU/L before treatment to 43.47 IU/L and SGPT levels increased by 107%, namely from 16.41 IU/L before treatment to 34.47 IU /L.. The Wilcoxon test showed a significant difference of 0.000 (p <0.05) for SGOT and SGPT levels before and after treatment.. Conclusion: there is a significant difference between SGOT and SGPT levels before and after treatment with antituberculosis drugs.
Secondary Data Analysis: Comparison of ESBL- and Carbapenemase-Producing Bacterial Resistance from Pneumonia Patient Sputum Samples Husjain Djajaningrat; Atiek Kusumah; Angki Purwanti; Diah Lestari; Tri Prasetyorini
Jurnal Kesehatan Cendikia Jenius Vol. 3 No. 1 (2025): Desember
Publisher : CV. CENDIKIA JENIUS INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70920/jenius.v3i1.341

Abstract

Antibiotic resistance mediated by Extended-Spectrum Beta-Lactamase (ESBL) and Carbapenemase-producing bacteria represents a serious challenge in the management of pneumonia. This study aimed to compare the resistance patterns of ESBL- and Carbapenemase-producing bacteria isolated from sputum samples of pneumonia patients in specialized and non-specialized care units at Bekasi Hospital. A comparative descriptive study with a cross-sectional approach was conducted using secondary data from sputum culture and antibiotic susceptibility testing collected between 2015 and 2024. A total of 116 bacterial isolates were included through total sampling, consisting of 58 isolates from specialized units and 58 from non-specialized units. Data were analyzed using univariate analysis and bivariate analysis with the Chi-square test. The results showed that ESBL-producing Klebsiella pneumoniae was the most predominant isolate (39.7%) and was evenly distributed between both care settings. The highest resistance was observed against beta-lactam and cephalosporin antibiotics, while Meropenem and Amikacin remained highly effective against ESBL-producing bacteria. No significant difference was found in the distribution of ESBL and Carbapenemase-producing bacteria between specialized and non-specialized units (p = 0.707). In conclusion, the widespread presence of resistant bacteria across all care units highlights the need to strengthen resistance surveillance, implement comprehensive antibiotic stewardship programs, and enforce strict infection prevention and control measures throughout hospital settings.
PENYULUHAN PENURUNAN KESADAHAN AIR SUMUR DENGAN TEKNIK PEMANASAN DAN PENDIAMAN PADA WARGA DESA LIGARMUKTI KABOPATEN BOGOR, JAWA BARAT Rizana Fajrunni’mah; Angki Purwanti; Diah Lestari; Bagya Mujianto; Tri Prasetyorini
Amaliah: Jurnal Pengabdian Kepada Masyarakat Vol 9 No 2 (2025): Amaliah Jurnal: Pengabdian kepada Masyarakat
Publisher : LPPI UMN AL WASHLIYAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32696/ajpkm.v9i2.6327

Abstract

Desa Ligarmukti Kabupaten Bogor Jawa Barat terletak di perbukitan kapur, dari penelitian diketahui air sumur di wilayah ini bersifat “air sadah” dan “air sangat sadah” dengan kesadahan termasuk kesadahan sementara. Warga desa Ligarmukti masih memanfaatkan air dengan kesadahan tinggi tersebut untuk minum dan memasak. Konsumsi air sadah secara rutin dan berkrepanjangan dapat menyebabkan gangguan kesehatan. Tujuan pengabdian ini untuk meningkatkan pengetahuan warga agar dapat menurunkan kesadahn air sampai ke tingkat “air agak sadah” yang layak untuk konsumsi. Metode pengabdian berupa penyuluhan dengan bantuan leaflet. Peserta pengabdian sebanyak 64 orang dari tiga RT. Keberhasilan pengabdian di evaluasi menggunakan pre dan post-test. Rerata pre-test berbeda signifikan dengan rerata post-test nilai p 0,000<α (0,05). Setelah penyuluhan terjadi kenaikan tingkat pengetahuan sebesar 89,42%. Untuk pengabdian selanjutnya disarankan penyuluhan tentang teknik penurunan kesadahan air untuk volume yang lebih besar dengan biaya terjangkau.
The Application of Menstrual Hygiene Management towards the Elementary Students Hygiene Personal Attitude during Menstruation Sitohang, Nur Asnah; Diah Lestari; Cut Adeya Adella; Nu Asiah
Caring: Indonesian Journal of Nursing Science Vol. 7 No. 2 (2025): Vol 7 No 2 2025 Caring: Indonesia Journal of Nursing
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijns.v7i2.21794

Abstract

The main problem among adolescents related to menstruation is the lack of knowledge about Menstrual Health Management (MHM) and poor water sanitation. This study aims to determine the effectiveness of MHM on the knowledge and personal hygiene behavior of elementary school students in Medan. The research employed a quasi-experimental design with a one-group pretest-posttest approach. The population is all elementary school students in grades 4 and 5. The sample included 67 female and 43 male students, totaling to 110 participants. Data were collected using a questionnaire administered before the intervention (pretest), followed by a health education program consisting of lectures, discussions, and role plays, supported by LCD/PowerPoint presentasions, leaflets, and videos, and then after the intervention (posttest).The sampling technique used was total sampling. Dependent t-test analysis was utilized to assess the data. The results showed a significant difference in respondents’ knowledge before and after the intervention. For attitudes, the mean difference was 3.440 with a p-value of 0.000, indicating a significant effect of the intervention on respondents’ attitudes. Specifically, for male students, the mean difference in knowledge was 7.721 (p = 0.000), and the mean difference in attitudes was 1.628 (p = 0.000), confirming a significant improvement in both knowledge and attitudes after the intervention. Therefore, it is recommended that health workers implement MHM education programs to improve adolescent reproductive health status. Keyword: Menstrual hygiene knowledge, Attitude, Elementary student management
Co-Authors Ahmad Sapani Aisyah Aisyah Angki Purwanti Angki Purwanti Atiek Kusumah Bagya Mujianto Ciek Julyati Hisyam CUT ADEYA ADELLA, CUT ADEYA Dean Handimulya Defano Tanur Dina Indarsita Fatwa Imelda Febri Wulan Dari Febrina Oktavinola Kaban Husjain Djajaningrat Husyain Djajaningrat Kana Hidayati Khoirun Nisah Marsya Nisa Razita Mayang Puti Seruni Muhlisah Lubis Nadia Dwi Nur Aufa Najwa Ahsanah Nu Asiah Nur Asnah Sitohang, Nur Asnah Nur Sakiyah Pane, Halimah Fitriani PUJI LESTARI Redi Hendika Reza Fansyuri Rangkuti Riadoh Riadoh Rizana Fajrunni’mah Salbiah Salbiah Salbiah Salbiah, Salbiah Salmiah Indriyani Sangkot Anisa Timbo Faritcan Parlaungan Siallagan Tri Prasetyorini Yasmine Amira Fadila