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All Journal Jurnal Kesehatan Masyarakat Indonesia The Indonesian Biomedical Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Majalah Biomorfologi (Biomorphology Journal) MAHESA : Malahayati Health Student Journal Holistik Jurnal Kesehatan
Bintoro, Siprianus Ugroseno Yudho
Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Surabaya 60132
Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Increased hs-CRP and Sepsis Influence the Occurrence of Thrombocytopenia in Severe and Critically Ill COVID-19 Patients Receiving Anticoagulants Ami Ashariati Prayoga; Siprianus Ugroseno Yudho Bintoro; Pradana Zaky Romadhon; Muhammad Noor Diansyah; Putu Niken Ayu Amrita; Merlyna Savitri; Choirina Windradi; Krisnina Nurul Widiyastuti
The Indonesian Biomedical Journal Vol 15, No 1 (2023)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v15i1.2045

Abstract

BACKGROUND: Despites its benefits, as one of COVID-19 principal treatments, anticoagulant raises a significant concern regarding the anticoagulant-related thrombocytopenia. However, up to date, there is lack of study examining anticoagulantinduced thrombocytopenia during COVID-19, hence this study was conducted to determine the factors inducing anticoagulant-induced thrombocytopenia in COVID-19 patients.METHODS: An observational cross-sectional study of 106 anticoagulant-treated COVID-19 subjects was conducted. Blood serum was drawn from subjects, then platelets, prothrombin time (PT), activated partial thromboplastin (aPPT), international ratio (INR), D-dimer, ferritin, fibrinogen, and high-sensitivity C-reactive protein (hs-CRP), were measured. For thrombocytopenia risk assessment, the 4T score was calculated. To assess the risk of thrombocytopenia. Statistical analysis using Chi-square and Mann-Whitney U test were performed and followed by multivariate analysis to examine the correlation among the thrombocytopenia risk factors.RESULTS: Significant differences were identified in the length of stay (LOS) (p=0.04), disease severity (p=0.021), sepsis (p=0.006), hs-CRP (p=0.003), and mortality rate (p=0.028) between thrombocytopenia and nonthrombocytopenia groups. A multivariate analysis through linear and logistic regression disclosed an increase in hs-CRP (OR=-0.29; p=0.045) and sepsis (OR=4.32; p=0.03) that precipitate the thrombocytopenia events.CONCLUSION: In severe and critically ill COVID-19 patients, the occurrence of thrombocytopenia was followed by an increase in inflammatory parameters such as D-dimer, fibrinogen, ferritin, hs-CRP and prolonged coagulation. The increase in hs-CRP and sepsis may raise the risk of thrombocytopenia, especially in severe and crtically ill cases of COVID-19.KEYWORDS: COVID-19, anticoagulant, thrombocytopenia, inflammation, infectious disease
Diagnostic Value of Determination Blast Cell Population Lineage Using WPC Scattergram Hematology Analyzer Nina Ratnasari; Arifoel Hajat; S. Ugroseno Yudho Bintoro
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 26 No. 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1585

Abstract

The diagnosis of hematology malignancies requires examination that includes morphology, immunophenotyping, and cytogenetics. Immunophenotyping is the most trusted examination in determining hematology malignancies lineage, but it is only available in large hospitals and the costs are relatively expensive, so the determination of lineage depends on bone marrow aspiration examination. Therefore it is necessary to have an easier and more reliable alternative to assist BMA morphology. White Precursor Cell (WPC) scattergram Sysmex XN-1000 has the capability to differentiate malignancy lineage. The purpose of this study was to determine the diagnostic value of determining lineage generated by WPC scattergram compared to the lineage from BMA examination. BMA blood samples were simultaneously examined by BMA morphology interpretation using microscope and WPC scattergram Sysmex XN-1000 examination. The hematology malignancies lineage resulting from BMA and WPC scattergram examination was then analyzed statistically to determine the suitability, sensitivity, and specificity. The results of determining the lineage of blast cell population based on WPC scattergram resulted in a suitability with a sensitivity of 93.75% and specificity of 94.74% for determining the hematological malignancy of myeloid lineage and 94.74% and 93.75% for lymphoid lineage, with a diagnostic accuracy of 94.91%. Based on this study it can be concluded that the WPC scattergram can determine the lineage of hematological malignancies with a suitability and high diagnostic value of lineage based on BMA morphology.
Hubungan rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh pada pasien dengan penyakit jantung koroner Raharjo, Budiono; Kurniawati, Renny; Wijayanti, Christina Destri Wiwis; Linggawan, Stephani; Sumarpo, Anton; Bintoro, Siprianus Ugroseno Yudho
Holistik Jurnal Kesehatan Vol. 19 No. 2 (2025): Volume 19 Nomor 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v19i2.651

Abstract

Background: The incidence of coronary heart disease continues to increase every year. The monocyte/high density lipoprotein (HDL) ratio has recently been proposed as a new predictor and prognostic indicator in cardiovascular disease. Obesity is one of the risk factors for coronary heart disease that can be measured using body mass index (BMI). Purpose: To determine the relationship between the monocyte/high density lipoprotein (HDL) ratio and body mass index (BMI) in patients with coronary heart disease. Method: This observational analytical study with a cross-sectional approach used research subjects with coronary heart disease at Mitra Keluarga Hospital, Waru during the period of January 2023 - January 2024. The sample in this study was taken by purposive sampling. The correlation test of the monocyte/high density lipoprotein (HDL) ratio with body mass index (BMI) was carried out using SPSS software version 29. Results: Body mass index in coronary heart patients was found that most patients were included in the type I obesity category as many as 9 people (30%). The monocyte/HDL ratio in coronary heart patients was found to be an average of 20.28. Conclusion: There is no significant relationship between the monocyte/HDL ratio and BMI in coronary heart patients. Suggestion: Further researchers can conduct similar research in hospital institutions with a larger sample size.   Keywords: Body Mass Index; High Density Lipoprotein; Monocyte.   Pendahuluan: Penyakit jantung koroner terus mengalami peningkatan setiap tahunnya. Rasio monosit/high density lipoprotein (HDL), baru-baru ini diusulkan sebagai prediktor dan indikator prognosis baru pada penyakit kardiovaskular. Obesitas merupakan salah satu faktor resiko penyakit jantung koroner yang dapat diukur menggunakan indeks massa tubuh (IMT). Tujuan: Untuk mengetahui hubungan rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh (IMT) pada pasien dengan penyakit jantung koroner. Metode: Penelitian analitik observasional dengan pendekatan cross sectional ini menggunakan subjek penelitian dengan penyakit jantung koroner di Rumah Sakit Mitra Keluarga, Waru selama rentang waktu bulan Januari 2023 – Januari 2024. Sampel dalam penelitian ini diambil secara purposive sampling. Uji korelasi rasio monosit/high density lipoprotein (HDL) dengan indeks massa tubuh (IMT) dilakukan dengan piranti lunak SPSS versi 29. Hasil: Indeks massa tubuh pada pasien jantung koroner didapatkan sebagian besar pasien termasuk dalam kategori obesitas tipe I sebanyak 9 orang (30%). Rasio monosit/HDL pada pasien jantung koroner didapatkan rata-rata sebesar 20.28. Simpulan: Tidak ditemukan adanya hubungan yang signifikan antara rasio monosit/HDL dengan IMT pasien jantung koroner. Saran: Peneliti selanjutnya dapat melakukan penelitian serupa pada instansi rumah sakit dengan jumlah sampel yang lebih besar.   Kata Kunci: High Density Lipoprotein; Indeks Massa Tubuh; Monosit.
Correlation between Neutrophil-to-Lymphocyte Ratio and Severity of Community-Acquired Pneumonia in Patients Almira, Naufalia Ghina; Hasan, Helmia; Wardhani, Puspa; Hernaningsih, Yetti; Bintoro, Siprianus Ugroseno Yudho; Romadhon, Pradana Zaky
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25024

Abstract

The high morbidity and mortality rates due to pneumonia in developing countries indicate that a more affordable marker is needed to determine the degree of inflammation in cases of pneumonia infection. The neutrophil-to-lymphocyte ratio (NLR) is a simple indicator used extensively in evaluating the systemic inflammatory response. An observational cross-sectional study of 297 pneumonia patients was conducted using medical records as the source document. The patients’ blood was taken during the hospital admission to obtain neutrophil and lymphocyte values. Meanwhile, the PSI score was used during the hospital admission to assess the severity of the pneumonia. Bivariate analysis using Spearman correlation was used to determine the correlation between NLR and pneumonia severity. The ROC curve was used to determine the cut-off value of NLR to distinguish mild from severe patients. The results of the Spearman correlation test analysis showed that the correlation between the NLR and the pneumonia severity was significantly positive (r = 0.130; p = 0.025). Furthermore, the median NLR value was higher in patients with severe pneumonia than in those with milder pneumonia severity (13.01 vs. 11.79 vs. 6.75). The NLR cut-off value of 9.07 was obtained to differentiate patients with mild severity and those with more severe disease. In conclusion, there is a correlation between the neutrophil-to-lymphocyte ratio and the severity of patients’ pneumonia.
The Assessment of Neutrophil-to-Lymphocyte Ratio in Obesity: A Descriptive Study on University Students in Surabaya, Indonesia Damayanti, Inggit; Raharjo, Budiono; Setiawan, Heru; Herawaty, Wike; Linggawan, Stephani; Sumarpo, Anton; Bintoro, Siprianus Ugroseno Yudho
MAHESA : Malahayati Health Student Journal Vol 5, No 5 (2025): Volume 5 Nomor 5 (2025)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v5i5.17939

Abstract

ABSTRACT The incidence of obesity worldwide is rapidly increasing, both in developed and developing countries. Obesity, particularly central obesity, is an inflammatory condition occurring within the body. The neutrophil-to-lymphocyte ratio (NLR) is a simple biomarker used to indicate the inflammatory response. This study aims to determine the profile of the neutrophil-to-lymphocyte ratio in students with obesity at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya.  This study employs a descriptive-analytic method with a cross-sectional approach. The study population comprises students from the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya; 47 individuals, with 30 obese individuals and 17 individuals with a normal BMI. The results showed that the average neutrophil-to-lymphocyte ratio (NLR) for individuals with a normal BMI is 1,95. In contrast, the average NLR for obese individuals is 2,09. There is an increase in the average neutrophil-to-lymphocyte ratio (NLR) among obese students at the Faculty of Medicine, Universitas Wijaya Kusuma Surabaya. Keywords: Obesity, Neutrophil, Lymphocyte, Neutrophil-To-Lymphocyte Ratio
Peran Pemeriksaan Mutasi Gen Dead-Box Helicase 41 (DDX41) pada Sindroma Mielodisplasia Hipoplastik Raharjo, Budiono; Linggawan, Stephani; Sumarpo, Anton; Imannuel, Erica Valencia; Supriadi, Vegy; Lukito, Diane; Raharjo, Yohanes Timothy; Devi, Wivina Riza; Bintoro, Siprianus Ugroseno Yudho
Majalah Kedokteran Indonesia Vol 75 No 5 (2025): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.75.5-2025-1847

Abstract

Introduction: DDX41 gene mutations can occur in hematopoietic malignancies, especially acute myeloid leukemia (AML) and myelodysplastic syndrome. The average incidence of myelodysplastic syndrome (MDS) in the general population is 4.5 out of 100,000 people per year. Myelodysplastic syndrome (MDS) can occur with different genetic mutations and will provide different prognoses and therapy results. Hypoplastic myelodysplastic syndrome (MDS) is often found in 10-15% of MDS patients. There have been no case reports or research studies in Indonesia that have reported a case of hypoplastic myelodysplastic syndrome associated with a mutation in the Dead Box Helicase 41 (DDX41) gene.Case Report: A 66-year-old man presented with complaints of weakness. The patient had a history of myelodysplastic syndrome diagnosed two years earlier. Bone marrow aspiration revealed cellularity with decreased granulopoiesis and thrombopoiesis, and myeloblasts accounted for 2.0%. Genetic testing using a Next Generation Sequencing (NGS) panel identified DDX41 p.(Pro258Leu) at 47.9%, DDX41 p.(Arg525His) at 1.7%, and ASXL1 p.(Gln977Ter) at 1.6%. The patient was treated with a combination therapy of venetoclax and azacitidine. Follow-up bone marrow aspiration showed improved cellularity, increased erythropoiesis activity, and a reduction in the number of dysplastic cells. Case Discussion: Mutations in the DDX41 gene can mostly be found in cases of hypoplastic myelodysplastic syndrome, while in normocellular or hypercellular myelodysplastic syndrome, genetic mutations such as SF3B1, TET2, STAG2, ASXL1, and BCOR are mostly found. The DDX41 gene is related to cellular molecules and innate immunity. The DDX41 gene mutation is a determining factor in the administration of chemotherapy. The DDX41 gene mutation is a determining factor in the selection of chemotherapy drugs.Conclusion: DDX41 genetic testing with NGS method is essential for determining the prognosis and appropriate therapy in the management of hypoplastic myelodysplastic syndrome cases.
Co-Authors Almira, Naufalia Ghina Ami Ashariati Ami Ashriati Prayoga Anton Sumarpo Arifoel Hajat Choirina Windradi Damayanti, Inggit Devi, Wivina Riza Elvan Dwi Widyadi Endang Retnowati Hasan, Helmia Herawaty, Wike Heru Setiawan Imannuel, Erica Valencia Kartika Prahasanti Katharina Ratri Benita Krisnina Nurul Widiyastuti Kurniawati, Renny LINGGAWAN, STEPHANI Lukito, Diane M. Rifqi Wiyono Made Putra Sedana Mahdi, Bagus Aulia Martono Tri Utomo Merlyna Savitri Merlyna Savitri Merlyna Savitri Merlyna Savitri Savitri Mia Ratwita Andarsini Muhammad Noor Diansyah Nina Ratnasari Primadita Syahbani Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita Putu Niken Ayu Amrita RAHARJO, BUDIONO Raharjo, Yohanes Timothy Rina Syarifah Salma Rizky Amalia Putri Romadhon, Pradana Zaky Ryzky Widi Atmaja Soebagjo, Hendrian Dwikoloso Supriadi, Vegy Wardhani, Puspa Wiharjo Hadisuwarno Wijayanti, Christina Destri Wiwis Yetti Hernaningsi Yetti Hernaningsih Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu