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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Kedokteran MNJ (Malang Neurology Journal) JOSSAE (Journal of Sport Science and Education) Jurnal Abdi Insani Acta Neurologica Indonesia Jurnal Kesehatan Masyarakat Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rivarti, Arina Windri
Departemen Fisiologi, Fakultas Kedokteran Universitas Mataram, Mataram, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Other

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Cognitive Decline Among the Middle-aged Living in the Coastal Area in Lombok Island Suryani, Dini; Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati; Zubaidi, Fitriannisa Faradina; Saputri, Legis Ocktaviana
Acta Neurologica Indonesia Vol. 3 No. 01 (2025): Acta Neurologica Indonesia
Publisher : Departemen Neurologi Fakultas Kedokteran Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69868/ani.v3i01.50

Abstract

INTRODUCTION: Dementia is a leading cause of disability, dependency and poor quality of life. Its prevalence has increased consistently in recent years. Coastal communities who have limited access to health services have a higher risk of developing degenerative diseases including dementia. METHOD: A total of 154 middle-age peoples from four coastal area were recruited in this study. Participants were interviewed to obtain data on sociodemographic characteristics, lifestyle and medical history, then completed neuropsychological tests. Cognitive function was assesed by Mini-cog instruments. RESULT: The number of participants with cognitive decline was 87 people (56%) out of a total of 154 participants. 66% of all participants with cognitive decline were female. History of hypertension (67%), DM (16%), 40% with a BMI ≥22.5, 23% with a history of smoking, and 45% of participants with a low activity level. Multiple linear regression shows that Age and history of Hypertension is associated with cognitive decline (Sig.0.005 and 0.037). DM, BMI, smoking history and activity level is not associated significantly. CONCLUSION: More than half of middle age people on the coast of Lombok Island have cognitive decline. Age and history of hypertension are influencing factors.
THE THE POTENTIAL ROLE OF NRF2 AS A TARGET SITE FOR THERAPEUTIC INTERVENTIONS IN ALZHEIMER'S DISEASE Rivarti, Arina Windri; Harahap, Herpan Syafii; Saputri, Legis Ocktaviana; Suryani, Dini; Rianawati, Sri Budhi
MNJ (Malang Neurology Journal) Vol. 11 No. 2 (2025): July
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2025.011.02.10

Abstract

Alzheimer's Disease (AD) is the most common form of dementia, characterized by progressive neurodegeneration leading to cognitive decline and memory impairment, affecting various cognitive functions. AD pathology involves the accumulation of neurotoxic substances such as amyloid beta (Aβ) and tau proteins, mitochondrial dysfunction, oxidative stress, and chronic neuroinflammation, resulting in synaptic loss and neuronal apoptosis. The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as a pivotal regulator of cellular defense mechanisms, including antioxidant response, autophagy, and inflammation. NRF2 not only inhibits Aβ synthesis and enhances tau protein clearance via autophagy but also reduces neuroinflammation by modulating microglial activation and cytokine production. Additionally, NRF2 activation preserves mitochondrial function by attenuating reactive oxygen species (ROS) production and sustaining mitochondrial biogenesis. Recent studies highlight the therapeutic potential of NRF2 activators, such as sulforaphane and echinacoside, in preclinical AD models, demonstrating reductions in Aβ and tau pathologies and improved cognitive outcomes. These findings underscore the multifaceted role of NRF2 in mitigating AD progression and its promise as a target for developing novel therapeutic interventions. By integrating NRF2-based strategies, future treatments may offer more effective approaches to combat the complex pathophysiology of AD.
Serum Clusterin Level Associated with Post-ischemic Stroke Cognitive Dysfunction Harahap, Herpan Syafii; Indriyana, Yanna; Rianawati, Sri Budhi; Arisetijono, Eko; Rivarti, Arina Windri
Jurnal Kesehatan Masyarakat Vol. 20 No. 3 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v20i3.4401

Abstract

The exploration of potential blood-based biomarkers that could be useful in the early detection of cognitive impairment associated with ischemic stroke is still being studied. The objective of this study was to examine the correlation between serum clusterin levels and the prevalence of cognitive impairment in individuals with ischemic stroke. A total of 86 outpatients with mild ischemic stroke within the first three months of its onset were recruited from three primary hospitals in Mataram, Indonesia. ELISA was used to measure the serum clusterin level. Patients’ sociodemographic and clinical data were also collected as covariates. The Montreal Cognitive Assessment-Indonesian version (MoCA-INA) instrument was used to evaluate cognitive status. The study used multivariate logistic regression analysis to investigate the effect of clusterin on the occurrence of cognitive impairment associated with ischemic stroke while controlling for other variables. Results: The multivariate logistic regression analysis revealed a significant correlation between elevated serum clusterin levels and a higher prevalence of cognitive impairment in ischemic stroke patients (odds ratio [OR] 3.56, 95% confidence interval [CI] 1.04-12.16, p = 0.043). Conclusion: Elevated serum clusterin levels have been associated with a higher occurrence of cognitive impairment in ischemic stroke patients.
Risk Factors for Cognitive Impairment in Adult Population of Coastal Area: A Cross-Sectional Study in Maringkik Island, Indonesia Harahap, Herpan Syafii; Rivarti, Arina Windri; Nurhidayati, Nurhidayati; Zubaidi, Fitriannisa Faradina; Suryani, Dini; Saputri, Legis Ocktaviana; Indrayana, Yanna; Andhera, Athalita; Hilam, Muhammad; Haq, Abiyyu Didar
Kesmas Vol. 19, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cognitive impairment is a medical condition commonly found in elderly populations, which can be due to vascular risk factors in patients. There remains limited data on risk factors for cognitive impairment among coastal region populations. This study aimed to investigate risk factors for cognitive impairment in the adult population of Maringkik Island, West Nusa Tenggara Province, Indonesia. Data collected were age, sex, education level, hypertension, antihypertensive treatment, diabetes mellitus, cigarette smoking, and body mass index status. A total of 114 participants were recruited using a consecutive sampling method. The participants’ cognitive function assessment used the Mini-Cog instrument. The cognitive impairment frequency in the island’s adult population was approximately 48.2%. The final model of multiple regression analysis showed that hypertension (OR: 2.3; 95%CI: 1.0 – 5.0; p-value: 0.045) was a characteristic associated with the cognitive impairment frequency. Thus, the high frequency of cognitive impairment and hypertension frequency as primary risk factors for cognitive impairment in the island’s adult population implies the need to develop strategies for detecting and managing hypertension and hypertension-related cognitive impairment in the population by local health authorities.
Co-Authors Ananda Amirah Balqis Ananda amirah Balqis Anang Hermansyah Andhera, Athalita Aurellia Wongso Prawiro Aurellia Wongso Prawiro Bambang Priyanto Dini Suryani Dini Suryani, Dini Eko Arisetijono Fitriannisa Faradina Zubaedi Fitriannisa Faradina Zubaidi Gama, Noviyanty Indjar Gina Aulia Azizaturrahmah Gina Aulia Azizaturrahmah Hanik Badriyah Hidayati,* Mohammad Hasan Machfoed,* Kuntoro,** Soetojo,*** Budi Santoso,**** Suroto,***** Budi Utomo****** Haq, Abiyyu Didar HERAWATI, LILIK Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Herpan Syafii Harahap Hilam, Muhammad Inayah Wulandari Inayah Wulandari Indrayana, Yanna Indriyana, Yanna Junian Cahyanto Wibawa Lalu Auliya Akraboe Littaqwa Legis Ocktaviana Saputri M Said Ramdlan Mahacita Andanalusia Mishael Enoch Stephen Mishael Enoch Stephen Muhammad Hilman Rizaldi Mus, Rosdiana Noviyanty Indjar Gama Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Nurhidayati Ocktaviana Saputri, Legis Ovia Intan Ristia Ovia Intan Ristia Restia Restia Sri Budhi Rianawati, Sri Budhi Syihabul muttaqin Syihabul muttaqin Wibawa, Junian Cahyanto Yanna Indrayana Yusra Pintaningrum Zubaidi, Fitriannisa Faradina