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Kajian Residu Tetrasiklin HCl dalam Daging dan Hati Ayam Broiler pada Beberapa Peternakan di Kabupaten Lamongan Menggunakan Metode Spektrofotometri Ultraviolet Fernanda, M.A. Hanny Ferry; Chrisnandari , Rosita Dwi
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.206

Tetracycline HCl is one of the most commonly used antibiotics in animal feed additives to control disease caused by bacteria. The dosage of antibiotics added to animal feed is sometimes not in accordance with existing regulations, causing residues in the body to be left behind. The purpose of this study was to determine the presence and levels of tetracycline HCl antibiotic residues in the meat and liver of broiler chickens on farms in Lamongan City by using the spectrophotometric method by selecting the maximum wavelength which was carried out by making the absorbance relationship curve and the wavelength of the standard solution at a certain concentration. The results of tetracycline antibiotic residues in boiler chicken meat and liver on the first farm showed that the residual levels of tetracycline HCl were 3,969.10 Â± 392.32 ppm and 14,247.74 Â± 2,632.63 ppm, on the second farm showed residual levels of tetracycline HCl. 5,470.03 Â± 512.76 ppm and 20,464.60 Â± 5,985.63 ppm, respectively, and the third farm showed that the remaining levels of tetracycline HCl were 7,032.37 Â± 971.99 ppm and 19,232.71 Â± 6,404.63 ppm. The results showed that the residual content of tetracycline HCl in broiler meat and liver exceeds the maximum residual content of tetracycline class of antibiotics in meat and milk based on SNI 01-6366-2000 which limits the residue to not more than 0.1 ppm.

Potensi Antimikroba Ekstrak Ethanol Ganoderma lucidum Menggunakan Metode Bioautografi terhadap Bakteri Escherichia coli dan Bacillus subtillis Sudarwati, Tri Puji Lestari; Fernanda, M.A. Hanny Ferry
Journal of Pharmacy and Science Vol. 6 No. 1 (2021): Journal of Pharmacy and Science
Publisher : Akademi Farmasi Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53342/pharmasci.v6i1.212

Potensi antibakteri ekstrak ethanol jamur lingzhi (Ganoderma lucidum) menggunakan metode analisis KLT bioautografi terhadap Escherichia coli dan Bacillus subtillis sebagai penelitian pendahuluan untuk mengetahui kandungan metabolit sekunder pada jamur lingzi. Soxhletasi merupakan metode untuk mengekstraksi serbuk jamur lingzhi menggunakan pelarut etanol. Bioautografi merupakan metode yang digunakan untuk mengetahui kandungan metabolit sekunder pada jamur lingzi dan potensi antibakteri. Konsentrasi yang digunakan yaitu: 2%, 4%, 6%, 8%dan 10%, dengan pengulangan sebanyak 5 kali. KLT bioautografi menggunakan n-butanol : Asam asetat glasial : Air (4:1:5) sebagai eluent. Analisis yang telah dilakukan menghasilkan 3 noda dengan Rf 0,5 dengan warna kuning, Rf 0,87 warna biru, Rf 0,93 warna coklat, dengan daerah hambatan pada noda coklat dengan Rf 0,93 merupakan senyawa triterpen. Hasil dari pengukuran nilai rata-rata zona hambat yang diperoleh terhadap bakteri E.coli adalah sebagai berikut, pada konsentrasi 2% 5,45 mm dengan kategori lemah, konsentrasi 4% 5,14 mm, konsentrasi 6% 5,48 mm, konsentrasi 8% 5,94 mm dan konsentrasi terbesar terdapat pada konsentrasi 10% 6,98 mm dengan kategori sedang. Pada bakteri Bakteri Bacillus subtillis konsentrasi 2% Sebesar 5,9 mm, Konsentrasi 4% Sebesar 6,34 mm, Konsentrasi 6% Sebesar 6,68 mm, Konsentrasi 8% Sebesar 7,88 mm, Dan Konsentrasi 10% Sebesar 8,6 mm dengan Kategori Sedang Maka dapat disimpulkan bahwa ekstrak jamur lingzhi memiliki aktivitas antibakteri terhadap bakteri Escherichia coli. Sehingga semakin besar konsentrasi yang digunakan, semakin besar pula aktivitasnya dalam menghambat pertumbuhan bakteri.

Analisis Kadar KCl dalam Sediaan Infus Premixed pada Kondisi Penyimpanan yang Berbeda Menggunakan Spektrofotomteri Serapan Atom Fernanda, M.A. Hanny Ferry; Dibah, Meilindah Farah; Nirwati, Klara Susi; Kristalinawati, Mepifany
Jurnal Dunia Farmasi Vol 8, No 1 (2023): Edisi Desember
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i1.5921

Pendahuluan: KCl merupakan elektrolit konsentrat pekat (High Alert) yang harus diwaspadai pengelolaan dan penyimpanannya. Dalam penggunaan secara intravena, KCl harus diencerkan terlebih dahulu dengan cairan infus yang sesuai, salah satunya dengan NaCl 0,9%. KCl 25 mix Pz 500 mL adalah salah satu sediaan steril yang digunakan untuk pengobatan pada pasien yang mengalami gangguan keseimbangan elektrolit cairan tubuh. Tujuan: Penelitian ini bertujuan untuk mengetahui perbedaan kadar KCl dalam KCl 25 mix PZ 500 ml, setelah disimpan dalam beberapa kondisi penyimpanan yang berbeda. Metode: Penelitian ini terdiri dari beberapa tahapan yaitu pengambilan sampel, preparasi sampel, penyimpanan sampel pada kondisi yang dikehendaki, kemudian analisa kuantitatif sampel dengan menggunakan metode Spektrofotometri Serapan Atom (SSA). Hasil: Rata-rata kadar KCl pada kondisi penyimpanan Suhu Ruang terkontrol (22 -25°C); Suhu lemari pendingin (2-8°C) ; Tanpa Sinar Matahari; Dengan Sinar Matahari; Suhu Kamar (25-30°C); Suhu Hangat (30-40°C) berturut-turut adalah 25,017 mEq; 27,499 mEq; 27,836 mEq; 30,070 mEq; 25,317 mEq; 28,683 mEq. Hasil dari Analisa statistika One-way Anova terhadap kontrol dan perlakuan menunjukkan nilai p = 0,5534 (Sig p0,05). Kesimpulan: Tidak ada perbedaan yang signifikan kadar KCl pada sediaan infus KCl 25 mix PZ 500 ml yang disimpan dalam beberapa kondisi penyimpanan yang berbeda.

Fraksinasi dan Identifikasi Ektrak Daun Mitragyna Speciosa Menggunakan Metode Kromatografi Fernanda, M.A. Hanny Ferry; Suryandari, Mercyska; Sudarwati, Tri Puji Lestari
FARMASIS: Jurnal Sains Farmasi Vol 2 No 2 (2021): Farmasis : Jurnal Sains Farmasi
Publisher : Universitas PGRI Adi Buana, Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/farmasis.v2i2.4072

Background: Mitragyna Speciosa or better known as Kratom is a typical plant from the Putusibau area, West Kalimantan. The most widely used part of this plant is the leaves. The kratom plant contains alkaloids, flavonoids, phenols, terpenoids-steroids, triterpenoids, saponins, and tannins. Alkaloid content is the most dominant and has benefits in this plant so it is necessary to do fractionation and identification of secondary metabolites. Objective: To fractionate and identify secondary metabolites from Mitragyna Speciosa leaf extract. Methods: The fractionation method was carried out using Column Chromatography while for identification using Thin Layer Chromatography. Results: 80 fractions were obtained from the column chromatography results, while the results of identification using thin layer chromatography showed that only the 2nd and 3rd fractions were obtained. The second fraction has two spots with Rf values of 0.51 and 0.73 and in the third fraction there are three spots with Rf values of 0.21; 0.52, and 0.74. Conclusion: Fractionation and identification by chromatographic method can be used as initial screening for secondary metabolite content in Mitragyna Speciosa leaf extract.

Penyuluhan Peningkatan Pemahaman Masyarakat terhadap Beyond Use Date Sediaan Obat pada Swamedikasi Secara Daring Fernanda, M.A. Hanny Ferry; Kusumo, Galuh Gondo
Jurnal Pelayanan dan Pengabdian Masyarakat (Pamas) Vol 7, No 4 (2023): Jurnal Pelayanan dan Pengabdian Masyarakat (PAMAS)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM Universitas Respati Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52643/pamas.v7i4.1491

Beyond Use Date (BUD) can be defined as the time limit for a drug product that is safe for use after compounding or after the primary packaging has been opened. In contrast to the Expired Date (ED) or expiration date which is the limit on the use of drugs listed on the drug packaging. This BUD is not listed on the drug packaging so people need to know about this BUD. This BUD really determines the time limit for a drug product that is still of good quality and is in a stable condition. Ideally, the BUD is determined based on the results of the drug product stability test and is listed on the packaging. However, when doing self-medication or self-medication, people usually only use the expiration date as a reference for the safety of drug use. Therefore, there is a need for community service activities to provide education to the community about knowledge of drug damage after the packaging is opened and before ED. The purpose of this activity is to increase public knowledge about the safety of pharmaceutical preparations as long as they are stored with a time limit after the packaging is opened. This activity was carried out online through the zoom meeting application on Saturday, April 10, 2021. The results of this activity provided information that the public could understand the Beyond Use Date material on the use of self-medication drugs properly. Keywords : Beyond Use Date, Expired Date, Self Medication

ANALISIS KANDUNGAN KAFEIN PADA MINUMAN KOPI SIAP SAJI MENGGUNAKAN METODE KROMATOGRAFI LAPIS TIPIS-GAMBAR DIGITAL Rahayu, Ni Luh Ika; Fernanda, M.A. Hanny Ferry
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1449

Caffeine is a colorless, crystalline powder that has a slightly bitter taste. One of them is ready-to-drink coffee, which can help increase concentration and is much loved. This study aimed to develop a semi-qualitative analysis of caffeine compounds in ready-to-drink coffee using the TLC method. The mobile phase used was methanol: ethyl acetate: acetic acid (3:1:6) with a saturation time of the mobile phase in the chamber of 20 minutes, and the stationary phase used silica gel 60 F254. The results obtained have a linearity (r) of 0,991413. As for the caffeine content in ready-to-drink coffee brand A was 99,37 mg; brand B was 144,81 mg, and brand C was 96,42 mg. It can be concluded that digital image processing using the semi-quantitative TLC method of ready-to-drink coffee contains positive caffeine compounds

Analisis Semikuantitatif Parasetamol Dalam Jamu Pegal Linu Menggunakan Pemrosesan Gambar Digital dari Hasil Kromatografi Lapis Tipis Fernanda, M.A. Hanny Ferry; Wardani, Ratih Kusuma
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.7

Jamu is a pharmaceutical preparation derived from plant simplicia and must meet quality requirements, one of which is that it must not contain medicinal chemicals (BKO). One of the herbs widely circulated and can be obtained freely in the community is herbal medicine for aches and pains. In herbal aches and pains, paracetamol is the BKO suspected to be used in this preparation. This study aimed to develop an analytical method to determine the content of paracetamol BKO in herbal pain relief semi-quantitatively using digital images obtained from Thin Layer Chromatography. The semi-quantitative analysis method is carried out by processing digital images using the qTLC application. The results of this study proved the presence of paracetamol BKO in herbal aches and pains qualitatively using the TLC method. Of the five samples analyzed, only one contained paracetamol BKO with an Rf value of 0.15, while the standard Rf was 0.14. The analysis was then continued with the determination of paracetamol levels semi-quantitatively using digital image processing from the Thin Layer Chromatography results. Based on the results of semi-quantitative analysis, it can be seen that the sample suspected to contain paracetamol contains paracetamol with a concentration of 1,491.31 ppm. The results of this study can provide accurate detection of paracetamol BKO compound determination and semi-quantification limits and have the potential for more quantitative analysis in herbal medicine.

Analisis Semikuantitatif Parasetamol Dalam Jamu Pegal Linu Menggunakan Pemrosesan Gambar Digital dari Hasil Kromatografi Lapis Tipis Fernanda, M.A. Hanny Ferry; Wardani, Ratih Kusuma
Pharmaceutical Journal of Indonesia Vol. 8 No. 1 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.008.01.7

Jamu is a pharmaceutical preparation derived from plant simplicia and must meet quality requirements, one of which is that it must not contain medicinal chemicals (BKO). One of the herbs widely circulated and can be obtained freely in the community is herbal medicine for aches and pains. In herbal aches and pains, paracetamol is the BKO suspected to be used in this preparation. This study aimed to develop an analytical method to determine the content of paracetamol BKO in herbal pain relief semi-quantitatively using digital images obtained from Thin Layer Chromatography. The semi-quantitative analysis method is carried out by processing digital images using the qTLC application. The results of this study proved the presence of paracetamol BKO in herbal aches and pains qualitatively using the TLC method. Of the five samples analyzed, only one contained paracetamol BKO with an Rf value of 0.15, while the standard Rf was 0.14. The analysis was then continued with the determination of paracetamol levels semi-quantitatively using digital image processing from the Thin Layer Chromatography results. Based on the results of semi-quantitative analysis, it can be seen that the sample suspected to contain paracetamol contains paracetamol with a concentration of 1,491.31 ppm. The results of this study can provide accurate detection of paracetamol BKO compound determination and semi-quantification limits and have the potential for more quantitative analysis in herbal medicine.

Pengemmbangan Media Pembelajaran Interaktif Berbasis Website Google Sites Pada Mata Pelajaran Perawatan Tangan dan Mewarnai Kuku (Manicure) di SMK Negeri 1 Lamongan Sherlita Restu Khairina; Biyan Yesi Wilujeng; Fernanda, M.A. Hanny Ferry; Maspiyah
Jurnal Tata Rias Vol. 14 No. 1 (2025): Jurnal Tata Rias Volume 14 Nomer 1 Tahun 2025
Publisher : Program Studi Pendidikan Tata Rias

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jtr.v14n1.66372

This research is motivated by the need for innovation in learning media that is in line with technological advancements to improve the quality of learning in vocational schools. The purpose of this study is to develop and design interactive learning media based on websites with the Google Sites platform, specifically for the subject of hand care and nail coloring (manicure). Field observations found at SMKN 1 Lamongan, the use of technology in the learning process, especially in learning media, is still very suboptimal, and there is no learning media that supports students' learning styles. Specifically, the main purpose of this study is as follows: 1) to review the feasibility of Google Sites website-based learning media, 2) to measure student learning outcomes, and 3) to determine students' responses to the learning media. The research method used is R&D with the ASSURE development model. The research subjects consisted of 26 students from the XII TKKR class. Data were collected through expert validation, cognitive tests (pre-test and post-test), psychomotor tests, and student response questionnaires. The validation results of the media feasibility showed an average score of 4.41 (88%) with the category "Very Feasible". Student learning outcomes in the cognitive aspect showed a significant increase, with pre-test scores of 61.35 and post-test scores of 86.35. The results of the Wilcoxon Signed Rank Test showed a Z value of -4.470 with an Asymp. Significance (2-tailed) of 0.000, which can be concluded that the significance value is 0.000 < 0.05. Based on these results, the null hypothesis (H0) stating that there is no significant difference between pre-test and post-test scores is rejected, while H1 is accepted. The results of student responses showed a positive response with an average score of 4.56 (91%) in the "Very Good" category. Thus, this study can be declared successful in improving the quality and quality of learning in the subject of hand care and nail coloring.

PENGEMBANGAN MEDIA PEMBELAJARAN VIDEO TUTORIAL TATA RIAS WAJAH PANGGUNG BERBASIS SIBI DI KARYA MULIA SURABAYA Shafiyyah, Salma; Lutfiati, Dewi; Fernanda, M.A. Hanny Ferry; Nia Kussianti
Jurnal Tata Rias Vol. 14 No. 2 (2025): Jurnal Tata Rias Volume 14 Nomer 2 Tahun 2025
Publisher : Program Studi Pendidikan Tata Rias

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/jtr.v14n2.69375

Practical learning of stage makeup for deaf students often faces obstacles due to the lack of accessible media that supports visual communication, particularly those utilizing the Indonesian Sign System (SIBI). Therefore, this study aimed to: (1) develop a SIBI-based video tutorial as an instructional medium for stage makeup competence; (2) assess the feasibility of the developed media; (3) measure students’ psychomotor learning outcomes after using the media; and (4) evaluate student responses to the SIBI-based video tutorial at SMALB-B Karya Mulia Surabaya. This research employed the 4D development model (Define, Design, Develop, Disseminate). The results showed that: (1) the media was successfully developed in the form of a ±7-minute video tutorial that integrated practical demonstrations, text, audio, and SIBI in a systematic manner; (2) the feasibility validation reached an average score of 88%, with media experts rating it at 92% (highly feasible), and both material and language experts giving 86% (feasible); (3) students' psychomotor learning outcomes improved, with the average knowledge test score increasing from 44.29 (pre-test) to 79.29 (post-test), and all students achieving psychomotor scores above the Minimum Mastery Criteria (KKTP), with an average of 83.8; and (4) student responses to the media were highly positive, with an average score of 4.35. These findings indicate that the SIBI-based video tutorial is both effective and feasible for use in practical learning among deaf students. Keywords: video tutorial, stage makeup, sign language, SIBI, deaf students.

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