Article Per Year (5 Year)
p-Index From 2020 - 2025
2.155
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Biosains Pascasarjana Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmamedika (Pharmamedica Journal) Jurnal Inovasi Farmasi Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal EduHealth Jurnal Pengabdian kepada Masyarakat Biomedika Pharmacon: Jurnal Farmasi Indonesia
Hidayati, Sholihatil
Unknown Affiliation
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 14 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 14 Documents
Search

 1   2 
The Effect of Banana Pell (Musa paradisiaca L) Ethanol Extract on The Blood Glucose Level of Diabetic Mice with Alloxan Induction Jazilah, Nur; Fifteen Aprila Fajrin; Hidayati, Sholihatil; Usman, Mohammad Rofik
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6555

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insufficient insulin hormones, or the inability to use insulin effectively. One of the traditional medicine use with DM is to control their blood glucose levels using herbal plants, namely the banana peel plant (Musa paradisiaca L.) which is rich in flavonoids, alkaloids, and tannins. This study aims to determine the effect of ethanol extract banana peel EEBP on glucose levels in mice with alloxan induction. The design of this study was a laboratory experiment, using male white mice (Mus musculus L) Balb/c strain, which were induced with alloxan at a dose of 200 mg/kg.bw. The mice were divided into six groups, namely normal, negative (CMC Na 0.5%), positive (glibenclamide 5 mg/kg.bw), and three groups of EEBP at a dose of 100 mg/kg.bw, 200 mg/kg.bw, and 400 mg/kg.bw. Blood glucose levels were evaluated on day 3 after induction, as well as day 7 and 14 after treatment. Blood glucose level data were analyzed using one-way ANOVA, followed by LSD post hoc test with 95% confidence level. The 400 mg/kg.bw dose of banana peel ethanol extract showed the highest percentage reduction in blood glucose levels, namely 65.83% ± 0.800, compared to other doses. Based on LSD statistical test, doses of 200 mg/kg.bw and 400 mg/kg.bw of EEBP showed no significant difference compared to the positive control (p>0.05). The optimal dose for reducing blood glucose levels in DM mice induced by alloxan is the treatment of EEBP in doses of 200 mg/kg.bw and 400 mg/kg.bw
Effect of Lime Juice (Citrus Aurantifolia) on Blood Urea Nitrogen and Creatinine Levels in Wistar Rats Induced by Gentamicin Sufi, Queen Nurul; Mufidah, Hartalina; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Gentamycin is an antibiotic that has the effect of acute kidney failure. Increased levels of BUN and Creatinine can characterize acute kidney failure. Lime juice (Citrus aurantifolia) contains flavonoid compounds as antioxidants that can regenerate kidney function. This study aims to determine the difference in BUN and Creatinine levels before and after being given lime juice. This study uses an experimental study design with a pretest-postest design. In the model mice, gentamicin was induced at a dose of 60 mg/KgBB for 10 days, and then BUN and creatinine levels were checked. This study was divided into 5 groups, including the negative, healthy, and treatment groups 1, 2, and 3, with a dose of lime juice 0.5 ml/KgBB, 1.0 ml/KgBB, and 1.5 ml/KgBB. The results showed that the average change in BUN levels before and after between groups was significant (sig < 0.05), and the average change in creatinine levels before and after between groups was significant (sig < 0.05). This study concluded that the average decrease in BUN levels in treatment group 3 was significant by 7.9 mg/dl, and the average decrease in creatinine levels in treatment groups 2 and 3 was significant by 0.8 mg/dl.
Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice Hidayati, Sholihatil
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15429

Abstract

Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days. Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.
Identification of Gamma-Aminobutyricacid (GABA) of Tempeh Made from Koro Kratok (Phaseolus lunatus) Bean and Beluntas (Plunchea indica) Leaves as Glucose Stabilizer Istiqomah, Istiqomah; Rini, Dina Mustika; Tania, Larisa; Hidayati, Sholihatil; Usman, Mohammad Rofik
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.645-654

Abstract

The tempeh available on the market is predominantly made from imported soybeans, but alternative formulations using locally sourced legumes, such as koro kratok (Phaseolus lunatus), have been explored. This study investigates the potential of koro kratok tempeh enriched with Plunchea indica (beluntas) leaves to improve its functionality. The study will evaluate gamma-aminobutyric acid (GABA) levels and physicochemical changes during fermentation. Tempeh was produced using different koro kratok-to-P. indica leaf ratios (100:0, 75:25, and 50:50). Key parameters observed included mycelium development and the content of fat, moisture, ash, protein, carbohydrates, and pH. Adding P. indica increased the fat content by 0.66–2.28%, the moisture content by 68.81–78.42%, and the ash content by 0.36–1.09%. Meanwhile, the protein content ranged from 6.62–8.87%, the carbohydrate content from 12.07–21.31%, and the pH between 4.21–4.25. The inclusion of P. indica also altered the profile of dominant volatile compounds. GABA was detected in all samples, and in vivo studies showed improved blood glucose levels and glucose tolerance in prediabetic rats. These results suggest that koro kratok tempeh enriched with P. indica leaves could be a promising functional food for regulating blood glucose.
Co-Authors Aggustin, Ayu Tri Agustin, Ayu Tri Amalia, Nabila Anas Fadli Wijaya Angger Putri M. Soleh, Ayu Anggia Destiawan, Rian Anggraeni, Linda Suci Any Guntarti Asista Indarusanti, Delvia Atmanegara, Stivani Yanti Ayu Susanti, Dhina Ayu Wulandari Citra Ariani Edityaningrum, Citra Destiawan, Rian Anggia Dina Trianggaluh Fauziah Fifteen Aprila Fajrin Hariani Nurjanah, Mutia Hayati, Farhatul Imroatul Muflihah, Ahdiah istiqomah istiqomah Kalyana Meta, Nilanda Laela Hayu Nurani Martina, Ina Moch Saiful Bachri Mohammad Rofik Usman Mufidah, Hartalina Muflihah, Ahdiah Imroatul Muhammad Ma'ruf Nabila, Talitha Vanian Nur Jazilah, Nur Permatasari, Shafira Restu Purwati, Aliyah Putra, Zulkarnain Permana Rini Sulistyawati Rini, Dina Mustika Rizka Handayani Rizki Amelia Salsa Safitri, Avrillia Sandi Basuki, Aditya Occy Sati, Wima Anggita Shinta Mayasari Siti Aisyah Soleh, Ayu angger Putri M. sufi, Queen Nurul Sulistyorini, Dwi Agustin Susanti, Dhina Ayu Swastika, Melur Tri Tania, Larisa Wima Anggitasari