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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Biosains Pascasarjana Biology, Medicine, & Natural Product Chemistry Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Farmamedika (Pharmamedica Journal) Jurnal Inovasi Farmasi Indonesia BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal EduHealth Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Masyarakat Biomedika Pharmacon: Jurnal Farmasi Indonesia
Hidayati, Sholihatil
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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The Effect of Banana Pell (Musa paradisiaca L) Ethanol Extract on The Blood Glucose Level of Diabetic Mice with Alloxan Induction Jazilah, Nur; Fifteen Aprila Fajrin; Hidayati, Sholihatil; Usman, Mohammad Rofik
Pharmacon: Jurnal Farmasi Indonesia Volume 21, No 2 (2024)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i2.6555

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia due to abnormalities in insulin secretion, insufficient insulin hormones, or the inability to use insulin effectively. One of the traditional medicine use with DM is to control their blood glucose levels using herbal plants, namely the banana peel plant (Musa paradisiaca L.) which is rich in flavonoids, alkaloids, and tannins. This study aims to determine the effect of ethanol extract banana peel EEBP on glucose levels in mice with alloxan induction. The design of this study was a laboratory experiment, using male white mice (Mus musculus L) Balb/c strain, which were induced with alloxan at a dose of 200 mg/kg.bw. The mice were divided into six groups, namely normal, negative (CMC Na 0.5%), positive (glibenclamide 5 mg/kg.bw), and three groups of EEBP at a dose of 100 mg/kg.bw, 200 mg/kg.bw, and 400 mg/kg.bw. Blood glucose levels were evaluated on day 3 after induction, as well as day 7 and 14 after treatment. Blood glucose level data were analyzed using one-way ANOVA, followed by LSD post hoc test with 95% confidence level. The 400 mg/kg.bw dose of banana peel ethanol extract showed the highest percentage reduction in blood glucose levels, namely 65.83% ± 0.800, compared to other doses. Based on LSD statistical test, doses of 200 mg/kg.bw and 400 mg/kg.bw of EEBP showed no significant difference compared to the positive control (p>0.05). The optimal dose for reducing blood glucose levels in DM mice induced by alloxan is the treatment of EEBP in doses of 200 mg/kg.bw and 400 mg/kg.bw
Effect of Lime Juice (Citrus Aurantifolia) on Blood Urea Nitrogen and Creatinine Levels in Wistar Rats Induced by Gentamicin Sufi, Queen Nurul; Mufidah, Hartalina; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.7163

Abstract

Gentamycin is an antibiotic that has the effect of acute kidney failure. Increased levels of BUN and Creatinine can characterize acute kidney failure. Lime juice (Citrus aurantifolia) contains flavonoid compounds as antioxidants that can regenerate kidney function. This study aims to determine the difference in BUN and Creatinine levels before and after being given lime juice. This study uses an experimental study design with a pretest-postest design. In the model mice, gentamicin was induced at a dose of 60 mg/KgBB for 10 days, and then BUN and creatinine levels were checked. This study was divided into 5 groups, including the negative, healthy, and treatment groups 1, 2, and 3, with a dose of lime juice 0.5 ml/KgBB, 1.0 ml/KgBB, and 1.5 ml/KgBB. The results showed that the average change in BUN levels before and after between groups was significant (sig < 0.05), and the average change in creatinine levels before and after between groups was significant (sig < 0.05). This study concluded that the average decrease in BUN levels in treatment group 3 was significant by 7.9 mg/dl, and the average decrease in creatinine levels in treatment groups 2 and 3 was significant by 0.8 mg/dl.
Antidiabetic Activity of Peperomia pellucida In Streptozotocin-Induced Diabetic Mice Hidayati, Sholihatil
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 2 (2021): (October 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i2.15429

Abstract

Background: Diabetes mellitus is a heterogeneous group of diseases in the form of disorders in the body's metabolism clinically. Peperomia pellucida herbs have phytochemical containing which is antidiabetic potential development. Objectives: This study was conducted to compare the antidiabetic activity of ethanol extract and n-hexane fraction of Peperomia pellucida. Material and Methods: This research was conducted by make diabetic mice with 50 mg/kg.bw of streptozotocin induction, which was then treated with ethanol extract and n-hexane fraction of Peperomia pellucida with doses 250 mg/kgbw for 7 days. Results: The results showed that the ethanol extract and n-hexane fraction of Peperomia pellucida reduced blood glucose levels in diabetic mice due to streptozotocin induction. The n-hexane fraction of Peperomia pellucida can lower blood glucose levels as much 244.00 ± 18.99 mg/dL better than the ethanol extract, which is 99.50 ± 28.17 mg/dL. Conclusions: Peperomia pellucida herb has the potential to be developed as an antidiabetic agent.
Identification of Gamma-Aminobutyricacid (GABA) of Tempeh Made from Koro Kratok (Phaseolus lunatus) Bean and Beluntas (Plunchea indica) Leaves as Glucose Stabilizer Istiqomah, Istiqomah; Rini, Dina Mustika; Tania, Larisa; Hidayati, Sholihatil; Usman, Mohammad Rofik
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.645-654

Abstract

The tempeh available on the market is predominantly made from imported soybeans, but alternative formulations using locally sourced legumes, such as koro kratok (Phaseolus lunatus), have been explored. This study investigates the potential of koro kratok tempeh enriched with Plunchea indica (beluntas) leaves to improve its functionality. The study will evaluate gamma-aminobutyric acid (GABA) levels and physicochemical changes during fermentation. Tempeh was produced using different koro kratok-to-P. indica leaf ratios (100:0, 75:25, and 50:50). Key parameters observed included mycelium development and the content of fat, moisture, ash, protein, carbohydrates, and pH. Adding P. indica increased the fat content by 0.66–2.28%, the moisture content by 68.81–78.42%, and the ash content by 0.36–1.09%. Meanwhile, the protein content ranged from 6.62–8.87%, the carbohydrate content from 12.07–21.31%, and the pH between 4.21–4.25. The inclusion of P. indica also altered the profile of dominant volatile compounds. GABA was detected in all samples, and in vivo studies showed improved blood glucose levels and glucose tolerance in prediabetic rats. These results suggest that koro kratok tempeh enriched with P. indica leaves could be a promising functional food for regulating blood glucose.
Immunomodulator Effect of Cnidoscolus aconitifolius Leaves Extract on CD4+ and CD8+ Expression in Salmonella typhimurium infected mice Hidayati, Sholihatil; Susanti, Dhina Ayu; Destiawan, Rian Anggia; Muflihah, Ahdiah Imroatul; Handayani, Rizka; Anggitasari, Wima
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27050

Abstract

Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person's immune system is weakened. Plant extracts are generally considered to be potential immunomodulatory agents developed, which have smaller side effects. Research shows that Cnidoscolus aconitifolius leaves have medicinal properties including as hepatoprotective, antidiabetic, and anticardiovascular. The results of the antioxidant activity test show the results that Cnidoscolus aconitifolius leaves extract (CAE) has potential as an antioxidant with a very strong category. This study was conducted to determine the effect of giving Japanese papaya leaf extract on CD4+ and CD8+ expression in Babl/c mice induced by Salmonella typhimurium bacteria. The study was started by preparing 70% ethanol extract from Cnidoscolus aconitifolius leaves and preparing 30 Babl/C mice as experimental animals which were divided into 6 groups (healthy control, negative control, positive control and treatment group by giving CAE dose of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw). Induction was carried out by oral infection with Salmonella thypimurium bacteria. After 3 days the infected mice were treated orally once a day for 7 days. Evaluation of CD4+ and CD8+ expression was carried out using the flowcytometer method of the lymph organs. Data analysis was carried out by the Anova test followed by the post hoc test (Tukey) using the SPSS for Windows application. The results showed that giving CAE at doses of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw could increase the expression ratio of CD4+ and CD8+, whereas giving CAE at a dose of 400 mg/kgbw showed significantly different results (p<0.05) to the negative control. This shows that the CAE has potential as an immunomodulatory agent that can improve immune function.
Pemanfaatan Tanaman Obat dalam Penanganan Masalah Kesehatan Masyarakat di Desa Gumuksari, Kalisat, Jember Hidayati, Sholihatil; Susanti, Dhina Ayu; Destiawan, Rian Anggia
Jurnal Pengabdian Masyarakat (JUDIMAS) Vol. 1 No. 2 (2023)
Publisher : Pusat Penelitian dan Pengabdian Masyarakat STIKes Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54832/judimas.v1i2.148

Abstract

Warga masyarakat di Desa Gumuksari sudah terbiasa memanfaatkan pekarangan yang berada di sekitar rumahnya untuk ditanami berbagai jenis tanaman. Dari berbagai macam tumbuhan yang hidup di pekarangan warga, banyak diantaranya yang merupakan tumbuhan yang dapat dipergunakan sebagai tanaman obat tradisional. Beberapa warga, kadang menggunakan tanaman-tanaman tersebut untuk mengobati keluhan kesehatan yang dirasakan, namun pemanfaatannya belum terlalu optimal karena selama ini penggunaan tanaman obat tradisional itu hanya didasarkan pada pendapat teman atau tetangga. Kegiatan penyuluhan telah dapat dilakukan dengan baik pada hari Minggu, tanggal 14 Agustus 2022. Hal ini terlihat dari keseriusan peserta dan sesi Tanya jawab yang terlihat manyarakat begitu antusias dengan menayakan beberapa pertanyaan. Penggunaan obat tradisional dalam mengatasi masalah kesehatan masyarakat merupakan solusi alternative terutama bagi masyarakat di desa yang memiliki tanah subur dan tanaman melimpah. Kemanjuran tanaman obat dalam mengatasi penyakit telah terbukti secara turun temurun dan telah direkomendasikan oleh pemerintah dan WHO.
Pemeriksaan Kesehatan Dan Edukasi Kesehatan Masyarakat Desa Kamal Dalam Upaya Mengontrol Kadar Gula Darah Aggustin, Ayu Tri; Wijaya, Anas Fadli; Muflihah, Ahdiah Imroatul; Hidayati, Sholihatil
PRAXIS: Jurnal Pengabdian kepada Masyarakat Vol. 2 No. 3 (2024): PRAXIS
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47776/praxis.v2i3.943

Abstract

This community service activity is a form of effort to support the government program "Healthy Communities that are Independent and Just. The target subjects for partners in this community service activity are the people in Kamal Village, Arjasa District, and Jember Regency. Preliminary studies have been carried out and show that the incidence rate in the village is very high. Thus, health checks and health promotion in an effort to control blood sugar levels through the use of natural germplasm are very necessary. The health checks that will be carried out include random blood sugar checks (GDS). The education provided can include understanding the causes, signs and symptoms, risk factors, and types of healthy nutrition to prevent and control complications of diabetes mellitus. Early screening can be done by carrying out laboratory examinations in the community. After the examination, it was discovered that some people experienced hyperglycemia and some experienced hypoglycemia. Through this activity, the public can understand the material presented and can find out their health status so that early prevention can be carried out.
Co-Authors Aggustin, Ayu Tri Agustin, Ayu Tri AHDIAH IMROATUL MUFLIHAH Amalia, Nabila Anas Fadli Wijaya Angger Putri M. Soleh, Ayu Anggitasari, Wima Anggraeni, Linda Suci Any Guntarti Asista Indarusanti, Delvia Atmanegara, Stivani Yanti Ayu Susanti, Dhina Ayu Wulandari Citra Ariani Edityaningrum, Citra Dina Trianggaluh Fauziah Fifteen Aprila Fajrin Hariani Nurjanah, Mutia Hayati, Farhatul Istiqomah Hariyanto Kalyana Meta, Nilanda Laela Hayu Nurani Martina, Ina Moch Saiful Bachri Mohammad Rofik Usman Mufidah, Hartalina Muhammad Ma'ruf Nabila, Talitha Vanian Nur Jazilah, Nur Permatasari, Shafira Restu Purwati, Aliyah Putra, Zulkarnain Permana RIAN ANGGIA DESTIAWAN Rini Sulistyawati Rini, Dina Mustika Rizka Handayani Rizki Amelia Salsa Safitri, Avrillia Sandi Basuki, Aditya Occy Sati, Wima Anggita Shinta Mayasari Siti Aisyah Soleh, Ayu angger Putri M. sufi, Queen Nurul Sulistyorini, Dwi Agustin Susanti, Dhina Ayu Swastika, Melur Tri Tania, Larisa Wima Anggitasari