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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of Biomedicine and Translational Research MEDISAINS Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science
Widianti, I Gusti Ayu
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Analisis Bibliometrik : Mekanisme Aksi dan Efektifitas Flavonoid Terhadap Gagal Ginjal Mathar, Muhammad Ashhabul Kahfi; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Widianti, I Gusti Ayu
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.19-28

Abstract

Flavonoids have strong antioxidant properties, which can reduce cell damage that can worsen kidney function. By reducing cellular oxidation, flavonoids help protect the kidneys from damage and inflammation that can lead to kidney failure. In addition, flavonoids also have anti-inflammatory properties to reduce chronic inflammation in the kidneys. Inflammation plays a key role in diseases such as kidney injury, diabetes, asthma, cardiovascular disease and cancer. Diet can affect various stages of inflammation and can have a significant impact on several inflammatory diseases. Increasing scientific evidence suggests that polyphenolic compounds, such as flavonoids, found in fruits, vegetables, nuts, or chocolate, can have anti-inflammatory properties. This reason clearly proves the importance of flavonoid antioxidant activity in inflammation therapy. The method used in this literature review is a bibliometric analysis by searching data through the PubMed database, and Google Scholar and Scopus. The search results of 10 appropriate journals, found that flavonoid compounds can inhibit regulatory enzymes or transcription factors that are important for controlling mediators involved in inflammation. 
Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging Suyanto, Maria Veronica Putri; Widianti, I Gusti Ayu
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.346-359

Abstract

The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.
Administration of Ethanol Extract of Black Soybean Seeds (Glycine max (L.) Merr.) on the Number of Ovarian Tertiary Follicles and Serum Estradiol Levels in Wistar-Strain Rats (Rattus novergicus) Exposed to Cigarette Smoke Widjaja, Danielle Karen; Ruma, I Made Winarsa; Widianti, I Gusti Ayu
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.26755

Abstract

Background: Premature ovarian insufficiency is ovarian aging that occurs before the age of 40, with a global prevalence of 1.1%. Premature ovarian insufficiency can be induced by environmental exposures, particularly through free radicals generated by cigarette smoke.Objective: The purpose of this study was to prove that the administration of ethanol extract of black soybean (Glycine max (L.) Merr.) can inhibit the decrease in ovarian tertiary follicle count and serum estradiol levels in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.Methods: This research is an experimental study with a post-test-only control group design involving 30 Wistar-strain rats (Rattus norvegicus) that met the inclusion criteria. The rats were divided into five groups: group N (normal), group K (control), and group P1-P3 which received black soybean seed extract (Glycine max (L.) Merr.) at doses of 375 mg/kgBW (P1), 750 mg/kgBW (P2), and 1500 mg/kgBW (P3) administered orally via gavage every day for 28 days. The control group and treatment groups were exposed to cigarette smoke, after the administration of the extract, for 2 hours per day, 5 days a week, for 28 days. Serum estradiol levels (ng/L) were measured using the ELISA method, and ovarian tissue samples were collected for counting the number of ovarian tertiary follicles.Results: There was a significant difference in serum estradiol levels (p < 0,001), with the highest serum estradiol level observed in Group P1 (564.4 ± 74.28) and the lowest in Group K (116,7 ± 38,01).  There was no significant difference in the number of ovarian tertiary follicles (p=0,645).Conclusion: The ethanol extract of black soybean seeds (Glycine max (L.) Merr.) at a dose of 375 mg/kg BW significantly inhibits the decrease in estradiol levels but did not affect the number of ovarian tertiary follicles in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.
Protective effects of Gyrinops versteegii leaf ethanol extract on Leydig cells and testosterone under excessive physical activity: an in vivo study Widianti, I Gusti Ayu; Wardana, Nyoman Gede; Widhiartini, Ida Ayu Alit; Pratiwi, Made Sindy Astri; Antari, Ni Wayan Sukma
MEDISAINS: Jurnal Ilmiah Ilmu-Ilmu Kesehatan Vol. 24 No. 1 (2026)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v24i1.28611

Abstract

Background: Excessive physical activity may lead to overtraining syndrome and increased oxidative stress, which can reduce Leydig cell count and testosterone levels. Gaharu (Gyrinops versteegii) leaf ethanol extract contains strong antioxidants that may counteract oxidative damage. However, the effects of excessive physical activity on Leydig cells and testosterone remain unexplored. Purpose: This study aimed to evaluate the protective effects of Gyrinops versteegii leaf ethanol extract on male reproductive parameters under excessive physical activity conditions. Methods: This experimental study employed a randomized, post-test control-group design. Twenty-five adult male Wistar rats were divided into five groups: normal control, excessive physical activity control, and three treatment groups receiving Gyrinops versteegii leaf ethanol extract at 100, 200, and 400 mg/kg BW. Leydig cell counts and serum testosterone levels were analyzed using ANOVA and correlation tests. Results: The highest Leydig cell count and testosterone level were observed in the 200 mg/kgBW group (28.92 cells and 1.822 ng/mL, respectively). Significant differences in Leydig cell counts were observed among groups (p<0.001), and a positive correlation between Leydig cell number and testosterone levels was observed (p=0.006). Conclusion: Gyrinops versteegii leaf ethanol extract demonstrated protective effects against reproductive impairment induced by excessive physical activity in vivo, with an optimal dose of 200 mg/kgBW.
Co-Authors Alamsyah, Ajib Zaim Aldri Frinaldi Bagus Komang Satriyasa Cahyani, A.A. Istri Nanda Pramesthi Chandra, Indah Mutia Edelweishia, Melissa I Nyoman Gede Wardana I Nyoman Mangku Karmaya I.A.A. Widhiartini Ida Ayu Ika Wahyuniari Irawan, Angeline Aprilia J. A. Pangkahila Kurniawan, Yukhi Laksmi, A. A. Ayu Widya Muhammad Ashhabul Kahfi Mathar Muliani . Muliani Muliani, Muliani Ni Made Linawati Ni Wayan Sukma Antari Pradnyandari, A. A. Ayu Vidya Pratiwi, Made Sindy Astri Ruma, I Made Winarsa Sitepu, Amanda Viani Maria Suyanto, Maria Veronica Putri Vanesa, Adeleida Sarah Wardana, Nyoman Gede Widjaja, Danielle Karen Wijaya Surya, I Gede Ngurah Harry Wiraputri, A. A. Wulanatalia