Article Per Year (5 Year)
p-Index From 2020 - 2025
2.255
P-Index
This Author published in this journals
All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science Jurnal Ners
Widianti, I Gusti Ayu
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

Published : 13 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 13 Documents
Search

 1   2 
Pengaruh Ekstrak Etanol Kubis Ungu terhadap Kadar Malondialdehida, Superoksida Dismutase dan Derajat Steatosis Hati pada Tikus Model NAFLD Dewi, Ni Made Gita Kusuma; Sugiritama, I Wayan; Widianti, I Gusti Ayu; Wardana, I Nyoman Gede; Ernawati, Desak Ketut; Mayura, I Putu Bayu
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.43013

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) adalah gangguan hati kronis yang ditandai dengan akumulasi lemak berlebih dalam hepatosit dan berkaitan dengan sindrom metabolik. Stres oksidatif berperan dalam progresi NAFLD, dengan kadar malondialdehida (MDA) dan aktivitas superoksida dismutase (SOD) sebagai biomarker. Kubis ungu (Brassica oleracea var. capitata L.) memiliki kandungan antosianin tinggi yang bersifat antioksidan, namun efek hepatoprotektifnya terhadap NAFLD masih perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk mengevaluasi efek hepatoprotektif ekstrak etanol kubis ungu terhadap kadar MDA dan SOD serta derajat steatosis hati pada tikus Wistar jantan yang diinduksi dengan diet tinggi lemak dan karbon tetraklorida (CCl₄). Studi ini menggunakan desain post-test only control group dengan empat kelompok: kontrol negatif dan tiga kelompok perlakuan yang menerima ekstrak etanol kubis ungu dengan dosis 100 mg/kg BB, 200 mg/kg BB, dan 400 mg/kg BB. Analisis menggunakan ANOVA dan uji post-hoc Tukey HSD menunjukkan bahwa ekstrak kubis ungu secara signifikan mencegah peningkatan kadar MDA (p < 0,05), mencegah penurunan aktivitas SOD (p < 0,05), serta mencegah peningkatan derajat steatosis, dengan dosis paling efektif 200 mg/kg BB. Hasil ini menunjukkan bahwa ekstrak etanol kubis ungu memiliki efek hepatoprotektif dan berpotensi sebagai agen terapeutik alami untuk pencegahan NAFLD.
Analisis Bibliometrik : Mekanisme Aksi dan Efektifitas Flavonoid Terhadap Gagal Ginjal Mathar, Muhammad Ashhabul Kahfi; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Widianti, I Gusti Ayu
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.19-28

Abstract

Flavonoids have strong antioxidant properties, which can reduce cell damage that can worsen kidney function. By reducing cellular oxidation, flavonoids help protect the kidneys from damage and inflammation that can lead to kidney failure. In addition, flavonoids also have anti-inflammatory properties to reduce chronic inflammation in the kidneys. Inflammation plays a key role in diseases such as kidney injury, diabetes, asthma, cardiovascular disease and cancer. Diet can affect various stages of inflammation and can have a significant impact on several inflammatory diseases. Increasing scientific evidence suggests that polyphenolic compounds, such as flavonoids, found in fruits, vegetables, nuts, or chocolate, can have anti-inflammatory properties. This reason clearly proves the importance of flavonoid antioxidant activity in inflammation therapy. The method used in this literature review is a bibliometric analysis by searching data through the PubMed database, and Google Scholar and Scopus. The search results of 10 appropriate journals, found that flavonoid compounds can inhibit regulatory enzymes or transcription factors that are important for controlling mediators involved in inflammation. 
Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging Suyanto, Maria Veronica Putri; Widianti, I Gusti Ayu
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.346-359

Abstract

The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.
Co-Authors Alamsyah, Ajib Zaim Aldri Frinaldi Bagus Komang Satriyasa Cahyani, A.A. Istri Nanda Pramesthi Chandra, Indah Mutia Desak Ketut Ernawati Dewi, Ni Made Gita Kusuma Edelweishia, Melissa I Nyoman Gede Wardana I Nyoman Mangku Karmaya I Putu Bayu Mayura, I Putu Bayu I Wayan Sugiritama Ida Ayu Ika Wahyuniari Irawan, Angeline Aprilia J. A. Pangkahila Kurniawan, Yukhi Laksmi, A. A. Ayu Widya Muhammad Ashhabul Kahfi Mathar Muliani . Muliani Muliani, Muliani Ni Made Linawati Pradnyandari, A. A. Ayu Vidya Sitepu, Amanda Viani Maria Suyanto, Maria Veronica Putri Vanesa, Adeleida Sarah Wijaya Surya, I Gede Ngurah Harry Wiraputri, A. A. Wulanatalia