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All Journal E-Jurnal Medika Udayana Jurnal Ilmu Kedokteran (Journal of Medical Science) Journal of Biomedicine and Translational Research Universa Medicina Indonesian Journal of Obstetrics & Gynecology Science Journal of Social Research
Widianti, I Gusti Ayu
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Analisis Bibliometrik : Mekanisme Aksi dan Efektifitas Flavonoid Terhadap Gagal Ginjal Mathar, Muhammad Ashhabul Kahfi; Linawati, Ni Made; Wahyuniari, Ida Ayu Ika; Widianti, I Gusti Ayu
Jurnal Ilmu Kedokteran Vol 19, No 1 (2025): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v19i1.2025.19-28

Abstract

Flavonoids have strong antioxidant properties, which can reduce cell damage that can worsen kidney function. By reducing cellular oxidation, flavonoids help protect the kidneys from damage and inflammation that can lead to kidney failure. In addition, flavonoids also have anti-inflammatory properties to reduce chronic inflammation in the kidneys. Inflammation plays a key role in diseases such as kidney injury, diabetes, asthma, cardiovascular disease and cancer. Diet can affect various stages of inflammation and can have a significant impact on several inflammatory diseases. Increasing scientific evidence suggests that polyphenolic compounds, such as flavonoids, found in fruits, vegetables, nuts, or chocolate, can have anti-inflammatory properties. This reason clearly proves the importance of flavonoid antioxidant activity in inflammation therapy. The method used in this literature review is a bibliometric analysis by searching data through the PubMed database, and Google Scholar and Scopus. The search results of 10 appropriate journals, found that flavonoid compounds can inhibit regulatory enzymes or transcription factors that are important for controlling mediators involved in inflammation. 
Protective role of melatonin in ultraviolet radiation- induced oxidative stress in human skin photoaging Suyanto, Maria Veronica Putri; Widianti, I Gusti Ayu
Universa Medicina Vol. 42 No. 3 (2023)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2023.v42.346-359

Abstract

The ultraviolet radiation of the sun that reaches the earth is made up of ultraviolet A (95%) and ultraviolet B (5%). Exposure to ultraviolet radiation (UVR) is the main factor in photoaging. Chronic exposure to sunlight acts as an environmental stressor, leading to oxidative damage or stress. Oxidative damage stimulates the accumulation of free radicals, such as reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are responsible for premature skin aging. Photoaged skin is characterized externally by irregular pigmentation, wrinkles, and reduced skin elasticity, and internally by the breakdown of dermal collagen and elastin. Free radicals can be scavenged and the skin can be protected from further oxidative damage by antioxidants. Melatonin is a hormone produced mainly by the pineal gland, as well as many other organs, including the skin. One of the functions of melatonin is exerted by the antioxidative melatoninergic system to prevent ultraviolet (UV)-induced skin photoaging. The aim of this review was to study the protective effect of melatonin on skin photoaging resulting from UVR exposure. The references were tracked using various databases, such as Google Scholar and PubMed with regard to publications in English for the last 5 years (2019-2023). Melatonin inhibits UVR-induced aging in multiple ways, such as protecting skin cells, binding free radicals, accelerating the activity of antioxidant enzymes, preventing increased mitochondrial membrane permeability, and assisting electron transport efficiency in the mitochondrial respiratory chain. Exogenous application of melatonin is usually by the oral route, but for localized effects on the skin, topical administration is recommended, with consideration of preparations with a better half-life and bioavailability. Understanding the protective antioxidant function of melatonin in UV-induced skin photoaging helps to optimize its application. The protective properties of melatonin against UVR-oxidative stress-induced photoaging will be further explored in this review.
The Relationship Between Knowledge And Preventive Behavior of Adhesive Capsulitis In Fried Rice Vendors In Denpasar City, Bali Province Widianti, I Gusti Ayu; Purantara, Anak Agung Ayu Tri Pradnya; Yuliana, Yuliana; Wirata, Gede
Journal of Social Research Vol. 5 No. 2 (2026): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v5i2.3007

Abstract

The culinary business, including fried rice vendors, had the potential to experience musculoskeletal complaints such as adhesive capsulitis (frozen shoulder), which was triggered by the lack of movement in the passive shoulder or movements inversely proportional to the activity of the opposite shoulder during work. Adhesive capsulitis was characterized by pain, stiffness, and loss of shoulder range of motion. Early management was important to prevent the disease from progressing to the frozen phase. A high level of knowledge could help an individual apply disease prevention behavior. This study aimed to analyze the relationship between knowledge and preventive behavior regarding adhesive capsulitis in the shoulders of cart-based fried rice vendors in Denpasar City, Bali Province. The research used an observational analytic design with a cross-sectional approach. The sample consisted of 40 cart-based fried rice vendors, selected using the purposive sampling technique. Data were collected through questionnaires and interviews. Data analysis was performed using the Spearman correlation test because the data scale was ordinal. The majority of respondents had a low level of knowledge (50.0%) and low preventive behavior (55.0%). The Spearman correlation test showed a significant (p=0.000), very strong (r=0.828), and unidirectional relationship between knowledge and preventive behavior regarding adhesive capsulitis. The conclusion of the study was that there was a significant, strong, and unidirectional relationship between knowledge and preventive behavior regarding adhesive capsulitis of fried rice vendors in Denpasar City, Bali Province.
Administration of Ethanol Extract of Black Soybean Seeds (Glycine max (L.) Merr.) on the Number of Ovarian Tertiary Follicles and Serum Estradiol Levels in Wistar-Strain Rats (Rattus novergicus) Exposed to Cigarette Smoke Widjaja, Danielle Karen; Ruma, I Made Winarsa; Widianti, I Gusti Ayu
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.26755

Abstract

Background: Premature ovarian insufficiency is ovarian aging that occurs before the age of 40, with a global prevalence of 1.1%. Premature ovarian insufficiency can be induced by environmental exposures, particularly through free radicals generated by cigarette smoke.Objective: The purpose of this study was to prove that the administration of ethanol extract of black soybean (Glycine max (L.) Merr.) can inhibit the decrease in ovarian tertiary follicle count and serum estradiol levels in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.Methods: This research is an experimental study with a post-test-only control group design involving 30 Wistar-strain rats (Rattus norvegicus) that met the inclusion criteria. The rats were divided into five groups: group N (normal), group K (control), and group P1-P3 which received black soybean seed extract (Glycine max (L.) Merr.) at doses of 375 mg/kgBW (P1), 750 mg/kgBW (P2), and 1500 mg/kgBW (P3) administered orally via gavage every day for 28 days. The control group and treatment groups were exposed to cigarette smoke, after the administration of the extract, for 2 hours per day, 5 days a week, for 28 days. Serum estradiol levels (ng/L) were measured using the ELISA method, and ovarian tissue samples were collected for counting the number of ovarian tertiary follicles.Results: There was a significant difference in serum estradiol levels (p < 0,001), with the highest serum estradiol level observed in Group P1 (564.4 ± 74.28) and the lowest in Group K (116,7 ± 38,01).  There was no significant difference in the number of ovarian tertiary follicles (p=0,645).Conclusion: The ethanol extract of black soybean seeds (Glycine max (L.) Merr.) at a dose of 375 mg/kg BW significantly inhibits the decrease in estradiol levels but did not affect the number of ovarian tertiary follicles in Wistar strain rats (Rattus norvegicus) exposed to cigarette smoke.
Co-Authors Alamsyah, Ajib Zaim Aldri Frinaldi Bagus Komang Satriyasa Cahyani, A.A. Istri Nanda Pramesthi Chandra, Indah Mutia Edelweishia, Melissa Gede Wirata I Nyoman Gede Wardana I Nyoman Mangku Karmaya Ida Ayu Ika Wahyuniari Irawan, Angeline Aprilia J. A. Pangkahila Kurniawan, Yukhi Laksmi, A. A. Ayu Widya Muhammad Ashhabul Kahfi Mathar Muliani . Muliani Muliani, Muliani Ni Made Linawati Pradnyandari, A. A. Ayu Vidya Purantara, Anak Agung Ayu Tri Pradnya Ruma, I Made Winarsa Sitepu, Amanda Viani Maria Suyanto, Maria Veronica Putri Vanesa, Adeleida Sarah Widjaja, Danielle Karen Wijaya Surya, I Gede Ngurah Harry Wiraputri, A. A. Wulanatalia Yuliana Yuliana