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All Journal Jurnal Pelita Pendidikan Biology, Medicine, & Natural Product Chemistry JURNAL PENDIDIKAN TAMBUSAI Bioscientist : Jurnal Ilmiah Biologi Continuous Education : Journal of Science and Research BIO-CONS: Jurnal Biologi dan Konservasi Journal of Managerial Sciences and Studies
Pranoto, Hendro
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Education Energy Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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The Ameliorative Effect of Apigenin in Plectranthus amboinicus Lour Spreng in the Treatment of Hepato-renal Carcinogenesis Induced Benzo(a)pyrene Silitonga, Melva; Pranoto, Hendro; Sinaga, Erlintan; Sipahutar, Feimmy Ruth Pratiwi; LumbanGaol, Adriana Yulinda Dumaria; Sinaga, Fajar Apollo
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1483-1490

Abstract

Benzo(a)pyrene (B(a)P) is the major cause of hepato-renal carcinogenesis. Apigenin in Plectranthus amboinicus (EPA), has indicated some biological activities such as antioxidant and antimutagenic activity. The aim of this study is to investigate the potential of apigenin in EPA as anti-cancer against chronic hepatorenal damage exposed to B(a)P. The rats of 4 groups (n=6) were divided as follows: Group I (P0) was given food and water ad-libitum; Group II (PB) was administered orally B(a)P 2 mg/kg BW; Group III (PB+E) received orally B(a)P 2 mg/kg BW and EPA 500 mg/kg; Group IV (PE) was administered orally EPA 500 mg/kg BW. The therapeutic effect of EPA was explored using network pharmacology and molecular docking. The results showed that Group III could significantly improve (P < 0.05) the hepatorenal function parameter, including DNA concentration. SGPT, SGOT, blood urea nitrogen, and creatinine compared to those treated with B(a)P. The outcome data pharmacology revealed 6 targets could be the main core target. The good binding affinity indicated Apigenin docked to AKT1 protein with -10.00 kcal/mol relevant to Doxorubicin as control drug. Our results provide a new insight of apigenin in EPA potentially suppressing the regulation of chemical carcinogenesis by B(a)P.
Co-Authors Aryeni Aryeni, Aryeni Fauziyah Harahap Febriyanti, Angelica GS , Achmad Daengs Hasibuan, Virda Kartika Lintiyaningrum, Indriyani Lubis, Khairiza Lumbangaol, Adriana Yulinda Dumaria Mahzura, Jihan Pradita Melva Silitonga Selvia Dewi Pohan Sinaga, Erlintan Sipahutar, Feimmy Ruth Pratiwi Sugeng Santoso Toni, Heri Wasesa, Tjandra Widya, Poppy Andra Windah, Putri Wiratna Zuhro, Diana