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Riswan, Muhammad
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Religion Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Other

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Effect of Hydroxychloroquine Therapy on Hematology and Ocular Manifestations of Systemic Lupus Erythematosus Patients Muhsin, Muhsin; Sylvawani, Mahriani; Abdullah, Vera; Nilawati, Enny; Riswan, Muhammad; Abdullah, Abdullah; Syukri, Maimun
eJournal Kedokteran Indonesia Vol. 13 No. 3 (2025): Vol. 13 No. 3 - Desember 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.1181.1

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects women and has various clinical manifestations involving multiple organs. The use of hydroxychloroquine (HCQ) provides some advantages. This study aimed to analyze hematological and ocular effects following short-term HCQ administration in SLE patients. A cross-sectional study was conducted from April to July 2022 at Zainoel Abidin Hospital, Banda Aceh, Indonesia, involving 23 female SLE patients. Blood laboratory parameters were assessed, and an ophthalmologist performed ocular examinations. The study showed an average hemoglobin of 11.6 g/dL. Other blood laboratory results were within normal limits. The mean duration of SLE diagnosis and HCQ use was 21.0 months and 9.7 months, respectively. There was no correlation between HCQ use duration and hematological parameters (hemoglobin, leukocytes, and thrombocytes; p values 0.38, 0.14, and 0.62, respectively). This study showed that only one SLE patient taking HCQ for less than five years had ocular problems. The prevalence of ocular and hematological effects in SLE patients treated with HCQ for less than five years is minimal.
Co-Authors . Roslidar Abdullah Abdullah Abdullah, Vera Adnan, Nazeli Andaiyani, Sri Ashar Ashar Azzaki Abubakar, Azzaki Bahrul Ulum Bambang Iswanto Driyo, Cipto Driyo Fahrudin, Adinandra Caesar Fananda, Fathurrahman Fauzi Yusuf, Fauzi Haris, Atikatu Putri Ibadurrahman Ibadurrahman Kalew, Ariel Caturputra Kurniawan, Yan Hendra Maghfirah, Desi Maimun Syukri, Maimun Mufaizin Muhsin Muhsin Naury, Chairullah Nilawati, Enny Novianty, Alda Novrilianti , Gracela Pratama, Gusva Rafi’i, Muhammad Rahman, Bayu Abdiar Ridha, Jamalur Saddami, Khairun Septya Maharani, Septya Sylvawani, Mahriani Widianto, Eri Yunisvita, Yunisvita