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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmagazine Jurnal Ilmiah Medicamento Poltekita: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Usadha Borneo Journal of Pharmacy
RR. Asih Juanita
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Edukasi Perilaku Hidup Sehat di Era Normal Baru Menggunakan Audiobook bagi Penyandang Disabilitas Sensorik Netra Dwi Arymbhi Sanjaya; Herleeyana Meriyani; RR. Asih Juanita; Nyoman Budiartha Siada
Poltekita: Jurnal Pengabdian Masyarakat Vol. 3 No. 4 (2022): Oktober - Desember
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (733.96 KB) | DOI: 10.33860/pjpm.v3i4.1136

Abstract

COVID-19 and changes in the health order in the new normal era have led to health problems, especially in blind people. Blind people have more difficulty accessing and getting health information. Good quality education and providing information with appropriate media are very important to improve a healthy lifestyle in the new normal era. Education and information about the healthy lifestyle in a new normal era with an audiobook aimed to improve knowledge about the healthy lifestyle in the new normal era at Dria-Raba Foundation. The method in this activity was to provide knowledge about the healthy lifestyle in new-normal using the audiobook to 23 blind people at Dria-Raba Foundation. A pre-test and post-test were analyzed using the Wilcoxon signed-rank test to evaluate the efficacy of the audiobook. The result showed a significant increase in knowledge from a score of 70 to 80 (p<0.05), thus education using the audiobook for blind people at the Dria-Raba Foundation to increase knowledge about a healthy lifestyle in new-normal. To improve the health quality of blind people, various types of audiobooks on health topics can be created. ABSTRAK Adanya pandemi Coronavirus Disease (COVID-19) dan perubahan tatanan kesehatan di era normal baru menyebabkan masalah terkait kesehatan yang dihadapi oleh penyandang disabilitas sensorik netra menjadi semakin kompleks. Penyandang disabilitas sensorik netra sulit untuk mendapatkan akses dan informasi tentang kesehatan. Dukungan berupa edukasi dan pemberian informasi dengan media yang sesuai menjadi sangat penting untuk memperbaiki perilaku hidup sehat di era normal baru. Pemberian edukasi terkait perilaku hidup sehat di era normal baru dengan menggunakan audiobook bertujuan untuk meningkatkan pengetahuan para penyandang disabilitas sensorik netra di Yayasan Dria-Raba tentang perilaku hidup sehat di era normal baru. Metode yang diterapkan dalam kegiatan pengabdian kepada masyarakat ini yaitu memberikan edukasi melalui audiobook kepada 23 orang penyandang disabilitas sensorik netra di Yayasan Dria-Raba. Untuk mengukur keberhasilan audiobook, dilakukan pre-test dan post-test yang kemudian dianalisis menggunakan uji Wilcoxon Signed-rank test. Hasil uji menunjukkan adanya peningkatan pengetahuan yang signifikan dari skor 70 menjadi 80 (p<0,05), sehingga dapat disimpulkan bahwa edukasi menggunakan audiobook bagi penyandang disabilitas sensorik netra di Yayasan Dria-Raba mampu meningkatkan pengetahuan para penyandang disabilitas sensorik netra tentang perilaku hidup sehat di era normal baru. Dalam hal meningkatkan kualitas kesehatan bagi para penyandang disabilitas sensorik netra, diharapkan dapat diciptakan berbagai audiobook dengan tema kesehatan lainnya.
Kajian Literatur: Study Design Dalam Farmakoepidemiologi Untuk Mengetahui Resistensi Bakteri Terhadap Antibiotik Herleeyana Meriyani; Dwi Arymbhi Sanjaya; Rr Asih Juanita; Nyoman Budiartha Siada
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 1 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i1.61651

Abstract

Penelitian terkait resistensi bakteri terhadap antibiotik dapat dilakukan dengan berbagai study design. Study design merupakan salah satu titik kritis dalam penelitian resistensi bakteri terhadap antibiotik. Penelitian ini bertujuan untuk memberikan gambaran kelebihan dan kekurangan dari study design yang digunakan dalam penelitian farmakoepidemiologi tentang resistensi bakteri terhadap antibiotik. Pencarian literatur dilakukan secara elektronik untuk artikel yang dipublikasikan tahun 2011 hingga 30 Juni 2021 pada basis data EBSCO, Plos One, Proquest, PubMed, ScienceDirect, dan Google Scholar. Kriteria inklusi meliputi original article dengan desain cohort (prospective dan retrospective), case control, cross-sectional dan ecological study; memiliki Digital Object Identifier (DOI); dipublikasi 10 tahun terakhir; serta mengunakan Bahasa Inggris. Artikel dalam bentuk review, tidak merupakan full text, dan artikel dengan jumlah sampel penelitian yang tidak jelas tidak disertakan dalam kajian ini. Artikel yang terkumpul dari 6 database sejumlah 209 artikel (EBSCO 45 artikel, Plos One 42 artikel, ProQuest 32 artikel, PubMed 68 artikel, ScienceDirect 19 artikel dan Google Scholar 3 artikel). Duplikasi artikel dieksklusi (29 artikel). Artikel tidak memenuhi kriteria inklusi (86 artikel), 64 artikel tidak relavan dengan tujuan penelitian, sehingga diperoleh 30 artikel dalam studi ini. Rancangan penelitian pada penelitian ini yaitu case-control (2 artikel), cohort-prospective (14 artikel), cohort-retrospective (5 artikel), cross-sectional (8 artikel) dan ecological study (1 artikel). Masing-masing rancangan memiliki kelebihan dan kekurangannya masing-masing. Pemilihan desain studi dalam penelitian resistensi bakteri terhadap antibiotik dilakukan sesuai dengan tujuan penelitian, jenis paparan yang diamati, jenis outcome serta tipe penelitian (comparative, correlative study) serta ketersediaan sumber daya dalam melakukan penelitian resistensi bakteri terhadap antibiotik.
Blush-On Compact Powder dengan Pewarna Alami dari Ekstrak Etanol Kulit Buah Naga (Hylocereus Lemairei) Ni Made Dharma Shantini Suena; Rr. Asih Juanita; Ni Putu Udayana Antari
Jurnal Penelitian Pendidikan IPA Vol 9 No 5 (2023): May
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i5.2445

Abstract

Cosmetics are one of the women's basic needs, but several cosmetic products on the market use synthetic dyes such as Rhodamine B, which cause various risks dangerous to health. Natural dyes are non-toxic, renewable, and environmentally friendly, one of which is anthocyanins found in dragon fruit peel. Blush-on is a cosmetic containing a dye that women often use. This study aimed to determine that the dragon fruit peel ethanolic extract can be used as a natural dye in blush-on compact powder preparations with good physical quality. Blush-on was made with various concentrations of dragon fruit peel ethanol extract of 20% (F1), 25% (F2), and 30% (F3). The preparations were observed for organoleptic and homogeneity, pH value, friability, and hedonic test during four weeks of storage, with descriptive data analysis. The results showed that dragon fruit peel extract blush-on did not meet some of the physical quality test requirements for blush-on. It is because the color of the blush-on should be red. However, the color of the preparation is white to brownish, and the preparation is also fragile. The preparation meets the requirements of homogeneity and pH value according to the physiological pH of the skin. It remains stable for four weeks of storage. F1 is the most preferred by panelists based on a preference test for the preparation's shape, color, and odor. Dragon fruit peel extract blush-on has not yet fulfilled its function as a decorative cosmetic to give color to the skin
Tren Penggunaan Antibiotik dan Profil Resistensi pada Kelompok Critical-Priority Bacteria di ICU Rumah Sakit “X” Provinsi Bali (2017-2019) Dwi Arymbhi Sanjaya; Rr Asih Juanita; Herleeyana Meriyani; Nyoman Budiartha Siada; Komang Triani Lestari
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 8, No 3 (2023)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v8i3.71717

Abstract

Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, dan Escherichia coli merupakan kelompok critical-priority bacteria yang telah mengalami multi drug resistant (MDR) dan sering ditemukan di Intensive Care Unit (ICU). Isolat bakteri-bakteri berjumlah lebih dari 75% mengalami MDR di ICU sebuah rumah sakit umum daerah di Bali, Indonesia. Penggunaan antibiotik yang tinggi berkaitan dengan tingkat resistensi bakteri terhadap antibiotik. Pola resistensi bakteri terhadap antibiotik dapat berbeda di setiap wilayah yang disebabkan oleh adanya perbedaan lingkungan dan perbedaan tingkat penggunaan antibiotik di wilayah tersebut. Penelitian ini bertujuan untuk mengetahui tren penggunaan antibiotik sistemik, pola resistensi dan hubungan antara tingkat penggunaan dengan persentase resistensi bakteri terhadap antibiotik pada kelompok critical-priority bacteria di ICU rumah sakit “X” provinsi Bali. Penelitian ini merupakan penelitian ekologikal yang menggunakan data sekunder selama tahun 2017-2019. Analisis tren penggunaan antibiotik dianalisis menggunakan time series analysis. Hubungan antara tingkat penggunaan antibiotik dan persentase resistensi bakteri prioritas kritis dianalisis dengan regresi linier. Hasil penelitian menunjukkan bahwa antibiotik gentamisin, amikasin, dan siprofloksasin mengalami peningkatan tren penggunaan sedangkan ampisilin, ampisilin-sulbaktam, seftazidim, dan meropenem mengalami penurunan tren penggunaan. Time series analysis menunjukkan penggunaan antibiotik yang fluktuatif. Selain itu, didapatkan bahwa A. baumannii masuk dalam dua kategori fenotipik CDC yaitu, carbNS_Acine dan MDR_Acine sedangkan K. pneumoniae masuk dalam kategori ESCklebsiella. Tingkat penggunaan antibiotik sistemik di ICU dengan persentase resistensi E. coli, K. pneumoniae, dan P. aeruginosa di ICU (p<0,05) terdapat hubungan signifikan, tetapi tidak terdapat hubungan yang signifikan antara penggunaan antibiotik sistemik pada pasien di ICU dengan persentase resistensi bakteri A. baumannii (p>0,05).
Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Dwi Arymbhi Sanjaya; Nyoman Budiartha Siada; Rr Asih Juanita; I Putu Yudistira Mahaputra; Made Gek Adisti Kamalia; Herleeyana Meriyani
Pharmaciana Vol 14, No 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Abstract

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.
Kualitas Penggunaan Antibiotik pada Pasien Community-Acquired Pneumonia di Salah Satu Rumah Sakit di Bali Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr. Asih; Siada, Nyoman Budiartha
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7592

Abstract

Community-acquired pneumonia (CAP) is an infectious disease with high morbidity and mortality rates. Antibiotics are essential therapies for bacterial CAP. The use of antibiotics is a critical point in CAP treatment. Inappropriate use of antibiotics leads to antibiotic resistance. The study aimed to evaluate the proper use of antibiotics in CAP patients and identify the relationship between the appropriate use of antibiotics and the use of single/combined antibiotics with prolonged length of stay. This study was a cross-sectional study with retrospective data collection at a general hospital in Bali. Evaluation of the proper use of antibiotics was done using the Gyssens algorithm. The relationship between the appropriate use of antibiotics and the type of antibiotic (single/combined) with the length of stay was carried out using the Chi-square test with a 95% confidence interval. There were 151 CAP patients as samples in this study consisting of 55.63% men and 44.37% women with a median age of 60 years (18-89). The appropriate use of antibiotics was 17.88%, while 82.18% of the total antibiotic use was inappropriate. The Inappropriate use of antibiotics in category IIA (incorrect dosage) is 3.97%, category IIIB (inappropriate interval) is 4.64%, category IVC (cheaper alternative antibiotics were available) is 41.72%, and category V (no indication) is 37.79%. There is no significant relationship between the appropriate use of antibiotics and prolonged LOS [p>0.05; OR: 1.132 (CI: 0.466-2.746)] however the use of antibiotics (single or in combination) significantly affects the prolonged LOS [p<0.05; OR: 0.027 (CI: 0.004-0.204)].
Studi Retrospektif Penggunaan Antibiotik pada Pasien Covid-19 dengan Pneumonia di Rumah Sakit “X” Provinsi Bali, Indonesia Siada, Nyoman Budiartha; Juanita, Rr Asih; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana
Jurnal Ilmiah Medicamento Vol 10 No 1 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i1.7637

Abstract

COVID-19 with bacterial pneumonia co-infection is a condition with bacteria present in COVID-19 patients. The prevalence of bacterial co-infection in COVID-19 patients ranges from 12.4%–50%. This study aims to determine the relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia. This research is an observational study with a cross-sectional approach. Data collection was carried out retrospectively on medical record data of COVID-19 inpatients with pneumonia co-infection at Hospital "X" Bali Province, Indonesia for the period January - December 2021. The sampling technique used total sampling according to inclusion and exclusion criteria. Appropriate use of antibiotics antibiotic was analyzed using Pharmaceutical Care Network Europe (PCNE) version 9.1. The patient severity index was an assessment based on the Pneumonia Severity Index (PSI) score. The relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection was analyzed using Fisher's test. Of the 80 COVID-19 inpatients with pneumonia co-infection, 90% experienced inappropriate use of antibiotics. Fisher's test results showed that there was no significant relationship between the appropriate use of antibiotics and the severity of inpatients with COVID-19 and pneumonia co-infection at Hospital "X" Bali Province, Indonesia (p > 0.05).
Revitalisasi Kulit dengan Body Scrub Kulit Buah Naga Merah: Dampak Variasi Asam Stearat dan Perbandingan dengan Produk Komersial Suena, Ni Made Dharma Shantini; Juanita, Rr. Asih; Wardani, I Gusti Agung Ayu Kusuma; Antari, Ni Putu Udayana
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.9883

Abstract

The red dragon fruit peel (Hylocereus lemairei (Hook.) Britton & Rose) is rich in antioxidants like vitamins C, E, and A, along with alkaloids, terpenoids, flavonoids, saponins, and tannins, which protect against free radical damage. Despite its benefits, the peel is underused. This study compares the formulation and physical quality of a body scrub made from red dragon fruit peel extract to commercial products. Stearic acid was added to enhance consistency and stability, and commercial products served as benchmarks due to their compliance with physical, microbiological, and chemical standards. Formulations with stearic acid at 5% (F1), 10% (F2), and 15% (F3) were tested for physical quality—organoleptic properties, homogeneity, pH, adhesion, and spreadability—over 63 days as an intermediate time points, at controlled room temperature. Data were analyzed using SPSS Statistics 20 with a 95% confidence level (α = 0.05). Results showed that all formulations maintained a consistent pH of 6 and homogeneity. The adhesion properties were consistent across all formulas, showing no significant difference (p = 0.815; p > 0.05). In contrast, the spreadability exhibited a statistically significant difference between formulas (p = 0.001; p < 0.05). Stability tests revealed no significant differences in physical quality over time, indicating that the formulations remained stable. The body scrub formulated with red dragon fruit peel extract demonstrated stability and quality comparable to commercially available product. This ensures that the active ingredients in the body scrub remain potent, enabling them to effectively deliver their antioxidant properties to the skin.
Eribulin Effectiveness and Safety in Metastatic Triple-Negative Breast Cancer: A Narrative Review Meriyani, Herleeyana; Sanjaya, Dwi Arymbhi; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Chusna, Nurul; Ketupapa, Florentina Gabriela
Borneo Journal of Pharmacy Vol. 8 No. 1 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i1.7913

Abstract

Triple-negative breast cancer is an aggressive and poor prognosis subtype of breast cancer. Eribulin has shown promise in the treatment of metastatic triple-negative breast cancer (mTNBC). This review aimed to provide a specific description, evidence, and discussion of the efficacy and safety of eribulin both as monotherapy and in combination with another agent in patients with mTNBC. The search was conducted in five databases (PubMed, ScienceDirect, PLoS One, Wiley Online Library, and Cochrane Library) towards published articles during the 2013-2023 period. A total of 237 articles were identified. After removing 69 duplicates, 168 articles underwent the screening process and 10 articles met the research criteria. Eribulin monotherapy effectiveness profile includes: overall survival (10.8-17.6 months), progression-free survival (2.8-3.2 months), partial response (21.0%-58.7%), progressive disease (15.5% -47.0%), and stable disease (28.8%-32%). However, there were no cases of complete response. Combination of eribulin with other agents' effectiveness profiles includes: overall survival (8.3-14.5 months), PFS (2.6-8.1 months), partial response (31.8-76.0%), complete response (2.4-8%), progressive disease (8.0-28%), and stable disease (8.0-52.3%). Eribulin monotherapy's safety profile is similar to that of combination therapy. No grade 5 adverse event was reported during monotherapy or in combination with other agents. The grade 4 adverse events reported are neutropenia, leukopenia, thrombocytopenia, anemia, peripheral neuropathy, fatigue, diarrhea, vomiting, dyspnea, back pain, arthralgia, febrile neutropenia, dyspnea, constipation, general physical health deterioration, alopecia. The all-grade adverse events with a percentage above 50% are neutropenia, leukopenia, thrombocytopenia, asthenia, alopecia, elevated AST, elevated ALT, hand-foot syndrome, fatigue, anemia, peripheral neuropathy, oral mucositis, and nausea.
Cross-resistance to antibiotics of Escherichia coli in the inpatient installation of general regional hospital “X” Bali, Indonesia Mahaputra, I Putu Yudistira; Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr Asih; Siada, Nyoman Budiartha; Kamalia, Made Gek Adisti; Adrianta, Ketut Agus; Noviani, Lusy
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.29209

Abstract

Escherichia coli (E. coli) is a critical-priority group of MDR bacteria and its spread can occur in hospital inpatient settings. Several studies showed that antibiotics consumption for inpatients can cause E. coli resistance to other antibiotics called cross-resistance. The aim of this study to determine the cross-resistance in E. coli to antibiotics in the inpatient installation of the regional general hospital "X" in Bali, Indonesia by analyzing the relationship between the antibiotic consumption and the percentage of antibiotic resistance of E. coli. This research is an ecological study with the independent variable is the antibiotics consumption defined as defined daily doses/100 bed-days and the dependent variable is the percentage of E. coli resistance during 2017-2020. The correlation between the level of antibiotic consumption and the percentage of E. coli resistance to antibiotics was analyzed using the Pearson correlation tests. The results showed that the consumption of tetracycline had a significant correlation with increased resistance of E. coli to meropenem and piperacillin-tazobactam (r=0.8-1.0; p<0.05). This showed that there is cross-resistance in E. coli. This incident is associated with selective pressure, horizontal and vertical gene transfer in E. coli. The consumption of tetracycline, apart from inducing the production of the tet gene which is the cause of resistance to tetracycline, can also induce the production of resistance genes to broad-spectrum beta-lactam antibiotics such as piperacillin-tazobactam and meropenem.
Co-Authors Chusna, Nurul Debby Juliadi Dewi Agustini, Ni Putu Dwi A. Sanjaya Dwi Arymbhi Sanjaya Dwi Arymbhi Sanjaya Dwi Arymbhi Sanjaya Herleeyana Meriyani Herleeyana Meriyani Herleeyana Meriyani I Gede Made Suradnyana I Putu Yudistira Mahaputra Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Komang Triani Lestari Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Meriyani, Herleeyana Ni Made Dharma Shantini Suena Ni Putu Udayana Antari Ni Wayan Sutariani Noviani, Lusy Nyoman B. Siada Nyoman Budiartha Siada Nyoman Budiartha Siada Nyoman Budiartha Siada Putu Sukma Purnamasari Suradnyana, I Gede Made Triska Ananda Rahayu Wardani, I Gusti Agung Ayu Kusuma