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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Farmasi Klinik Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmagazine Jurnal Ilmiah Medicamento Poltekita: Jurnal Pengabdian Masyarakat Jurnal Pengabdian kepada Masyarakat Usadha Borneo Journal of Pharmacy
RR. Asih Juanita
Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Efektivitas dan Efek Samping pada Terapi Multi-Drug-Resistant Tuberculosis (MDR-TB): Kajian Literatur Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Noviani, Lusy
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9685

Abstract

Multi-drug-resistant tuberculosis (MDR-TB) leads to a reduced cure rate for tuberculosis treatment. The global number of MDR-TB cases remained relatively stable between 2015 and 2020 but increased in 2021. In 2020, the World Health Organization (WHO) estimated 437,000 MDR-TB cases worldwide, which rose to 450,000 cases in 2021. Various treatment regimens recommended by the WHO require a review of the literature on the efficacy and side effects of drug use in MDR-TB. This review aims to provide updated information that can be used as a reference for the early identification and management of side effects. The article was a narrative review that collected and analyzed information from various international articles on databases such as PubMed, PlosOne, and ScienceDirect from January 2014 to June 2024. A total of six relevant articles were synthesized from 609 articles. The effectiveness of MDR-TB therapy with WHO-recommended drugs has shown a high cure rate (cured>50%). The incidence of side effects in MDR-TB therapy is smaller compared to the effectiveness of treatment. However, a study conducted at Wuhan Jinyintan Hospital in China from July 2019 to December 2020 showed that all study subjects experienced side effects. This included nausea and vomiting from protionamide, gatifloxacin, and ethambutol; hyperuricemia from pyrazinamide, and hyperpigmentation from clofazimine. It is recommended that a therapy regimen be selected based on culture test results, patient conditions, and drug availability in each country.
Faktor-Faktor yang Mempengaruhi Lama Rawat Inap Pasien Dengue Hemorrhagic Fever di Salah Satu Rumah Sakit Umum Daerah di Bali Siada, Nyoman Budiartha; Juanita, Rr Asih
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.9852

Abstract

The World Health Organization (WHO) reported one to five million dengue infections from 2020 to 2022. According to Indonesian Health Profile data in 2020, the province of Bali had the highest Dengue Hemorrhagic Fever (DHF) Incidence Rate (IR), 273.1 morbidity, and a Case Fatality Rate (CFR) of 0.2%. The longer the patient's stay, the greater the costs are incurred for hospital treatment. Therefore, this study aims to analyze the factors influencing the length of stay of DHF patients with complications and comorbidities. This study was an observational study. Medical record data of DHF patients with complications and comorbidities were collected using a retrospective technique from January 2020 to December 2020 during hospitalization at a regional public hospital in Bali. The independent variables in this study include age, the severity of DHF, complications and comorbidities, and the amount of fluid therapy patients use during hospitalization. The dependent variable in this study is the patient's length of stay. The relationship between the independent and dependent variables was analyzed using logistic regression with a significance level set at p<0.05. There were 115 hospitalized DHF patients with complications and comorbidities, consisting of 52% males and 48% females. Most patients were in the age range of 6-11 years (43%). Based on the analysis that has been carried out, there is a factor that is significantly related to the length of stay of DHF patients, namely the use of the amount of fluid therapy (p=0.02). The findings of this study support the evaluation of DHF therapy, particularly in selecting the type and volume of fluids.
Penggunaan Antibiotik dan Resistensi Escherichia coli and Klebsiella pneumoniae: Studi Ekologikal Lima Tahun di Sebuah Rumah Sakit Umum Daerah Sanjaya, Dwi Arymbhi; Meriyani, Herleeyana; Juanita, Rr. Asih; Siada, Nyoman Budiartha; Mahaputra, Yudistira; Kamalia, Made Gek Adisti
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.11156

Abstract

Antibiotic resistance is a growing global health threat, partly driven by high antibiotic consumption. The World Health Organization (WHO) has identified critical-priority bacteria, including Escherichia coli and Klebsiella pneumoniae, due to their increasing resistance to multiple antibiotics. This study aimed to evaluate the correlation between antibiotic consumption and resistance rates in Escherichia coli and Klebsiella pneumoniae. This ecological study was conducted at a Regional Hospital in Indonesia based on retrospective inpatient data from January 2019 to December 2023. The population in this study is all data on systemic antibiotic consumption based on the J01 category of the Anatomical Therapeutic Chemical/Defined Daily Dose (ATC/DDD) classification system and antibiogram from inpatient databases. Pearson and Spearman’s rank correlation analyses were performed to examine the associations between systemic antibiotic consumption levels and the percentage of Escherichia coli and Klebsiella pneumoniae resistance to other antibiotics. The most frequently used antibiotics were cefixime (305.664 DDD/100 bed-days), levofloxacin (139.552 DDD/100 bed-days), and ceftriaxone (109.805 DDD/100 bed-days). A strong and statistically significant correlation was observed between doxycycline consumption and Escherichia coli resistance to meropenem (r=0.894; p=0.041). Moreover, consumption levels of cefazolin, ceftazidime, cefepime, and ciprofloxacin were correlated with Escherichia coli resistance to ceftriaxone (p<0.05), while cefoperazone use demonstrated a very strong and statistically significant correlation with Escherichia coli resistance to ampicillin-sulbactam (r=0.952; p=0.012). Conversely, no significant correlation was found between antibiotic consumption and resistance in Klebsiella pneumoniae, suggesting that alternative factors such as intrinsic resistance mechanisms, mobile genetic elements, and environmental reservoirs may influence resistance development.
Formulasi Dan Uji Mutu Fisik Sediaan Foot Lotion Ekstrak Etanol Daun Sirih (Piper bettle L.) Dengan Variasi Konsentrasi Asam Stearat Juliadi, Debby; Juanita, Rr Asih; Dewi Agustini, Ni Putu
Usadha Vol 2 No 1 (2023): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v2i1.6420

Abstract

Betel leaf extract (Piper bettle L.) is known to contain flavonoid compounds that have antibacterial activity. Betel leaf extract needs to be formulated as a foot preparation lotion to increase the comfort of use as a topical antibacterial. The composition of the emulsifier influences the physical stability of the preparation foot lotion used. This study aims to determine the variation of stearic acid preparations foot lotion, which has good physical quality and is stable in storage. This research is purely experimental laboratory research that aims at development (development), namely developing something in an existing field (development of test methods, drug formulation). The observed responses were the physical quality of the preparations, which included organoleptic tests, homogeneity tests, pH tests, spreadability tests, and adhesion tests. The physical quality of preparations of foot lotion was analyzed descriptively. This research began with a maceration process using 70% ethanol to obtain a thick betel leaf extract (Piper bettle L.). This study made three preparation formulas with foot lotion with stearic acid concentrations of 10%, 12.5%, and 15%. The preparations that have been made are then tested for their physical quality and stability during four weeks of storage. The results of this study indicate that the preparations obtained foot lotion betel leaf ethanol extract (Piper bettle L.) with a variation of stearic acid of 10% to produce preparations of foot lotion with good physical quality seen from organoleptic tests, homogeneity, pH, spreadability, and adhesion and stable in storage for four weeks.
Co-Authors Chusna, Nurul Debby Juliadi Dewi Agustini, Ni Putu Dwi A. Sanjaya Dwi Arymbhi Sanjaya Dwi Arymbhi Sanjaya Dwi Arymbhi Sanjaya Herleeyana Meriyani Herleeyana Meriyani Herleeyana Meriyani I Gede Made Suradnyana I Putu Yudistira Mahaputra Kamalia, Made Gek Adisti Ketupapa, Florentina Gabriela Ketut Agus Adrianta Komang Triani Lestari Made Gek Adisti Kamalia Mahaputra, I Putu Yudistira Mahaputra, Yudistira Meriyani, Herleeyana Ni Made Dharma Shantini Suena Ni Putu Udayana Antari Ni Wayan Sutariani Noviani, Lusy Nyoman B. Siada Nyoman Budiartha Siada Nyoman Budiartha Siada Nyoman Budiartha Siada Putu Sukma Purnamasari Suradnyana, I Gede Made Triska Ananda Rahayu Wardani, I Gusti Agung Ayu Kusuma