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All Journal E-Jurnal Medika Udayana Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Riset Kefarmasian Indonesia Jurnal Ilmiah Medicamento Media Farmasi Indonesia Usadha
Suradnyana, I Gede Made
Fakultas Farmasi Universitas Mahasaraswati Denpasar
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Formulasi Dan Uji Mutu Fisik Dari Granul Effervescent Ekstrak Daun Salam (Syzyginum polyanthum) Dewi, Ni Luh Samila; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7180

Abstract

  Bay leaf is one plant that has benefits as traditional medicine, acting as an antioxidant with flavonoid content. The processing is still very simple, which has an impact on the short shelf life of the herb. One alternative to prevent this is to formulat e bay leaf extract into effervescent granule preparations, which provide a more comfortable feeling with a large concentration of active substances. This study aims to determine the difference in the physical quality of effervescent granule preparations wit h variations of effervescent salts and to determine the concentration of acids and bases that produce effervescent granules of bay leaf extract with good physical quality. In 3 effervescent granule preparation formulas, the variation in acid and base concentrations (citric acid, tartric acid, and sodium bicarbonate) is F1 by 9.4%; 18.7%; 27%, F2 by 8.6%; 17.2%; 29%, and F3 by 7.9%; 15.8%; 31%. Physical quality evaluation of effervescent granule preparations includes organoleptis, flow velocity, rest angle, disperse time, pH, and moisture content. Quantitative data were analyzed with the One Way Anova test to determine the difference in physical quality of the three effervescent granule preparation formulas. Based on the results of physical quality tests, the three greenish-white granule formulas were obtained, the characteristic smell of bay leaf extract, and the granule form with a flow speed of 10 g / second, a stati onary angle in the range of 31-35 °, a dispersion time of < 5 minutes, a pH in the range of 5-6, and a moisture content of < 5 minutes. The results of One Way Anova testing found that the three formulas with variations of effervescent salts have different physical qualities, and acid-base concentrations that produce good physical qualities, namely F1 and F3
Formulasi dan Uji Mutu Fisik Sediaan Lip Balm Ekstrak Umbi Bit (Beta vulgaris L.) Tiarini, Diah Galuh; Suradnyana, I Gede Made; Juliadi, Debby
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7181

Abstract

Dry and chapped lips are one of the problems often faced by some people that will cause pain and discomfort. Lip balm is made from the main ingredient oil or fat that will provide moisture to the lips. The addition of color to lip balm preparations will add its own attractiveness, especially for women, because occasionally it can help improve facial aesthetics. Beetroot (Beta vulgaris L.) It is one of the plants that contains betacyanin pigment which has the potential as a natural dye and has very strong antioxidant activity. The purpose of this study was to determine whether there was a difference in the physical quality of lip balm preparations with variations in beetroot extract (Beta vulgaris L). This research is a laboratory study by formulating beetroot ethanol extract into lip balm preparations in 3 formulas with variations in extract concentration, namely formula I (6%), formula II (10%), and formula III (14%). Physical quality tests of the preparations observed are organoleptis, homogeneity, adhesion, and dispersion. Analysis of organoleptical data and homogeneity was carried out descriptively while the results of adhesion and dispersion tests were analyzed with inferential statistics using IBM SPSS statistics 26 at a 95% confidence level with the One-Way ANOVA test. The results of this study showed that there were differences in the physical quality of beetroot extract lip balm (Beta vulgaris L.) at a FI (6%) with a FII (10%) and FIII (14%) especially in the dosage color, adhesion, and spreadability.
Formulasi Dan Uji Mutu Fisik Sediaan Sabun Padat Dengan Penambahan Ekstrak Etanol Buah Pepaya (Carica papaya L.) Putra, Aditya; Sanjiwani, Ni Made Sukma; Suradnyana, I Gede Made; Dewi Agustini, Ni Putu
Usadha Vol 3 No 3 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i3.7296

Abstract

Papaya fruit contains secondary metabolite compounds such as saponins. The secondary metabolites needed in soap production are saponins. The purpose of this study was to determine whether the addition of ethanol extract of papaya fruit (Carica papaya L.) with concentrations of 2.4 and 6% in solid soap preparations can produce good physical quality and to determine the difference between formula 0 (without extract) and formula I, II and III (with extract concentrations of 2, 4 and 6%) in the physical quality obtained. This research is an experimental study, starting with making extracts formulated into solid soap form with variations in extract concentrations of 2.4 and 6%. The soap produced is white in formula 0 and formula I with an aria fragrance aroma. In contrast, formula II is yellow and formula III is orange with the aroma of papaya fruit ethanol extract and in the four formulas obtained a solid preparation. The homogeneity test results on all formulas are homogeneous. The pH test results obtained the lowest pH value in formula II and formula III with a pH value of 9 while the highest pH value was obtained in formula 0 with a pH value of 11. The test results of the height and stability of the foam obtained the highest foam height in formula III (7.43 cm) with foam stability of 66.82% while the lowest foam height was obtained in formula 0 (6.23 cm) with foam stability of 78.59%. The results of the physical quality test show that the soap meets homogeneous criteria, pH ranges from 9-11, has a foam height of 1.3-22 cm and foam stability between 60-90% in accordance with the requirements of SNI No. 3532-2016.
Kajian Etnofarmasi Kelompok Masyarakat Banjar Subamia Kelong, Tabanan Bali Perayanthi, Reni; Anita Dewi, Ni Luh Kade Arman; Kusuma Yuda, Putu Era Sandhi; Cahyaningsih, Erna; Vernandes Sasadara, Maria Malida; Suradnyana, I Gede Made; Sugiyanto, Milyadi
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7369

Abstract

  Bali is rich in culture and traditions passed down from generation to generation, especially in the ethnopharmacy aspect as a traditional medecine. This research aims to study ethnopharmacy aspects of the application of herbal plants as traditional medicine including plant parts, processing methods, indications, and usage of herbal plants in Banjar Subamia Kelong, Tabanan, Bali. This research was carried out using survey methods, direct observation in the field, and interviews. This research identified 20 types of plants that are generally used by the community in the Banjar Subamia Kelong. The plant parts generally used are leaves (60%), stems (15%), rhizomes (15%) and fruit (10%). Most of the plants are processed by boiling (60%). These medicinal plants are mostly used orally (65%), and the general indication is to treat joint problems, such as muscle pain and gout (25%).
Formulasi Dan Evaluasi Mutu Fisik Granul Ekstrak Etanol Kunyit Putih (Curcuma zedoaria) Dengan Variasi Konsentrasi Bahan Pengikat Polivinil Pirolidon Apriliani, Wayan; Juliadi, Debby; Suradnyana, I Gede Made
Usadha Vol 3 No 2 (2024): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v3i2.7578

Abstract

  White turmeric (Curcuma zedoaria) is a medicinal plant that Indonesian people widely use as a treatment for a disease. This plant is processed by blending it and serving it as a traditional medicine. However, the method of processing which is still very traditional allows errors in processing to make the efficacy of white turmeric not optimal, besides that the preparations that are processed cannot be used for a long time. Granule is a solid dosage form intended for oral use, the advantage of this preparation is the flexible dosage weight which allows for the formulation of large amounts of active ingredients such as most extracts. This study aims to obtain white turmeric ethanol extract granules with varying concentrations of polyvinyl pyrrolidone, namely 1%, 3%, and 5% which have good physical quality. The test results from this study showed that the physical quality of the preparation was good, in which the organoleptic preparation obtained was light yellow, smelled of orange aroma, and granular form. The granule compressibility test of the three formulas complied with the requirements because it was <20%. The granule flow rate test showed that the three formulas met the requirements, namely >10 gram/second. Test angle of repose of the three formula granules meet the requirements> 40o. The granule soluble time test showed that the three formulas met the requirements, namely <5 minutes and the granule water content test of the three formulas met the requirements, namely <5%. Polyvinyl pyrrolidone (PVP) binders with concentrations of 1%, 3%, and 5% produced good granules.
Formulasi dan Uji Stabilitas Krim Ekstrak Aseton Biji Alpukat Suradnyana, I Gede Made; Mendra, Ni Nyoman Yudianti; Juliadi, Debby; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 10 No 2 (2024): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v10i2.8728

Abstract

UV radiation can cause skin damage, thus requiring sunscreen and antioxidants for protection. Sunscreen absorbs or reflects UV rays, while antioxidants help increase antioxidant levels in skin tissues. Avocado seeds have potential as sunscreen and antioxidant agents, as the seed extract contains catechin, which can inhibit the enzymes tyrosinase, elastase, hyaluronidase, and collagenase. This study aims to determine the physical and chemical stability and the sunscreen and antioxidant activity of acetone avocado seed extract cream. The research stages included phytochemical screening, determination of total flavonoid content, antioxidant activity of the extract, cream formulation, physical and chemical stability tests, and sunscreen and antioxidant activity stability tests. The results showed that the extract tested positive for flavonoids, tannins, triterpenoids, phenols, and saponins. The extract's total flavonoid content and IC50 were 68.58±0.88 mg QE/100 g and 7.14 µg/ml, respectively. After six months of storage, there were changes in the color and spreadability of the cream. The spreadability significantly decreased from 50.87±3.17 to 35.21±2.09 g.cm/second, the total flavonoid content decreased from 9.16±0.27 to 4.48±0.16 mg QE/100 g, and the antioxidant activity significantly decreased from 7.41 to 18.72 µg/ml. Additionally, there was a significant increase in the SPF value from 1.62±0.01 to 1.87±0.06. Based on these results, the acetone avocado seed extract cream was unstable regarding physical, chemical, sunscreen, and antioxidant activity after six months of storage at room temperature. To improve the stability of the preparation, buffering in an acidic environment, adding antioxidants such as ascorbic acid, and storing at a cool temperature, are recommended.
Pemberdayaan masyarakat melalui pemanfaatan tanaman herbal sebagai obat rumahan dalam upaya peningkatan kesehatan keluarga Mendra, Ni Nyoman Yudianti; Suradnyana, I Gede Made; Juliadi, Debby; Wardani, I Gusti Agung Ayu Kusuma; Sari, Gusti Ayu Putu Laksmi Puspa
Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Vol 8 No 2 (2025): Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS)
Publisher : University of Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jipemas.v8i2.22713

Abstract

Lansia memiliki keterbatasan dalam konsumsi obat akibat penurunan fungsi organ, sehingga diperlukan alternatif yang lebih aman, seperti bahan alam. Beberapa tanaman herbal yang juga merupakan bumbu dapur, mengandung metabolit sekunder yang efektif sebagai analgetik dan antiinflamasi. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan keterampilan lansia dalam memanfaatkan bumbu dapur sebagai minyak gosok. Kegiatan ini mengadopsi metode Participatory Action Research (PAR), dengan melibatkan peserta secara aktif dalam identifikasi kebutuhan, pelatihan, dan praktik pembuatan sediaan. Kegiatan ini melibatkan 50 peserta yoga lansia dari komunitas Gumuh Ayu yang aktif berlatih yoga dan memiliki perhatian pada kesehatan. Selama kegiatan, peserta menunjukkan antusiasme tinggi dan berpartisipasi aktif. Evaluasi kegiatan melalui observasi menunjukkan peningkatan pengetahuan dan keterampilan peserta dalam meracik minyak gosok yang dapat diterapkan untuk kebutuhan pribadi maupun peluang usaha. Pendekatan integratif yang menggabungkan edukasi dan praktik pemanfaatan tanaman herbal berbasis komunitas ini terbukti efektif dan relevan diterapkan di kalangan lansia, terlebih lagi kegiatan berupaya sebagai peningkatan kesehatan keluarga. Program ini berpotensi berkelanjutan melalui integrasi dalam kegiatan rutin komunitas dan pengembangan produk berbasis tanaman herbal.
Formulasi dan Evaluasi Mutu Fisik Lip balm dari Ekstrak Kulit Buah Hylocereus lemairei dengan Variasi Konsentrasi Cera Alba Suena, Ni Made Dharma Shantini; Intansari, Ni Putu Ocha Indira; Suradnyana, I Gede Made; Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana
Usadha Vol 1 No 3 (2022): Usadha: Jurnal Integrasi Obat Tradisional
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/usadha.v1i3.5583

Abstract

Red dragon fruit skin (Hylocereus lemairei) contains flavonoid compounds (polyphenols), and vitamins C and E which play the main role as antioxidants, so they are good for moisturizing, nourishing, and maintaining skin health. Lip balm is a cosmetic preparation with main components such as waxes, fats, and oils from natural or synthesized extracts to prevent dryness by increasing lip moisture. The stability of preparation is very important in maintaining the physical quality of the preparation until it reaches the consumer. This study aims to determine the concentration of Cera alba as a stiffening agent needed to produce lip balm preparations of red dragon fruit skin extract (Hylocereus lemairei) with good physical quality. The response observed was the physical quality of the lip balm preparation which included organoleptic, homogeneity, pH, adhesion, and mechanical strength of the lip balm. Data analysis was carried out descriptively. This research begins with the extraction process of red dragon fruit skin using an ultrasonic wave-assisted maceration method using 96% ethanol and 1% HCl. In this study, a lip balm formulation was made from red dragon fruit peel extract with various concentrations of Cera alba 5% (F1), 10% (F2), and 15% (F3) as a stiffening agent. The resulting preparations were stored for 28 days, and their physical quality was observed. The results showed that lip balm preparations F3 produced good physical quality of lip balm preparations during storage. Dragon fruit peel extract can be properly formulated using Cera alba at a concentration of 15% to become a lip balm preparation that has high-quality physical characteristics and has the potential to be developed into a cosmetic preparation that is able to maintain skin moisture, especially the lips.
Co-Authors Aditya Putra, Aditya Anita Dewi, Ni Luh Kade Arman Apriliani, Wayan Debby Juliadi Dewi Agustini, Ni Putu Dewi, Ni Luh Samila Erna Cahyaningsih I Kadek Wirata I Komang Gede Mahardika Intansari, Ni Putu Ocha Indira Kusuma Yuda, I Putu Era Sandhi Kusuma Yuda, Putu Era Sandhi Megawati, Fitria Mendra, Ni Nyoman Yudianti Ni Made Dharma Shantini Suena Ni Made Dwi Mara Widyani Nayaka Ni Made Puspayanti, Ni Made Ni Made Sukma Sanjiwani Ni Putu Gek Dyah Citra Vitaloka Ni Putu Udayana Antari Nyoman Budiartha Siada Perayanthi, Reni Puspita Wati, Ni Putu Rahadi , I Wayan Surya RR. Asih Juanita Sari, Gusti Ayu Putu Laksmi Puspa Sugiyanto, Milyadi Tiarini, Diah Galuh Vernandes Sasadara, Maria Malida Wardani, I Gusti Agung Ayu Kusuma Wirata, I Kadek