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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Pharmaceutical Science and Technology MPI (Media Pharmaceutica Indonesiana) Pharmascience Jurnal Ilmiah Farmasi Farmasyifa Borneo Journal Of Pharmascientech SPIN: Jurnal Kimia & Pendidikan Kimia Lombok Journal of Science Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal Borneo Literasi: Jurnal Pengabdian Masyarakat dan Inovasi Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Jurnal Farmasi SYIFA Jurnal Farmasi dan Farmakoinformatika Borneo Journal of Pharmacy Jurnal Abdimas Multidisiplin Jurnal Pharma Bhakta Jurnal Sains dan Kesehatan
Astuti, Karunita Ika
Fakultas Farmasi, Universitas Borneo Lestari, Banjarbaru, Kalimantan Selatan, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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UJI TOKSISITAS AKUT EKSTRAK ETANOL 70% BUNGA TELANG (Clitoria ternatea L.) TERHADAP TIKUS BETINA GALUR WISTAR DENGAN METODE OECD 425 Sartika Dewi; Karunita Ika Astuti; Esty Restiana Rusida
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.10420

Abstract

Bunga telang (Clitoria ternatea L.) sebagai alternatif pengobatan penyakit degeneratif salah satunya untuk penurunan kadar glukosa dalam darah dan dalam pengembangannya sebagai obat, perlu dilakukan uji keamanan bahan alam dengan menguji toksisitas dari bunga telang. Penelitian ini untuk mengetahui gejala toksisitas dan nilai LD50 dengan metode OECD 425. Hewan uji tikus betina galur wistar dibagi menjadi kontrol negatif (Na-CMC) dan kelompok perlakuan (ekstrak etanol 70% bunga telang (Clitoria ternatea L.)) dengan dosis 2000 mg/kgBB. Hewan uji diamati gejala-gejala toksisitas meliputi berat badannya dan tanda toksisitas lainnya selama 14 hari. Pengamatan yang dilakukan meliputi tremor (gemetar), konvulsi (kejang), latergi (lesu), diare, koma dan mati. Hasil menunjukkan nilai LD50 ekstrak etanol 70% bunga telang (Clitoria ternatea L.) adalah >2000 mg/kgBB, berdasarkan klasifikasi BPOM termasuk dalam kategori 4 yaitu toksik ringan. Hasil pengamatan hewan uji tidak mengalami gejala-gejala toksisitas, dan tidak mengalami perubahan bermakna pada berat badan hewan uji pada kontrol negatif dan kontrol perlakuan (p>0,05)
UJI EFEKTIVITAS ANTIBAKTERI INFUSA DAUN SIRSAK TUA (Annona muricata L.) TERHADAP Propionibacterium acnes Fitriyanti; Ari Surya Pratama; Karunita Ika Astuti
Jurnal Penelitian dan Kajian Ilmiah Kesehatan Politeknik Medica Farma Husada Mataram Vol. 5 No. 2 (2019): JURNAL PENELITIAN DAN KAJIAN ILMIAH KESEHATAN POLITEKNIK MEDICA FARMA HUSADA MA
Publisher : Politeknik Medica Farma Husada Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.988 KB) | DOI: 10.33651/jpkik.v5i2.4

Abstract

Acne is a skin disease. One of the common bacteria that infects acne is Propionibacterium acnes. Natural ingredient that can be used to treat acne is Annona muricata L. leaves. This study aims to determine the compound content and effective concentration of antibacterial infusion of old Annona muricata L leaves against p.acnes bacteria. This research is experimental by using the liquid dilution method, solid dilution method, and the diffusion well method. The extraction method used in this study is an infusion. Infusion test solution using concentrations of 1.56%; 3.12%; 6.25%; 12.5%; 25%; 50%; 100%; and 200%. The results of this study are old Annona muricata L leaves infusion containing flavonoid compounds, saponins, and tannins. The results of the dilution test obtained the MIC value at a concentration of 25% and the MBC value was found at a concentration of 100%. In the dilution test the infusion of old Annona muricata L leaves infusion with concentrations of 100% and 200% has strong antibacterial activity and effective concentrations or MEC infusion and old Annona muricata L are found at concentrations of 100% with an average inhibition zone diameter of 11 mm (strong category).
Gambaran Penggunaan Obat Hipertensi pada Pasien Rawat Jalan di Puskesmas X Kabupaten Tanah Laut Kalimantan Selatan Karunita Ika Astuti; Uswatun Rahimah; Depy Oktapian Akbar
BORNEO JOURNAL OF PHARMASCIENTECH Vol 6 No 1 (2022): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v6i1.366

Abstract

Hypertension is one of the causes of early death when a concern all over the world which killed 8 million worldwide and almost 1.5 million people per year in the Southeast Asia region. The problem of hypertension will continue to develop if it is not handled properly it is estimated that 1.56 billion adults will be affected by hypertension in 2025. The purpose of this study is to find out the description of the use of hypertension drugs in one of Puskesmas in Tanah Laut from April to May 2019. This research was carried out observational with a cross sectional approach to 300 samples. Based on the gendre of the 300 prescriptions most women were 230 (77%) cases compared to men 70 (23%), the most prescribed drugs were in the age group 46-55 years had the largest number as hypertension sufferers with a percentage of 44 % or 132 patients, nifedipin (61%) 2,669 tablets and the number of patients 148 people (49%).
Uji Daya Hambat Ekstrak Etanol 96% Daun Jeruk Purut (Citrus Hystrix D.C. ) Terhadap Propionibacterium Acnes Fitriyanti Fitriyanti; Syaid Nofal Assegaf; Karunita Ika Astuti
BORNEO JOURNAL OF PHARMASCIENTECH Vol 6 No 2 (2022): Borneo Journal of Pharmascientech
Publisher : Universitas Borneo Lestari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v6i2.471

Abstract

Acne is a disease on the surface of the skin that often causes pain and leaves red, pus-filled spots. The plant that can be developed as an antibacterial is the citrus tribe which is also useful as a flavor enhancer in cooking, namely kaffir lime leaves (Citrus hystrix D.C). The purpose of this study was to test the activity of 96% ethanol extract of kaffir lime leaves against the inhibition of the acne-causing bacteria Propionibacterium acnes. In testing the antibacterial activity of this study using a good method. Based on the results of phytochemical screening, the extract was positive for flavonoids, saponins, tannins, and steroids. Based on the test results of measuring the diameter of the inhibition zone of kaffir lime leaf extract at a concentration of 100%; 80%; 60%; 40%; 20%; and 10% by 22.133 mm; 19,333 mm; 17,266 mm; 15,933 mm, 14.9 mm; and 12.133 mm. Data were analyzed using SPSS with Mann Whitney to obtain a significant value for each concentration variation, with a value of sig <0.05, which means that there are significant differences in each treatment group.
Activity of Kersen (Muntingia calabura L.) and Kasturi (Mangifera casturi Kosterm.) Extract as Afrodisiac Karunita Ika Astuti; Aristha N. Putri; Revita Saputri; Ika P. Sari; Teuku N.S. Sulaiman
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 2 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i2.37862

Abstract

Kasturi (Mangifera casturi Kosterm.) is a typical plant of South Kalimantan, and Kersen (Muntingiacalabura L) contains flavonoids and steroids was empirically used for aphrodisiac. However, nopreclinical trials using that extracts. This research to test the aphrodisiac activity to optimal dose isobtained and the possibility of a synergistic or toxic effect if the two extracts are combined. Thestudy aimed to determine of secondary metabolites and the aphrodisiac effect of extracts. The testused a completely randomized design into 8 groups. Parameters measured were frequency approach(introduction), riding (climbing), and mating (coitus). The results showed the Kasturi have of flavonoid,Steroid, and Phenol. Kersen extract have contained saponins, phenol, flavonoid, steroid. Kersen extract200 mg/kg BW dose shows the highest rather than the others. The combination of kersen and kasturiextracts of 100 mg/kgBW and 200 mg/kg BW doses did not show better effect when compared to asingle dose. It can be concluded that the aphrodisiac activity in the combination of kersen and kasturiextracts tends not synergis.
PERBANDINGAN KADAR GLUKOSA DARAH DAN HBA1C PADA INSULIN GLARGINE DAN DETEMIR PASIEN DIABETES MELITUS TYPE 2 DI RUMAH SAKIT UMUM DAERAH ULIN BANJARMASIN helmina wati; Karunita Ika Astuti; Syahrizal Ramadhani; Guntur Kurniawan; Aprilia Rahmadina; Sari Wahyunita
Jurnal Ilmiah Farmasi 2023: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2023.art5

Abstract

Background: Based on the International Diabetes Federation, the prevalence of diabetes in 2030 will be around 438 million people. In 2019, type 2 diabetes mellitus caused 4.2 million deaths in the world. Diabetes mellitus is a metabolic disorder that requires long-term therapy. Insulin is one of the therapies for type 2 diabetes mellitus. Parameters for monitoring the success of therapy were plasma glucose levels and Hba1c values.Objective: This study aimed to compare the values of plasma glucose and glycosylated hemoglobin (Hba1c) in insulin glargine and detemir patients with type 2 diabetes mellitus (DM) at Ulin Regional Public Hospital, Banjarmasin.Method: This study used a cross-sectional study design in March-May 2022 in 60 patients with type 2 DM at Ulin Regional Public Hospital, Banjarmasin. The data taken was in the form of fasting plasma glucose (FPG), 2-hour post-load plasma glucose (OGTT), and Hba1c values for 12 weeks. Statistical analysis was performed using the Mann-Whitney test with a confidence level of 95%. Results: The results showed that the average pre-post glargine FPG values were 212-139,6 mg/dL and the pre-post detemir FPG values were 224.6-159.8 mg/dL. Hba1c values in patients using glargine pre-post were 9.1% and 8.3%, and the average Hba1c values on insulin detemir pre-post were 9.28% and 8.29%.Conclusion: In therapy using insulin glargine compared to detemir, there was no significant difference between KGDP, KGD2PP, and Hba1C (p> 0.05). Intisari Latar belakang: Berdasarkan International Diabetes Federation (IDF), prevalensi DM tipe 2 tahun 2030 berkisar 438 juta orang. Pada tahun 2019, DM tipe 2 menyebabkan 4,2 juta kematian di dunia. Diabetes mellitus merupakan penyakit gangguan metabolisme yang membutuhkan terapi jangka panjang, dan insulin merupakan salah satu terapi DM tipe 2. Parameter untuk monitoring keberhasilan terapi dapat dilihat berdasar nilai kadar glukosa darah dan nilai Hba1c. Tujuan: Membandingkan nilai Kadar Glukosa Darah Puasa (KGDP), Kadar Glukosa Darah 2 jam Post Prandial (KGD2PP), dan Hba1c pada insulin glargine dan insulin detemir pasien DM tipe 2 di Rumah Sakit Umum Daerah (RSUD) Ulin, Banjarmasin.Metode: Penelitian menggunakan rancangan cross sectional selama bulan Maret-Mei 2022 pada 60 pasien rawat jalan DM tipe 2 di RSUD Ulin Banjarmasin. Data yang diambil berupa nilai KGDP, KGD2PP dan Hba1c selama 12 minggu. Analisis statistik dilakukan menggunakan analisis mann-whitney test dengan tingkat kepercayaan 95%. Hasil: Hasil penelitian menunjukkan nilai rata-rata nilai KGDP glargine pre-post adalah 212 – 139,6 mg/dL dan nilai KGDP detemir pre-post adalah 224,6 – 159,8 mg/dL. Hba1c pada pasien yang menggunakan glargine pre-post adalah 9,1% dan 8,3% serta rata-rata nilai Hba1c pada insulin detemir pre-post adalah 9,28% dan 8,29%.Kesimpulan: Terapi menggunakan insulin glargine dibandingkan detemir tidak terdapat perbedaan yang signifikan antara nilai KGDP, KGD2PP, dan Hba1C p>0,05).Kata kunci: KGDP, KDG2PP, Hba1c, glargine, detemir
EFEKTIVITAS KOMBINASI EKSTRAK ETANOL 70% DAUN RAMANIA (Bouea macrophylla Griffith) dan GLIBENKLAMID DENGAN METODE INTOLERANSI GLUKOSA Karunita Ika Astuti; Fitriyanti Fitriyanti; Hadirvika Tjuthiyanda
Jurnal Ilmiah Farmasi 2023: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2023.art4

Abstract

Background: Diabetes mellitus is a chronic disease in which the body cannot produce insulin effectively. Glibenclamide is often used either in single preparations or in combination. Ramania (Bouea macrophylla Griffith) is one of the typical Kalimantan plants for diabetes treatment.Objective: Determine the best concentration of a combination of the extract of ramania leaves with glibenclamide as an antidiabetic.Method: This study used the oral glucose tolerance test (OGTT). Twenty-four mice were divided into six groups: a negative control (Na-CMC0.5%), a glucose control, a positive control (glibenclamide 5 mg/kgBW), and a combination group of 70% ethanol extract of ramania leaves (125, 250, and 500 mg/kgBW) with glibenclamide 5 mg/kgBW. Mice were induced by oral glucose to experience hyperglycemia. The results were measured at 0 minutes before treatment and at 30, 60, 90, and 120 minutes.Results: A combination extract of ramania leaves and glibenclamide with doses of 25 and 500 mg had an effect on glucose-induced male white mice.Conclusion: The best combination dose of 500 mg of extract and glibenclamide was obtained. Intisari Latar belakang: Diabetes Melitus merupakan kondisi kronis yang disebabkan kurang efektifnya insulin bekerja. Glibenklamid merupakan salah satu obat antidiabetes oral yang sering digunakan baik dalam sediaan tunggal ataupun kombinasi. Ramania (Bouea macrophylla Griffith) merupakan tanaman khas Kalimantan yang dapat digunakan sebagai pengobatan diabetes. Tujuan: Mengetahui konsentrasi terbaik dari kombinasi ekstrak etanol 70% daun ramania dengan glibenklamid sebagai antidiabetes. Metode: Uji yang digunakan dalam penelitian ini adalah uji toleransi glukosa oral (UTGO). Hewan uji menggunakan mencit putih jantan yang dibagi menjadi enam kelompok, yaitu kelompok kontrol (Na-CMC 0,5%), kontrol positif (glibenklamid 5 mg/kg BB), kelompok kombinasi ekstrak etanol 70% daun ramania 125; 250; dan 500 mg/kgBB - glibenklamid 5 mg/kg BB. Mencit pada semua kelompok diinduksi glukosa secara oral agar mengalami hiperglikemia. Kadar glukosa darah ditentukan pada menit ke-0, 30, 60, 90, 120 setelah induksi glukosa. Selanjutnya dilakukan perhitungan nilai AUC0-120 serta dianalisis dengan menggunakan SPSS bertaraf kepercayaan 95%.Hasil: Semua kelompok dosis kombinasi ramania-glibenklamid menunjukkan tidak adanya perbedaan bermakna dengan kontrol positif sehingga berdasarkan nilai AUC0-120 menunjukkan kombinasi ekstrak dan glibenklamid dengan dosis 125 mg/KgBB memberikan efek antihiperglikemik terbaik.Kesimpulan: Diperoleh kombinasi terbaik dengan dosis 125 mg/KgBB yang dikombinasikan dengan glibenklamid.Kata kunci : Ramania, antidiabetes, intoleransi glukosa, kombinasi, glibenklamid
PENGARUH TOGA (TANAMAN OBAT KELUARGA) SEBAGAI TERAPI PENDAMPING HIPERTENSI BERDASARKAN OUTCOME TERAPI HIPERTENSI DI UPTD PUSKESMAS TELANG SIONG Monalissa Indriani; Karunita Ika Astuti; Revita Saputri
Jurnal Farmasi dan Farmakoinformatika Vol 2, No 1 (2024)
Publisher : Universitas Gunadarma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35760/jff.2024.v2i1.9188

Abstract

Pelayanan Kesehatan Tradisional menyatakan bahwa masyarakat Indonesia dapat memanfaatkan TOGA (Tanaman Obat Keluarga) pada pengobatan hipertensi yang merupakan salah satu kegiatan program kesehatan yang ada di UPTD Puskesmas Telang Siong. Penelitian ini bertujuan untuk mengetahui pengaruh TOGA (Tanaman Obat Keluarga) sebagai terapi pendamping hipertensi berdasarkan Outcome tekanan darah. Desain penelitian adalah Post-test Only Control Group Design. Sampel penelitian menggunakan rumus Slovin diperoleh 94 sampel. Penelitian dilakukan dengan mengambil data tekanan darah pasien hipertensi pada Rekam Medis UPTD Puskesmas Telang Siong yang diperoleh dari pengukuran lansung menggunakan tensimeter/sphygmomanometer dan stetoskop. Selanjutnya data penggunaan TOGA (Tanaman Obat Keluarga) diperoleh dari hasil wawancara pasien yang sudah menandatangani informed consent. Hasil penelitian diperoleh data pasien penderita hipertensi yang menggunakan obat hipertensi tunggal mengalami penurunan tekanan darah menjadi normal (< 140/90 mmHg) yaitu dari pasien 54 orang penderita hipertensi menjadi 18 orang (33,3 %). Sedangkan yang menggunakan obat dan TOGA (Tanaman Obat Keluarga) sebagai terapi pendamping hipertensi mengalami penurunan tekanan darah menjadi normal (< 140/90 mmHg) yaitu dari 40 orang penderita hipertensi menjadi 22 orang (55%). Hasil uji wilcoxon diperoleh nilai signifikansi < 0.05 berarti ada pengaruh TOGA (Tanaman Obat Keluarga) terhadap terapi hipertensi.
Antidiarrheal Activity of Ethanolic Extract of Vernonia amygdalina Del Leaves againts Male Mice Induced by Oleum Ricini Karunita Ika Astuti; Lusiana Dwi Wulandari; Eka Fitri Susiani
Borneo Journal of Pharmacy Vol. 2 No. 1 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i1.707

Abstract

Leaves of Vernonia amygdalina Del. is one of the alternative plants that people use as antidiarrheal in Martapura, Banjar. The purpose of research to determine the antidiarrheal activity and the effectiveness of ethanolic extract of leaves against male mice. The negative control was given NaCMC 0.5% orally, positive control was given Loperamide HCl 0.005 mg/20 g orally, and groups of ethanolic extract of leaves were given dosages in 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW orally. After 1 hour of treatment, the groups were induced by Oleum ricini orally and were observed for 4 hours. Based on three parameters were frequency, weight, and consistency of diarrhea. From the results observation of that negative control, positive control, EEDA 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW for diarrhea frequency parameter was 7.4 ± 2.30; 2 ± 1.22; 5.8 ± 3.34; 6.2 ± 4.08; 2.4 ± 1.67; the weight parameter was 1.34 ± 0.43; 0.38 ± 0.29;0.66 ± 0.56; 0.57 ± 0.38; 0.49 ± 0.33 and then consistency of diarrhea with EEDA 400 mg/kg BW improved the consistency at 180 minutes compared to control group at 210 minutes. In conclusion, from all parameters of ethanolic extract of Vernonia amygdalina Del. leaves can give an antidiarrhea effect with optimum dosage is 400 mg/kg BW.
Antibacterial Activity Test of Ethanol Extract Pineapple (Ananas comosus (L.) Merr.) Peel against Growth of Propionibacterium acnes Fitriyanti Fitriyanti; Muhammad Nur Rahman Hendrawan; Karunita Ika Astuti
Borneo Journal of Pharmacy Vol. 2 No. 2 (2019): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v2i2.928

Abstract

Pineapple peel (Ananas comosus (L.) Merr.) is waste from the pineapple fruit. The purpose of this study was to determine the content of pineapple peel extract and to antibacterial activity in various concentrations effective in inhibiting the growth of Propionibacterium acnes. The pineapple peel extract is made by using the extraction method in the form of maceration. The method used in the inhibitory test using the three replication samples in each treatment group. The sample consisted of 10 treatment groups ie pineapple peel extract concentration 12.5%, 25%, 37.5%, 50%, 62.5%, 75%, 87.5%, and 100%, as well as positive and negative control. The results obtained from pineapple peel screening contain flavonoid and saponin compounds. The data analysis shows that pineapple peel extract concentrations of 50%, 62.5%, 75%, 87.5%, and 100% had inhibitory zones with the medium-strong category while clindamycin as the control has a strong inhibition zone. The conclusion of this research proves that pineapple peel extract has antibacterial power to P. acnes with effective concentration is 100% with the strong category.
Co-Authors Aditya Noviadi Agung Biworo Akbar, Depy Oktapian Akhmad Junaidi Alista, Siti Aprilia Rahmadina Ari Surya Pratama Aristha N. Putri Baiq Nurdiana Ulfa Bella Rosalina Endah Dharmayati, Evy Eka Fitri Susiani fitriyanti fitriyanti Fitriyanti, Fitriyanti Guntur Kurniawan Hadirvika Tjuthiyanda Helmina Wati Hendrya Legenda Herliana Dewi Hidayati, Listya Nor Ika P. Sari Khoerul Anwar Lusiana Dwi Wulandari Mariani Monalissa Indriani Muhammad Hidayatullah Muhammad Nazhir Muhammad Nur Rahman Hendrawan Norhasanah Norhasanah Nur Huda Nurul Hikmah Pangestika, Indira Adi Rahmatullah, Satrio Wibowo Rahmi Muthia Rizaldi, Gusti Rusida, Esty Restiana Sandi, Dita Ayulia Dwi Saputri, Revita Sari Wahyunita Sartika Dewi Sunarti, Lisa Syahrizal Ramadhani Syaid Nofal Assegaf Teuku N.S. Sulaiman Uswatun Rahimah Vebruati Vebruati Wahyudin Wahyudin