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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Global Health Management Journal PREPOTIF : Jurnal Kesehatan Masyarakat Tunas Medika Jurnal Kedokteran & Kesehatan Indonesian Journal of Applied Research (IJAR) JPM: JURNAL PENGABDIAN MASYARAKAT PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) International Journal of Health and Pharmaceutical (IJHP) Jurnal Sehat Indonesia (JUSINDO) InaBHS (Indonesian Journal of Biomedicine and Health Science)
Marfuati, Sri
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Journal : global health management journal

 1 
Effectiveness of Gedong Gincu Mango Leaf Extract Gel (Mangifera indica L. var. Gedong gincu) on Cut Wound Healing in Male White Rats (Rattus norvegicus) of the Wistar Strain Loren, Azzahro Maharani; Wirandoko, Ignatius Hapsoro; Marfuati, Sri
GHMJ (Global Health Management Journal) Vol. 7 No. 3s (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-741041

Abstract

Background: The Indonesia Basic Health Research data show the prevalence of wounds including incision/scratches/stab wounds reaches 20.1%. Natural herbal products play an important role in the wound healing process functioning as anti-inflammatories, antioxidants, antimicrobials, and collagen formation. Mango leaves are often considered waste even though they have many health benefits with the high content of coactive compounds, such as alkaloids, flavonoids, tannins, and saponins which are good for cut wound healing. The use of gel is more stable and controlled release compared to other topical preparations. Gedong Gincu mangoes originating from West Java have unique properties and they are marketed widely in some areas including Cirebon. Aims: This study aims to identify the most effective concentration of Gedong Gincu mango leaf extract on cut wound healing in male white rats (Rattus norvegicus) of the Wistar Strain. Methods: This study used a post-test-only control group design. The extract gel used three levels of concentration, namely 40%, 50%, and 60%. The positive control used 10% povidone iodine while the negative control used a gel base. The gel was applied to the cut wound twice a day for 14 days. Results: The average length of the cut wound was 0.916 cm, 0.912 cm, and 1.050 cm for concentration levels of 40%, 50%, and 60%. For the positive and negative controls, it reached 0.996 cm and 0.702 cm respectively. This indicates no significant difference in the length of the cut wound with a p-value of 0.121 (p>0.05). The wound healing process was effective at a concentration level of 60% as indicated by the disappearance of erythema and edema. Conclusion: Mango leaf extract gel (Mangifera indica L.var. Gedong Gincu) is effective in healing cut wounds with the disappearance of erythema and edema in male white rats (Rattus norvegicus) Wistar strain with a concentration of 60%. Received: 25 September 2024  |  Reviewed: 19 October 2024  |  Revised: 30 November 2024  |  Accepted: 15 December 2024.
The Relationship between Characteristics with Medication Adherence and Quality of Life among the Pulmonary Tuberculosis Patients at the Cirebon City Community Lung Health Center, Indonesia Dewi, Asri Permata; Zaidah, Niklah; Marfuati, Sri
GHMJ (Global Health Management Journal) Vol. 8 No. 3 (2025)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-831245

Abstract

Background: Tuberculosis (TB) is one of the top ten causes of death worldwide, caused by the Mycobacterium tuberculosis germ. Adherence to medication is a key factor in successful treatment and efforts to improve the quality of life of TB patients. Aims: Analyzing the relationship between characteristics with medication adherence and quality of life of pulmonary TB patients at the Cirebon City Community Lung Health Center. Methods: This study used an analytic observation method with a Cross Sectional design. The measuring instruments used were medical records and questionnaires that had been tested for validity and reliability, with a total of 131 respondents of pulmonary TB patients at the Cirebon City Community Lung Health Center (BKPM). Results : The most common characteristics were adult age 90.8%, female gender 56.5%, secondary education 50.4%, student 28.2%, length of treatment at the advanced stage 59.5%, adherent to taking medication 87.0%, good quality of life 54.2%. Based on the Chi-Square test, the relationship between characteristics and drug compliance from age p-value=0.189, gender p-value=0.320, education p-value=0.447, occupation p-value=0.594, length of treatment p-value=0.014. The relationship between characteristics and quality of life from age p-value=0.688, gender p-value=0.550, education p-value=0.838, occupation p-value=0.519, length of treatment p-value=0.604. Based on the logistic regression test, the relationship between characteristics and drug compliance from age p-value=0.058, length of treatment p-value=0.006. Conclusion: There is no relationship between age, gender, education, and occupation with medication adherence (p>0.05). Whereas in the length of treatment there is a relationship with adherence to taking medication. There is no relationship between characteristics and quality of life of pulmonary TB patients (p>0.05). The characteristic most associated with adherence to taking medication is length of treatment (p=0.006). Future researchers are advised to explore other factors that may be related to medication adherence and quality of life in patients with pulmonary TB.
Improving Pulmonary Tuberculosis Treatment Adherence: The role of patient knowledge in Cirebon, West Java, Indonesia Marfuati, Sri; Fitriani, Hikmah; Weni, Mustika; Riawan, Firanda Putri
GHMJ (Global Health Management Journal) Vol. 7 No. 2 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-72987

Abstract

Background: With 10 million cases around the world, pulmonary tuberculosis (TB) has been classified as a highly contagious disease and mostly affecting low and middle countries. Having the second highest incident cases in West Java of Indonesia, Cirebon becomes a challenging city in order to reduce the number of TB cases in the country. Aims: This study aims to identify the patients’ knowledge and treatment phases, and how the two factors encourage patients to comply with their medication. Methods :  This cross-sectional observational study was conducted among 91 new pulmonary tuberculosis patients at the Cirebon City Community Lung Health Centre, selected using random sampling. Not only respondent characteristics, but also data on the patients' knowledge levels, treatment phases, and medication adherence were collected using a questionnaire and medical records. To assess the relationship between these variables, the collected data was then analyzed using the Spearman Correlation test. Ethical clearance was obtained from the Health Research Ethics Commission, and informed consent was gathered from all participants. Results: This study reveals the most updated characteristics of the Tuberculosis patients at the Cirebon City Community Lung Health Center aged 15-64 years old with treatment duration ranged 1-6 months. The majority have insufficient knowledge about tuberculosis (45.1%), and 75.8% of patients adhered to their prescribed medication regimen, regardless of their knowledge level. The data indicates a significant positive correlation between knowledge level and medication adherence (p = 0.015), with 95% of patients with good knowledge adhering to treatment compared to only 34% with poor knowledge. Furthermore, there is a significant relationship between adherence and treatment duration (p = 0.002), as 85% of patients who adhered to treatment did so for more than two months. Conclusion: The study shows that patients with better knowledge of tuberculosis are more likely to stick to their medication, which also leads to longer treatment durations. Given the high incidence of TB in the region, these findings suggest the need for targeted educational programs to enhance patients' understanding of TB, thereby improving adherence to treatment protocols. Received: 20 May 2024, Reviewed: 09 June 2024, Revised: 26 August 2024, Accepted: 30 August 2024.
Effectiveness of Mango Gedong Gincu Peel Extract Gel (Mangifera indica L.) on Cut Wounds in Male Wistar White Rats (Rattus norvegicus) Fathunnisa, Firda; Marfuati, Sri; Fitriani, Hikmah
GHMJ (Global Health Management Journal) Vol. 7 No. 3 (2024)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-731060

Abstract

Background: A wound is an injury to a part of the body where the skin and the underlying tissue lose continuity. The wound healing is a complex process consisting inflammatory phase, proliferation phase, and maturation phase. Open wounds often occur in everyday life and if left behind and untreated can potentially lead to bacterial infection. Mango gedong gincu peel extract (Mangifera indica L.) contains flavonoids, tannins, phenols, triterpenoids, steroids, alkaloids, and saponins which have roles in wound healing. Aims: To analyses the effectiveness of mango gedong gincu peel extract gel (Mangifera indica L.) against the healing of cut wounds in male wistar white rats (Rattus norvegicus). Methods: The study was an experimental study with a post-test only control group design using 25 male wistar white rat as the subject and was carried out in the FK UGJ Research Laboratory. The study used five groups : negative control group, positive control group, and treatment group using mango gedong gincu peel extract gel (Mangifera indica L.) with concentrations of 5%, 10%, and 15%. Results: The results of the study revealed that mango (Mangifera indica L.) gedong gincu peel is a source of various phytochemical such as flavonoids, tannins, phenols, triterpenoids, steroids, alkaloids, and saponins. This study showed that the 5% and 10% concentration treatment groups had the same average length measurement wound of 0.86 cm. The fastest observation of erythema was the 5% concentration group with a healing rate of 8 days, in the observation of edema the 10% concentration group was the fastest of 6 days, and the observation long of healing time was 5% and 10% concentration had the same rate of 11 days. Conclusion: Mango gedong gincu peel extract gel (Mangifera indica L.) was effective against wound healing with optimum concentrations of 5% and 10% which gives the best healing effect against wounds in male wistar white rats (Rattus norvegicus). Received: 25 September 2024  |  Reviewed: 22 October 2024  | Revised: 05 November 2024  |  Accepted: 09 November 2024.
The Antibacterial Activity Test using Ethyl Acetate Fraction from Kersen Leaves (Muntingia calabura L.) against the Staphylococcus aureus Fadilah, Mutiara; Weni, Mustika; Marfuati, Sri
GHMJ (Global Health Management Journal) Vol. 9 No. 1 (2026)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-911232

Abstract

Background: Staphylococcus aureus is a common cause of skin and soft tissue infections (pyoderma) and has developed resistance to multiple antibiotics. Kersen (Muntingia calabura L.) leaves contain bioactive compounds such as flavonoids, triterpenoids, steroids, tannins, and saponins, which have been reported to possess antibacterial properties. Aim: This study aimed to evaluate the in vitro antibacterial activity of the ethyl acetate fraction of M. calabura leaves against S. aureus. Methods: An experimental study with a post-test-only control group design was conducted. Phytochemical screening was performed to identify the secondary metabolites present in the fraction. Antibacterial testing was done using the well diffusion method on Mueller-Hinton Agar (MHA). Five treatment groups (ethyl acetate fractions at concentrations of 100%, 60%, 20%, 10%, and 1%) were compared to a negative control (10% DMSO) and a positive control (doxycycline). Inhibition zones were measured manually in millimeters and analyzed using one-way ANOVA (p < 0.05). Results: The ethyl acetate fraction demonstrated a concentration-dependent antibacterial effect. Mean ± SD inhibition zones were 17.20 ± 1.92 mm (100%), 12.94 ± 1.13 mm (60%), 7.99 ± 0.70 mm (20%), 7.34 ± 0.35 mm (10%), and 6.71 ± 0.85 mm (1%). The positive control showed a significantly higher inhibition zone (33.82 ± 1.62 mm), while the negative control showed no inhibition. Phytochemical screening of the kersen leaf ethyl acetate fraction includes tannins, saponins, steroids, triterpenoids, and phenolics. Conclusion: The ethyl acetate fraction of M. calabura leaves exhibited antibacterial activity against S. aureus. These findings support its potential development as a plant-based antibacterial agent, although further in vivo studies are needed.
Co-Authors Abda Abda Amal, Ichlasul Apriyanto, Dadan Ramadhan Dewi, Asri Permata Emallia Fitriani Fadilah, Mutiara Fathunnisa, Firda Fauzah, Shofa Nur Hery Widijanto Hikmah Fitriani Ignatius Hapsoro Wirandoko Istiharah, Sherin Nadia Istisakinah, Rini Januar, Henny Sholihat Loren, Azzahro Maharani Nasution, Aulia Ananta Nur Aisyah, Tiara Nurbaiti Putri, Inayati Diana Rafsanjani, Ali Rafi Rama Samara Brajawikalpa Riawan, Firanda Putri Thysa Thysmelia Affandi Weni, Mustika Witri Pratiwi Zaidah, Niklah